Abstract:
:Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriate. Using pharmacotherapy to counter adverse effects of cooling or to treat an intrinsic process under hypothermic conditions requires understanding how hypothermia will influence the clinical effects of the drug, including the drug's pharmacokinetics and pharmacodynamics. The pharmacologic aspects of therapeutic hypothermia in relation to physiology and adverse effects are reviewed.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Arpino PA,Greer DMdoi
10.1592/phco.28.1.102subject
Has Abstractpub_date
2008-01-01 00:00:00pages
102-11issue
1eissn
0277-0008issn
1875-9114journal_volume
28pub_type
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