Clinical implications of vancomycin heteroresistant and intermediately susceptible Staphylococcus aureus.

abstract：STUDY OBJECTIVE:To determine whether early administration of adjuvant β-lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection. DESIGN:Retrospective, multic...

journal_title：Pharmacotherapy

authors： Casapao AM,Jacobs DM,Bowers DR,Beyda ND,Dilworth TJ,REACH-ID Study Group.

更新日期：2017-11-01 00:00:00

abstract：:To determine salary and selected fringe benefits of members of the Ambulatory Care Practice and Research Network of the American College of Clinical Pharmacy, we developed a self-administered questionnaire that surveyed demographic information, schooling and training, academic appointments, yearly salary (as of Februa...

journal_title：Pharmacotherapy

authors： Anastasio GD,Shaughnessy AF

更新日期：1997-05-01 00:00:00

abstract：:Ketorolac tromethamine is a highly potent member of a class of compounds having both analgesic and antiinflammatory activity. In animal pain models using underlying inflammation, ketorolac markedly inhibited the pain response and increased the pain threshold; it did not exhibit any narcotic or central nervous system d...

journal_title：Pharmacotherapy

authors： Rooks WH 2nd

更新日期：1990-01-01 00:00:00

abstract：:Lymphoid malignancies comprise a heterogeneous group of disorders originating from clonal proliferation of B or T lymphocytes. Treatment of lymphoid neoplasms has traditionally been pursued with cytotoxic chemotherapy. To improve efficacy and ameliorate the adverse effects associated with classic chemotherapy, molecul...

journal_title：Pharmacotherapy

authors： Bhatt V,Alejandro L,Michael A,Ganetsky A

更新日期：2014-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the bioavailability and renal elimination of para-aminosalicylic acid (PAS) and its inactive metabolite acetyl-para-aminosalicylic acid (AcPAS) from a new PAS formulation. DESIGN:(a) Single-dose pharmacokinetic study in healthy volunteers; (b) Day-1 and day-8 pharmacokinetic comparison in ...

journal_title：Pharmacotherapy

authors： Peloquin CA,Henshaw TL,Huitt GA,Berning SE,Nitta AT,James GT

更新日期：1994-01-01 00:00:00

abstract：:Ongoing improvements in immunosuppression and posttransplantation care have dramatically improved patient and graft outcomes after transplantation. The frequency of graft loss due to acute rejection has declined considerably as a result of the availability of a variety of more potent immunosuppressive agents and proba...

journal_title：Pharmacotherapy

authors： Lo A,Alloway RR

更新日期：2002-03-01 00:00:00

abstract：:Limited data are available on ceftolozane/tazobactam dosing in patients receiving continuous renal replacement therapy (CRRT). Thus we performed a pharmacokinetic analysis of intravenous ceftolozane/tazobactam in a critically ill patient receiving CRRT at our medical center. A 47-year-old critically ill man with multi...

journal_title：Pharmacotherapy

authors： Bremmer DN,Nicolau DP,Burcham P,Chunduri A,Shidham G,Bauer KA

更新日期：2016-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the activity of CYP2D6, N-acetylation, and xanthine oxidase, three drug-metabolizing enzyme systems, in patients with cystic fibrosis and compare the findings with those in individuals without the disease. DESIGN:Prospective cohort study. SETTING:General pediatrics service. PATIENTS:Fift...

journal_title：Pharmacotherapy

authors： Bosso JA,Liu Q,Evans WE,Relling MV

更新日期：1996-09-01 00:00:00

abstract：STUDY OBJECTIVE:To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN:Prospective follow-up study. DATA SOURCE:General practitioners' computerized patients records (intervention ...

journal_title：Pharmacotherapy

authors： van der Elst ME,Bouvy ML,de Blaey CJ,de Boer A

更新日期：2006-02-01 00:00:00

abstract：:The pharmacokinetics of methylprednisolone sodium succinate (MPHS) and methylprednisolone (MP) were determined in six patients undergoing open heart surgery with cardiopulmonary bypass. Plasma concentrations of both compounds were measured by high-performance liquid chromatography after doses of MPHS of 1.7-2.4 g. The...

journal_title：Pharmacotherapy

authors： Kong AN,Jungbluth GL,Pasko MT,Beam TR,Jusko WJ

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of an evidence-based, systematic approach to hypertension care involving comanagement of patients by primary care physicians and clinical pharmacists versus usual care in reducing blood pressure in patients with uncontrolled hypertension. METHODS:Patients in a staff model medical...

journal_title：Pharmacotherapy

authors： Borenstein JE,Graber G,Saltiel E,Wallace J,Ryu S,Archi J,Deutsch S,Weingarten SR

更新日期：2003-02-01 00:00:00

abstract：:The authors sought to evaluate the impact on length of hospital stay and treatment duration of morphine after implementation of a change in the institutional protocol for managing neonatal abstinence syndrome (NAS) in an effort to improve patient outcomes. A single-center, retrospective chart review was conducted at a...

journal_title：Pharmacotherapy

authors： DeAtley HN,Burton A,Fraley MD,Haltom J

更新日期：2017-07-01 00:00:00

abstract：:Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihyperte...

journal_title：Pharmacotherapy

authors： Barksdale JD,Gardner SF

更新日期：1999-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effectiveness and safety of enoxaparin therapy in a neonatal intensive care unit (NICU). DESIGN:Retrospective chart review. SETTING:Level III NICU in a Canadian academic center. PATIENTS:All neonates treated with enoxaparin while in the NICU between January 1, 1998, and June 1, 2006. ...

journal_title：Pharmacotherapy

authors： Malowany JI,Knoppert DC,Chan AK,Pepelassis D,Lee DS

更新日期：2007-09-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the occurrence of bleeding and venous thromboembolic (VTE) events in patients receiving rivaroxaban, warfarin, or warfarin with the addition of enoxaparin during the immediate postoperative period following major orthopedic surgery. METHODS:Patients older than 18 years who received at leas...

journal_title：Pharmacotherapy

authors： Cieri NE,Kusmierski K,Lackie C,Van Opdorp A,Hassan AK

更新日期：2017-02-01 00:00:00

abstract：:Abstract Cetuximab and panitumumab, monoclonal antibodies used to target the epidermal growth factor receptor (EGFR), were recently approved by the United States Food and Drug Administration for use as single agents or in combination with other chemotherapy drugs in the treatment of metastatic colorectal cancer. The a...

journal_title：Pharmacotherapy

authors： Patel DK

更新日期：2008-11-01 00:00:00

abstract：:We sought to summarize and assess original evaluations of the economic impact of clinical pharmacy services published from 1996-2000, and to provide recommendations and methodologic considerations for future research. A systematic literature search was conducted to identify articles that were then blinded and randomly...

journal_title：Pharmacotherapy

authors： Schumock GT,Butler MG,Meek PD,Vermeulen LC,Arondekar BV,Bauman JL,2002 Task Force on Economic Evaluation of Clinical Pharmacy Services of the American College of Clinical Pharmacy.

更新日期：2003-01-01 00:00:00

abstract：:Starting lipid-lowering therapy in the hospital, especially with statins, has become an important component in the management of patients with acute coronary syndromes (ACS). It improves outcomes and increases patient motivation and long-term adherence. In addition, discontinuation of statin therapy in patients with A...

journal_title：Pharmacotherapy

authors： Paradiso-Hardy FL,Gordon WL,Jackevicius CA,Kertland HR,Pearson GJ,Pickering JL,Poirier L,Semchuk BM,Verret L

更新日期：2003-04-01 00:00:00

abstract：:Two patients with chronic kidney disease experienced a major bleeding event, retroperitoneal hematoma, requiring a blood transfusion after the administration of enoxaparin. The first patient was a 61-year-old Caucasian woman with multiple comorbidities, including chronic kidney disease stage 4. She received subcutaneo...

journal_title：Pharmacotherapy

authors： Malik A,Capling R,Bastani B

更新日期：2005-05-01 00:00:00

abstract：:We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...

journal_title：Pharmacotherapy

authors： Zimmermann AE,Katona BG,Plaisance KI

更新日期：1995-01-01 00:00:00

abstract：:Stroke is the third most common cause of death in the United States and is the number one cause of long-term disability. Legislative mandates, largely the result of the American Heart Association, American Stroke Association, and Brain Attack Coalition working cooperatively, have resulted in nationwide standardization...

journal_title：Pharmacotherapy

authors： Baldwin K,Orr S,Briand M,Piazza C,Veydt A,McCoy S

更新日期：2010-05-01 00:00:00

abstract：:Recombinant tissue plasminogen activator (t-PA) is a synthetic fibrinolytic protein which activates plasminogen or converts plasminogen to plasmin specifically in the presence of fibrin. With its "clot-selectivity", t-PA is capable of lysing clots without having a significant effect on circulating plasminogen. In cont...

journal_title：Pharmacotherapy

authors： Rogers SD,Riemersma LB,Clements SD

更新日期：1987-01-01 00:00:00

abstract：:This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...

journal_title：Pharmacotherapy

authors： Cooney GF,Mochon M,Kaiser B,Dunn SP,Goldsmith B

更新日期：1995-05-01 00:00:00

abstract：:Peripheral blood has replaced bone marrow as a source of hematopoietic stem cells for autologous rescue after high-dose chemotherapy. Patients who receive peripheral blood stem cell (PBSC) transplants experience rapid and sustained hematopoietic reconstitution. As a result, transplant-related mortality is now less tha...

journal_title：Pharmacotherapy

authors： Yee GC

更新日期：1996-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the ability of seven widely known herbal references and electronic databases to answer questions about herbal products asked at drug information centers. DESIGN:Cross-sectional study. SETTING:Five academic and institutional drug information centers. METHODS:Fifty-seven herbal-related ques...

journal_title：Pharmacotherapy

authors： Walker JB

更新日期：2002-12-01 00:00:00

abstract：:Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriat...

journal_title：Pharmacotherapy

authors： Arpino PA,Greer DM

更新日期：2008-01-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the pharmacokinetic profile of palifermin after intravenous dosing with either a collapsed dose of 180 microg/kg/day for 1 day or a standard dose of 60 microg/kg/day for 3 days, before and after myeloablative chemoradiotherapy and peripheral blood progenitor cell (PBPC) transplantation. DESIG...

journal_title：Pharmacotherapy

authors： Zia-Amirhosseini P,Hurd DD,Salfi M,Cheah TC,Aycock J,Cesano A

更新日期：2007-10-01 00:00:00

abstract：:Original research, reviews, and case reports discussing viral infectivity of blood- and plasma-derived products were reviewed to determine the potential viral infectivity of human serum albumin (HSA) and plasma protein fraction (PPF). Data concerning viral infectivity viral screening and inactivation procedures, and v...

journal_title：Pharmacotherapy

authors： Erstad BL

更新日期：1996-11-01 00:00:00

abstract：:A 58-year-old man went to his physician with complaints of midepigastric pain, flatulence, belching, and shortness of breath. During a physical examination, the patient was in no acute distress. The patient underwent an ultrasound examination, which revealed cholelithiasis, a laparoscopic cholecystectomy, which reveal...

journal_title：Pharmacotherapy

authors： Baker EL,Baker WL,Cloney DJ

更新日期：2007-02-01 00:00:00

abstract：:Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagulants are recommended for secondary stroke prevention in patients with AF. The optimal time to initiate anticoagulant t...

journal_title：Pharmacotherapy

authors： Smythe MA,Parker D,Garwood CL,Cuker A,Messé SR

更新日期：2020-01-01 00:00:00