Abstract:
:A new transdermal drug-delivery system that administers the synthetic opioid fentanyl through intact skin was evaluated for 24 hours postoperatively in eight patients who had undergone orthopedic surgery. Plasma samples were obtained over a 72-hour period for pharmacokinetic analysis in five patients. The patients were also evaluated intensively for adequacy of analgesia, frequency of nausea and sedation, and occurrence of ventilatory depression. A median lag time of 2.25 hours after application of the transdermal system was observed before the appearance of fentanyl in the blood. Median peak concentration and time to peak were 1.0 ng/ml and 22 hours, respectively. The apparent elimination of fentanyl after transdermal administration is prolonged relative to previously reported values. Absorption analysis indicates zero-order fentanyl administration, and in addition, suggests deposition of drug in an epidermal site, with the resultant prolonged absorption process giving the appearance of slow elimination. No significant toxicities were observed. Four patients required no additional analgesia. No consistent correlations among fentanyl concentration and any clinical values were observed. Transdermal administration of fentanyl appears to be a viable alternative to conventional routes of narcotic administration and warrants further study.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Plezia PM,Kramer TH,Linford J,Hameroff SRdoi
10.1002/j.1875-9114.1989.tb04096.xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
2-9issue
1eissn
0277-0008issn
1875-9114journal_volume
9pub_type
临床试验,杂志文章相关文献
PHARMACOTHERAPY文献大全abstract::Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described. In addition, cardiac adverse effects usually develop after at least 6 days of therapy. We describe a 54-year-old, human immunodeficien...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.2005.25.6.899
更新日期:2005-06-01 00:00:00
abstract:STUDY OBJECTIVE:To contrast the characteristics of two groups of anabolic-androgenic steroid (AAS) users-those with versus those without AAS dependence. DESIGN:Subanalysis of data from the Anabolic 500, a cross-sectional survey. PARTICIPANTS:One hundred twelve male AAS-dependent users and 367 AAS-nondependent users w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01123
更新日期:2012-10-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effectiveness and safety of enoxaparin therapy in a neonatal intensive care unit (NICU). DESIGN:Retrospective chart review. SETTING:Level III NICU in a Canadian academic center. PATIENTS:All neonates treated with enoxaparin while in the NICU between January 1, 1998, and June 1, 2006. ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.9.1263
更新日期:2007-09-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effectiveness, safety, and costs associated with a formulary conversion from amlodipine to alternative calcium channel blockers. DESIGN:Retrospective study. SETTING:Veterans Affairs Medical Center. PATIENTS:One hundred patients with hypertension who were receiving amlodipine. INTERVE...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.20.13.1072.35022
更新日期:2000-09-01 00:00:00
abstract::Pharmacists are uniquely qualified to play essential roles in the clinical implementation of pharmacogenomics. However, specific responsibilities and resources needed for these roles have not been defined. We describe roles for pharmacists that emerged in the clinical implementation of genotype-guided clopidogrel ther...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1481
更新日期:2014-10-01 00:00:00
abstract::Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long-term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e-cigarettes, are increasingly used for tobacco cessation. Because e-...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2103
更新日期:2018-05-01 00:00:00
abstract::Hypoactive sexual desire disorder (HSDD) affects nearly 1 in 10 women. Thus, it is essential for pharmacists and other health care providers to be comfortable when discussing a patient's sexual health to ensure appropriate triage so that the specific causes of HSDD can be identified and potential recommendations provi...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1209
更新日期:2013-04-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the impact of having an antimicrobial allergy label in the medical record on clinical outcomes in hospitalized patients. DESIGN:Retrospective cohort study. SETTING:Urban academic teaching hospital. PATIENTS:A total of 11,872 adults admitted to nonsurgical patient care wards who received ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.8.742
更新日期:2011-08-01 00:00:00
abstract::Postoperative pain is one of the most common forms of acute pain. Optimal pain management decreases the stress response to surgery, reduces complications, improves recovery time, and results in improved economic and quality-of-life outcomes. A preoperative, multimodal approach to postoperative analgesia can be achieve...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.24.17.1714.52339
更新日期:2004-12-01 00:00:00
abstract::We cared for a 4-year-old patient who had undergone orthotopic liver transplantation and was placed on a ventilator for respiratory distress associated with Pneumocystis carinii pneumonia. The neuromuscular blocking agent pancuronium bromide 1.0-1.2 mg every hour as needed was used to facilitate artificial ventilation...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.1989.tb04121.x
更新日期:1989-01-01 00:00:00
abstract::Cefepime is a new extended-spectrum cephalosporin with gram-positive and gram-negative coverage including Staphylococcus aureus and Pseudomonas aeruginosa. We evaluated the drug's plasma, peritoneal fluid, and appendix tissue concentrations in patients with a postoperative diagnosis of perforated or gangrenous appendi...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-01-01 00:00:00
abstract::The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2246
更新日期:2019-05-01 00:00:00
abstract::Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel res...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.3.265
更新日期:2010-03-01 00:00:00
abstract::Opioid-related adverse drug events (ORADEs) can have a significant impact on patient recovery after surgery. This review investigates the impact of two ORADEs, respiratory depression and postoperative ileus (POI), on clinical and economic outcomes. Opioid-induced ventilatory impairment is a potentially serious ORADE t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2012.01178.x
更新日期:2012-09-01 00:00:00
abstract::Fluconazole is a commonly prescribed antifungal agent with a favorable safety profile. A patient experienced agranulocytosis and eosinophilia associated with the drug. Similar bone marrow-suppressive effect due to the azoles is rarely described in the English-language literature. ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.20.5.484.35058
更新日期:2000-04-01 00:00:00
abstract::Recent evidence suggests that periodontal disease may predispose to atherosclerotic cardiovascular disease. Data support mechanisms of host-derived local and systemic proinflammatory responses similar to atherosclerosis, consisting of monocytic-derived cytokines and other inflammatory mediators, which are induced by p...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.9.805.35189
更新日期:2000-07-01 00:00:00
abstract::A 53-year-old woman with an intraabdominal infection secondary to Candida albicans experienced hyperbilirubinemia after receiving amphotericin B in two different formulations--amphotericin B deoxycholate and amphotericin B lipid complex. Only a few case reports of amphotericin B-induced hyperbilirubinemia have been do...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.7.1011
更新日期:2006-07-01 00:00:00
abstract::The renal pharmacologic effects of intravenous dopamine in doses of 0.5-3.0 micrograms/kg/min include increases in renal blood flow, glomerular filtration rate, solute excretion, and urine flow. Clinical studies revealed that low-dose dopamine can reverse oliguria, but these studies were poorly controlled, were confou...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.1986.tb03492.x
更新日期:1986-11-01 00:00:00
abstract::Struvite calculi result from urinary tract infections secondary to urease-producing bacteria. To prevent recurrent infection and stone formation complete removal of struvite calculi is recommended. Two illustrative reports of patients with renal struvite calculi are presented in which 10% hemiacidrin (Renacidin) irrig...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.1983.tb03300.x
更新日期:1983-11-01 00:00:00
abstract::A 58-year-old man went to his physician with complaints of midepigastric pain, flatulence, belching, and shortness of breath. During a physical examination, the patient was in no acute distress. The patient underwent an ultrasound examination, which revealed cholelithiasis, a laparoscopic cholecystectomy, which reveal...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.2.299
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:As tenofovir disoproxil fumarate substantially increases plasma concentrations of didanosine in patients with human immunodeficiency virus-1 infection, we sought to determine whether tenofovir and didanosine showed a similar intracellular interaction in human peripheral blood mononuclear cells (PBMCs). DESIG...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.6.695.32189
更新日期:2003-06-01 00:00:00
abstract::Antiretroviral (ART) therapy for the treatment of human immunodeficiency virus (HIV) infection has undergone significant changes over the past 30 years. Many single-tablet regimens (STRs), including newer fixed-dose combination (FDC) tablets, are available, offering patients several options for choosing a treatment re...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2055
更新日期:2018-01-01 00:00:00
abstract::Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The mai...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.3.298
更新日期:2011-03-01 00:00:00
abstract::Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriat...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.28.1.102
更新日期:2008-01-01 00:00:00
abstract::The clinical and economic impacts of bacterial resistance are substantial. The development of bacterial resistance during a course of therapy often leads to clinical failure, prolonged hospitalization, increased morbidity, mortality, and increased health care costs. Resistance has been reported to occur most frequentl...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::Starting lipid-lowering therapy in the hospital, especially with statins, has become an important component in the management of patients with acute coronary syndromes (ACS). It improves outcomes and increases patient motivation and long-term adherence. In addition, discontinuation of statin therapy in patients with A...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.4.506.32129
更新日期:2003-04-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the pharmacokinetic disposition of tobramycin in children undergoing stem cell transplantation (SCT) after intravenous administration either every 24 hours or every 8 hours, and to use this information to create initial dosing guidelines for administration every 24 hours in this patient popu...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.24.6.564.34743
更新日期:2004-05-01 00:00:00
abstract::Pseudomonas aeruginosa is one of the leading gram-negative organisms associated with nosocomial infections. The increasing frequency of multi-drug-resistant Pseudomonas aeruginosa (MDRPA) strains is concerning as efficacious antimicrobial options are severely limited. By searching MEDLINE from January 1966-February 20...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.2005.25.10.1353
更新日期:2005-10-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.28.9.1098
更新日期:2008-09-01 00:00:00
abstract::This study compared limited sampling methods (LSM) of estimating area under the plasma concentration versus time curve (AUC) based on a Bayesian regularized neural network, the Bayesian approach, and multiple forward stepwise regression models from selected concentration-time points. Plasma concentration versus time d...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.8.1044.32872
更新日期:2003-08-01 00:00:00