Abstract:
:Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are independent of their effects on the cardiovascular system. Indeed, both in vitro and in vivo studies suggested that they may possess immunosuppressive properties. Their actions at the cellular level in both the afferent and efferent arms of the immune system indicate that alone, as well as in combination with cyclosporine, these agents possess immunosuppressive properties that may potentially benefit the transplant population.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Chitwood KK,Heim-Duthoy KLsubject
Has Abstractpub_date
1993-09-01 00:00:00pages
447-54issue
5eissn
0277-0008issn
1875-9114journal_volume
13pub_type
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