Hospitalizations because of hypoglycemia in users of animal and human insulins. 2. Experience in the United States.

abstract：STUDY OBJECTIVE:To determine the effect of standardized Ginkgo biloba leaf extracts (GBE) on outcome parameters of hemostasis associated with risk of bleeding. DESIGN:Meta-analysis of 18 randomized controlled trials. SUBJECTS:A total of 1985 adults were enrolled to receive either GBE or placebo; 87% were patients wit...

journal_title：Pharmacotherapy

authors： Kellermann AJ,Kloft C

更新日期：2011-05-01 00:00:00

abstract：:Levonorgestrel implants (Norplant) are an alternative to oral contraceptives and medroxyprogesterone acetate intramuscular injections. An interaction may exist between levonorgestrel and agents that induce the hepatic microsomal enzyme system. A 21-year-old woman with a history of a seizure disorder, treated with phen...

journal_title：Pharmacotherapy

authors： Shane-McWhorter L,Cerveny JD,MacFarlane LL,Osborn C

更新日期：1998-11-01 00:00:00

abstract：:A prospective cohort study was conducted in 35 hospitals with oncology units to determine the incidence of symptomatic cardiotoxicity in patients receiving continuous infusions of 5-fluorouracil (5-FU), and to identify risk factors that could contribute to the development of 5-FU-associated cardiotoxicity. A sample of...

journal_title：Pharmacotherapy

authors： Meyer CC,Calis KA,Burke LB,Walawander CA,Grasela TH

更新日期：1997-07-01 00:00:00

abstract：:Certain enteric ailments are particularly common among homosexual men. They are primarily infectious diseases and include not only such common venereal diseases as gonorrhea and syphilis but also infections not usually regarded as being sexually transmitted. Among the latter are shigellosis, salmonellosis, giardiasis,...

journal_title：Pharmacotherapy

authors： Baker RW,Peppercorn MA

更新日期：1982-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...

journal_title：Pharmacotherapy

authors： Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SL

更新日期：2012-07-01 00:00:00

abstract：STUDY OBJECTIVES:To identify subsequent therapies used after first-line therapies in patients with advanced non-small cell lung cancer (NSCLC), compare overall survival (OS) associated with subsequent therapies, and evaluate factors associated with OS in these patients. METHODS:The study was a retrospective cohort ana...

journal_title：Pharmacotherapy

authors： Afanasjeva J,Hui RL,Spence MM,Chang J,Schottinger JE,Millares M,Rashid N

更新日期：2016-10-01 00:00:00

abstract：:Infections caused by yeasts and molds continue to be associated with high rates of morbidity and mortality in both immunocompromised and immunocompetent patients. Many antifungal drugs have been developed over the past 15 years to aid in the management of these infections. However, treatment is still not optimal, as t...

journal_title：Pharmacotherapy

authors： Mohr J,Johnson M,Cooper T,Lewis JS,Ostrosky-Zeichner L

更新日期：2008-05-01 00:00:00

abstract：:Meglumine antimoniate was administered to a patient with visceral leishmaniasis with normal renal function. Soon after the first intramuscular administration of meglumine antimoniate 20 mg/kg, equivalent to 510 mg antimony (Sb), the patient developed septic shock with oliguria. Creatinine clearance decreased to 23 ml/...

journal_title：Pharmacotherapy

authors： Hantson P,Luyasu S,Haufroid V,Lambert M

更新日期：2000-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and plasma protein binding of eprosartan in hepatic disease. DESIGN:Single-dose, parallel-group study. SETTING:Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma. PATIENTS:Eight healthy subjects with norm...

journal_title：Pharmacotherapy

authors： Tenero D,Martin D,Chapelsky M,Ilson B,Boike S,Patterson S,Keogh J,Rodriguez S,Jorkasky D

更新日期：1998-01-01 00:00:00

abstract：:A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...

journal_title：Pharmacotherapy

authors： Naro A,Bramanti P,Calabrò RS

更新日期：2014-12-01 00:00:00

abstract：:Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of meth...

journal_title：Pharmacotherapy

authors： Krantz MJ,Garcia JA,Mehler PS

更新日期：2005-04-01 00:00:00

abstract：:Since the discovery of penicillin 80 years ago, gram-negative bacteria have become proficient at evading the lethal activity of β-lactam antibiotics, principally through the production of β-lactamases. The rapid emergence of penicillinases in both gram-positive and gram-negative bacteria led to the development of ceph...

journal_title：Pharmacotherapy

authors： Rapp RP,Urban C

更新日期：2012-05-01 00:00:00

abstract：:Dabigatran, a direct thrombin inhibitor, is an oral anticoagulant indicated for the prevention of stroke in patients with atrial fibrillation (AF) and for the treatment and prevention of deep vein thrombosis and pulmonary embolism. Dabigatran, as well as the other new anticoagulants-rivaroxaban, apixaban, and edoxaban...

journal_title：Pharmacotherapy

authors： Wiggins BS,Northup A,Johnson D,Senfield J

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Our patient experienced acute renal failure but not fulminant hepatic failure from acetaminophen toxicity. OBJECTIVE:To review the clinical and laboratory characteristics of similar cases of acetaminophen nephrotoxicity. METHODS:A MEDLINE search and medical record search at two large teaching hospitals. R...

journal_title：Pharmacotherapy

authors： Eguia L,Materson BJ

更新日期：1997-03-01 00:00:00

abstract：:Ondansetron hydrochloride dihydrate is a 5-hydroxytryptamine (5-HT3) antagonist that was recently approved by the Food and Drug Administration for the treatment of chemotherapy-induced emesis. The mechanism of action is thought to be due to competitive inhibition of specific serotonin receptors in the central nervous ...

journal_title：Pharmacotherapy

authors： Burnette PK,Perkins J

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVE:To review quantitatively and qualitatively the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database to provide clinicians with a general understanding of the comparative occurrence of clinically meaningful adverse events associated with 15 antimicrobial new molecular en...

journal_title：Pharmacotherapy

authors： Khadem TM,van Manen RP,Brown J

更新日期：2014-12-01 00:00:00

abstract：:A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight patients who had undergone orthopedic surgery. Plasma samples were obtained over a 72-hour period for pharmacokinetic analysis in five patients. The patients wer...

journal_title：Pharmacotherapy

authors： Plezia PM,Kramer TH,Linford J,Hameroff SR

更新日期：1989-01-01 00:00:00

abstract：:Disseminated herpes simplex virus (HSV) infection in neonates represents a devastating entity that yields high mortality. Acyclovir is the primary antiviral agent used to treat life-threatening HSV infections in neonates; however, even though the agent has reduced morbidity overall from these infections, mortality wit...

journal_title：Pharmacotherapy

authors： Cies JJ,Moore WS 2nd,Miller K,Small C,Carella D,Conley S,Parker J,Shea P,Chopra A

更新日期：2015-02-01 00:00:00

abstract：:Endothelin (ET)-1 is an endothelium-derived peptide with potent vasoconstrictor and proliferative properties. The ET system is activated in several cardiovascular disease states associated with functional and structural vascular changes, including hypertension and heart failure. The two ET receptor subtypes are known ...

journal_title：Pharmacotherapy

authors： Ergul A

更新日期：2002-01-01 00:00:00

abstract：:This article on pharmacoepidemiology, the second of two parts, is a more focused discussion of the methodology of cohort studies and case-control studies, the basic methodologies of which were discussed in part I. The nested case-control study incorporates the strengths of both the cohort and case-control studies but ...

journal_title：Pharmacotherapy

authors： Etminan M

更新日期：2004-09-01 00:00:00

abstract：:During the past decade, patient safety issues during care transitions have gained greater attention at both the local and national level. Readmission rates to U.S. hospitals are high, often because of poor care transitions. Serious adverse drug events (ADEs) caused by an incomplete understanding of changes in complex ...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Hume AL,Kirwin J,Bieber HL,Couchenour RL,Hall DL,Kennedy AK,LaPointe NM,Burkhardt CD,Schilli K,Seaton T,Trujillo J,Wiggins B

更新日期：2012-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine rates of drug-induced, rare, serious adverse events affecting the liver, kidneys, skin, or blood, occurring within 45 days of completing a prescription or refill for itraconazole or fluconazole. DESIGN:Population-based follow-up study SETTING:United Kingdom-based General Practice Research...

journal_title：Pharmacotherapy

authors： Bradbury BD,Jick SS

更新日期：2002-06-01 00:00:00

abstract：:Pharmacists are uniquely qualified to play essential roles in the clinical implementation of pharmacogenomics. However, specific responsibilities and resources needed for these roles have not been defined. We describe roles for pharmacists that emerged in the clinical implementation of genotype-guided clopidogrel ther...

journal_title：Pharmacotherapy

authors： Owusu-Obeng A,Weitzel KW,Hatton RC,Staley BJ,Ashton J,Cooper-Dehoff RM,Johnson JA

更新日期：2014-10-01 00:00:00

abstract：:Stenotrophomonas maltophilia, Burkholderia cepacia complex, Elizabethkingia spp., Chryseobacterium spp., Achromobacter spp., and Alcaligenes spp. are less-common non-lactose-fermenting bacteria that have emerged as important opportunistic pathogens. Patients at the highest risk for these infections include the immunoc...

journal_title：Pharmacotherapy

authors： Spencer HK,Spitznogle SL,Borjan J,Aitken SL

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of telephone follow-up on the physical well-being dimension of health-related quality of life in patients with cancer. DESIGN:Randomized, controlled trial. SETTING:Public teaching hospital. PATIENTS:One hundred fifty patients with cancer who were discharged to home from the hospital....

journal_title：Pharmacotherapy

authors： Beney J,Devine EB,Chow V,Ignoffo RJ,Mitsunaga L,Shahkarami M,McMillan A,Bero LA

更新日期：2002-10-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the effectiveness of darbepoetin alfa with epoetin alfa (recombinant human erythropoietin [rHuEPO]) for achieving transfusion independence and increasing hemoglobin concentrations in critically ill patients. DESIGN:Retrospective, descriptive study. SETTING:Level I trauma center intensive ca...

journal_title：Pharmacotherapy

authors： Voils SA,Harpe SH,Brophy GM

更新日期：2007-04-01 00:00:00

abstract：STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...

journal_title：Pharmacotherapy

authors： Locke C,Ravnan SL,Patel R,Uchizono JA

更新日期：2005-05-01 00:00:00

abstract：:Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration approved two new lipoglycopeptides, oritavancin and dalbavancin, for ...

journal_title：Pharmacotherapy

authors： Roberts KD,Sulaiman RM,Rybak MJ

更新日期：2015-10-01 00:00:00

abstract：:The risk of venous thromboembolism (VTE) in patients with cancer is 6-12-fold higher than in the general population, and VTE is the second leading cause of death in this population, after cancer itself. The etiology underlying the increased risk of VTE is multifactorial and complex, involving patient-, tumor-, and tre...

journal_title：Pharmacotherapy

authors： Saraiya B,Goodin S

更新日期：2009-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the safety, tolerability, and pharmacokinetic profile of fosphenytoin, a water-soluble phenytoin prodrug, after intramuscular and intravenous administration. DESIGN:Open-label study of intramuscular administration, and double-blind, randomized study of intravenous administration. SETTING:S...

journal_title：Pharmacotherapy

authors： Boucher BA,Feler CA,Dean JC,Michie DD,Tipton BK,Smith KR Jr,Kramer RE,Young B,Parks BR Jr,Kugler AR

更新日期：1996-07-01 00:00:00