Hepatic drug metabolism in critical illness.

Abstract:

:Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in clinical studies. For this reason, in vitro and animal models were developed to investigate the effects of critical illness on hepatic drug metabolism. Specifically, those with sepsis, septic shock, hemorrhagic shock, trauma, neurotrauma, and burns are populations that have been studied. Most of this research, however, has not led to established guidelines for the administration of drugs in these populations.

journal_name

Pharmacotherapy

journal_title

Pharmacotherapy

authors

McKindley DS,Hanes S,Boucher BA

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

759-78

issue

4

eissn

0277-0008

issn

1875-9114

journal_volume

18

pub_type

杂志文章,评审
  • Pharmacokinetics of daptomycin in a critically ill adolescent with vancomycin-resistant enterococcal endocarditis.

    abstract::Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms. Our search of the literature found no published pediatric pharmacokinetic data. We report the use of pharmacokinetic analysis of daptomycin in a 13-year-old boy with vancomycin-resistant Enterococcus faecium endocarditis...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.26.5.694

    authors: Akins RL,Haase MR,Levy EN

    更新日期:2006-05-01 00:00:00

  • Severe hypoglycemia from Helicobacter pylori triple-drug therapy and insulin detemir drug interaction.

    abstract::Two drugs commonly used in triple-drug therapy for treatment of a Helicobacter pylori infection, clarithromycin and omeprazole, have rarely been associated with hypoglycemia when given alone. No documented interactions between H. pylori treatment with clarithromycin, amoxicillin, and omeprazole and insulin detemir hav...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.1228

    authors: Otsuka SH

    更新日期:2013-04-01 00:00:00

  • ACCP Clinical Pharmacist Competencies.

    abstract::The purpose of the American College of Clinical Pharmacy (ACCP) is to advance human health by extending the frontiers of clinical pharmacy. Consistent with this mission and its core values, ACCP is committed to ensuring that clinical pharmacists possess the knowledge, skills, attitudes, and behaviors necessary to deli...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.1923

    authors: Saseen JJ,Ripley TL,Bondi D,Burke JM,Cohen LJ,McBane S,McConnell KJ,Sackey B,Sanoski C,Simonyan A,Taylor J,Vande Griend JP

    更新日期:2017-05-01 00:00:00

  • Efficacy and Safety of the Use of Pulmonary Arterial Hypertension Pharmacotherapy in Patients with Pulmonary Hypertension Secondary to Left Heart Disease: A Systematic Review.

    abstract::Pulmonary hypertension (PH) is often caused by left heart disease (LHD) such as heart failure (HF) or valvular heart disease. Historically, few randomized controlled trials have evaluated the off-label use of medications for treating pulmonary arterial hypertension (PAH) in patients with PH-LHD. However, multiple rand...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2314

    authors: Kido K,Coons JC

    更新日期:2019-09-01 00:00:00

  • Therapeutic drug monitoring of antimycobacterial drugs in patients with both tuberculosis and advanced human immunodeficiency virus infection.

    abstract:STUDY OBJECTIVE:To determine the feasibility of therapeutic drug monitoring for adjusting low serum antimycobacterial concentrations in patients with both tuberculosis and advanced human immunodeficiency virus (HIV). DESIGN:Retrospective cohort study. DATA SOURCE:De-identified dataset from a tuberculosis clinic. PAT...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.29.5.503

    authors: Holland DP,Hamilton CD,Weintrob AC,Engemann JJ,Fortenberry ER,Peloquin CA,Stout JE

    更新日期:2009-05-01 00:00:00

  • Evaluation of the total cost of treating elderly hypertensive patients with ACE inhibitors: a comparison of older and newer agents.

    abstract::We compared total costs and adherence to the regimen of older versus newer angiotensin-converting enzyme (ACE) inhibitors for the treatment of elderly patients with hypertension. A computer search using the data base of a health care insurer identified 6176 subjects age 65 years or older who had ICD-9 coding for hyper...

    journal_title:Pharmacotherapy

    pub_type: 临床试验,杂志文章

    doi:

    authors: Small RE,Freeman-Arnold SB,Goode JV,Pyles MA

    更新日期:1997-09-01 00:00:00

  • Reduction in warfarin adverse events requiring patient hospitalization after implementation of a pharmacist-managed anticoagulation service.

    abstract:STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.25.5.685.63582

    authors: Locke C,Ravnan SL,Patel R,Uchizono JA

    更新日期:2005-05-01 00:00:00

  • Renal Transplant Acute Rejection with Lower Mycophenolate Mofetil Dosing and Proton Pump Inhibitors or Histamine-2 Receptor Antagonists.

    abstract:BACKGROUND:Pharmacokinetic data show reduced mycophenolic acid levels in renal transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. This reduced exposure could increase rejection risk. The typical initial MMF dose post renal transplantation is 2 g/day, which often re...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2037

    authors: Patel KS,Stephany BR,Barnes JF,Bauer SR,Spinner ML

    更新日期:2017-12-01 00:00:00

  • Guideline-Directed Medical Therapy and Survival Following Hospitalization in Patients with Heart Failure.

    abstract:BACKGROUND:Modification of guideline-directed medical therapy (GDMT) in hospitalized patients with heart failure (HF) has not been extensively evaluated. METHODS:The community surveillance arm of the Atherosclerosis Risk in Communities Study identified 6959 HF hospitalizations from 2005-2011. Predictors of GDMT modifi...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,多中心研究

    doi:10.1002/phar.2091

    authors: Tran RH,Aldemerdash A,Chang P,Sueta CA,Kaufman B,Asafu-Adjei J,Vardeny O,Daubert E,Alburikan KA,Kucharska-Newton AM,Stearns SC,Rodgers JE

    更新日期:2018-04-01 00:00:00

  • Resolution of tumor pain with EMLA cream.

    abstract::A 69-year-old woman was admitted for control of intractable rectal pain caused by a 4-cm malignant mass. She was treated successfully with EMLA (eutectic mixture of local anesthetics) cream applied every 8 hours and covered with a Xeroform dressing. Despite an increase in tumor size to 6 cm, her pain control was maint...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Stegman MB,Stoukides CA

    更新日期:1996-07-01 00:00:00

  • Pharmacodynamics of trimethoprim-sulfamethoxazole in Listeria meningitis: a case report.

    abstract::Infections in the cerebrospinal fluid (CSF) occur in an area of impaired host defenses; therefore, bactericidal antibiotics that reach adequate concentrations in the CSF are necessary for treatment. Measurements of antibiotic penetration into the CSF include CSF inhibitory and bactericidal titers, the absolute antibio...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Friedrich LV,White RL,Reboli AC

    更新日期:1990-01-01 00:00:00

  • Management of venous thromboembolism and the potential to impact overall survival in patients with cancer.

    abstract::The risk of venous thromboembolism (VTE) in patients with cancer is 6-12-fold higher than in the general population, and VTE is the second leading cause of death in this population, after cancer itself. The etiology underlying the increased risk of VTE is multifactorial and complex, involving patient-, tumor-, and tre...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.29.11.1344

    authors: Saraiya B,Goodin S

    更新日期:2009-11-01 00:00:00

  • A retrospective review and assessment of benzodiazepines in the treatment of alcohol withdrawal in hospitalized patients.

    abstract::Little information has been published concerning differences among the benzodiazepines in treating hospitalized patients with severe symptoms of alcohol withdrawal. We attempted to determine the length and type of hospital stay, and the pattern and appropriateness of administration, dosage requirements, and costs asso...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Hoey LL,Nahum A,Vance-Bryan K

    更新日期:1994-09-01 00:00:00

  • Argatroban therapy for antithrombin deficiency and mesenteric thrombosis: case report and review of the literature.

    abstract::Antithrombin deficiency is a hypercoagulable state that can increase the risk for thrombosis, especially in the presence of other procoagulant triggers. Unfractionated heparin and low-molecular-weight heparins may not provide effective anticoagulation since they require antithrombin for activity. Direct thrombin inhib...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.24.6.659.34745

    authors: Dager WE,Gosselin RC,Owings JT

    更新日期:2004-05-01 00:00:00

  • Decreased antimicrobial resistance after changes in antibiotic use.

    abstract::Vancomycin-resistant enterococci (VRE) and methicillin-oxacillin-resistant Staphylococcus aureus (MRSA) originally predominated in large medical centers; however, these isolates are now common in community hospitals and community clinics. No simple answer is available regarding control of antimicrobial-resistant bacte...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.19.12.129s.31702

    authors: Smith DW

    更新日期:1999-08-01 00:00:00

  • Recommendations for generating, evaluating, and implementing drug-drug interaction evidence.

    abstract::In October 2009, a 2-day, multistakeholder, national conference was held in Rockville, Maryland, to discuss and propose methods to improve the drug-drug interaction (DDI) evidence base and its evaluation and integration into clinical decision support (CDS) systems. The conference featured participants representing con...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/j.1875-9114.2012.01024.x

    authors: Hines LE,Malone DC,Murphy JE

    更新日期:2012-04-01 00:00:00

  • Neurotoxicity associated with ceftazidime therapy in geriatric patients with renal dysfunction.

    abstract::Ceftazidime, a beta-lactamase-stable, third-generation cephalosporin, is widely used for the treatment of serious gram-negative infections. Neurotoxicity has rarely been associated with the drug; however, two of our patients developed ceftazidime-induced neurotoxicity that produced confusion, disorientation, agitation...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Slaker RA,Danielson B

    更新日期:1991-01-01 00:00:00

  • Evaluation of the ability of seven herbal resources to answer questions about herbal products asked in drug information centers.

    abstract:STUDY OBJECTIVE:To evaluate the ability of seven widely known herbal references and electronic databases to answer questions about herbal products asked at drug information centers. DESIGN:Cross-sectional study. SETTING:Five academic and institutional drug information centers. METHODS:Fifty-seven herbal-related ques...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.22.17.1611.34126

    authors: Walker JB

    更新日期:2002-12-01 00:00:00

  • Resolution of a phytobezoar with Aldoph's Meat Tenderizer.

    abstract::A 58-year-old man went to his physician with complaints of midepigastric pain, flatulence, belching, and shortness of breath. During a physical examination, the patient was in no acute distress. The patient underwent an ultrasound examination, which revealed cholelithiasis, a laparoscopic cholecystectomy, which reveal...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.27.2.299

    authors: Baker EL,Baker WL,Cloney DJ

    更新日期:2007-02-01 00:00:00

  • Severe withdrawal syndrome possibly associated with cessation of a midazolam and fentanyl infusion.

    abstract::A 40-month-old child was sedated with a fentanyl and midazolam infusion for 7 days. After the drugs were discontinued he became unresponsive and globally aphasic, and had marked thrombocytosis. He was hospitalized for 4 weeks, during which time his motor and cognitive status slowly improved, and had almost returned to...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/j.1875-9114.1995.tb02877.x

    authors: Ducharme MP,Munzenberger P

    更新日期:1995-09-01 00:00:00

  • Clostridium difficile-associated disease: an emerging threat to patient safety: insights from the Society of Infectious Diseases Pharmacists.

    abstract::A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as se...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.26.3.299

    authors: Owens RC

    更新日期:2006-03-01 00:00:00

  • A double-blind, placebo-controlled evaluation of intranasal metoclopramide in the prevention of postoperative nausea and vomiting.

    abstract::Nausea and vomiting are common complaints in the postoperative period and contribute to patient distress and delay of discharge for outpatient surgical procedures. Laparoscopic procedures are associated with a high incidence of postoperative nausea and vomiting (PONV) episodes. Parenteral use of metoclopramide prevent...

    journal_title:Pharmacotherapy

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Wagner BK,Berman SL,Devitt PA,Halvorsen MB,O'Hara DA

    更新日期:1996-11-01 00:00:00

  • Physiology of the parietal cell and therapeutic implications.

    abstract::The field of acid suppression has been advanced by therapeutics of increasing specificity for inhibiting gastric acid secretion. Particularly important are proton pump inhibitors (PPIs), which inhibit the activity of the gastric acid pump (H+,K(+)-adenosine triphosphatase), the final common step in gastric acid produc...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.23.13.68s.31931

    authors: Sachs G

    更新日期:2003-10-01 00:00:00

  • Effects of buprenorphine on cardiac repolarization in a patient with methadone-related torsade de pointes.

    abstract::Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of meth...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.25.4.611.61020

    authors: Krantz MJ,Garcia JA,Mehler PS

    更新日期:2005-04-01 00:00:00

  • Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide.

    abstract:OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.2478

    authors: Rizk HG,Lee JA,Liu YF,Endriukaitis L,Isaac JL,Bullington WM

    更新日期:2020-12-01 00:00:00

  • Patient drug attributions and postmarketing surveillance.

    abstract::Although studies have shown that patients can distinguish probable adverse drug reactions (ADRs) from adverse clinical events (ACEs) caused by other factors, it is not known whether these attribution judgments add any independent validity to other accepted methods of identifying ADRs, such as physician assessments or ...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Fisher S,Bryant SG,Kent TA,Davis JE

    更新日期:1994-03-01 00:00:00

  • Treatment options for nausea and vomiting during pregnancy.

    abstract::Nausea and vomiting, common symptoms during pregnancy, often are regarded as an unpleasant but normal part of pregnancy during the first and early second trimesters. Nausea and vomiting of pregnancy (NVP) occurs in approximately 75-80% of pregnant women. The exact etiology and pathogenesis of NVP are poorly understood...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章,评审

    doi:10.1592/phco.26.9.1273

    authors: Badell ML,Ramin SM,Smith JA

    更新日期:2006-09-01 00:00:00

  • Vitamin K-independent warfarin resistance after concurrent administration of warfarin and continuous enteral nutrition.

    abstract:STUDY OBJECTIVE:To assess the influence of withholding continuous enteral nutrition for 1 hour before and after warfarin administration compared with the coadministration of warfarin with continuous enteral nutrition on changes in international normalized ratios (INRs). DESIGN:Retrospective, crossover case series. SE...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1592/phco.28.3.308

    authors: Dickerson RN,Garmon WM,Kuhl DA,Minard G,Brown RO

    更新日期:2008-03-01 00:00:00

  • Recommendations for meeting the pediatric patient's need for a clinical pharmacist: a joint opinion of the Pediatrics Practice and Research Network of the American College of Clinical Pharmacy and the Pediatric Pharmacy Advocacy Group.

    abstract::Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP Pediatrics PRN) released an opinion paper in 2005 with recommendations for improving the quality and quantity of pediatric pharmacy education in coll...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:10.1002/phar.1246

    authors: Bhatt-Mehta V,Buck ML,Chung AM,Farrington EA,Hagemann TM,Hoff DS,LaRochelle JM,Pettit RS,Phan H,Potts AL,Smith KP,Parrish RH 2nd

    更新日期:2013-02-01 00:00:00

  • Salary survey of ambulatory care clinical pharmacists.

    abstract::To determine salary and selected fringe benefits of members of the Ambulatory Care Practice and Research Network of the American College of Clinical Pharmacy, we developed a self-administered questionnaire that surveyed demographic information, schooling and training, academic appointments, yearly salary (as of Februa...

    journal_title:Pharmacotherapy

    pub_type: 杂志文章

    doi:

    authors: Anastasio GD,Shaughnessy AF

    更新日期:1997-05-01 00:00:00