Benzalkonium Chloride: A Bronchoconstricting Preservative in Continuous Albuterol Nebulizer Solutions.

abstract：STUDY OBJECTIVE:To categorize institutional review board (IRB) challenges and solutions encountered in a multicenter practice-based research network (PBRN) study and to assess the impact of IRB requirements on the willingness of individual principal investigators (PIs) to participate in future PBRN studies. DESIGN:Des...

journal_title：Pharmacotherapy

authors： Maclaughlin EJ,Ardery G,Jackson EA,Ives TJ,Young RB,Fike DS,Carter BL

更新日期：2013-09-01 00:00:00

abstract：:Antiretroviral therapy has significantly improved the typical course of human immunodeficiency virus (HIV) infection in industrialized nations, and life expectancies associated with the infection have increased. However, infection rates have generally remained unchanged, with increases noted among certain subpopulatio...

journal_title：Pharmacotherapy

authors： Romanelli F,Murphy B

更新日期：2010-10-01 00:00:00

abstract：:Stroke is the third most common cause of death in the United States and is the number one cause of long-term disability. Legislative mandates, largely the result of the American Heart Association, American Stroke Association, and Brain Attack Coalition working cooperatively, have resulted in nationwide standardization...

journal_title：Pharmacotherapy

authors： Baldwin K,Orr S,Briand M,Piazza C,Veydt A,McCoy S

更新日期：2010-05-01 00:00:00

abstract：:The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...

journal_title：Pharmacotherapy

authors： Bailie GR,Uhlig K,Levey AS

更新日期：2005-04-01 00:00:00

abstract：:Atherosclerosis, the great killer of Western society, probably is initiated when the balance of subendothelial lipoproteins and oxidation potential is upset. Oxidation products, especially oxidized low-density lipoprotein, set into motion the cascading of numerous pathways, culminating in the fibrous atherosclerotic p...

journal_title：Pharmacotherapy

authors： Meyers DG,Maloley PA

更新日期：1993-11-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the prevalence of hyperlipidemia and the effectiveness of hyperlipidemia management in a large population of transplant recipients. A secondary objective was to assess the effect of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III guidelines on hyperlipidemia man...

journal_title：Pharmacotherapy

authors： Schonder KS,McKaveney TP,Lynch KJ

更新日期：2005-07-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...

journal_title：Pharmacotherapy

authors： DeRonde KJ,Girotto JE,Nicolau DP

更新日期：2018-10-01 00:00:00

abstract：:Torsades de pointes is a polymorphic ventricular tachycardia characterized by marked QT prolongation on the electrocardiogram. It can be induced by both antiarrhythmic and nonantiarrhythmic drugs, such as quinidine and erythromycin. No extensive literature documents an interaction between quinidine and erythromycin wh...

journal_title：Pharmacotherapy

authors： Lin JC,Quasny HA

更新日期：1997-05-01 00:00:00

abstract：:Abstract Cetuximab and panitumumab, monoclonal antibodies used to target the epidermal growth factor receptor (EGFR), were recently approved by the United States Food and Drug Administration for use as single agents or in combination with other chemotherapy drugs in the treatment of metastatic colorectal cancer. The a...

journal_title：Pharmacotherapy

authors： Patel DK

更新日期：2008-11-01 00:00:00

abstract：:A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...

journal_title：Pharmacotherapy

authors： Havrda DE,Rathbun S,Scheid D

更新日期：2001-03-01 00:00:00

abstract：:Neuroleptic malignant syndrome (NMS) is an idiosyncratic and uncommon but serious adverse effect that has been reported with both typical and atypical antipsychotic agents. We describe a 58-year-old man with Down syndrome and dementia who was receiving low-dose olanzapine and rivastigmine therapy; he developed NMS 4 m...

journal_title：Pharmacotherapy

authors： Stevens DL,Lee MR,Padua Y

更新日期：2008-03-01 00:00:00

abstract：STUDY OBJECTIVE:To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN:Prospective follow-up study. DATA SOURCE:General practitioners' computerized patients records (intervention ...

journal_title：Pharmacotherapy

authors： van der Elst ME,Bouvy ML,de Blaey CJ,de Boer A

更新日期：2006-02-01 00:00:00

abstract：:We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed dif...

journal_title：Pharmacotherapy

authors： Desai KR,Burdette SD,Polenakovik HM,Hagaman J,Pleiman CM

更新日期：2013-07-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the appropriate compartmental and noncompartmental pharmacokinetic parameters for intravenous piperacillin and tazobactam. DESIGN:Sequential selection of patients entered into a randomized, open-label clinical efficacy trial. SETTING:Los Angeles County-University of Southern California Me...

journal_title：Pharmacotherapy

authors： Jhee SS,Kern JW,Burm JP,Yellin AE,Gill MA

更新日期：1995-07-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GMCSF) is a hematopoietic protein that has been studied both in vitro and in vivo in human immunodeficiency virus (HIV) infection. Since both HIV infection primarily and zidovudine (formerly AZT) treatment secondarily may result in neutropenia, administration of GMCSF ...

journal_title：Pharmacotherapy

authors： Hewitt RG,Morse GD

更新日期：1992-01-01 00:00:00

abstract：:Ziconotide intrathecal infusion was recently approved by the United States Food and Drug Administration for the treatment of intractable severe chronic pain. Patients with neuropathic pain make up a significant population among those who experience chronic pain for which there are less than optimal pharmacotherapeutic...

journal_title：Pharmacotherapy

authors： Wermeling DP,Berger JR

更新日期：2006-03-01 00:00:00

abstract：:In an open-label study of alprazolam in five bipolar-I depressed patients, three patients remitted completely, one failed to respond, and one responded transiently, based on the Hamilton Rating Scale and Beck Depression Inventory scores. Further studies of alprazolam as an antidepressant are warranted. ...

journal_title：Pharmacotherapy

authors： Rush AJ,Schlesser MA,Erman M,Fairchild C

更新日期：1984-01-01 00:00:00

abstract：STUDY OBJECTIVES:To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension, to compare the characteristics of patients who withdrew with those of patients who completed the study, and...

journal_title：Pharmacotherapy

authors： Rozenfeld Y,Hunt JS

更新日期：2006-11-01 00:00:00

abstract：:Evidence and inferences from clinical research, clinical observation, and literature review support an etiologic paradigm for the pathophysiology of spinal cord injury (SCI). According to this paradigm, changes in immunoregulation and in the activation of cytokines or intercellular adhesion molecules (ICAMs) contribut...

journal_title：Pharmacotherapy

authors： Segal JL

更新日期：2005-02-01 00:00:00

abstract：:Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP Pediatrics PRN) released an opinion paper in 2005 with recommendations for improving the quality and quantity of pediatric pharmacy education in coll...

journal_title：Pharmacotherapy

authors： Bhatt-Mehta V,Buck ML,Chung AM,Farrington EA,Hagemann TM,Hoff DS,LaRochelle JM,Pettit RS,Phan H,Potts AL,Smith KP,Parrish RH 2nd

更新日期：2013-02-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did no...

journal_title：Pharmacotherapy

authors： Shields SA,Gregor KJ,Young CH,James SP

更新日期：1998-11-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the hemodynamic and electrocardiographic effects of a single dose of commercially available bitter-orange dried-fruit extract, which is increasingly being used in dietary supplements. DESIGN:Randomized, double-blind, placebo-controlled, crossover study. SETTING:University of Connecticut, S...

journal_title：Pharmacotherapy

authors： Min B,Cios D,Kluger J,White CM

更新日期：2005-12-01 00:00:00

abstract：:Infections caused by yeasts and molds continue to be associated with high rates of morbidity and mortality in both immunocompromised and immunocompetent patients. Many antifungal drugs have been developed over the past 15 years to aid in the management of these infections. However, treatment is still not optimal, as t...

journal_title：Pharmacotherapy

authors： Mohr J,Johnson M,Cooper T,Lewis JS,Ostrosky-Zeichner L

更新日期：2008-05-01 00:00:00

abstract：:We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total...

journal_title：Pharmacotherapy

authors： Ross SD,Akhras KS,Zhang S,Rozinsky M,Nalysnyk L

更新日期：2001-08-01 00:00:00

abstract：:Cyclosporine can be given intravenously or orally, as a solution or soft gelatin capsule. Because of the drug's poor water solubility, ethoxylated plant fats and ethanol are added to the commercially available dosage forms. ...

journal_title：Pharmacotherapy

authors： Yee GC

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Anticoagulation monitoring during transition from direct oral anticoagulants (DOAC) to heparin infusions is a significant challenge. Factor Xa inhibitors influence the heparin calibrated antifactor Xa assay. The University of Virginia (UVA) Medical Center utilized a corrected antifactor Xa assay (c-AXA) duri...

journal_title：Pharmacotherapy

authors： Plum MD,Hedrick JN,Hockman R,Bazydlo L,Palkimas S

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic data show reduced mycophenolic acid levels in renal transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. This reduced exposure could increase rejection risk. The typical initial MMF dose post renal transplantation is 2 g/day, which often re...

journal_title：Pharmacotherapy

authors： Patel KS,Stephany BR,Barnes JF,Bauer SR,Spinner ML

更新日期：2017-12-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the safety and efficacy of rabbit antithymocyte globulin (r-ATG) with basiliximab in renal transplant recipients for whom an early steroid withdrawal (ESW) regimen was planned. DESIGN:Single-center, retrospective, cohort study. SETTING:Tertiary care medical center, including inpatient hospi...

journal_title：Pharmacotherapy

authors： Martin ST,Roberts KL,Malek SK,Tullius SG,Vadivel N,De Serres S,Grafals M,Elsanjak A,Filkins BA,Chandraker A,Gabardi S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is a centrally acting α-2 receptor agonist used to maintain light analgosedation in mechanically ventilated adults. This study was conducted to determine factors predictive of successful maintenance of light sedation (Richmond Agitation-Sedation Scale (RASS) 0 to -2) for ≥60% of the first 48 ...

journal_title：Pharmacotherapy

authors： DiCesare MA,Rech MA,DeMott JM

更新日期：2021-01-09 00:00:00