Genetic causes of clopidogrel nonresponsiveness: which ones really count?

abstract：:Concerns about cross-allergenicity between sulfonamide antibiotics and nonantibiotic, sulfonamide-containing drugs persist and can complicate patients' drug therapy unnecessarily. No interaction between the human immune system and the sulfonamide functional group has been demonstrated. The immunologic determinant of t...

journal_title：Pharmacotherapy

authors： Brackett CC,Singh H,Block JH

更新日期：2004-07-01 00:00:00

abstract：:Verapamil and diltiazem are effective in terminating paroxysmal supraventricular tachycardias and slowing ventricular response during atrial fibrillation or flutter. Results from clinical trials for each individual drug demonstrate comparative efficacy rates, and both drugs share the same contraindications and relativ...

journal_title：Pharmacotherapy

authors： Cheiman DM,Shea BF,Kelly RA

更新日期：1996-09-01 00:00:00

abstract：:Nausea and vomiting, common symptoms during pregnancy, often are regarded as an unpleasant but normal part of pregnancy during the first and early second trimesters. Nausea and vomiting of pregnancy (NVP) occurs in approximately 75-80% of pregnant women. The exact etiology and pathogenesis of NVP are poorly understood...

journal_title：Pharmacotherapy

authors： Badell ML,Ramin SM,Smith JA

更新日期：2006-09-01 00:00:00

abstract：:The traditional role of theophylline as a bronchodilator has been expanded by recent findings that suggest this drug has more than smooth muscle relaxant properties. Several investigators indicate that theophylline has an inotropic effect on respiratory muscle, causing enhanced muscular contraction and prevention of m...

journal_title：Pharmacotherapy

authors： Landsberg KF,Vaughan LM,Heffner JE

更新日期：1990-01-01 00:00:00

abstract：:We conducted a meta-analysis to determine what factors in treatment regimens for Helicobacter pylori are associated with increased discontinuation rates. Studies were selected from the 1990-1996 MEDLINE data base, and references in published articles and reviews were obtained. Each article was uniformally abstracted f...

journal_title：Pharmacotherapy

authors： Buring SM,Winner LH,Hatton RC,Doering PL

更新日期：1999-03-01 00:00:00

abstract：:The basic tenet of pharmaceutical care asserts that the delivery of optimal, cost-effective pharmacotherapy can be best achieved by identifying, resolving, and preventing drug-related problems. Drug use evaluation (DUE) is one of the primary tools used to achieve these ends. Fluoroquinolone antimicrobials meet Joint C...

journal_title：Pharmacotherapy

authors： Guay DR,Covington TR,Alexander VL

更新日期：1993-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the safety, tolerability, and pharmacokinetic profile of fosphenytoin, a water-soluble phenytoin prodrug, after intramuscular and intravenous administration. DESIGN:Open-label study of intramuscular administration, and double-blind, randomized study of intravenous administration. SETTING:S...

journal_title：Pharmacotherapy

authors： Boucher BA,Feler CA,Dean JC,Michie DD,Tipton BK,Smith KR Jr,Kramer RE,Young B,Parks BR Jr,Kugler AR

更新日期：1996-07-01 00:00:00

abstract：:Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...

journal_title：Pharmacotherapy

authors： Redman AR

更新日期：2001-02-01 00:00:00

abstract：:In recent years, there have been many updates in hormonal emergency contraception. Levonorgestrel emergency contraception has been available for several years to prevent pregnancy when used within 72 hours after unprotected intercourse or contraceptive failure, and it was recently approved for nonprescription status f...

journal_title：Pharmacotherapy

authors： Shrader SP,Hall LN,Ragucci KR,Rafie S

更新日期：2011-09-01 00:00:00

abstract：:Children warrant access to care from clinical pharmacists trained in pediatrics. The American College of Clinical Pharmacy Pediatrics Practice and Research Network (ACCP Pediatrics PRN) released an opinion paper in 2005 with recommendations for improving the quality and quantity of pediatric pharmacy education in coll...

journal_title：Pharmacotherapy

authors： Bhatt-Mehta V,Buck ML,Chung AM,Farrington EA,Hagemann TM,Hoff DS,LaRochelle JM,Pettit RS,Phan H,Potts AL,Smith KP,Parrish RH 2nd

更新日期：2013-02-01 00:00:00

abstract：:Advances in the care of critically ill patients and in diagnostic techniques, such as fiberoptic endoscopy, have enabled greater recognition of stress-related mucosal damage (SRMD). This condition is distinguished from chronic peptic ulcer disease by its greater number of lesions, proximal location in the acid-produci...

journal_title：Pharmacotherapy

authors： Peura DA

更新日期：1987-01-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did no...

journal_title：Pharmacotherapy

authors： Shields SA,Gregor KJ,Young CH,James SP

更新日期：1998-11-01 00:00:00

abstract：:We conducted a systematic review of randomized, controlled, monotherapy trials since 1990 of oral antihypertensive agents in patients with essential hypertension. Our objective was to quantify the frequency of discontinuation of antihypertensive agents due to adverse events from a meta-analysis of the studies. A total...

journal_title：Pharmacotherapy

authors： Ross SD,Akhras KS,Zhang S,Rozinsky M,Nalysnyk L

更新日期：2001-08-01 00:00:00

abstract：:The pharmacokinetic characteristics of levofloxacin, moxifloxacin, and gatifloxacin include excellent oral bioavailability (90-99%), extensive penetration into tissues and body fluids, and an elimination half-life (6-12 hrs) that allows for once-daily dosing in patients with normal renal function. Levofloxacin and gat...

journal_title：Pharmacotherapy

authors： Rodvold KA,Neuhauser M

更新日期：2001-10-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...

journal_title：Pharmacotherapy

authors： Gomes DM,Ward KE,LaPlante KL

更新日期：2015-04-01 00:00:00

abstract：:Hypertension and diabetes appear to increase coronary heart disease risk in part by causing an abnormality in lipid metabolism. Most affected are patients with familial dyslipidemic hypertension (FDH) and noninsulin-dependent diabetes mellitus (NIDDM). The lipid disorders most often encountered in these patients are i...

journal_title：Pharmacotherapy

authors： McKenney JM

更新日期：1993-07-01 00:00:00

abstract：:Certain demographic, practice, staffing, and pharmacist satisfaction variables may contribute to dispensing errors. A survey was randomly mailed to 7298 (50%) Texas pharmacists, of which 2862 were returned (39% response rate). Responders were 2437 pharmacists who indicated that they were in practice. Of these, 535 (23...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL

更新日期：2001-05-01 00:00:00

abstract：:Acute myeloid leukemia (AML), a clonal hematologic malignancy that results in bone marrow failure, is the most common acute leukemia in adults (median age of diagnosis 67 yrs), and treatment options, especially in the elderly population, are limited. Induction chemotherapy with 7 + 3, the combination of continuous-inf...

journal_title：Pharmacotherapy

authors： Stansfield LC,Pollyea DA

更新日期：2017-12-01 00:00:00

abstract：:Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are...

journal_title：Pharmacotherapy

authors： Chitwood KK,Heim-Duthoy KL

更新日期：1993-09-01 00:00:00

abstract：:Data obtained from 23 critically ill patients treated with intravenous ciprofloxacin in two clinical trials were used to validate prospectively a previously developed maximum a posteriori (MAP)-Bayesian estimator and optimal plasma-sampling strategy (OSS). Dosages ranged from 200 mg every 12 hours to 400 mg every 8 ho...

journal_title：Pharmacotherapy

authors： Amsden GW,Ballow CH

更新日期：1996-09-01 00:00:00

abstract：INTRODUCTION:Vancomycin (VAN) is associated with an increased risk of acute kidney injury (AKI). Evidence is conflicting regarding the risk of AKI when VAN is combined with an antipseudomonal β-lactam. OBJECTIVES:To determine the comparative incidence of AKI when VAN is combined with piperacillin-tazobactam (PTZ) or m...

journal_title：Pharmacotherapy

authors： Robertson AD,Li C,Hammond DA,Dickey TA

更新日期：2018-12-01 00:00:00

abstract：:Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...

journal_title：Pharmacotherapy

authors： Nemerovski CW,Salinitri FD,Morbitzer KA,Moser LR

更新日期：2012-11-01 00:00:00

abstract：:This commentary from the 2010 Task Force on Acute Care Practice Model of the American College of Clinical Pharmacy was developed to compare and contrast the "unit-based" and "service-based" orientation of the clinical pharmacist within an acute care pharmacy practice model and to offer an informed opinion concerning w...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Haas CE,Eckel S,Arif S,Beringer PM,Blake EW,Lardieri AB,Lobo BL,Mercer JM,Moye P,Orlando PL,Wargo K

更新日期：2012-02-01 00:00:00

abstract：:Two analyses were conducted to compare the cost-effectiveness of different intravenous immunoglobulin (IGIV) formulations: IGIV purified by caprylate precipitation and chromatography (IGIV-C) and IGIV manufactured by an older solvent-detergent method (IGIV-S/D). The results indicated that IGIV-C is associated with cos...

journal_title：Pharmacotherapy

authors： Mahadevia PJ

更新日期：2005-11-01 00:00:00

abstract：:Subtherapeutic tacrolimus trough concentrations were noted in a 52-year-old woman who had undergone liver transplantation. Her tacrolimus dosage was increased from 7 to 28 mg twice/day, and ketoconazole therapy was added; however, her tacrolimus concentration remained undetectable. Metoclopramide 10 mg 4 times/day was...

journal_title：Pharmacotherapy

authors： Prescott WA Jr,Callahan BL,Park JM

更新日期：2004-04-01 00:00:00

abstract：:The primary objective of this study was to determine if a pharmacist-managed anticoagulation monitoring service (AMS) improved the outcomes of patients receiving warfarin in a family practice setting and was cost effective in treating and preventing thromboembolic disorders. A retrospective chart review was performed ...

journal_title：Pharmacotherapy

authors： Wilt VM,Gums JG,Ahmed OI,Moore LM

更新日期：1995-11-01 00:00:00

abstract：:Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is associated with high morbidity and mortality. Traditionally, antistaphylococcal penicillins (ASPs) have been considered the agents of choice for the treatment of MSSA bacteremia. Vancomycin has been demonstrated to have poorer outcomes in several studi...

journal_title：Pharmacotherapy

authors： Li J,Echevarria KL,Traugott KA

更新日期：2017-03-01 00:00:00

abstract：:Good admissions decisions are essential for identifying successful students and good practitioners. Various parameters have been shown to have predictive power for academic success. Previous academic performance, the Pharmacy College Admissions Test (PCAT), and specific prepharmacy courses have been suggested as acade...

journal_title：Pharmacotherapy

authors： Allen DD,Bond CA

更新日期：2001-07-01 00:00:00

abstract：:Several worldwide initiatives involve pharmacy education and practice; however, the International Pharmaceutical Federation is the only worldwide pharmacy organization currently in existence. This is the first report of the good pharmacy practice initiative published in the United States. We hope that it will stimulat...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL,Claesson C

更新日期：1995-09-01 00:00:00

abstract：:After injecting the solution extracted from a Primatene Mist inhaler, a patient experienced epinephrine overdose that resulted in an acute myocardial infarction and acute renal failure. The exact amount of epinephrine injected was unknown, but was thought to be between 82.5 and 124 mg, more than 25 times higher than t...

journal_title：Pharmacotherapy

authors： Woodard ML,Brent LD

更新日期：1998-05-01 00:00:00