The use of intravenous nitroglycerin in cardiovascular disease.

abstract：:The frequency of type 2 diabetes mellitus is increasing at an alarming rate. Prediabetes, also referred to as impaired glucose tolerance (IGT) and/or impaired fasting glucose, is a major risk factor for development of type 2 diabetes mellitus. In addition, IGT has been associated with an increased risk of cardiovascul...

journal_title：Pharmacotherapy

authors： Irons BK,Mazzolini TA,Greene RS

更新日期：2004-03-01 00:00:00

abstract：:The newer quinolone antibiotics, including levofloxacin, moxifloxacin, and gatifloxacin, offer coverage of the likely pathogens in community-acquired pneumonia (CAP) and have been shown to be safe and effective treatments for CAP. Two of these agents, levofloxacin and gatifloxacin, have pharmacokinetic and antibacteri...

journal_title：Pharmacotherapy

authors： Press RA

更新日期：2001-07-01 00:00:00

abstract：:The risk of venous thromboembolism (VTE) in patients with cancer is 6-12-fold higher than in the general population, and VTE is the second leading cause of death in this population, after cancer itself. The etiology underlying the increased risk of VTE is multifactorial and complex, involving patient-, tumor-, and tre...

journal_title：Pharmacotherapy

authors： Saraiya B,Goodin S

更新日期：2009-11-01 00:00:00

abstract：:Although studies have shown that patients can distinguish probable adverse drug reactions (ADRs) from adverse clinical events (ACEs) caused by other factors, it is not known whether these attribution judgments add any independent validity to other accepted methods of identifying ADRs, such as physician assessments or ...

journal_title：Pharmacotherapy

authors： Fisher S,Bryant SG,Kent TA,Davis JE

更新日期：1994-03-01 00:00:00

abstract：:After injecting the solution extracted from a Primatene Mist inhaler, a patient experienced epinephrine overdose that resulted in an acute myocardial infarction and acute renal failure. The exact amount of epinephrine injected was unknown, but was thought to be between 82.5 and 124 mg, more than 25 times higher than t...

journal_title：Pharmacotherapy

authors： Woodard ML,Brent LD

更新日期：1998-05-01 00:00:00

abstract：:In recent years, there have been many updates in hormonal emergency contraception. Levonorgestrel emergency contraception has been available for several years to prevent pregnancy when used within 72 hours after unprotected intercourse or contraceptive failure, and it was recently approved for nonprescription status f...

journal_title：Pharmacotherapy

authors： Shrader SP,Hall LN,Ragucci KR,Rafie S

更新日期：2011-09-01 00:00:00

abstract：:Cabozantinib is an oral small-molecule multitargeted tyrosine kinase inhibitor (TKI) that may confer an advantage over other TKIs that target a single receptor. It was approved by the U.S. Food and Drug Administration for the treatment of both advanced renal cell carcinoma and progressive metastatic medullary thyroid ...

journal_title：Pharmacotherapy

authors： Markowitz JN,Fancher KM

更新日期：2018-03-01 00:00:00

abstract：:A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...

journal_title：Pharmacotherapy

authors： Havrda DE,Rathbun S,Scheid D

更新日期：2001-03-01 00:00:00

abstract：:Albuterol is a 50:50 mixture of R-albuterol, the active enantiomer, and S-albuterol, which appears to be inactive in humans. The Food and Drug Administration recently approved levalbuterol, the pure R-isomer, as a preservative-free nebulizer solution. Published studies indicate that it is neither safer nor more effect...

journal_title：Pharmacotherapy

authors： Asmus MJ,Hendeles L

更新日期：2000-02-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the cost-effectiveness of intravenous plus oral amiodarone, atrial septal pacing, and both strategies combined to prevent atrial fibrillation after open heart surgery. Secondary objectives were to compare the cost-effectiveness of amiodarone versus no amiodarone and of pacing versus no pacin...

journal_title：Pharmacotherapy

authors： Reddy P,Kalus JS,Caron MF,Horowitz S,Karapanos A,Coleman CI,Kluger J,White CM

更新日期：2004-08-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...

journal_title：Pharmacotherapy

authors： Zhao Q,Wojcik MA,Parier JL,Pesco-Koplowitz L

更新日期：2001-02-01 00:00:00

abstract：:The Institute of Medicine has identified adverse drug events as factors that significantly contribute to increased patient morbidity and mortality. As critically ill patients receive numerous drugs to treat a multitude of complicated health problems, they are at high risk for adverse drug events. Sedation is often a k...

journal_title：Pharmacotherapy

authors： Corbett SM,Montoya ID,Moore FA

更新日期：2008-02-01 00:00:00

abstract：:Ondansetron hydrochloride dihydrate is a 5-hydroxytryptamine (5-HT3) antagonist that was recently approved by the Food and Drug Administration for the treatment of chemotherapy-induced emesis. The mechanism of action is thought to be due to competitive inhibition of specific serotonin receptors in the central nervous ...

journal_title：Pharmacotherapy

authors： Burnette PK,Perkins J

更新日期：1992-01-01 00:00:00

abstract：:Multiple myeloma is the second most common type of hematologic malignancy. It is a B-cell malignancy that affects the bone marrow and often results in thrombocytopenia as well as renal dysfunction. Treatment options range from oral and intravenous chemotherapy to bone marrow transplantation and supportive care. Carfil...

journal_title：Pharmacotherapy

authors： Shely RN,Ratliff PD

更新日期：2014-05-01 00:00:00

abstract：:Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of meth...

journal_title：Pharmacotherapy

authors： Krantz MJ,Garcia JA,Mehler PS

更新日期：2005-04-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of Niaspan--a niacin preparation with both immediate- and extended-release characteristics--on lipid and glycemic control in patients with type 2 diabetes. DESIGN:Retrospective study SETTING:Private-practice endocrinology group. PATIENTS:Thirty-two patients (mean age 60 yrs; 7...

journal_title：Pharmacotherapy

authors： Kane MP,Hamilton RA,Addesse E,Busch RS,Bakst G

更新日期：2001-12-01 00:00:00

abstract：:During the past decade, the incidence and severity of Clostridium difficile infection (CDI) have significantly increased, leading to a rise in CDI-associated hospitalizations, health care costs, and mortality. Although treatment options exist for CDI, recurrence is frequent following treatment. Furthermore, patients w...

journal_title：Pharmacotherapy

authors： Kufel WD,Devanathan AS,Marx AH,Weber DJ,Daniels LM

更新日期：2017-10-01 00:00:00

abstract：:In a 10-year (1979-1988) follow-up study of young insulin-dependent diabetics carried out at Group Health Cooperative of Puget Sound, the frequency of hospitalization for hypoglycemia remained constant. During the early years only animal insulins were available; during the latter years, human insulins were used in a m...

journal_title：Pharmacotherapy

authors： Jick SS,Derby LE,Gross KM,Jick H

更新日期：1990-01-01 00:00:00

abstract：:A 64-year-old woman receiving intravenous chemotherapy for stage IIIB non-small cell lung cancer experienced acute arterial thrombosis of the distal radial and entire ulnar arteries with subsequent arterial occlusion of the right popliteal artery. Two separate arterial occlusions occurred after administration of cispl...

journal_title：Pharmacotherapy

authors： Cool RM,Herrington JD,Wong L

更新日期：2002-09-01 00:00:00

abstract：:Fluoxetine hydrochloride is the sixth most prescribed drug in the United States and is administered to treat major depression. A cadaveric skin donation was obtained from a 46-year-old woman who died as a result of a fluoxetine overdose. Due to the potential penetration of the drug and its major metabolite, norfluoxet...

journal_title：Pharmacotherapy

authors： Neudeck BL,Taddonio TE,Garner WL,Welage LS

更新日期：1998-07-01 00:00:00

abstract：:Certification of pharmacotherapy specialists is proceeding smoothly. Modifications to the examination process, which include reapportioning domains, offering the examination at several sites, and establishing the recertification process, have occurred. The guidelines for petitioners and structure of specialization con...

journal_title：Pharmacotherapy

authors： Zarowitz BJ,Vlasses PH,Dukes GE,Gal P,Miller WA,Porter WC,Rush DR,Schneider P,Talbert RL

更新日期：1993-05-01 00:00:00

abstract：:Death is the ultimate adverse drug event. Despite its importance, the frequency of fatal adverse drug events is unknown. Estimates in the United States are as high as 140,000/year, although this number is heavily disputed. Potential reasons and risks for fatal adverse drug events, as well as epidemiologic designs for ...

journal_title：Pharmacotherapy

authors： Kelly WN

更新日期：2001-05-01 00:00:00

abstract：:With the emergence of new anticoagulants, clinicians need a thorough understanding of coagulation assays. Various laboratory assays exist to measure the effectiveness of anticoagulants. Coagulation assays are the primary method for measuring the effectiveness of anticoagulants; therefore, a comprehensive understanding...

journal_title：Pharmacotherapy

authors： Peters GL,Erwin PB,Pitlick MK,Stacy ZA

更新日期：2013-11-01 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading gram-negative organisms associated with nosocomial infections. The increasing frequency of multi-drug-resistant Pseudomonas aeruginosa (MDRPA) strains is concerning as efficacious antimicrobial options are severely limited. By searching MEDLINE from January 1966-February 20...

journal_title：Pharmacotherapy

authors： Obritsch MD,Fish DN,MacLaren R,Jung R

更新日期：2005-10-01 00:00:00

abstract：STUDY OBJECTIVE:Lack of blood pressure control is often seen in hypertensive patients concomitantly taking antituberculosis medications due to the complex drug-drug interactions between rifampin and antihypertensive drugs. Therefore, it is of clinical importance to understand the underlying mechanisms of these interact...

journal_title：Pharmacotherapy

authors： Liu W,Yan T,Chen K,Yang L,Benet LZ,Zhai S

更新日期：2020-04-01 00:00:00

abstract：:Good admissions decisions are essential for identifying successful students and good practitioners. Various parameters have been shown to have predictive power for academic success. Previous academic performance, the Pharmacy College Admissions Test (PCAT), and specific prepharmacy courses have been suggested as acade...

journal_title：Pharmacotherapy

authors： Allen DD,Bond CA

更新日期：2001-07-01 00:00:00

abstract：:Atherosclerosis, the great killer of Western society, probably is initiated when the balance of subendothelial lipoproteins and oxidation potential is upset. Oxidation products, especially oxidized low-density lipoprotein, set into motion the cascading of numerous pathways, culminating in the fibrous atherosclerotic p...

journal_title：Pharmacotherapy

authors： Meyers DG,Maloley PA

更新日期：1993-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the frequency of medication errors, as well as the severity of harm resulting from these errors, related to the prescription, transcription, preparation, and administration of parenteral nutrition formulations. DESIGN:Prospective, observational study. SETTING:471-bed, academic teaching ho...

journal_title：Pharmacotherapy

authors： Sacks GS,Rough S,Kudsk KA

更新日期：2009-08-01 00:00:00

abstract：STUDY OBJECTIVE:To assess patients' perception of care delivery by anticoagulation clinics (ACs) throughout Alberta, Canada. DESIGN:Prospective postal survey. SETTING:Therapy provision by an AC to ambulatory-based patients for a minimum of 3 months across the province. PATIENTS:A total of 1687 patients (67.9%) recei...

journal_title：Pharmacotherapy

authors： Bungard TJ,Barry AR,Jones C,Brocklebank C

更新日期：2013-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the impact of having an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. DESIGN:Retrospective cohort study. SETTING:Urban academic teaching hospital. PATIENTS:A total of 11,872 adults admitted to nonsurgical patient care wards who received ...

journal_title：Pharmacotherapy

authors： Charneski L,Deshpande G,Smith SW

更新日期：2011-08-01 00:00:00