Atorvastatin calcium: an addition to HMG-CoA reductase inhibitors.

abstract：:Hypoactive sexual desire disorder (HSDD) affects nearly 1 in 10 women. Thus, it is essential for pharmacists and other health care providers to be comfortable when discussing a patient's sexual health to ensure appropriate triage so that the specific causes of HSDD can be identified and potential recommendations provi...

journal_title：Pharmacotherapy

authors： Lodise NM

更新日期：2013-04-01 00:00:00

abstract：:Major depression afflicts a significant percentage of the population, and optimum therapy is often limited by the poor tolerability and lethality in overdose of the tricyclic antidepressants. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline, and, more recently, paroxetine are viewed as welcom...

journal_title：Pharmacotherapy

authors： Nemeroff CB

更新日期：1994-03-01 00:00:00

abstract：:Original research, reviews, and case reports discussing viral infectivity of blood- and plasma-derived products were reviewed to determine the potential viral infectivity of human serum albumin (HSA) and plasma protein fraction (PPF). Data concerning viral infectivity viral screening and inactivation procedures, and v...

journal_title：Pharmacotherapy

authors： Erstad BL

更新日期：1996-11-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...

journal_title：Pharmacotherapy

authors： Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

更新日期：2010-12-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the safety and efficacy of rabbit antithymocyte globulin (r-ATG) with basiliximab in renal transplant recipients for whom an early steroid withdrawal (ESW) regimen was planned. DESIGN:Single-center, retrospective, cohort study. SETTING:Tertiary care medical center, including inpatient hospi...

journal_title：Pharmacotherapy

authors： Martin ST,Roberts KL,Malek SK,Tullius SG,Vadivel N,De Serres S,Grafals M,Elsanjak A,Filkins BA,Chandraker A,Gabardi S

更新日期：2011-06-01 00:00:00

abstract：:Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described. In addition, cardiac adverse effects usually develop after at least 6 days of therapy. We describe a 54-year-old, human immunodeficien...

journal_title：Pharmacotherapy

authors： Antoniou T,Gough KA

更新日期：2005-06-01 00:00:00

abstract：:Struvite calculi result from urinary tract infections secondary to urease-producing bacteria. To prevent recurrent infection and stone formation complete removal of struvite calculi is recommended. Two illustrative reports of patients with renal struvite calculi are presented in which 10% hemiacidrin (Renacidin) irrig...

journal_title：Pharmacotherapy

authors： Massaro FJ,Weiner B,Sant GR,Meares EM Jr

更新日期：1983-11-01 00:00:00

abstract：STUDY OBJECTIVES:To examine potential threats to internal and external study validity caused by differential patient withdrawal from a randomized controlled trial evaluating pharmacist management of hypertension, to compare the characteristics of patients who withdrew with those of patients who completed the study, and...

journal_title：Pharmacotherapy

authors： Rozenfeld Y,Hunt JS

更新日期：2006-11-01 00:00:00

abstract：:Infections caused by multidrug-resistant Acinetobacter baumannii have become a therapeutic challenge for clinicians worldwide. Although colistin and tigecycline have been successful in treating patients with these infections, these agents are not available on a worldwide basis. We describe four critically ill patients...

journal_title：Pharmacotherapy

authors： Lee NY,Wang CL,Chuang YC,Yu WL,Lee HC,Chang CM,Wang LR,Ko WC

更新日期：2007-11-01 00:00:00

abstract：STUDY OBJECTIVES:To develop and validate an improved unfractionated heparin (UFH) dosage protocol, using antifactor Xa levels as the outcome variable. DESIGN:Prospective case series. SETTING:A 625-bed, adults-only private, tertiary care teaching hospital. PATIENTS:Three hundred seventy-two patients receiving UFH for...

journal_title：Pharmacotherapy

authors： Rosborough TK,Shepherd MF

更新日期：2004-06-01 00:00:00

abstract：:Diazepam is frequently the subject of review by various agencies and institutions charged with determining whether or not to substitute another, more economical drug--in most instances, chlordiazepoxide. A review of the comparative literature has shown that, on clinical and pharmacokinetic grounds, chlordiazepoxide is...

journal_title：Pharmacotherapy

authors： Baskin SI,Esdale A

更新日期：1982-03-01 00:00:00

abstract：:Albuterol is a 50:50 mixture of R-albuterol, the active enantiomer, and S-albuterol, which appears to be inactive in humans. The Food and Drug Administration recently approved levalbuterol, the pure R-isomer, as a preservative-free nebulizer solution. Published studies indicate that it is neither safer nor more effect...

journal_title：Pharmacotherapy

authors： Asmus MJ,Hendeles L

更新日期：2000-02-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...

journal_title：Pharmacotherapy

authors： Seto AC,Kenyon K,Wittkowsky AK

更新日期：2008-09-01 00:00:00

abstract：STUDY OBJECTIVE:To investigate potential associations between the histamine N-methyltransferase (HNMT) gene, HNMT, C314T (Thr105Ile) polymorphism and atopic dermatitis in a cohort of Caucasian children. DESIGN:Prospective, multicenter, genotype-association study. SETTING:Four academic, tertiary care medical centers w...

journal_title：Pharmacotherapy

authors： Kennedy MJ,Loehle JA,Griffin AR,Doll MA,Kearns GL,Sullivan JE,Hein DW

更新日期：2008-12-01 00:00:00

abstract：:Carbamazepine is a potent anticonvulsant agent with proven efficacy in the treatment of partial and tonic-clonic seizures. An epileptic child treated with therapeutic dosages of carbamazepine developed severe hepatitis and hepatic insufficiency. She had a positive response to withdrawal of the drug and administration ...

journal_title：Pharmacotherapy

authors： Morales-Diaz M,Pinilla-Roa E,Ruiz I

更新日期：1999-02-01 00:00:00

abstract：:Synercid (RP 59500), the first injectable streptogramin antibiotic, is composed of two semisynthetic pristinamycin derivatives, quinupristin and dalfopristin. Individually, each component has bacteriostatic activity against staphylococci and streptococci, but together, the agents exhibit synergy, leading to bactericid...

journal_title：Pharmacotherapy

authors： Delgado G Jr,Neuhauser MM,Bearden DT,Danziger LH

更新日期：2000-12-01 00:00:00

abstract：STUDY OBJECTIVES:To determine whether glomerular filtration rate (GFR) changes during induction chemotherapy in children with leukemia, and to examine GFR as a determinant of pharmacokinetic variability of methotrexate clearance. DESIGN:Prospective, unblinded observational study in consecutive patients. SETTING:A res...

journal_title：Pharmacotherapy

authors： Murry DJ,Synold TW,Pui CH,Rodman JH

更新日期：1995-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine prescribing patterns and clinical outcomes of enoxaparin for anticoagulation of atrial fibrillation. DESIGN:Retrospective analysis. SETTING:A 650-bed, tertiary care, community teaching hospital. SUBJECTS:Two hundred thirteen patients who received enoxaparin for thromboprophylaxis during ...

journal_title：Pharmacotherapy

authors： Khazan M,Scheuering S,Adamson R,Mathis AS

更新日期：2003-05-01 00:00:00

abstract：:We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total...

journal_title：Pharmacotherapy

authors： Ross SD,Akhras KS,Zhang S,Rozinsky M,Nalysnyk L

更新日期：2001-08-01 00:00:00

abstract：:Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriat...

journal_title：Pharmacotherapy

authors： Arpino PA,Greer DM

更新日期：2008-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the microbiologic and clinical outcomes of patients with extended-spectrum beta-lactamase (ESBL)-producing isolates over a 2-year period. DESIGN:Retrospective analysis. SETTING:Tertiary care teaching hospital. PATIENTS:Twenty-one patients with cultures of confirmed ESBL-producing Escheric...

journal_title：Pharmacotherapy

authors： Burgess DS,Hall RG 2nd,Lewis JS 2nd,Jorgensen JH,Patterson JE

更新日期：2003-10-01 00:00:00

abstract：:Nabilone, a synthetic cannabinoid, is approved in many countries including, but not limited to, Canada, the United States, Mexico, and the United Kingdom for the treatment of severe nausea and vomiting associated with chemotherapy. Clinical evidence is emerging for its use in managing pain conditions with different et...

journal_title：Pharmacotherapy

authors： Tsang CC,Giudice MG

更新日期：2016-03-01 00:00:00

abstract：:Endothelin (ET)-1 is an endothelium-derived peptide with potent vasoconstrictor and proliferative properties. The ET system is activated in several cardiovascular disease states associated with functional and structural vascular changes, including hypertension and heart failure. The two ET receptor subtypes are known ...

journal_title：Pharmacotherapy

authors： Ergul A

更新日期：2002-01-01 00:00:00

abstract：:In critically ill patients with acute renal failure, continuous arteriovenous hemodiafiltration (CAVHD) has become an increasing popular supportive technique. An adult with acute renal failure during CAVHD therapy received fluconazole. Drug clearance by the hemodiafilter system and its total body clearance during the ...

journal_title：Pharmacotherapy

authors： Nicolau DP,Crowe H,Nightingale CH,Quintiliani R

更新日期：1994-07-01 00:00:00

abstract：:Epinephrine overdose induces many negative complications in adults because of its alpha- and beta-adrenoreceptor activity. However, complications in newborns or children are rarely described. A 4-day-old, 2004-g female newborn was inadvertently given epinephrine at 100 times the usual dose; she developed hypokalemia a...

journal_title：Pharmacotherapy

authors： Fang W,Chen JY,Fang Y,Huang JL

更新日期：2005-09-01 00:00:00

abstract：:Antithrombin deficiency is a hypercoagulable state that can increase the risk for thrombosis, especially in the presence of other procoagulant triggers. Unfractionated heparin and low-molecular-weight heparins may not provide effective anticoagulation since they require antithrombin for activity. Direct thrombin inhib...

journal_title：Pharmacotherapy

authors： Dager WE,Gosselin RC,Owings JT

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To compare changes in United States pharmacy practice faculty demographics from 1995-2001 and to discuss the implications for junior faculty development. METHODS:Demographic data were extracted from the American Association of Colleges of Pharmacy institutional research system for academic years 1995-1996 an...

journal_title：Pharmacotherapy

authors： Raehl CL

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To describe the legal, professional, and consumer status of prescribers dispensing legend and over-the-counter drugs in the United States. METHODS:Legal and academic databases were searched to identify those states that permit prescribers to dispense medications to patients and any limitations on such practi...

journal_title：Pharmacotherapy

authors： Munger MA,Ruble JH,Nelson SD,Ranker L,Petty RC,Silverstein S,Barton E,Feehan M

更新日期：2014-10-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and plasma protein binding of eprosartan in hepatic disease. DESIGN:Single-dose, parallel-group study. SETTING:Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. PATIENTS:Eight healthy subjects with norm...

journal_title：Pharmacotherapy

authors： Tenero D,Martin D,Chapelsky M,Ilson B,Boike S,Patterson S,Keogh J,Rodriguez S,Jorkasky D

更新日期：1998-01-01 00:00:00

abstract：:Graves' disease is an autoimmune disorder in which inappropriate stimulation of the thyroid gland results in unregulated secretion of thyroid hormones resulting in hyperthyroidism. Graves' disease is the most common cause of autoimmune hyperthyroidism during pregnancy. Treatment options for Graves' disease include thi...

journal_title：Pharmacotherapy

authors： Prunty JJ,Heise CD,Chaffin DG

更新日期：2016-01-01 00:00:00