Aminoglycoside pharmacokinetic parameters in neurocritical care patients undergoing induced hypothermia.

abstract：:Certification of pharmacotherapy specialists is proceeding smoothly. Modifications to the examination process, which include reapportioning domains, offering the examination at several sites, and establishing the recertification process, have occurred. The guidelines for petitioners and structure of specialization con...

journal_title：Pharmacotherapy

authors： Zarowitz BJ,Vlasses PH,Dukes GE,Gal P,Miller WA,Porter WC,Rush DR,Schneider P,Talbert RL

更新日期：1993-05-01 00:00:00

abstract：:Original research, reviews, and case reports discussing viral infectivity of blood- and plasma-derived products were reviewed to determine the potential viral infectivity of human serum albumin (HSA) and plasma protein fraction (PPF). Data concerning viral infectivity viral screening and inactivation procedures, and v...

journal_title：Pharmacotherapy

authors： Erstad BL

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:To compare changes in United States pharmacy practice faculty demographics from 1995-2001 and to discuss the implications for junior faculty development. METHODS:Demographic data were extracted from the American Association of Colleges of Pharmacy institutional research system for academic years 1995-1996 an...

journal_title：Pharmacotherapy

authors： Raehl CL

更新日期：2002-04-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the efficacy of a single, low-dose injection of botulinum toxin type A in relieving pain in Korean patients with piriformis syndrome resistant to conventional therapy, and to assess the drug's influence on these patients' quality of life. DESIGN:Prospective, single-site, open-label trial. ...

journal_title：Pharmacotherapy

authors： Yoon SJ,Ho J,Kang HY,Lee SH,Kim KI,Shin WG,Oh JM

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Our patient experienced acute renal failure but not fulminant hepatic failure from acetaminophen toxicity. OBJECTIVE:To review the clinical and laboratory characteristics of similar cases of acetaminophen nephrotoxicity. METHODS:A MEDLINE search and medical record search at two large teaching hospitals. R...

journal_title：Pharmacotherapy

authors： Eguia L,Materson BJ

更新日期：1997-03-01 00:00:00

abstract：:Fentanyl iontophoretic transdermal system (ITS) is a novel, patient-activated drug delivery device used for the management of acute postoperative pain in the hospital setting. This credit-card-sized device uses an imperceptible current of 170 milliampere to actively deliver a fentanyl hydrochloride 40-microg dose into...

journal_title：Pharmacotherapy

authors： Herndon CM

更新日期：2007-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether alvimopan for prevention of postoperative ileus in patients undergoing small- or large-bowel resection by laparotomy is associated with lower total costs compared with standard care. DESIGN:Pharmacoeconomic analysis using a formal decision model. DATA SOURCE:Four phase III clinica...

journal_title：Pharmacotherapy

authors： Touchette DR,Yang Y,Tiryaki F,Galanter WL

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy of a single dose of basiliximab with two doses in preventing acute rejection in selected low-risk renal transplant recipients. METHODS:This observational study of 760 kidney transplant recipients considered to be at low immunologic risk (peak panel reactive antibody less than 10%) co...

journal_title：Pharmacotherapy

authors： Cunningham KC,Hager DR,Fischer J,D'Alessandro AM,Leverson GE,Kaufman DB,Djamali A

更新日期：2016-07-01 00:00:00

abstract：:For many years, a regimen of fluorouracil and cisplatin has been the standard of care for the treatment of patients with metastatic gastric cancer. More recently, triplet regimens that incorporate fluorouracil and cisplatin with epirubicin (ECF) or docetaxel are being used in the management of patients with metastatic...

journal_title：Pharmacotherapy

authors： Comella P,Franco L,Casaretti R,de Portu S,Menditto E

更新日期：2009-03-01 00:00:00

abstract：STUDY OBJECTIVES:To determine changes in bone mineral density (BMD) and T scores of patients after 2 years of teriparatide therapy, and to determine the number of fractures that occurred during therapy. DESIGN:Prospective, observational study. SETTING:Pharmacist-run teriparatide clinic in a private-practice endocrino...

journal_title：Pharmacotherapy

authors： Stroup JS,Rivers SM,Abu-Baker AM,Kane MP

更新日期：2007-06-01 00:00:00

abstract：:A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...

journal_title：Pharmacotherapy

authors： Roth MT,Westman EC

更新日期：2002-06-01 00:00:00

abstract：:Thirty-six indigent patients hospitalized within 6 months of study initiation and who met criteria were enrolled in a 6-month assistance program to determine if provision of both medical care and prescription drugs at no cost would be associated with a change in overall health care charges secondary to a change in the...

journal_title：Pharmacotherapy

authors： Nykamp D,Ruggles D

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVES:To explore the illicit use of specific prescription stimulants among college students and add to our understanding of reasons (motives) and routes of administration associated with illicit use of these drugs. METHODS:A random sample of 4580 college students self-administered a Web-based survey. The survey c...

journal_title：Pharmacotherapy

authors： Teter CJ,McCabe SE,LaGrange K,Cranford JA,Boyd CJ

更新日期：2006-10-01 00:00:00

abstract：:Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...

journal_title：Pharmacotherapy

authors： Redman AR

更新日期：2001-02-01 00:00:00

abstract：:The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...

journal_title：Pharmacotherapy

authors： Bailie GR,Uhlig K,Levey AS

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Anticoagulation monitoring during transition from direct oral anticoagulants (DOAC) to heparin infusions is a significant challenge. Factor Xa inhibitors influence the heparin calibrated antifactor Xa assay. The University of Virginia (UVA) Medical Center utilized a corrected antifactor Xa assay (c-AXA) duri...

journal_title：Pharmacotherapy

authors： Plum MD,Hedrick JN,Hockman R,Bazydlo L,Palkimas S

更新日期：2020-09-01 00:00:00

abstract：:Disseminated herpes simplex virus (HSV) infection in neonates represents a devastating entity that yields high mortality. Acyclovir is the primary antiviral agent used to treat life-threatening HSV infections in neonates; however, even though the agent has reduced morbidity overall from these infections, mortality wit...

journal_title：Pharmacotherapy

authors： Cies JJ,Moore WS 2nd,Miller K,Small C,Carella D,Conley S,Parker J,Shea P,Chopra A

更新日期：2015-02-01 00:00:00

abstract：:Use of the Molecular Adsorbent Recirculating System (MARS) as a liver support device continues to grow worldwide. Various components of the MARS circuit remove both protein-bound and water-soluble molecules. Little is known about the extent of the enhanced clearance mechanisms used in MARS therapy on drug elimination....

journal_title：Pharmacotherapy

authors： Personett HA,Larson SL,Frazee EN,Nyberg SL,El-Zoghby ZM

更新日期：2015-08-01 00:00:00

abstract：STUDY OBJECTIVE:To perform a cost-effectiveness analysis comparing three treatment approaches during nonurgent percutaneous coronary intervention (PCI): bivalirudin with provisional glycoprotein (GP) IIb-IIIa inhibitor therapy, unfractionated heparin (UFH) with eptifibatide, and UFH with abciximab. DESIGN:Literature-b...

journal_title：Pharmacotherapy

authors： Summers KM,Holdford DA,Crouch MA

更新日期：2006-05-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of Clostridium difficile infection (CDI) at one community hospital by identifying patients with stool samples positive for C. difficile toxin A or B, and to compare the incidence with a 2008 national estimate; and to determine which patient characteristics and concomitant ant...

journal_title：Pharmacotherapy

authors： King RN,Lager SL

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...

journal_title：Pharmacotherapy

authors： Rizk HG,Lee JA,Liu YF,Endriukaitis L,Isaac JL,Bullington WM

更新日期：2020-12-01 00:00:00

abstract：:Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...

journal_title：Pharmacotherapy

authors： Nutescu EA,Spinler SA,Dager WE,Bussey HI

更新日期：2004-10-01 00:00:00

abstract：:Use of oral N-acetylcysteine for preventing radiographic contrast material-induced nephropathy (RCIN) has become widespread, despite conflicting results from clinical trials and meta-analyses. The variability in study results may reflect differences in baseline risks in study patients, hydration regimens, choice of co...

journal_title：Pharmacotherapy

authors： Shalansky SJ,Vu T,Pate GE,Levin A,Humphries KH,Webb JG

更新日期：2005-08-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects. DESIGN:Two randomized, open-label, crossover, drug-drug interaction studies. SETTING:Clinical research facilities in the United States ...

journal_title：Pharmacotherapy

authors： Smit JW,Oh C,Rengelshausen J,Terlinden R,Ravenstijn PG,Wang SS,Upmalis D,Mangold B

更新日期：2010-01-01 00:00:00

abstract：:Fatigue is one of the most debilitating and common symptoms associated with hematologic and oncologic disorders and treatment strategies. Patient factors influence etiology and symptom manifestation, which in turn affect diagnosis, management, and monitoring. Fatigue instruments can assist with the identification, man...

journal_title：Pharmacotherapy

authors： Schwartz AH

更新日期：2002-11-01 00:00:00

abstract：:Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...

journal_title：Pharmacotherapy

authors： Nemerovski CW,Salinitri FD,Morbitzer KA,Moser LR

更新日期：2012-11-01 00:00:00

abstract：:We investigated the effect of endotoxemia on alpha1-adrenergic receptor-mediated smooth muscle contraction as measured by mean arterial pressure (MAP) in response to incremental doses of a vasopressor. Twelve male Sprague-Dawley rats were randomized to receive parenteral nutrition alone (PN) or in combination with a c...

journal_title：Pharmacotherapy

authors： Dickerson RN,Lima JJ,Kuhl DA,Brown RO,Hak LJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:There is a high prevalence of HIV infection in Newark, New Jersey, with University Hospital admitting approximately 600 HIV-infected patients per year. Medication errors involving antiretroviral therapy (ART) could significantly affect treatment outcomes. The goal of this study was to evaluate the effectiven...

journal_title：Pharmacotherapy

authors： Zucker J,Mittal J,Jen SP,Cheng L,Cennimo D

更新日期：2016-03-01 00:00:00

abstract：:The use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) has significantly reduced morbidity and mortality across the continuum of vascular disease. The utilization of these agents, however, remains suboptimal. The drugs are not prescribed in many patients because of concerns ...

journal_title：Pharmacotherapy

authors： Epstein BJ

更新日期：2004-05-01 00:00:00

abstract：STUDY OBJECTIVES:To develop and validate a self-assessment adherence tool for imatinib in patients with chronic myeloid leukemia (CML), and to correlate the use of this tool with response to treatment and adverse effects. DESIGN:Retrospective cohort study. SETTING:Regional cancer center in France. PATIENTS:Forty-six...

journal_title：Pharmacotherapy

authors： Daouphars M,Ouvry M,Lenain P,Rouvet J,Jardin F,Bubenheim M,Varin R

更新日期：2013-02-01 00:00:00