Insulin glargine and cancer risk: an opinion statement of the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy.

abstract：STUDY OBJECTIVE:To evaluate the impact of a hospital-acquired pneumonia (HAP) protocol on appropriateness of empiric antibiotic therapy, antibiotic deescalation, antibiotic duration, patient mortality, and length of stay. DESIGN:Before- and after-study of protocol implementation. SETTING:A 450-bed, academic medical c...

journal_title：Pharmacotherapy

authors： Lancaster JW,Lawrence KR,Fong JJ,Doron SI,Garpestad E,Nasraway SA,Devlin JW

更新日期：2008-07-01 00:00:00

abstract：:Beta-blockers are an important cardiovascular drug class, recommended as first-line treatment of numerous diseases such as heart failure, hypertension, and angina, as well as treatment after myocardial infarction. However, responses to a beta-blocker are variable among patients. Results of numerous studies now suggest...

journal_title：Pharmacotherapy

authors： Shin J,Johnson JA

更新日期：2007-06-01 00:00:00

abstract：:Patients enrolled in a fixed-dose clinical trial of oral ciprofloxacin had trough concentrations measured to document absorption and monitor compliance. The objective was to determine whether any demographic characteristics might be important predictors of the concentrations. Stepwise multivariate linear regression re...

journal_title：Pharmacotherapy

authors： Paladino JA,Forrest A,Wilton JH

更新日期：1993-09-01 00:00:00

abstract：STUDY OBJECTIVES:To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension, to compare the characteristics of patients who withdrew with those of patients who completed the study, and...

journal_title：Pharmacotherapy

authors： Rozenfeld Y,Hunt JS

更新日期：2006-11-01 00:00:00

abstract：:A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, pr...

journal_title：Pharmacotherapy

authors： Andersen JM,Tiede JJ

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To determine if asthma control improves in patients who receive physician-pharmacist collaborative management (PPCM) during visits to primary care medical offices. DESIGN:Prospective pre-post study of patients who received the intervention in primary care offices for 9 months. The primary outcome was the sum...

journal_title：Pharmacotherapy

authors： Gums TH,Carter BL,Milavetz G,Buys L,Rosenkrans K,Uribe L,Coffey C,MacLaughlin EJ,Young RB,Ables AZ,Patel-Shori N,Wisniewski A

更新日期：2014-10-01 00:00:00

abstract：:Thirty-six indigent patients hospitalized within 6 months of study initiation and who met criteria were enrolled in a 6-month assistance program to determine if provision of both medical care and prescription drugs at no cost would be associated with a change in overall health care charges secondary to a change in the...

journal_title：Pharmacotherapy

authors： Nykamp D,Ruggles D

更新日期：2000-02-01 00:00:00

abstract：:A man anticoagulated with warfarin 57.5 mg/week (international normalized ratio [INR] 1.94) was diagnosed with nonsmall cell lung cancer and prescribed weekly gemcitabine. With the first dose of the first cycle, his INR rose to 3.52, and his weekly warfarin dose was decreased to 52.5 mg. The lower warfarin dose was co...

journal_title：Pharmacotherapy

authors： Kinikar SA,Kolesar JM

更新日期：1999-11-01 00:00:00

abstract：:Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (NOAC) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life-threatening ble...

journal_title：Pharmacotherapy

authors： Sigawy C,Apter S,Vine J,Grossman E

更新日期：2015-07-01 00:00:00

abstract：STUDY OBJECTIVES:To determine changes in bone mineral density (BMD) and T scores of patients after 2 years of teriparatide therapy, and to determine the number of fractures that occurred during therapy. DESIGN:Prospective, observational study. SETTING:Pharmacist-run teriparatide clinic in a private-practice endocrino...

journal_title：Pharmacotherapy

authors： Stroup JS,Rivers SM,Abu-Baker AM,Kane MP

更新日期：2007-06-01 00:00:00

abstract：:Nabilone, a synthetic cannabinoid, is approved in many countries including, but not limited to, Canada, the United States, Mexico, and the United Kingdom for the treatment of severe nausea and vomiting associated with chemotherapy. Clinical evidence is emerging for its use in managing pain conditions with different et...

journal_title：Pharmacotherapy

authors： Tsang CC,Giudice MG

更新日期：2016-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the feasibility of therapeutic drug monitoring for adjusting low serum antimycobacterial concentrations in patients with both tuberculosis and advanced human immunodeficiency virus (HIV). DESIGN:Retrospective cohort study. DATA SOURCE:De-identified dataset from a tuberculosis clinic. PAT...

journal_title：Pharmacotherapy

authors： Holland DP,Hamilton CD,Weintrob AC,Engemann JJ,Fortenberry ER,Peloquin CA,Stout JE

更新日期：2009-05-01 00:00:00

abstract：:Fentanyl iontophoretic transdermal system (ITS) is a novel, patient-activated drug delivery device used for the management of acute postoperative pain in the hospital setting. This credit-card-sized device uses an imperceptible current of 170 milliampere to actively deliver a fentanyl hydrochloride 40-microg dose into...

journal_title：Pharmacotherapy

authors： Herndon CM

更新日期：2007-05-01 00:00:00

abstract：:Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, occurring in up to 65% of cardiac surgical patients. It is a condition associated with increased morbidity, increased length of hospital stay, and increased health care costs. One of the many potential causes of POAF is...

journal_title：Pharmacotherapy

authors： Worden JC,Asare K

更新日期：2014-11-01 00:00:00

abstract：:Cyclosporine can be given intravenously or orally, as a solution or soft gelatin capsule. Because of the drug's poor water solubility, ethoxylated plant fats and ethanol are added to the commercially available dosage forms. ...

journal_title：Pharmacotherapy

authors： Yee GC

更新日期：1991-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the extent of hospital-based clinical pharmacy services in 1992. DESIGN:National survey with trend comparison to 1989. SETTING:All 1597 United States acute care, general medical-surgical and pediatric hospitals with 50 or more licensed beds and one or more full-time pharmacists (43% of al...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL,Pitterle ME

更新日期：1994-05-01 00:00:00

abstract：STUDY OBJECTIVES:To assess the effectiveness of pretreatment with ibuprofen or acetaminophen compared with no pretreatment in decreasing adverse events in children and adolescents receiving the first and second series of pamidronate therapy; and to compare the effectiveness of ibuprofen versus acetaminophen for prevent...

journal_title：Pharmacotherapy

authors： Robinson RE,Nahata MC,Hayes JR,Batisky DL,Bates CM,Mahan JD

更新日期：2004-02-01 00:00:00

abstract：:We examined whether low doses of phenytoin, which should be associated with few dose-related side effects, may increase the levels of high-density lipoprotein (HDL) cholesterol. Of 35 healthy adult men who consented to participate, 31 completed the study. They took no medications and consumed no alcohol during the stu...

journal_title：Pharmacotherapy

authors： McKenney JM,Petrizzi KS,Briggs GC,Wright JT Jr

更新日期：1992-01-01 00:00:00

abstract：:The American College of Clinical Pharmacy (ACCP) published an initial white paper on herbal products in 2000. Since then, the global market for natural products has continued to expand, with tens of millions of consumers using such products on an annual basis in the United States alone. However, despite this expansion...

journal_title：Pharmacotherapy

authors： Gabay M,Smith JA,Chavez ML,Goldwire M,Walker S,Coon SA,Gosser R,Hume AL,Musselman M,Phillips J,Abe AM

更新日期：2017-01-01 00:00:00

abstract：:A 71-year-old Caucasian woman was admitted to the hospital with right-sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3 degrees F. Four bloo...

journal_title：Pharmacotherapy

authors： Pound MW,Fulton KB,Chima CO

更新日期：2007-01-01 00:00:00

abstract：:Fluoxetine hydrochloride is the sixth most prescribed drug in the United States and is administered to treat major depression. A cadaveric skin donation was obtained from a 46-year-old woman who died as a result of a fluoxetine overdose. Due to the potential penetration of the drug and its major metabolite, norfluoxet...

journal_title：Pharmacotherapy

authors： Neudeck BL,Taddonio TE,Garner WL,Welage LS

更新日期：1998-07-01 00:00:00

abstract：:Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...

journal_title：Pharmacotherapy

authors： Redman AR

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:There are limited markers that could facilitate individualized tacrolimus treatment in the early posttransplantation period. Genetic factors have been found to play critical roles in determining tacrolimus pharmacokinetics. OBJECTIVE:We aimed to examine the association of donor and recipient Toll-like recep...

journal_title：Pharmacotherapy

authors： Ou B,Liu Y,Zhang T,Sun Y,Chen J,Peng Z

更新日期：2019-01-01 00:00:00

abstract：:Personalized medicine has been a mainstay and in practice in transplant pharmacotherapy since the advent of the field. Decisions pertaining to the diagnosis, selection, and monitoring of transplant pharmacotherapy are aimed toward the individual, the allograft, and the overall immunologic needs of the patient. Recent ...

journal_title：Pharmacotherapy

authors： Maldonado AQ,West-Thielke P,Joyal K,Marks CR

更新日期：2020-11-06 00:00:00

abstract：:Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihyperte...

journal_title：Pharmacotherapy

authors： Barksdale JD,Gardner SF

更新日期：1999-05-01 00:00:00

abstract：:Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence of abuse potential. Buspirone is both a dopamine agonist and anta...

journal_title：Pharmacotherapy

authors： Goldberg HL

更新日期：1984-11-01 00:00:00

abstract：:Acute myeloid leukemia (AML), a clonal hematologic malignancy that results in bone marrow failure, is the most common acute leukemia in adults (median age of diagnosis 67 yrs), and treatment options, especially in the elderly population, are limited. Induction chemotherapy with 7 + 3, the combination of continuous-inf...

journal_title：Pharmacotherapy

authors： Stansfield LC,Pollyea DA

更新日期：2017-12-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS...

journal_title：Pharmacotherapy

authors： Hendeles L,Davison D,Harman E,Sherman JM

更新日期：1999-11-01 00:00:00

abstract：:Females of childbearing age represent a large population of solid organ transplant recipients. With fertility commonly restored after transplantation, the possibility of pregnancy becomes a reality for many patients. Since the first published report of a successful pregnancy after solid organ transplantation in 1963, ...

journal_title：Pharmacotherapy

authors： Casale JP,Doligalski CT

更新日期：2016-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the safety, tolerability, and pharmacokinetic profile of fosphenytoin, a water-soluble phenytoin prodrug, after intramuscular and intravenous administration. DESIGN:Open-label study of intramuscular administration, and double-blind, randomized study of intravenous administration. SETTING:S...

journal_title：Pharmacotherapy

authors： Boucher BA,Feler CA,Dean JC,Michie DD,Tipton BK,Smith KR Jr,Kramer RE,Young B,Parks BR Jr,Kugler AR

更新日期：1996-07-01 00:00:00