Symptomatic cardiotoxicity associated with 5-fluorouracil.

abstract：:Treating elderly debilitated patients with symptomatic bradyarrhythmia may be difficult. Traditional therapy includes use of limited resources (intensive care unit monitoring) and expensive interventions (permanent pacemaker insertion). When a pacemaker is not ideal or appropriate, yet intervention is desired to impro...

journal_title：Pharmacotherapy

authors： Kragie L,Sekovski B

更新日期：1992-01-01 00:00:00

abstract：:The efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitors canagliflozin, dapagliflozin, and empagliflozin in reducing hyperglycemia in patients with type 2 diabetes is well documented. In addition, positive effects have been observed with these agents on nonglycemic variables, such as reductions in body we...

journal_title：Pharmacotherapy

authors： Trujillo JM,Nuffer WA

更新日期：2017-04-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the effectiveness of pharmacist-administered diabetes mellitus education and management services on selected diabetes performance measures. Additional goals were to compare outcomes with goals specified for patients with diabetes by the National Committee for Quality Assurance (NCQA) and id...

journal_title：Pharmacotherapy

authors： Ragucci KR,Fermo JD,Wessell AM,Chumney EC

更新日期：2005-12-01 00:00:00

abstract：:The American College of Clinical Pharmacy (ACCP) published an initial white paper on herbal products in 2000. Since then, the global market for natural products has continued to expand, with tens of millions of consumers using such products on an annual basis in the United States alone. However, despite this expansion...

journal_title：Pharmacotherapy

authors： Gabay M,Smith JA,Chavez ML,Goldwire M,Walker S,Coon SA,Gosser R,Hume AL,Musselman M,Phillips J,Abe AM

更新日期：2017-01-01 00:00:00

abstract：:Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in intensive care unit (ICU) settings worldwide. We used a nine-step decision-making algorithm to determine whether therapeutic monitoring of midazolam in the ICU is warranted. Midazolam has a higher clearance and shorter half-li...

journal_title：Pharmacotherapy

authors： Spina SP,Ensom MH

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:It is known that γ-glutamyl hydrolase (GGH) is involved in the disposition of methotrexate (MTX), and GGH activity is regulated by DNA methylation in acute lymphoblastic leukemia (ALL) cells. The present study explores the methylation status of the GGH promoter in peripheral blood and its association with MT...

journal_title：Pharmacotherapy

authors： Wang SM,Kong XY,Li M,Sun LL,Yan D

更新日期：2020-07-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the appropriate compartmental and noncompartmental pharmacokinetic parameters for intravenous piperacillin and tazobactam. DESIGN:Sequential selection of patients entered into a randomized, open-label clinical efficacy trial. SETTING:Los Angeles County-University of Southern California Me...

journal_title：Pharmacotherapy

authors： Jhee SS,Kern JW,Burm JP,Yellin AE,Gill MA

更新日期：1995-07-01 00:00:00

abstract：:A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...

journal_title：Pharmacotherapy

authors： Vandell AG,DiPiro JT

更新日期：2002-05-01 00:00:00

abstract：:Two analyses were conducted to compare the cost-effectiveness of different intravenous immunoglobulin (IGIV) formulations: IGIV purified by caprylate precipitation and chromatography (IGIV-C) and IGIV manufactured by an older solvent-detergent method (IGIV-S/D). The results indicated that IGIV-C is associated with cos...

journal_title：Pharmacotherapy

authors： Mahadevia PJ

更新日期：2005-11-01 00:00:00

abstract：:A 37-year-old Hispanic man with advanced acquired immunodeficiency syndrome developed extensive pulmonary disease with persistent cough, fever, night sweats, worsening dyspnea, and weight loss. Sputum samples showed scant growth of acid-fast bacilli. He failed to respond to the standard tuberculosis regimen of isoniaz...

journal_title：Pharmacotherapy

authors： Kang-Birken SL,Prichard JG

更新日期：2006-11-01 00:00:00

abstract：:We retrospectively reviewed the charts of 120 patients who received an initial prescription of iron from a resident physician in internal medicine to determine how accurately house officers diagnose iron-deficiency anemia before initiating iron therapy. Each patient's laboratory records were reviewed for the 3-month p...

journal_title：Pharmacotherapy

authors： Abernathy KA,Meuleman JR

更新日期：1996-05-01 00:00:00

abstract：:We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total...

journal_title：Pharmacotherapy

authors： Ross SD,Akhras KS,Zhang S,Rozinsky M,Nalysnyk L

更新日期：2001-08-01 00:00:00

abstract：:Addressing the issue of unintended pregnancy is a national priority. One proposed strategy to reduce unintended pregnancy is to improve access to oral contraceptives by changing them to over-the-counter (OTC) status. Existing data indicate that oral contraceptives meet safety criteria required of OTC products. Availab...

journal_title：Pharmacotherapy

authors： McIntosh J,Rafie S,Wasik M,McBane S,Lodise NM,El-Ibiary SY,Forinash A,Kachlic MD,Rowe E,Besinque K

更新日期：2011-04-01 00:00:00

abstract：:Panic disorder is a frequently chronic condition with extensive patterns of psychiatric comorbidity. Optimum pharmacotherapy with traditional agents is limited by side effects, long-term tolerability, and other problems. Recent research findings support the characterization of panic disorder as an illness involving de...

journal_title：Pharmacotherapy

authors： DeVane CL

更新日期：1997-03-01 00:00:00

abstract：:Infections caused by multidrug-resistant Acinetobacter baumannii have become a therapeutic challenge for clinicians worldwide. Although colistin and tigecycline have been successful in treating patients with these infections, these agents are not available on a worldwide basis. We describe four critically ill patients...

journal_title：Pharmacotherapy

authors： Lee NY,Wang CL,Chuang YC,Yu WL,Lee HC,Chang CM,Wang LR,Ko WC

更新日期：2007-11-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...

journal_title：Pharmacotherapy

authors： Gomes DM,Ward KE,LaPlante KL

更新日期：2015-04-01 00:00:00

abstract：:Therapeutic goals for atrial fibrillation (AF) include ventricular rate control, stroke prevention, conversion to normal sinus rhythm, and maintenance of normal sinus rhythm. The optimal strategy of rate versus rhythm control for acute management of patients with AF is a continuing debate. However, selected patients m...

journal_title：Pharmacotherapy

authors： Slavik RS,Zed PJ

更新日期：2004-06-01 00:00:00

abstract：:Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and curre...

journal_title：Pharmacotherapy

authors： Barber KE,Bell AM,Wingler MJB,Wagner JL,Stover KR

更新日期：2018-12-01 00:00:00

abstract：:A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...

journal_title：Pharmacotherapy

authors： Christiansen SR,Broniscer A,Panetta JC,Stewart CF

更新日期：2009-07-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：:The Internet is an excellent source of drug and poison information. Despite the relative case and minimal costs associated with accessing the Internet, many pharmacists and other health care professionals have been slow to adopt this new technology. ...

journal_title：Pharmacotherapy

authors： Marra CA,Lynd LD,McKerrow R,Carleton BC

更新日期：1996-07-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and use of intravenous human cytomegalovirus immune globulin (CytoGam) in allogeneic bone marrow transplantation (BMT). DESIGN:Prospective, nonrandomized, nonblinded, single-center study. SETTING:University teaching hospital. PATIENTS:Five consecutive patients with he...

journal_title：Pharmacotherapy

authors： DeRienzo SY,Chiang KY,O'Neal WM,Godder K,Abhyankar S,Christiansen NP,Bridges KD,Henslee-Downey PJ

更新日期：2000-10-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...

journal_title：Pharmacotherapy

authors： Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

更新日期：2010-12-01 00:00:00

abstract：:Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), which is a subtype of non-Hodgkin lymphoma, are relatively uncommon lymphoproliferative types of cancer. These malignancies are highly curable with initial treatment. Nonetheless, some patients are refractory to or relapse after first- and seco...

journal_title：Pharmacotherapy

authors： Newland AM,Li JX,Wasco LE,Aziz MT,Lowe DK

更新日期：2013-01-01 00:00:00

abstract：STUDY OBJECTIVES:To assess the effectiveness of pretreatment with ibuprofen or acetaminophen compared with no pretreatment in decreasing adverse events in children and adolescents receiving the first and second series of pamidronate therapy; and to compare the effectiveness of ibuprofen versus acetaminophen for prevent...

journal_title：Pharmacotherapy

authors： Robinson RE,Nahata MC,Hayes JR,Batisky DL,Bates CM,Mahan JD

更新日期：2004-02-01 00:00:00

abstract：:Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long-term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e-cigarettes, are increasingly used for tobacco cessation. Because e-...

journal_title：Pharmacotherapy

authors： Franks AS,Sando K,McBane S

更新日期：2018-05-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the safety and efficacy of aerosolized ceftazidime for prevention of ventilator-associated pneumonia (VAP) and to evaluate the effects of the drug on the proinflammatory response. DESIGN:Prospective, randomized, double-blind, placebo-controlled clinical trial. SETTING:University teaching ...

journal_title：Pharmacotherapy

authors： Wood GC,Boucher BA,Croce MA,Hanes SD,Herring VL,Fabian TC

更新日期：2002-08-01 00:00:00

abstract：:The renal pharmacologic effects of intravenous dopamine in doses of 0.5-3.0 micrograms/kg/min include increases in renal blood flow, glomerular filtration rate, solute excretion, and urine flow. Clinical studies revealed that low-dose dopamine can reverse oliguria, but these studies were poorly controlled, were confou...

journal_title：Pharmacotherapy

authors： Dasta JF,Kirby MG

更新日期：1986-11-01 00:00:00

abstract：:A retrospective study evaluated the success of dosages of simvastatin lower than the 10-20 mg/day recommended by the manufacturer in patients with hypercholesterolemia. Records of 95 patients enrolled in a pharmacist-managed lipid clinic receiving stable dosages of simvastatin were reviewed. Data collected were demogr...

journal_title：Pharmacotherapy

authors： Rindone JP

更新日期：1999-04-01 00:00:00

abstract：:Postoperative pain is one of the most common forms of acute pain. Optimal pain management decreases the stress response to surgery, reduces complications, improves recovery time, and results in improved economic and quality-of-life outcomes. A preoperative, multimodal approach to postoperative analgesia can be achieve...

journal_title：Pharmacotherapy

authors： Stephens JM,Pashos CL,Haider S,Wong JM

更新日期：2004-12-01 00:00:00