Determination of fluoxetine and norfluoxetine concentrations in cadaveric allograft skin.

abstract：:We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new beta-lactam-beta-lactamase inhibitor. Piperacillin-tazobactam has a wide spectrum of activity that includes gram-positive organisms such as staphylococci and streptococc...

journal_title：Pharmacotherapy

authors： Daniel KP,Krop LC

更新日期：1996-03-01 00:00:00

abstract：:Atrial fibrillation is the most common sustained cardiac arrhythmia and is associated with thromboembolic events and hemodynamic impairment that results in considerable morbidity, mortality, and cost. Cardioversion to sinus rhythm is a common approach to the treatment of these patients. However, cardioversion is assoc...

journal_title：Pharmacotherapy

authors： Wodlinger AM,Pieper JA

更新日期：2003-01-01 00:00:00

abstract：:A 26-year-old woman developed significant unilateral anterior cervical and supraclavicular lymphadenopathy 3 days after receiving her first dose (of a total of three doses) of human papilloma virus (HPV) vaccine. She had no history of lymphadenopathy after other previous immunizations, and had received no vaccines oth...

journal_title：Pharmacotherapy

authors： Studdiford J,Lamb K,Horvath K,Altshuler M,Stonehouse A

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Modification of guideline-directed medical therapy (GDMT) in hospitalized patients with heart failure (HF) has not been extensively evaluated. METHODS:The community surveillance arm of the Atherosclerosis Risk in Communities Study identified 6959 HF hospitalizations from 2005-2011. Predictors of GDMT modifi...

journal_title：Pharmacotherapy

authors： Tran RH,Aldemerdash A,Chang P,Sueta CA,Kaufman B,Asafu-Adjei J,Vardeny O,Daubert E,Alburikan KA,Kucharska-Newton AM,Stearns SC,Rodgers JE

更新日期：2018-04-01 00:00:00

abstract：:We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total...

journal_title：Pharmacotherapy

authors： Ross SD,Akhras KS,Zhang S,Rozinsky M,Nalysnyk L

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:To describe the legal, professional, and consumer status of prescribers dispensing legend and over-the-counter drugs in the United States. METHODS:Legal and academic databases were searched to identify those states that permit prescribers to dispense medications to patients and any limitations on such practi...

journal_title：Pharmacotherapy

authors： Munger MA,Ruble JH,Nelson SD,Ranker L,Petty RC,Silverstein S,Barton E,Feehan M

更新日期：2014-10-01 00:00:00

abstract：STUDY OBJECTIVES:To characterize patient sociodemographics and health, describe vancomycin treatment parameters and clinician-rated outcomes, and determine costs associated with treatment including preparation and administration, adverse events, and toxicity. DESIGN:A prospective study to develop a model for costs ass...

journal_title：Pharmacotherapy

authors： Garrelts JC,Horst WD,Silkey B,Gagnon S

更新日期：1994-07-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and plasma protein binding of eprosartan in hepatic disease. DESIGN:Single-dose, parallel-group study. SETTING:Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. PATIENTS:Eight healthy subjects with norm...

journal_title：Pharmacotherapy

authors： Tenero D,Martin D,Chapelsky M,Ilson B,Boike S,Patterson S,Keogh J,Rodriguez S,Jorkasky D

更新日期：1998-01-01 00:00:00

abstract：:Developing clinical pharmacists' research skills and their ability to compete for extramural funding is an important component of the American College of Clinical Pharmacy's (ACCP) vision for pharmacists to play a prominent role in generating the new knowledge used to guide patient pharmacotherapy. Given the recent em...

journal_title：Pharmacotherapy

authors： Parker RB,Ellingrod V,DiPiro JT,Bauman JL,Blouin RA,Welage LS

更新日期：2013-12-01 00:00:00

abstract：:Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15-year-old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentration dependent, an...

journal_title：Pharmacotherapy

authors： Cox TH,Baillie GM,Baliga P

更新日期：1997-11-01 00:00:00

abstract：:The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...

journal_title：Pharmacotherapy

authors： Brooks KM,Sherman EM,Egelund EF,Brotherton A,Durham S,Badowski ME,Cluck DB

更新日期：2019-05-01 00:00:00

abstract：:The systemic polymyxins, colistin and polymyxin B, are increasingly used for multidrug-resistant bacterial infections and have a long history of dose-limiting toxicity. This review summarizes the most recent available information about the mechanisms, incidence, risk factors, and minimization strategies for polymyxin ...

journal_title：Pharmacotherapy

authors： Justo JA,Bosso JA

更新日期：2015-01-01 00:00:00

abstract：:A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...

journal_title：Pharmacotherapy

authors： Christiansen SR,Broniscer A,Panetta JC,Stewart CF

更新日期：2009-07-01 00:00:00

abstract：:An area of unidirectional conduction block is one requirement for reentrant arrhythmias to occur. Functional block caused by dispersion of repolarization and refractoriness is the most probable mechanism of drug-induced unidirectional conduction block. We assessed the effects of lidocaine on spatial dispersion of myoc...

journal_title：Pharmacotherapy

authors： Sims JJ,Winecoff AP,Ujhelyi MR

更新日期：1997-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the toxicity of amphotericin B deoxycholate formulations. DESIGN:In vitro experiment. SETTING:University research center. MATERIAL:Human mononuclear THP-1 cells. INTERVENTION:The human mononuclear cells were exposed in vitro for 2 hours to the following deoxycholate formulations of ampho...

journal_title：Pharmacotherapy

authors： Cleary JD,Rogers PD,Chapman SW

更新日期：2003-05-01 00:00:00

abstract：:The traditional role of theophylline as a bronchodilator has been expanded by recent findings that suggest this drug has more than smooth muscle relaxant properties. Several investigators indicate that theophylline has an inotropic effect on respiratory muscle, causing enhanced muscular contraction and prevention of m...

journal_title：Pharmacotherapy

authors： Landsberg KF,Vaughan LM,Heffner JE

更新日期：1990-01-01 00:00:00

abstract：:The management of heart failure is complex. Initiating and maintaining drug therapy in patients with heart failure can be challenging. Many factors influence the heart failure syndrome and are important to account for when evaluating these patients. Concomitant diseases such as ischemic heart disease and hypertension ...

journal_title：Pharmacotherapy

authors： Gattis WA

更新日期：2000-11-01 00:00:00

abstract：:Atorvastatin calcium is an HMG-coenzyme A (CoA) reductase inhibitor that was approved by the Food and Drug Administration on December 17, 1996. Like other such agents, it inhibits the action of HMG-CoA reductase and thereby decreases endogenous cholesterol synthesis, leading to a decrease in circulating low-density li...

journal_title：Pharmacotherapy

authors： Chong PH,Seeger JD

更新日期：1997-11-01 00:00:00

abstract：:Albuterol is a 50:50 mixture of R-albuterol, the active enantiomer, and S-albuterol, which appears to be inactive in humans. The Food and Drug Administration recently approved levalbuterol, the pure R-isomer, as a preservative-free nebulizer solution. Published studies indicate that it is neither safer nor more effect...

journal_title：Pharmacotherapy

authors： Asmus MJ,Hendeles L

更新日期：2000-02-01 00:00:00

abstract：:Graves' disease is an autoimmune disorder in which inappropriate stimulation of the thyroid gland results in unregulated secretion of thyroid hormones resulting in hyperthyroidism. Graves' disease is the most common cause of autoimmune hyperthyroidism during pregnancy. Treatment options for Graves' disease include thi...

journal_title：Pharmacotherapy

authors： Prunty JJ,Heise CD,Chaffin DG

更新日期：2016-01-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the occurrence of bleeding and venous thromboembolic (VTE) events in patients receiving rivaroxaban, warfarin, or warfarin with the addition of enoxaparin during the immediate postoperative period following major orthopedic surgery. METHODS:Patients older than 18 years who received at leas...

journal_title：Pharmacotherapy

authors： Cieri NE,Kusmierski K,Lackie C,Van Opdorp A,Hassan AK

更新日期：2017-02-01 00:00:00

abstract：:Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in clinical studies. For this reason, in vitro and animal models were developed to investigate the effects of critical illness on hepatic drug metabolism...

journal_title：Pharmacotherapy

authors： McKindley DS,Hanes S,Boucher BA

更新日期：1998-07-01 00:00:00

abstract：:The development of an intravenous form of nitroglycerin has further enhanced the role of nitrates in the therapy of cardiovascular disorders. This new preparation permits prompt initiation of therapy and rapid attainment of high systemic levels; because of its short half-life, rapid dose titration is both feasible and...

journal_title：Pharmacotherapy

authors： Jaffe AS,Roberts R

更新日期：1982-09-01 00:00:00

abstract：:Colistin, the most widely used polymyxin antibiotic, was originally introduced in the late 1950s before the establishment of the present-day drug approval process. Originally shelved due to toxicity concerns, colistin, in the form of its inactive prodrug colistin methanesulfonate, has undergone a renaissance in the pa...

journal_title：Pharmacotherapy

authors： Ortwine JK,Kaye KS,Li J,Pogue JM

更新日期：2015-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether early administration of adjuvant β-lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection. DESIGN:Retrospective, multic...

journal_title：Pharmacotherapy

authors： Casapao AM,Jacobs DM,Bowers DR,Beyda ND,Dilworth TJ,REACH-ID Study Group.

更新日期：2017-11-01 00:00:00

abstract：:Oropharyngeal candidiasis may be the first manifestation of human immunodeficiency viral (HIV) infection, and more than 90% of patients with the acquired immunodeficiency syndrome (AIDS) develop the disease. Although numerous antifungal agents are available, azoles, both topical (clotrimazole) and systemic (fluconazol...

journal_title：Pharmacotherapy

authors： Vazquez JA

更新日期：1999-01-01 00:00:00

abstract：:Fluconazole is a commonly prescribed antifungal agent with a favorable safety profile. A patient experienced agranulocytosis and eosinophilia associated with the drug. Similar bone marrow-suppressive effect due to the azoles is rarely described in the English-language literature. ...

journal_title：Pharmacotherapy

authors： Wong-Beringer A,Shriner K

更新日期：2000-04-01 00:00:00

abstract：:The role of the formulary system for effective cost containment is becoming increasingly important. With antimicrobial agents taking up a large proportion of most pharmaceutical budgets, this group of agents is an obvious target for cost reduction. The responsible interchange of selected antimicrobial agents offers a ...

journal_title：Pharmacotherapy

authors： Wright DB

更新日期：1991-01-01 00:00:00

abstract：:In an open-label study of alprazolam in five bipolar-I depressed patients, three patients remitted completely, one failed to respond, and one responded transiently, based on the Hamilton Rating Scale and Beck Depression Inventory scores. Further studies of alprazolam as an antidepressant are warranted. ...

journal_title：Pharmacotherapy

authors： Rush AJ,Schlesser MA,Erman M,Fairchild C

更新日期：1984-01-01 00:00:00

abstract：:Resistance of nosocomial and community-acquired pathogens to antimicrobial agents is a serious problem with significant clinical consequences. Microbiologic surveillance data, such as those provided by the National Nosocomial Infections Surveillance System, supply information on current nosocomial pathogens in the Uni...

journal_title：Pharmacotherapy

authors： Thornsberry C

更新日期：1995-01-01 00:00:00