Phosphorylation of nucleoside analog antiretrovirals: a review for clinicians.

abstract：:A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, wi...

journal_title：Pharmacotherapy

authors： McMahon FG,Vargas R

更新日期：1993-07-01 00:00:00

abstract：STUDY OBJECTIVES:To assess the use and safety of concurrent administration of voriconazole and sirolimus-which is contraindicated-and to determine approaches for appropriately managing patients who receive both drugs. DESIGN:Retrospective medical record review. SETTING:University-affiliated medical center. PATIENTS:...

journal_title：Pharmacotherapy

authors： Surowiec D,DePestel DD,Carver PL

更新日期：2008-06-01 00:00:00

abstract：:Fluoxetine hydrochloride is the sixth most prescribed drug in the United States and is administered to treat major depression. A cadaveric skin donation was obtained from a 46-year-old woman who died as a result of a fluoxetine overdose. Due to the potential penetration of the drug and its major metabolite, norfluoxet...

journal_title：Pharmacotherapy

authors： Neudeck BL,Taddonio TE,Garner WL,Welage LS

更新日期：1998-07-01 00:00:00

abstract：:Dabigatran, a direct thrombin inhibitor, is an oral anticoagulant indicated for the prevention of stroke in patients with atrial fibrillation (AF) and for the treatment and prevention of deep vein thrombosis and pulmonary embolism. Dabigatran, as well as the other new anticoagulants-rivaroxaban, apixaban, and edoxaban...

journal_title：Pharmacotherapy

authors： Wiggins BS,Northup A,Johnson D,Senfield J

更新日期：2016-02-01 00:00:00

abstract：:A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...

journal_title：Pharmacotherapy

authors： Naro A,Bramanti P,Calabrò RS

更新日期：2014-12-01 00:00:00

abstract：:Although in the last few years new antidepressants have become available in the United States, responses in many patients differ, from none, to partial, to delayed therapeutic response to the agents. If the antidepressant properties of these drugs could be enhanced or accelerated, it might be possible to improve patie...

journal_title：Pharmacotherapy

authors： Puzantian T,Kawase K

更新日期：1999-02-01 00:00:00

abstract：STUDY OBJECTIVES:To assess the effectiveness of pretreatment with ibuprofen or acetaminophen compared with no pretreatment in decreasing adverse events in children and adolescents receiving the first and second series of pamidronate therapy; and to compare the effectiveness of ibuprofen versus acetaminophen for prevent...

journal_title：Pharmacotherapy

authors： Robinson RE,Nahata MC,Hayes JR,Batisky DL,Bates CM,Mahan JD

更新日期：2004-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the ability of seven widely known herbal references and electronic databases to answer questions about herbal products asked at drug information centers. DESIGN:Cross-sectional study. SETTING:Five academic and institutional drug information centers. METHODS:Fifty-seven herbal-related ques...

journal_title：Pharmacotherapy

authors： Walker JB

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...

journal_title：Pharmacotherapy

authors： Rizk HG,Lee JA,Liu YF,Endriukaitis L,Isaac JL,Bullington WM

更新日期：2020-12-01 00:00:00

abstract：:Surgical hemostasis may be achieved by using a number of physical, chemical, or biologic methods. One such method is with topical thrombin; however, one member of that class of drugs, bovine-derived thrombin, is associated with potentially serious consequences such as development of immune-mediated coagulopathy. This ...

journal_title：Pharmacotherapy

authors： Naoum JJ

更新日期：2009-07-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the effect of a standard meal on bioavailability of bromfenac, and on the relative analgesic efficacy and adverse effect liability of bromfenac 25 mg, naproxen sodium 550 mg, and acetaminophen 325 mg in the treatment of pain after orthopedic surgery. DESIGN:Randomized, double-blind, single...

journal_title：Pharmacotherapy

authors： Forbes JA,Sandberg RA,Bood-Björklund L

更新日期：1998-05-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the safety and efficacy of rabbit antithymocyte globulin (r-ATG) with basiliximab in renal transplant recipients for whom an early steroid withdrawal (ESW) regimen was planned. DESIGN:Single-center, retrospective, cohort study. SETTING:Tertiary care medical center, including inpatient hospi...

journal_title：Pharmacotherapy

authors： Martin ST,Roberts KL,Malek SK,Tullius SG,Vadivel N,De Serres S,Grafals M,Elsanjak A,Filkins BA,Chandraker A,Gabardi S

更新日期：2011-06-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the impact of having an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. DESIGN:Retrospective cohort study. SETTING:Urban academic teaching hospital. PATIENTS:A total of 11,872 adults admitted to nonsurgical patient care wards who received ...

journal_title：Pharmacotherapy

authors： Charneski L,Deshpande G,Smith SW

更新日期：2011-08-01 00:00:00

abstract：:Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, occurring in up to 65% of cardiac surgical patients. It is a condition associated with increased morbidity, increased length of hospital stay, and increased health care costs. One of the many potential causes of POAF is...

journal_title：Pharmacotherapy

authors： Worden JC,Asare K

更新日期：2014-11-01 00:00:00

abstract：:A 71-year-old Caucasian woman was admitted to the hospital with right-sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3 degrees F. Four bloo...

journal_title：Pharmacotherapy

authors： Pound MW,Fulton KB,Chima CO

更新日期：2007-01-01 00:00:00

abstract：:Little information has been published concerning differences among the benzodiazepines in treating hospitalized patients with severe symptoms of alcohol withdrawal. We attempted to determine the length and type of hospital stay, and the pattern and appropriateness of administration, dosage requirements, and costs asso...

journal_title：Pharmacotherapy

authors： Hoey LL,Nahum A,Vance-Bryan K

更新日期：1994-09-01 00:00:00

abstract：:Clinical pharmacists must often interpret and use data derived from observational studies when making clinical decisions and recommendations, answering drug information questions, and educating patients about drug therapy. This is the third article in a three-part series intended to enhance clinical pharmacists' under...

journal_title：Pharmacotherapy

authors： Shields KM,DiPietro NA,Kier KL

更新日期：2011-02-01 00:00:00

abstract：:Pneumocystis carinii pneumonia (PCP) is the most common illness associated with the acquired immunodeficiency syndrome (AIDS) in the United States and also occurs in immunocompromised persons not infected with the human immunodeficiency virus.. Several advances have taken place in the treatment and prophylaxis of PCP,...

journal_title：Pharmacotherapy

authors： Warren E,George S,You J,Kazanjian P

更新日期：1997-09-01 00:00:00

abstract：:Exenatide is an incretin mimetic indicated for the treatment of type 2 diabetes mellitus in combination with a sulfonylurea, a thiazolidinedione, metformin, or metformin plus a sulfonylurea or thiazolidinedione. Exenatide lowers postprandial blood glucose levels by stimulating glucose-dependent insulin secretion, inhi...

journal_title：Pharmacotherapy

authors： Sheffield CA,Kane MP,Busch RS

更新日期：2007-10-01 00:00:00

abstract：:The popularity of amiodarone has grown due to its effectiveness in converting arrhythmia and its formulation availability. Formulations of the drug also contain iodine; the iodine content is 75 mg in a 200-mg tablet of amiodarone and 18.7 mg/ml in the intravenous solution. Approximately 10% of the iodine content of or...

journal_title：Pharmacotherapy

authors： Brouse SD,Phillips SM

更新日期：2005-03-01 00:00:00

abstract：:A 23-year-old man was brought to the emergency department after eating four boxes of brodifacoum-containing rodenticide over a 4-day interval and pieces from approximately two bottles of glass over the previous 2 weeks. He was asymptomatic but his prothrombin time was markedly elevated with an international normalized...

journal_title：Pharmacotherapy

authors： Tsutaoka BT,Miller M,Fung SM,Patel MM,Olson KR

更新日期：2003-09-01 00:00:00

abstract：STUDY OBJECTIVES:To characterize the steady-state pharmacokinetics of intravenous levetiracetam in neurocritical care patients requiring seizure prophylaxis after a neurologic injury and to determine which dosing regimens achieve serum concentrations within the recommended therapeutic range of 6-20 μg/ml. DESIGN. Prosp...

journal_title：Pharmacotherapy

authors： Spencer DD,Jacobi J,Juenke JM,Fleck JD,Kays MB

更新日期：2011-10-01 00:00:00

abstract：:A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight patients who had undergone orthopedic surgery. Plasma samples were obtained over a 72-hour period for pharmacokinetic analysis in five patients. The patients wer...

journal_title：Pharmacotherapy

authors： Plezia PM,Kramer TH,Linford J,Hameroff SR

更新日期：1989-01-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the effects of atorvastatin on low-density lipoprotein cholesterol (LDL) particle size and C-reactive protein (CRP) concentrations in patients undergoing long-term hemodialysis. Another objective was to compare the effects of atorvastatin on lipoprotein profiles as determined by direct ver...

journal_title：Pharmacotherapy

authors： Dornbrook-Lavender KA,Joy MS,Denu-Ciocca CJ,Chin H,Hogan SL,Pieper JA

更新日期：2005-03-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those of oral ondansetron plus dexamethasone administered before emetogenic chemotherapy. DESIGN:Randomized, prospective, multicenter, open-label study. SETTINGS:University-teaching hospital and veterans he...

journal_title：Pharmacotherapy

authors： Herrington JD,Kwan P,Young RR,Lagow E,Lagrone L,Riggs MW

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy of a single dose of basiliximab with two doses in preventing acute rejection in selected low-risk renal transplant recipients. METHODS:This observational study of 760 kidney transplant recipients considered to be at low immunologic risk (peak panel reactive antibody less than 10%) co...

journal_title：Pharmacotherapy

authors： Cunningham KC,Hager DR,Fischer J,D'Alessandro AM,Leverson GE,Kaufman DB,Djamali A

更新日期：2016-07-01 00:00:00

abstract：:We evaluated the efficacy and tolerability of amphotericin B triglyceride emulsion in 16 patients with acquired immunodeficiency syndrome-related candidal esophagitis and cryptococcosis, compared with standard amphotericin B in 24 patients. Compared with the conventional formulation, the fat emulsion was administered ...

journal_title：Pharmacotherapy

authors： Manfredi R,Chiodo F

更新日期：1998-09-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if transitioning patients from a pharmacist- managed anticoagulation clinic after stabilization of warfarin therapy to physician-managed care alters the quality of anticoagulation care. DESIGN:Retrospective medical record review. SETTING:Pharmacist-managed, urban academic medical center-b...

journal_title：Pharmacotherapy

authors： Garwood CL,Dumo P,Baringhaus SN,Laban KM

更新日期：2008-01-01 00:00:00

abstract：STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...

journal_title：Pharmacotherapy

authors： Locke C,Ravnan SL,Patel R,Uchizono JA

更新日期：2005-05-01 00:00:00

abstract：STUDY OBJECTIVE:To quantify the relative risk of cardiovascular events associated with microalbuminuria in patients with both diabetes mellitus and hypertension. DESIGN:A structured literature search from January 1990-December 2002 using MEDLINE, IPA, and CINAHL. MEASUREMENTS AND MAIN RESULTS:We identified original s...

journal_title：Pharmacotherapy

authors： Park HY,Schumock GT,Pickard AS,Akhras K

更新日期：2003-12-01 00:00:00