Amphotericin B-associated hyperbilirubinemia: case report and review of the literature.

abstract：STUDY OBJECTIVE:A safe alternative to erythropoiesis-stimulating agents to treat anemia is warranted in patients with cancer and anemia; thus the objective of this trial was to compare the efficacy and safety of intravenous (IV) iron isomaltoside with oral iron in patients with cancer and anemia by testing the noninfer...

journal_title：Pharmacotherapy

authors： Birgegård G,Henry D,Glaspy J,Chopra R,Thomsen LL,Auerbach M

更新日期：2016-04-01 00:00:00

abstract：:We compared total costs and adherence to the regimen of older versus newer angiotensin-converting enzyme (ACE) inhibitors for the treatment of elderly patients with hypertension. A computer search using the data base of a health care insurer identified 6176 subjects age 65 years or older who had ICD-9 coding for hyper...

journal_title：Pharmacotherapy

authors： Small RE,Freeman-Arnold SB,Goode JV,Pyles MA

更新日期：1997-09-01 00:00:00

abstract：:Patients with various rheumatologic and inflammatory disease states commonly require drugs known to decrease the inflammatory or autoimmune response for adequate control of their condition. Such drugs include nonsteroidal antiinflammatory drugs (NSAIDs), cyclooxygenase (COX)-2 inhibitors, corticosteroids, disease-modi...

journal_title：Pharmacotherapy

authors： Busti AJ,Hooper JS,Amaya CJ,Kazi S

更新日期：2005-11-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GMCSF) is a hematopoietic protein that has been studied both in vitro and in vivo in human immunodeficiency virus (HIV) infection. Since both HIV infection primarily and zidovudine (formerly AZT) treatment secondarily may result in neutropenia, administration of GMCSF ...

journal_title：Pharmacotherapy

authors： Hewitt RG,Morse GD

更新日期：1992-01-01 00:00:00

abstract：:Good admissions decisions are essential for identifying successful students and good practitioners. Various parameters have been shown to have predictive power for academic success. Previous academic performance, the Pharmacy College Admissions Test (PCAT), and specific prepharmacy courses have been suggested as acade...

journal_title：Pharmacotherapy

authors： Allen DD,Bond CA

更新日期：2001-07-01 00:00:00

abstract：:Currently available anesthetic induction agents provide adequate hypnosis but are not ideal, particularly in the high risk patient (ASA class III-V), because most cause myocardial and/or respiratory depression and some have other important side effects. Etomidate was recently marketed as an intravenous anesthetic indu...

journal_title：Pharmacotherapy

authors： Giese JL,Stanley TH

更新日期：1983-09-01 00:00:00

abstract：PURPOSE:Neurocritically ill patients have clinically significant alterations in pharmacokinetic parameters of renally eliminated medications that may result in subtherapeutic plasma and cerebrospinal fluid antibiotic concentrations. METHODS:We conducted a prospective randomized open-label study of adult neurocriticall...

journal_title：Pharmacotherapy

authors： Kassel LE,Van Matre ET,Foster CJ,Fish DN,Mueller SW,Sherman DS,Wempe MF,MacLaren R,Neumann RT,Kiser TH

更新日期：2018-09-01 00:00:00

abstract：:Ondansetron hydrochloride dihydrate is a 5-hydroxytryptamine (5-HT3) antagonist that was recently approved by the Food and Drug Administration for the treatment of chemotherapy-induced emesis. The mechanism of action is thought to be due to competitive inhibition of specific serotonin receptors in the central nervous ...

journal_title：Pharmacotherapy

authors： Burnette PK,Perkins J

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the safety and efficacy of aerosolized ceftazidime for prevention of ventilator-associated pneumonia (VAP) and to evaluate the effects of the drug on the proinflammatory response. DESIGN:Prospective, randomized, double-blind, placebo-controlled clinical trial. SETTING:University teaching ...

journal_title：Pharmacotherapy

authors： Wood GC,Boucher BA,Croce MA,Hanes SD,Herring VL,Fabian TC

更新日期：2002-08-01 00:00:00

abstract：:The systemic polymyxins, colistin and polymyxin B, are increasingly used for multidrug-resistant bacterial infections and have a long history of dose-limiting toxicity. This review summarizes the most recent available information about the mechanisms, incidence, risk factors, and minimization strategies for polymyxin ...

journal_title：Pharmacotherapy

authors： Justo JA,Bosso JA

更新日期：2015-01-01 00:00:00

abstract：:The basic tenet of pharmaceutical care asserts that the delivery of optimal, cost-effective pharmacotherapy can be best achieved by identifying, resolving, and preventing drug-related problems. Drug use evaluation (DUE) is one of the primary tools used to achieve these ends. Fluoroquinolone antimicrobials meet Joint C...

journal_title：Pharmacotherapy

authors： Guay DR,Covington TR,Alexander VL

更新日期：1993-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effectiveness, safety, and costs associated with a formulary conversion from amlodipine to alternative calcium channel blockers. DESIGN:Retrospective study. SETTING:Veterans Affairs Medical Center. PATIENTS:One hundred patients with hypertension who were receiving amlodipine. INTERVE...

journal_title：Pharmacotherapy

authors： Parra D,Beckey NP,Korman L

更新日期：2000-09-01 00:00:00

abstract：:Cefepime is a new extended-spectrum cephalosporin with gram-positive and gram-negative coverage including Staphylococcus aureus and Pseudomonas aeruginosa. We evaluated the drug's plasma, peritoneal fluid, and appendix tissue concentrations in patients with a postoperative diagnosis of perforated or gangrenous appendi...

journal_title：Pharmacotherapy

authors： Okamoto MP,Chin A,Gill MA,Yellin AE,Berne TV,Heseltine PN,Appleman MD,Knupp CA,Sclar DA

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Twice/day dosing of insulin glargine has been used to treat hyperglycemia in clinical practice; however, data supporting its use in the critically ill population are lacking. This study was designed to evaluate the safety and efficacy of twice/day insulin glargine in critically ill patients. METHODS:A retros...

journal_title：Pharmacotherapy

authors： Fox MA,Perry MC,Liu-DeRyke X

更新日期：2020-03-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the absorption profile of cyclosporine after preprandial administration with that after postprandial administration, and to determine which administration time resulted in a more stable absorption profile and the timing of the drug concentration that was the most reliable marker for monitorin...

journal_title：Pharmacotherapy

authors： Kusaba T,Konno Y,Hatta S,Fujino T,Yasuda T,Miura H,Sasaki H,Okabayashi J,Murao M,Sakurada T,Imai G,Shirai S,Kuboshima S,Shima Y,Ogimoto G,Sato T,Masuhara K,Kimura K

更新日期：2005-01-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of hepatotoxicity in critically ill patients who were treated with voriconazole and to identify potential risk factors for voriconazole-associated hepatotoxicity in these patients. DESIGN:Single-center prospective observational study. SETTING:Intensive care unit (ICU) in a ...

journal_title：Pharmacotherapy

authors： Wang Y,Wang T,Xie J,Yang Q,Zheng X,Dong W,Xing J,Wang X,Dong Y

更新日期：2016-07-01 00:00:00

abstract：:Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (NOAC) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life-threatening ble...

journal_title：Pharmacotherapy

authors： Sigawy C,Apter S,Vine J,Grossman E

更新日期：2015-07-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...

journal_title：Pharmacotherapy

authors： Zhao Q,Wojcik MA,Parier JL,Pesco-Koplowitz L

更新日期：2001-02-01 00:00:00

abstract：:The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...

journal_title：Pharmacotherapy

authors： Bailie GR,Uhlig K,Levey AS

更新日期：2005-04-01 00:00:00

abstract：STUDY OBJECTIVES:To determine if low-dose lovastatin in combination with niacin causes a greater percentage reduction in low-density lipoprotein (LDL) cholesterol than lovastatin alone, and to determine if the combination increases the risk of serious adverse effects. design. Prospective, randomized, open-label, clinic...

journal_title：Pharmacotherapy

authors： Gardner SF,Schneider EF,Granberry MC,Carter IR

更新日期：1996-05-01 00:00:00

abstract：STUDY OBJECTIVE:To establish the clinical equivalence (noninferiority) of one tablet containing abacavir 300 mg-lamivudine 150 mg-zidovudine 300 mg (Trizivir) versus a tablet containing lamivudine 150 mg-zidovudine 300 mg (Combivir) given with one abacavir (ABC) 300-mg tablet, administered twice/day, in antiretroviral-...

journal_title：Pharmacotherapy

authors： Fischl MA,Burnside AE Jr,Farthing CE,Thompson MA,Bellos NC,Williams VC,Kauf TL,Wannamaker PG,Shaefer MS,ESS40005 Study Team.

更新日期：2003-11-01 00:00:00

abstract：:The immune system is a complex network of components functioning to provide host defense. This network consists of immunologic cells and their products (e.g., interleukins and colony-stimulating factors), organs, tissues, complement, and major histocompatibility complex antigens. These components are organized into sp...

journal_title：Pharmacotherapy

authors： McIntyre WJ,Tami JA

更新日期：1992-01-01 00:00:00

abstract：:Meta-analyses are key components of evidence-based decision making. The numbers of meta-analyses published in different areas of health care increased dramatically during the past 10 years. Many of them covered different pharmacologic interventions, making them useful resources to clinical pharmacists. Although a well...

journal_title：Pharmacotherapy

authors： Etminan M,Levine M

更新日期：1999-06-01 00:00:00

abstract：:Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration approved two new lipoglycopeptides, oritavancin and dalbavancin, for ...

journal_title：Pharmacotherapy

authors： Roberts KD,Sulaiman RM,Rybak MJ

更新日期：2015-10-01 00:00:00

abstract：STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...

journal_title：Pharmacotherapy

authors： Locke C,Ravnan SL,Patel R,Uchizono JA

更新日期：2005-05-01 00:00:00

abstract：:Opioid-related adverse drug events (ORADEs) can have a significant impact on patient recovery after surgery. This review investigates the impact of two ORADEs, respiratory depression and postoperative ileus (POI), on clinical and economic outcomes. Opioid-induced ventilatory impairment is a potentially serious ORADE t...

journal_title：Pharmacotherapy

authors： Barletta JF

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Modification of guideline-directed medical therapy (GDMT) in hospitalized patients with heart failure (HF) has not been extensively evaluated. METHODS:The community surveillance arm of the Atherosclerosis Risk in Communities Study identified 6959 HF hospitalizations from 2005-2011. Predictors of GDMT modifi...

journal_title：Pharmacotherapy

authors： Tran RH,Aldemerdash A,Chang P,Sueta CA,Kaufman B,Asafu-Adjei J,Vardeny O,Daubert E,Alburikan KA,Kucharska-Newton AM,Stearns SC,Rodgers JE

更新日期：2018-04-01 00:00:00

abstract：STUDY OBJECTIVES:To develop and validate an improved unfractionated heparin (UFH) dosage protocol, using antifactor Xa levels as the outcome variable. DESIGN:Prospective case series. SETTING:A 625-bed, adults-only private, tertiary care teaching hospital. PATIENTS:Three hundred seventy-two patients receiving UFH for...

journal_title：Pharmacotherapy

authors： Rosborough TK,Shepherd MF

更新日期：2004-06-01 00:00:00

abstract：:A 37-year-old Hispanic man with advanced acquired immunodeficiency syndrome developed extensive pulmonary disease with persistent cough, fever, night sweats, worsening dyspnea, and weight loss. Sputum samples showed scant growth of acid-fast bacilli. He failed to respond to the standard tuberculosis regimen of isoniaz...

journal_title：Pharmacotherapy

authors： Kang-Birken SL,Prichard JG

更新日期：2006-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the efficacy of reteplase administration in clearing hemodialysis catheters. DESIGN:Open-label, uncontrolled, observational trial. SETTING:University medical center. PATIENTS:Thirty-four patients with end-stage renal disease undergoing long-term hemodialysis. INTERVENTION:Patients had du...

journal_title：Pharmacotherapy

authors： Hilleman DE,Dunlay RW,Packard KA

更新日期：2003-02-01 00:00:00