Concomitant therapy with anxiolytics or hypnotics and maintenance of initial SSRI therapy.

abstract：:A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight patients who had undergone orthopedic surgery. Plasma samples were obtained over a 72-hour period for pharmacokinetic analysis in five patients. The patients wer...

journal_title：Pharmacotherapy

authors： Plezia PM,Kramer TH,Linford J,Hameroff SR

更新日期：1989-01-01 00:00:00

abstract：:The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...

journal_title：Pharmacotherapy

authors： Bailie GR,Uhlig K,Levey AS

更新日期：2005-04-01 00:00:00

abstract：STUDY OBJECTIVE:Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interact...

journal_title：Pharmacotherapy

authors： Liu W,Yan T,Chen K,Yang L,Benet LZ,Zhai S

更新日期：2020-04-01 00:00:00

abstract：:We examined whether low doses of phenytoin, which should be associated with few dose-related side effects, may increase the levels of high-density lipoprotein (HDL) cholesterol. Of 35 healthy adult men who consented to participate, 31 completed the study. They took no medications and consumed no alcohol during the stu...

journal_title：Pharmacotherapy

authors： McKenney JM,Petrizzi KS,Briggs GC,Wright JT Jr

更新日期：1992-01-01 00:00:00

abstract：:Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures against depolymerization. Although its clinical development had been hampered by misconceptions about its pharmacology, its scarcity, difficulties extracting i...

journal_title：Pharmacotherapy

authors： Kohler DR,Goldspiel BR

更新日期：1994-01-01 00:00:00

abstract：:Opioid-related adverse drug events (ORADEs) can have a significant impact on patient recovery after surgery. This review investigates the impact of two ORADEs, respiratory depression and postoperative ileus (POI), on clinical and economic outcomes. Opioid-induced ventilatory impairment is a potentially serious ORADE t...

journal_title：Pharmacotherapy

authors： Barletta JF

更新日期：2012-09-01 00:00:00

abstract：:The renal pharmacologic effects of intravenous dopamine in doses of 0.5-3.0 micrograms/kg/min include increases in renal blood flow, glomerular filtration rate, solute excretion, and urine flow. Clinical studies revealed that low-dose dopamine can reverse oliguria, but these studies were poorly controlled, were confou...

journal_title：Pharmacotherapy

authors： Dasta JF,Kirby MG

更新日期：1986-11-01 00:00:00

abstract：:This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...

journal_title：Pharmacotherapy

authors： Cooney GF,Mochon M,Kaiser B,Dunn SP,Goldsmith B

更新日期：1995-05-01 00:00:00

abstract：:Exenatide is an incretin mimetic indicated for the treatment of type 2 diabetes mellitus in combination with a sulfonylurea, a thiazolidinedione, metformin, or metformin plus a sulfonylurea or thiazolidinedione. Exenatide lowers postprandial blood glucose levels by stimulating glucose-dependent insulin secretion, inhi...

journal_title：Pharmacotherapy

authors： Sheffield CA,Kane MP,Busch RS

更新日期：2007-10-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) has resulted in significant morbidity and mortality reductions. Lifelong antiretroviral therapy must be incorporated into each patient's medical regimen. Patients with HIV may also have simultaneous chronic medical conditions, resultin...

journal_title：Pharmacotherapy

authors： Fulco PP,Zingone MM,Higginson RT

更新日期：2008-07-01 00:00:00

abstract：:Levodopa is one of the principal agents administered to treat patients with Parkinson's disease (PD). Several pharmacologic strategies can limit its side effects and enhance its activity. Although certain exceptions apply, dosage adjustments and drug changes should be instituted slowly. Levodopa is typically introduce...

journal_title：Pharmacotherapy

authors： Berchou RC

更新日期：2000-01-01 00:00:00

abstract：STUDY OBJECTIVES:To develop and validate an improved unfractionated heparin (UFH) dosage protocol, using antifactor Xa levels as the outcome variable. DESIGN:Prospective case series. SETTING:A 625-bed, adults-only private, tertiary care teaching hospital. PATIENTS:Three hundred seventy-two patients receiving UFH for...

journal_title：Pharmacotherapy

authors： Rosborough TK,Shepherd MF

更新日期：2004-06-01 00:00:00

abstract：:A few reports in the literature describe zidovudine (AZT) pharmacokinetics in patients undergoing hemodialysis; however, the effect of continuous ambulatory peritoneal dialysis (CAPD) on the drug's disposition has not been studied. The pharmacokinetics of AZT were evaluated in five patients, age 37-62 years, who were ...

journal_title：Pharmacotherapy

authors： Kremer D,Munar MY,Kohlhepp SJ,Swan SK,Stinnett EA,Gilbert DN,Young EW,Bennett WM

更新日期：1992-01-01 00:00:00

abstract：:Little information has been published concerning differences among the benzodiazepines in treating hospitalized patients with severe symptoms of alcohol withdrawal. We attempted to determine the length and type of hospital stay, and the pattern and appropriateness of administration, dosage requirements, and costs asso...

journal_title：Pharmacotherapy

authors： Hoey LL,Nahum A,Vance-Bryan K

更新日期：1994-09-01 00:00:00

abstract：:We evaluated the efficacy and tolerability of amphotericin B triglyceride emulsion in 16 patients with acquired immunodeficiency syndrome-related candidal esophagitis and cryptococcosis, compared with standard amphotericin B in 24 patients. Compared with the conventional formulation, the fat emulsion was administered ...

journal_title：Pharmacotherapy

authors： Manfredi R,Chiodo F

更新日期：1998-09-01 00:00:00

abstract：:The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...

journal_title：Pharmacotherapy

authors： Rafie S,McIntosh J,Shealy KM,Borgelt LM,Forinash A,Shrader SP,Koepf ER,McClendon KS,Griffin BL,Horlen C,Karaoui LR,Rowe EL,Lodise NM,Wigle PR

更新日期：2014-09-01 00:00:00

abstract：:Advances in the care of critically ill patients and in diagnostic techniques, such as fiberoptic endoscopy, have enabled greater recognition of stress-related mucosal damage (SRMD). This condition is distinguished from chronic peptic ulcer disease by its greater number of lesions, proximal location in the acid-produci...

journal_title：Pharmacotherapy

authors： Peura DA

更新日期：1987-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of Niaspan--a niacin preparation with both immediate- and extended-release characteristics--on lipid and glycemic control in patients with type 2 diabetes. DESIGN:Retrospective study SETTING:Private-practice endocrinology group. PATIENTS:Thirty-two patients (mean age 60 yrs; 7...

journal_title：Pharmacotherapy

authors： Kane MP,Hamilton RA,Addesse E,Busch RS,Bakst G

更新日期：2001-12-01 00:00:00

abstract：:We conducted a meta-analysis to determine what factors in treatment regimens for Helicobacter pylori are associated with increased discontinuation rates. Studies were selected from the 1990-1996 MEDLINE data base, and references in published articles and reviews were obtained. Each article was uniformally abstracted f...

journal_title：Pharmacotherapy

authors： Buring SM,Winner LH,Hatton RC,Doering PL

更新日期：1999-03-01 00:00:00

abstract：:Addressing the issue of unintended pregnancy is a national priority. One proposed strategy to reduce unintended pregnancy is to improve access to oral contraceptives by changing them to over-the-counter (OTC) status. Existing data indicate that oral contraceptives meet safety criteria required of OTC products. Availab...

journal_title：Pharmacotherapy

authors： McIntosh J,Rafie S,Wasik M,McBane S,Lodise NM,El-Ibiary SY,Forinash A,Kachlic MD,Rowe E,Besinque K

更新日期：2011-04-01 00:00:00

abstract：:Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric asse...

journal_title：Pharmacotherapy

authors： Fazel MT,Jedlowski PM,Cravens RB Jr,Erstad BL

更新日期：2017-12-01 00:00:00

abstract：:Limited data are available on ceftolozane/tazobactam dosing in patients receiving continuous renal replacement therapy (CRRT). Thus we performed a pharmacokinetic analysis of intravenous ceftolozane/tazobactam in a critically ill patient receiving CRRT at our medical center. A 47-year-old critically ill man with multi...

journal_title：Pharmacotherapy

authors： Bremmer DN,Nicolau DP,Burcham P,Chunduri A,Shidham G,Bauer KA

更新日期：2016-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and use of intravenous human cytomegalovirus immune globulin (CytoGam) in allogeneic bone marrow transplantation (BMT). DESIGN:Prospective, nonrandomized, nonblinded, single-center study. SETTING:University teaching hospital. PATIENTS:Five consecutive patients with he...

journal_title：Pharmacotherapy

authors： DeRienzo SY,Chiang KY,O'Neal WM,Godder K,Abhyankar S,Christiansen NP,Bridges KD,Henslee-Downey PJ

更新日期：2000-10-01 00:00:00

abstract：:Diabetes mellitus has reached epidemic proportions worldwide, eliciting extensive research on both the disease process and its treatment. Regardless of diabetes type, the progressive nature of the disease makes insulin the long-term mainstay of diabetes management. Recently, the insulin analog glargine was reported in...

journal_title：Pharmacotherapy

authors： Edwards KL,Riche DM,Stroup JS,Goldman-Levine JD,Padiyara RS,Cross LB,Kane MP

更新日期：2010-09-01 00:00:00

abstract：:Methotrexate, administered for treatment of pediatric and adult malignancies, is a direct renal toxin, which can lead to renal dysfunction, decreased methotrexate clearance, elevated methotrexate concentrations, and systemic toxicity. Although plasma methotrexate concentrations have been shown to decline precipitously...

journal_title：Pharmacotherapy

authors： Vilay AM,Mueller BA,Haines H,Alten JA,Askenazi DJ

更新日期：2010-01-01 00:00:00

abstract：:Many physiologic differences between children and adults can result in age-related differences in pharmacokinetics. Understanding the effects of age on bioavailability, volume of distribution, protein binding, hepatic metabolic isoenzymes, and renal elimination can provide insight into optimizing doses for pediatric p...

journal_title：Pharmacotherapy

authors： Anderson GD,Lynn AM

更新日期：2009-06-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of hepatotoxicity in critically ill patients who were treated with voriconazole and to identify potential risk factors for voriconazole-associated hepatotoxicity in these patients. DESIGN:Single-center prospective observational study. SETTING:Intensive care unit (ICU) in a ...

journal_title：Pharmacotherapy

authors： Wang Y,Wang T,Xie J,Yang Q,Zheng X,Dong W,Xing J,Wang X,Dong Y

更新日期：2016-07-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacodynamics of four intravenous antimicrobial regimens-ceftriaxone 1 g, gatifloxacin 400 mg, levofloxacin 500 mg, and levofloxacin 750 mg, each every 24 hours-against recent Streptococcus pneumoniae isolates. DESIGN:Pharmacodynamic analysis using Monte Carlo simulation. DATA SOURC...

journal_title：Pharmacotherapy

authors： Frei CR,Burgess DS

更新日期：2005-09-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effects of mild-to-moderate induced hypothermia-a neuroprotectant and/or therapeutic strategy for the management of intracranial hypertension in neurologically injured patients-on the pharmacokinetics of aminoglycoside therapy. DESIGN:Pharmacokinetic analysis. SETTING:Critical care un...

journal_title：Pharmacotherapy

authors： Mercer JM,Neyens RR

更新日期：2010-07-01 00:00:00

abstract：STUDY OBJECTIVES:To determine changes in bone mineral density (BMD) and T scores of patients after 2 years of teriparatide therapy, and to determine the number of fractures that occurred during therapy. DESIGN:Prospective, observational study. SETTING:Pharmacist-run teriparatide clinic in a private-practice endocrino...

journal_title：Pharmacotherapy

authors： Stroup JS,Rivers SM,Abu-Baker AM,Kane MP

更新日期：2007-06-01 00:00:00