Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide.

abstract：:Meclofenamate sodium was compared, double-blind, with codeine and placebo for the treatment of acute episiotomy pain. One hundred sixty-eight women with moderate or severe episiotomy pain after normal delivery were assigned randomly to one of four treatment groups: one received meclofenamate sodium 200 mg at dose 1 an...

journal_title：Pharmacotherapy

authors： Hebertson RM,Storey N,Turner JL

更新日期：1986-09-01 00:00:00

abstract：:Diabetes mellitus has reached epidemic proportions worldwide, eliciting extensive research on both the disease process and its treatment. Regardless of diabetes type, the progressive nature of the disease makes insulin the long-term mainstay of diabetes management. Recently, the insulin analog glargine was reported in...

journal_title：Pharmacotherapy

authors： Edwards KL,Riche DM,Stroup JS,Goldman-Levine JD,Padiyara RS,Cross LB,Kane MP

更新日期：2010-09-01 00:00:00

abstract：:Anemia is an undertreated but common complication of cancer and is associated with debilitating symptoms that impair the patient's ability to perform daily functions of life. Treatment with darbepoetin alfa, a novel erythropoiesis-stimulating protein, is appropriate for chemotherapy-induced anemia. Guidelines on darbe...

journal_title：Pharmacotherapy

authors： Bloomfield M,Jaresko G,Zarek J,Dozier N

更新日期：2003-12-01 00:00:00

abstract：:Clinical pharmacists must often interpret and use data derived from observational studies when making clinical decisions and recommendations, answering drug information questions, and educating patients about drug therapy. This is the third article in a three-part series intended to enhance clinical pharmacists' under...

journal_title：Pharmacotherapy

authors： Shields KM,DiPietro NA,Kier KL

更新日期：2011-02-01 00:00:00

abstract：:Nucleoside analogs (zidovudine, didanosine, zalcitabine, stavudine, abacavir, lamivudine) have been administered as antiretroviral agents for more than a decade. They undergo anabolic phosphorylation by intracellular kinases to form triphosphates, which inhibit human immunodeficiency virus replication by competitively...

journal_title：Pharmacotherapy

authors： Stein DS,Moore KH

更新日期：2001-01-01 00:00:00

abstract：:Certification of pharmacotherapy specialists is proceeding smoothly. Modifications to the examination process, which include reapportioning domains, offering the examination at several sites, and establishing the recertification process, have occurred. The guidelines for petitioners and structure of specialization con...

journal_title：Pharmacotherapy

authors： Zarowitz BJ,Vlasses PH,Dukes GE,Gal P,Miller WA,Porter WC,Rush DR,Schneider P,Talbert RL

更新日期：1993-05-01 00:00:00

abstract：:A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight patients who had undergone orthopedic surgery. Plasma samples were obtained over a 72-hour period for pharmacokinetic analysis in five patients. The patients wer...

journal_title：Pharmacotherapy

authors： Plezia PM,Kramer TH,Linford J,Hameroff SR

更新日期：1989-01-01 00:00:00

abstract：:Clinical outcomes that measure how patients feel, function, or survive are the most important and relevant outcomes of therapy in clinical trials and in clinical practice. Surrogate end points, which do not directly measure clinical benefit to the patient, may function as substitutes for clinical end points in clinica...

journal_title：Pharmacotherapy

authors： Powers JH

更新日期：2005-12-01 00:00:00

abstract：:Therapeutic goals for atrial fibrillation (AF) include ventricular rate control, stroke prevention, conversion to normal sinus rhythm, and maintenance of normal sinus rhythm. The optimal strategy of rate versus rhythm control for acute management of patients with AF is a continuing debate. However, selected patients m...

journal_title：Pharmacotherapy

authors： Slavik RS,Zed PJ

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:As one of the most accessible health care professionals, pharmacists are in an ideal position to provide tobacco-cessation and prevention services. Although there is growing interest in expanding the pharmacist's role in tobacco treatment, few published studies have assessed the efficacy or effectiveness of ...

journal_title：Pharmacotherapy

authors： Dent LA,Harris KJ,Noonan CW

更新日期：2007-07-01 00:00:00

abstract：:The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...

journal_title：Pharmacotherapy

authors： Lee CR,Thrasher KA

更新日期：2001-10-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of a high-fat breakfast on single-dose, zidovudine (ZDV) pharmacokinetics. DESIGN:Open-label, randomized, crossover study. PATIENTS:Eighteen asymptomatic subjects (12 men, 6 women) infected with the human immunodeficiency virus (mean CD4 cell counts of 512 +/- 178/mm3). INTERV...

journal_title：Pharmacotherapy

authors： Shelton MJ,Portmore A,Blum MR,Sadler BM,Reichman RC,Morse GD

更新日期：1994-11-01 00:00:00

abstract：:The use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) has significantly reduced morbidity and mortality across the continuum of vascular disease. The utilization of these agents, however, remains suboptimal. The drugs are not prescribed in many patients because of concerns ...

journal_title：Pharmacotherapy

authors： Epstein BJ

更新日期：2004-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the relationship between impaired renal function and antifactor Xa activity in patients receiving dalteparin. DESIGN:Open-label prospective study. SETTING:Inpatient and outpatient units of a large teaching hospital. SUBJECTS:Eleven patients with renal impairment and 11 control subjects wi...

journal_title：Pharmacotherapy

authors： Shprecher AR,Cheng-Lai A,Madsen EM,Cohen HW,Sinnett MJ,Wong ST,Billett HH

更新日期：2005-06-01 00:00:00

abstract：:Females of childbearing age represent a large population of solid organ transplant recipients. With fertility commonly restored after transplantation, the possibility of pregnancy becomes a reality for many patients. Since the first published report of a successful pregnancy after solid organ transplantation in 1963, ...

journal_title：Pharmacotherapy

authors： Casale JP,Doligalski CT

更新日期：2016-09-01 00:00:00

abstract：STUDY OBJECTIVE:To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. DESIGN:Sixty-four-question survey SETTING:University of Minnesota. SUBJECTS:One hundred sixty-eight male and female Asian and Asian-American students, mean age 21 +/- 3.4 years. MAIN RES...

journal_title：Pharmacotherapy

authors： Nguyen DN,O'Connell MB

更新日期：2002-08-01 00:00:00

abstract：:Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...

journal_title：Pharmacotherapy

authors： Redman AR

更新日期：2001-02-01 00:00:00

abstract：:Dabigatran, a direct thrombin inhibitor, is an oral anticoagulant indicated for the prevention of stroke in patients with atrial fibrillation (AF) and for the treatment and prevention of deep vein thrombosis and pulmonary embolism. Dabigatran, as well as the other new anticoagulants-rivaroxaban, apixaban, and edoxaban...

journal_title：Pharmacotherapy

authors： Wiggins BS,Northup A,Johnson D,Senfield J

更新日期：2016-02-01 00:00:00

abstract：:We conducted a meta-analysis to determine what factors in treatment regimens for Helicobacter pylori are associated with increased discontinuation rates. Studies were selected from the 1990-1996 MEDLINE data base, and references in published articles and reviews were obtained. Each article was uniformally abstracted f...

journal_title：Pharmacotherapy

authors： Buring SM,Winner LH,Hatton RC,Doering PL

更新日期：1999-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS...

journal_title：Pharmacotherapy

authors： Hendeles L,Davison D,Harman E,Sherman JM

更新日期：1999-11-01 00:00:00

abstract：:Recombinant tissue plasminogen activator (t-PA) is a synthetic fibrinolytic protein which activates plasminogen or converts plasminogen to plasmin specifically in the presence of fibrin. With its "clot-selectivity", t-PA is capable of lysing clots without having a significant effect on circulating plasminogen. In cont...

journal_title：Pharmacotherapy

authors： Rogers SD,Riemersma LB,Clements SD

更新日期：1987-01-01 00:00:00

abstract：:Antimicrobial lung penetration is thought to be predictive of efficacy in the treatment of lower respiratory tract infections. Lung penetration studies are commonly conducted with new antimicrobial agents to elucidate their potential utility in treating such infections. Although some very useful information may emerge...

journal_title：Pharmacotherapy

authors： Ritrovato CA,Deeter RG

更新日期：1991-01-01 00:00:00

abstract：:We compared total costs and adherence to the regimen of older versus newer angiotensin-converting enzyme (ACE) inhibitors for the treatment of elderly patients with hypertension. A computer search using the data base of a health care insurer identified 6176 subjects age 65 years or older who had ICD-9 coding for hyper...

journal_title：Pharmacotherapy

authors： Small RE,Freeman-Arnold SB,Goode JV,Pyles MA

更新日期：1997-09-01 00:00:00

abstract：:Paclitaxel is a mainstay in the treatment of ovarian and breast cancers, and its use in other malignancies is being explored. Although it has great clinical utility, the drug and its formulation components pose a number of challenges to pharmacists and nurses. Paclitaxel is insoluble in water and is formulated in an e...

journal_title：Pharmacotherapy

authors： Trissel LA

更新日期：1997-09-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the bioavailability and renal elimination of para-aminosalicylic acid (PAS) and its inactive metabolite acetyl-para-aminosalicylic acid (AcPAS) from a new PAS formulation. DESIGN:(a) Single-dose pharmacokinetic study in healthy volunteers; (b) Day-1 and day-8 pharmacokinetic comparison in ...

journal_title：Pharmacotherapy

authors： Peloquin CA,Henshaw TL,Huitt GA,Berning SE,Nitta AT,James GT

更新日期：1994-01-01 00:00:00

abstract：:During the past decade, the incidence and severity of Clostridium difficile infection (CDI) have significantly increased, leading to a rise in CDI-associated hospitalizations, health care costs, and mortality. Although treatment options exist for CDI, recurrence is frequent following treatment. Furthermore, patients w...

journal_title：Pharmacotherapy

authors： Kufel WD,Devanathan AS,Marx AH,Weber DJ,Daniels LM

更新日期：2017-10-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the safety and efficacy of aerosolized ceftazidime for prevention of ventilator-associated pneumonia (VAP) and to evaluate the effects of the drug on the proinflammatory response. DESIGN:Prospective, randomized, double-blind, placebo-controlled clinical trial. SETTING:University teaching ...

journal_title：Pharmacotherapy

authors： Wood GC,Boucher BA,Croce MA,Hanes SD,Herring VL,Fabian TC

更新日期：2002-08-01 00:00:00

abstract：:We conducted an extensive literature review to evaluate the appropriate use, route, and dose of vitamin K to reverse excessive anticoagulation. Issues such as sample size, study design, different patient populations, and various study end points confounded results. Of 18 studies published, 8 enrolled 229 patients to e...

journal_title：Pharmacotherapy

authors： Taylor CT,Chester EA,Byrd DC,Stephens MA

更新日期：1999-12-01 00:00:00

abstract：:Since the discovery of penicillin 80 years ago, gram-negative bacteria have become proficient at evading the lethal activity of β-lactam antibiotics, principally through the production of β-lactamases. The rapid emergence of penicillinases in both gram-positive and gram-negative bacteria led to the development of ceph...

journal_title：Pharmacotherapy

authors： Rapp RP,Urban C

更新日期：2012-05-01 00:00:00

abstract：:Oropharyngeal candidiasis may be the first manifestation of human immunodeficiency viral (HIV) infection, and more than 90% of patients with the acquired immunodeficiency syndrome (AIDS) develop the disease. Although numerous antifungal agents are available, azoles, both topical (clotrimazole) and systemic (fluconazol...

journal_title：Pharmacotherapy

authors： Vazquez JA

更新日期：1999-01-01 00:00:00