Abstract:
:We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total of 190 studies met inclusion criteria. The highest frequency of discontinuations due to adverse events (DAEs) occurred with calcium channel blockers (6.7%) and alpha-adrenergic blockers (6.0%); the lowest with diuretics and angiotensin receptor blockers (each 3.1%). Only in calcium channel blocker studies was the frequency of DAEs greater in treated patients than in patients receiving placebo, but the difference was not significant. This systematic review suggests that the frequency of DAEs in monotherapy antihypertensive trials varies across drug classes and should be considered when choosing drugs for patients with essential hypertension.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Ross SD,Akhras KS,Zhang S,Rozinsky M,Nalysnyk Ldoi
10.1592/phco.21.11.940.34520subject
Has Abstractpub_date
2001-08-01 00:00:00pages
940-53issue
8eissn
0277-0008issn
1875-9114journal_volume
21pub_type
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