Abstract:
:In critically ill patients with acute renal failure, continuous arteriovenous hemodiafiltration (CAVHD) has become an increasing popular supportive technique. An adult with acute renal failure during CAVHD therapy received fluconazole. Drug clearance by the hemodiafilter system and its total body clearance during the CAVHD period were 23-28 ml/minute and 22 ml/minute, respectively, indicating that the rate of systemic clearance was solely dependent on CAVHD in this patient. Total body clearance, area under the curve, and half-life values for this patient closely resembled those in healthy subjects. These observations suggest that patients treated with fluconazole during CAVHD should receive standard maintenance dosages, and neither supplementation nor dosage adjustment is required.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Nicolau DP,Crowe H,Nightingale CH,Quintiliani Rsubject
Has Abstractpub_date
1994-07-01 00:00:00pages
502-5issue
4eissn
0277-0008issn
1875-9114journal_volume
14pub_type
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