Abstract:
:Torsades de pointes is a polymorphic ventricular tachycardia characterized by marked QT prolongation on the electrocardiogram. It can be induced by both antiarrhythmic and nonantiarrhythmic drugs, such as quinidine and erythromycin. No extensive literature documents an interaction between quinidine and erythromycin when the agents are administered orally. A 95-year-old man received oral quinidine and erythromycin for the treatment of atrial fibrillation and community-acquired pneumonia. He developed torsades de pointes and subsequently cardiac arrest. Since erythromycin and quinidine are known to cause arrhythmias individually, caution and close monitoring are necessary when the drugs are administered concomitantly.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Lin JC,Quasny HAsubject
Has Abstractpub_date
1997-05-01 00:00:00pages
626-30issue
3eissn
0277-0008issn
1875-9114journal_volume
17pub_type
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