Abstract:
STUDY OBJECTIVE:Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interactions to help formulate recommendations on the use of antihypertensive drugs in patients taking these medications concomitantly. Our objective was to assess the reliability of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to predict potential interactions between rifampin and antihypertensive drugs and thus provide recommendations on the choice of antihypertensive drugs in patients receiving rifampin. DESIGN:Evidence-based in vitro and in vivo predictions of drug-drug interactions. MEASUREMENTS AND MAIN RESULTS:We systematically evaluated interactions between rifampin and antihypertensive drugs using the theory of the BDDCS, taking into consideration the role of drug transporters and metabolic enzymes involved in these interactions. We provide recommendations on the selection of antihypertensive drugs for patients with tuberculosis. Antihypertensive drugs approved by the U.S. Food and Drug Administration and the China National Medical Products Administration were included in this study. The drugs were classified into four categories under the BDDCS classification. Detailed information on cytochrome P450 (CYP) enzymes and drug transporters for each antihypertensive drug was searched in PubMed and other electronic databases. This information was combined with the effects of rifampin on CYP enzymes and drug transporters, and the direction and relative extent of the potential interactions between rifampin and antihypertensive drugs were predicted. Recommendations were then made using the theory of BDDCS. A thorough systematic literature review was performed, and data from all published human studies and case reports were summarized for the validation of our predictions. Interventional and observational studies published in PubMed and two Chinese databases (CNKI and WanFang) through December 16, 2019, were included, and data were extracted for validation of the predictions. Using the BDDCS theory, class 3 active drugs were predicted to exhibit minimal interactions with rifampin. On reviewing case reports and pre-post studies, the predictions we made were found to be reliable. When antituberculosis medications that include rifampin are started in patients with hypertension, it is recommended that the use of calcium channel blockers and classes 1 and 2 β-blockers be avoided. Angiotensin-converting enzyme inhibitors, olmesartan, class 3 β-blockers, spironolactone, and hydrochlorothiazide would be preferable because clinically relevant interactions would not be expected. CONCLUSION:Application of the BDDCS to predict interactions between rifampin and antihypertensive drugs for patients with both tuberculosis and hypertension was found to be reliable. It should be noted, however, that based on the CYP enzyme and drug transporter information we reviewed, the mechanisms of all of the interactions could not be elucidated, and the predictions are only based on theory. The real effects of rifampin on antihypertensive drugs need to be further observed. More studies in both animals and humans are needed in the future.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Liu W,Yan T,Chen K,Yang L,Benet LZ,Zhai Sdoi
10.1002/phar.2380subject
Has Abstractpub_date
2020-04-01 00:00:00pages
274-290issue
4eissn
0277-0008issn
1875-9114journal_volume
40pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract:STUDY OBJECTIVE:To assess the reproducibility of Naranjo Adverse Drug Reaction Probability Scale (APS) scores in published case reports. DESIGN:Reliability analysis. MEASUREMENTS AND MAIN RESULTS:Randomly selected case reports using the APS were identified from the Web of Science database. The APS scores were blinded...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1496
更新日期:2014-11-01 00:00:00
abstract::Idiopathic recurrent pericarditis (IRP) can be challenging to treat. Even after guideline-directed first-line treatment consisting of aspirin (ASA) or a nonsteroidal antiinflammatory drug (NSAID) in combination with colchicine therapy, recurrences still occur in greater than 20% of patients. Many patients then require...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1897
更新日期:2017-03-01 00:00:00
abstract:STUDY OBJECTIVES:To compare the cost-effectiveness of intravenous plus oral amiodarone, atrial septal pacing, and both strategies combined to prevent atrial fibrillation after open heart surgery. Secondary objectives were to compare the cost-effectiveness of amiodarone versus no amiodarone and of pacing versus no pacin...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.24.11.1013.36132
更新日期:2004-08-01 00:00:00
abstract::Rapacuronium is a new steroidal, nondepolarizing, neuromuscular blocking agent. It appears to be the least potent of all available nondepolarizing muscle relaxants. Its onset of action resembles that of succinylcholine, and its recovery times are shorter than those of other nondepolarizing agents. The clinical duratio...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.19.15.1118.30572
更新日期:1999-10-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the number of women who have menopausal symptoms after discontinuing hormone therapy, to determine how many of these women subsequently require nonhormonal alternatives to manage their symptoms, and to assess the effectiveness of those therapies. DESIGN:One-year retrospective study. SETTI...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.10.1403
更新日期:2006-10-01 00:00:00
abstract::To determine salary and selected fringe benefits of members of the Ambulatory Care Practice and Research Network of the American College of Clinical Pharmacy, we developed a self-administered questionnaire that surveyed demographic information, schooling and training, academic appointments, yearly salary (as of Februa...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Atherosclerosis, the great killer of Western society, probably is initiated when the balance of subendothelial lipoproteins and oxidation potential is upset. Oxidation products, especially oxidized low-density lipoprotein, set into motion the cascading of numerous pathways, culminating in the fibrous atherosclerotic p...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00
abstract::Certification of pharmacotherapy specialists is proceeding smoothly. Modifications to the examination process, which include reapportioning domains, offering the examination at several sites, and establishing the recertification process, have occurred. The guidelines for petitioners and structure of specialization con...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract::The development of an intravenous form of nitroglycerin has further enhanced the role of nitrates in the therapy of cardiovascular disorders. This new preparation permits prompt initiation of therapy and rapid attainment of high systemic levels; because of its short half-life, rapid dose titration is both feasible and...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.1982.tb03197.x
更新日期:1982-09-01 00:00:00
abstract::Recombinant human erythropoietin reverses the severe anemia associated with end-stage renal disease. Mean half-life values after a single intravenous bolus dose range from 4-13 hours. Renal clearance is not a significant route of elimination. Dosing schedules in chronic renal failure involve a single intravenous bolus...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract:OBJECTIVE:To describe the legal, professional, and consumer status of prescribers dispensing legend and over-the-counter drugs in the United States. METHODS:Legal and academic databases were searched to identify those states that permit prescribers to dispense medications to patients and any limitations on such practi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1461
更新日期:2014-10-01 00:00:00
abstract::Two patients with chronic kidney disease experienced a major bleeding event, retroperitoneal hematoma, requiring a blood transfusion after the administration of enoxaparin. The first patient was a 61-year-old Caucasian woman with multiple comorbidities, including chronic kidney disease stage 4. She received subcutaneo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.25.5.769.63596
更新日期:2005-05-01 00:00:00
abstract::Thrombin, a serine protease, is the keystone of the twin processes of hemostasis and thrombosis. Through procoagulant, anticoagulant, and antifibrinolytic mechanisms, thrombin helps maintain vascular integrity in the face of hemorrhage. These same mechanisms, however, allow for the pathologic formation of thrombi in r...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.10.90s.33617
更新日期:2002-06-01 00:00:00
abstract::The prevalence of diabetes mellitus has grown to staggering numbers, and its incidence is expected to rise in the next 2 decades. The need for novel approaches to treat hyperglycemia cannot be ignored. Current agents have been shown to modestly improve glycemia and in some cases prevent complications of diabetes, but ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/PHAR.1010
更新日期:2012-01-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate potential associations between the histamine N-methyltransferase (HNMT) gene, HNMT, C314T (Thr105Ile) polymorphism and atopic dermatitis in a cohort of Caucasian children. DESIGN:Prospective, multicenter, genotype-association study. SETTING:Four academic, tertiary care medical centers w...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究
doi:10.1592/phco.28.12.1495
更新日期:2008-12-01 00:00:00
abstract::Albuterol is a 50:50 mixture of R-albuterol, the active enantiomer, and S-albuterol, which appears to be inactive in humans. The Food and Drug Administration recently approved levalbuterol, the pure R-isomer, as a preservative-free nebulizer solution. Published studies indicate that it is neither safer nor more effect...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.3.123.34776
更新日期:2000-02-01 00:00:00
abstract::The effect of treatment for hepatitis C viral infection on hemoglobin A(1c) (A1C) levels is not well described in the literature. We describe a 59-year-old man with type 2 diabetes mellitus whose A1C level became falsely low when ribavirin and peginterferon alfa-2b therapy were started for treatment of hepatitis C. Af...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.29.1.121
更新日期:2009-01-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.4.405
更新日期:2010-04-01 00:00:00
abstract::Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of meth...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.25.4.611.61020
更新日期:2005-04-01 00:00:00
abstract::A 63-year-old man with ventricular tachycardia (VT) refractory to drug therapy was admitted for surgical ablation of the VT with coronary artery bypass graft surgery. He developed increased theophylline concentrations with decreased calculated theophylline clearance after propafenone therapy for recurrent VT was initi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Antiretroviral (ART) therapy for the treatment of human immunodeficiency virus (HIV) infection has undergone significant changes over the past 30 years. Many single-tablet regimens (STRs), including newer fixed-dose combination (FDC) tablets, are available, offering patients several options for choosing a treatment re...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2055
更新日期:2018-01-01 00:00:00
abstract::Acute myeloid leukemia (AML), a clonal hematologic malignancy that results in bone marrow failure, is the most common acute leukemia in adults (median age of diagnosis 67 yrs), and treatment options, especially in the elderly population, are limited. Induction chemotherapy with 7 + 3, the combination of continuous-inf...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2039
更新日期:2017-12-01 00:00:00
abstract::Ceftazidime, a beta-lactamase-stable, third-generation cephalosporin, is widely used for the treatment of serious gram-negative infections. Neurotoxicity has rarely been associated with the drug; however, two of our patients developed ceftazidime-induced neurotoxicity that produced confusion, disorientation, agitation...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Clarithromycin is rarely reported to cause disturbances in anticoagulation. Theoretically, clarithromycin administered concurrently with warfarin could result in enhanced anticoagulation, since many properties of clarithromycin are similar to those of erythromycin, which interacts with warfarin. A search of the Nation...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.28.9.1098
更新日期:2008-09-01 00:00:00
abstract::Levodopa is one of the principal agents administered to treat patients with Parkinson's disease (PD). Several pharmacologic strategies can limit its side effects and enhance its activity. Although certain exceptions apply, dosage adjustments and drug changes should be instituted slowly. Levodopa is typically introduce...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.2.33s.34632
更新日期:2000-01-01 00:00:00
abstract::Verapamil and diltiazem are effective in terminating paroxysmal supraventricular tachycardias and slowing ventricular response during atrial fibrillation or flutter. Results from clinical trials for each individual drug demonstrate comparative efficacy rates, and both drugs share the same contraindications and relativ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1996-09-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the toxicity of amphotericin B deoxycholate formulations. DESIGN:In vitro experiment. SETTING:University research center. MATERIAL:Human mononuclear THP-1 cells. INTERVENTION:The human mononuclear cells were exposed in vitro for 2 hours to the following deoxycholate formulations of ampho...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.5.572.32209
更新日期:2003-05-01 00:00:00
abstract::The risk of venous thromboembolism (VTE) in patients with cancer is 6-12-fold higher than in the general population, and VTE is the second leading cause of death in this population, after cancer itself. The etiology underlying the increased risk of VTE is multifactorial and complex, involving patient-, tumor-, and tre...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.29.11.1344
更新日期:2009-11-01 00:00:00
abstract::In patients infected with chronic hepatitis B virus (HBV) that goes untreated, therapeutic options are limited once the disease decompensates, and orthotopic liver transplantation is often the only treatment available to save the patient's life. After liver transplantation, combined therapy with hepatitis B immune glo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1306
更新日期:2013-09-01 00:00:00