Abstract:
STUDY OBJECTIVE:To determine rates of drug-induced, rare, serious adverse events affecting the liver, kidneys, skin, or blood, occurring within 45 days of completing a prescription or refill for itraconazole or fluconazole. DESIGN:Population-based follow-up study SETTING:United Kingdom-based General Practice Research Database. PATIENTS:Total of 54,803 users of either fluconazole or itraconazole. MAIN RESULTS:Four patients were identified with illnesses for which a drug-induced etiology could not be ruled out; one with an elevated liver function test while taking itraconazole, one with thrombocytopenia, one with neutropenia, and one with an abnormal liver function test just after receiving fluconazole. For itraconazole the rate was 3.2/100,000 prescriptions (95% confidence interval [CI] 0.6-17.9) for serious, adverse liver events; for fluconazole 2.8/100,000 prescriptions (95% CI 0.8-10.3) for serious, adverse blood events and 1.4/100,000 prescriptions (95% CI 0.25-8.2) for serious, adverse liver events. CONCLUSION:Itraconazole and fluconazole do not commonly cause rare, serious adverse events affecting the liver, kidneys, skin, or blood.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Bradbury BD,Jick SSdoi
10.1592/phco.22.9.697.34072subject
Has Abstractpub_date
2002-06-01 00:00:00pages
697-700issue
6eissn
0277-0008issn
1875-9114journal_volume
22pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract::Levodopa is one of the principal agents administered to treat patients with Parkinson's disease (PD). Several pharmacologic strategies can limit its side effects and enhance its activity. Although certain exceptions apply, dosage adjustments and drug changes should be instituted slowly. Levodopa is typically introduce...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.2.33s.34632
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Allopurinol is a drug indicated for the treatment and prevention of gout. Through various theorized mechanisms, there has been an observed benefit in reducing aggression in patients with dementia who are refractory to traditional interventions. This case series of eight patients reports the use of allopurinol...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1943
更新日期:2017-06-01 00:00:00
abstract::The atypical antipsychotic agents clozapine and risperidone bring new insight into the care and treatment of patients with schizophrenia. Since their introduction, several names (e.g., novel, atypical, serotonergic-dopaminergic antagonist) have been used to describe the nature of these compounds. The agents are unique...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-11-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the efficacy of reteplase administration in clearing hemodialysis catheters. DESIGN:Open-label, uncontrolled, observational trial. SETTING:University medical center. PATIENTS:Thirty-four patients with end-stage renal disease undergoing long-term hemodialysis. INTERVENTION:Patients had du...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.23.2.137.32086
更新日期:2003-02-01 00:00:00
abstract::Methotrexate, a folic acid antagonist, is being employed more frequently in an attempt to control rheumatoid arthritis that has not responded adequately to conventional therapies. Systemic administration of 7.5-15 mg weekly in a pulse fashion appears to be effective without precipitating serious adverse effects. Conce...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.1986.tb03472.x
更新日期:1986-07-01 00:00:00
abstract::Although studies have shown that patients can distinguish probable adverse drug reactions (ADRs) from adverse clinical events (ACEs) caused by other factors, it is not known whether these attribution judgments add any independent validity to other accepted methods of identifying ADRs, such as physician assessments or ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract::The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.21.15.1240.33897
更新日期:2001-10-01 00:00:00
abstract::We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The antiretroviral combination of emtricitabine-tenofovir disoproxil fumarate (FTC/TDF) was approved by the U.S. Food and Drug Administration for use as pre-exposure prophylaxis (PrEP) in individuals at high risk for acquiring human immunodeficiency virus (HIV) in July 2012. Since then, Centers for Disease Control and...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2240
更新日期:2019-04-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the impact of having an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. DESIGN:Retrospective cohort study. SETTING:Urban academic teaching hospital. PATIENTS:A total of 11,872 adults admitted to nonsurgical patient care wards who received ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.8.742
更新日期:2011-08-01 00:00:00
abstract::Lenalidomide is commonly used for multiple myeloma as either induction or maintenance therapy. The agent is associated with a host of adverse effects, but hypoglycemia has only been reported in one phase I trial in patients with solid tumors. We describe a 74-year-old woman who experienced grade 3 hypoglycemia (blood ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2061
更新日期:2018-01-01 00:00:00
abstract::Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric asse...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2044
更新日期:2017-12-01 00:00:00
abstract::The authors sought to evaluate the impact on length of hospital stay and treatment duration of morphine after implementation of a change in the institutional protocol for managing neonatal abstinence syndrome (NAS) in an effort to improve patient outcomes. A single-center, retrospective chart review was conducted at a...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1966
更新日期:2017-07-01 00:00:00
abstract::Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, complex, idiosyncratic drug reaction that can be fatal. Systemic symptoms include lymphadenopathy, hepatic failure, and possibly renal failure. The syndrome has been primarily associated with anticonvulsants, whereas antimicrobials are less ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1142
更新日期:2012-12-01 00:00:00
abstract::A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as se...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.26.3.299
更新日期:2006-03-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the efficacy of a single, low-dose injection of botulinum toxin type A in relieving pain in Korean patients with piriformis syndrome resistant to conventional therapy, and to assess the drug's influence on these patients' quality of life. DESIGN:Prospective, single-site, open-label trial. ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.27.5.657
更新日期:2007-05-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the hemodynamic and electrocardiographic effects of a single dose of commercially available bitter-orange dried-fruit extract, which is increasingly being used in dietary supplements. DESIGN:Randomized, double-blind, placebo-controlled, crossover study. SETTING:University of Connecticut, S...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1592/phco.2005.25.12.1719
更新日期:2005-12-01 00:00:00
abstract::A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.21.3.355.34208
更新日期:2001-03-01 00:00:00
abstract::In patients infected with chronic hepatitis B virus (HBV) that goes untreated, therapeutic options are limited once the disease decompensates, and orthotopic liver transplantation is often the only treatment available to save the patient's life. After liver transplantation, combined therapy with hepatitis B immune glo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1306
更新日期:2013-09-01 00:00:00
abstract::Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), which is a subtype of non-Hodgkin lymphoma, are relatively uncommon lymphoproliferative types of cancer. These malignancies are highly curable with initial treatment. Nonetheless, some patients are refractory to or relapse after first- and seco...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1170
更新日期:2013-01-01 00:00:00
abstract::A 69-year-old woman was admitted for control of intractable rectal pain caused by a 4-cm malignant mass. She was treated successfully with EMLA (eutectic mixture of local anesthetics) cream applied every 8 hours and covered with a Xeroform dressing. Despite an increase in tumor size to 6 cm, her pain control was maint...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the relationship between two widely used, generic health-related quality of life (HRQOL) measures, Short Form-12 (SF-12) and EuroQol's EQ-5D, and potentially inappropriate drug use in an elderly cohort. DESIGN:Longitudinal retrospective cohort study. DATA SOURCE:Medical Expenditure Pane...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.6.768
更新日期:2006-06-01 00:00:00
abstract::A man anticoagulated with warfarin 57.5 mg/week (international normalized ratio [INR] 1.94) was diagnosed with nonsmall cell lung cancer and prescribed weekly gemcitabine. With the first dose of the first cycle, his INR rose to 3.52, and his weekly warfarin dose was decreased to 52.5 mg. The lower warfarin dose was co...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.19.16.1331.30873
更新日期:1999-11-01 00:00:00
abstract::In October 2009, a 2-day, multistakeholder, national conference was held in Rockville, Maryland, to discuss and propose methods to improve the drug-drug interaction (DDI) evidence base and its evaluation and integration into clinical decision support (CDS) systems. The conference featured participants representing con...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01024.x
更新日期:2012-04-01 00:00:00
abstract::Exenatide is an incretin mimetic indicated for the treatment of type 2 diabetes mellitus in combination with a sulfonylurea, a thiazolidinedione, metformin, or metformin plus a sulfonylurea or thiazolidinedione. Exenatide lowers postprandial blood glucose levels by stimulating glucose-dependent insulin secretion, inhi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.10.1449
更新日期:2007-10-01 00:00:00
abstract::Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1127
更新日期:2012-11-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate claims-related treatment adherence, health care resource utilization, and associated costs of therapy conversion from an insulin vial and syringe to a premixed biphasic insulin analog pen device among privately insured patients with type 2 diabetes mellitus. DESIGN:Retrospective, longitudin...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.7.948
更新日期:2007-07-01 00:00:00
abstract::A 63-year-old man with ventricular tachycardia (VT) refractory to drug therapy was admitted for surgical ablation of the VT with coronary artery bypass graft surgery. He developed increased theophylline concentrations with decreased calculated theophylline clearance after propafenone therapy for recurrent VT was initi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::The effect of treatment for hepatitis C viral infection on hemoglobin A(1c) (A1C) levels is not well described in the literature. We describe a 59-year-old man with type 2 diabetes mellitus whose A1C level became falsely low when ribavirin and peginterferon alfa-2b therapy were started for treatment of hepatitis C. Af...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.29.1.121
更新日期:2009-01-01 00:00:00
abstract::Olanzapine has been associated with insulin resistance and new-onset diabetes mellitus. A 27-year-old African-American man developed new-onset severe hyperglycemia-glucose 1240 mg/dl, with ketonuria and acidosis, but no weight gain-2 years after starting olanzapine. Although his diabetes was stabilized with insulin, h...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.17.1448.34421
更新日期:2001-11-01 00:00:00