Issues in developing an outpatient deep venous thrombosis treatment program: university hospital experience.

abstract：:Hospital pharmacists are often consulted for their knowledge about coagulation and therapeutic interventions for the management of critical bleeding. Many pharmacotherapies are available for this purpose, both systemic and topical, and others are in development. These agents and their mechanisms of action are reviewed...

journal_title：Pharmacotherapy

authors： Voils S

更新日期：2007-09-01 00:00:00

abstract：:Nucleoside analogs (zidovudine, didanosine, zalcitabine, stavudine, abacavir, lamivudine) have been administered as antiretroviral agents for more than a decade. They undergo anabolic phosphorylation by intracellular kinases to form triphosphates, which inhibit human immunodeficiency virus replication by competitively...

journal_title：Pharmacotherapy

authors： Stein DS,Moore KH

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:Vancomycin (VAN) is associated with an increased risk of acute kidney injury (AKI). Evidence is conflicting regarding the risk of AKI when VAN is combined with an antipseudomonal β-lactam. OBJECTIVES:To determine the comparative incidence of AKI when VAN is combined with piperacillin-tazobactam (PTZ) or m...

journal_title：Pharmacotherapy

authors： Robertson AD,Li C,Hammond DA,Dickey TA

更新日期：2018-12-01 00:00:00

abstract：:Pulmonary hypertension (PH) is often caused by left heart disease (LHD) such as heart failure (HF) or valvular heart disease. Historically, few randomized controlled trials have evaluated the off-label use of medications for treating pulmonary arterial hypertension (PAH) in patients with PH-LHD. However, multiple rand...

journal_title：Pharmacotherapy

authors： Kido K,Coons JC

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Historically, there is perceived pressure to achieve therapeutic levels of tacrolimus quickly after heart transplant (HT). We evaluated the association between time within therapeutic tacrolimus range and time to therapeutic trough and rejection in the 30 days following HT. METHODS:This is a single-center r...

journal_title：Pharmacotherapy

authors： Baker WL,Steiger S,Martin S,Patel N,Radojevic J,Darsaklis K,O'Bara L,Kutzler H,Dougherty J,Feingold A,Hammond J,Fusco D,Gluck JA

更新日期：2019-05-01 00:00:00

abstract：:The frequency of type 2 diabetes mellitus is increasing at an alarming rate. Prediabetes, also referred to as impaired glucose tolerance (IGT) and/or impaired fasting glucose, is a major risk factor for development of type 2 diabetes mellitus. In addition, IGT has been associated with an increased risk of cardiovascul...

journal_title：Pharmacotherapy

authors： Irons BK,Mazzolini TA,Greene RS

更新日期：2004-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects. DESIGN:Two randomized, open-label, crossover, drug-drug interaction studies. SETTING:Clinical research facilities in the United States ...

journal_title：Pharmacotherapy

authors： Smit JW,Oh C,Rengelshausen J,Terlinden R,Ravenstijn PG,Wang SS,Upmalis D,Mangold B

更新日期：2010-01-01 00:00:00

abstract：:Peripheral blood has replaced bone marrow as a source of hematopoietic stem cells for autologous rescue after high-dose chemotherapy. Patients who receive peripheral blood stem cell (PBSC) transplants experience rapid and sustained hematopoietic reconstitution. As a result, transplant-related mortality is now less tha...

journal_title：Pharmacotherapy

authors： Yee GC

更新日期：1996-05-01 00:00:00

abstract：STUDY OBJECTIVES:To characterize the steady-state pharmacokinetics of intravenous levetiracetam in neurocritical care patients requiring seizure prophylaxis after a neurologic injury and to determine which dosing regimens achieve serum concentrations within the recommended therapeutic range of 6-20 μg/ml. DESIGN. Prosp...

journal_title：Pharmacotherapy

authors： Spencer DD,Jacobi J,Juenke JM,Fleck JD,Kays MB

更新日期：2011-10-01 00:00:00

abstract：:Vancomycin-resistant enterococci (VRE) and methicillin-oxacillin-resistant Staphylococcus aureus (MRSA) originally predominated in large medical centers; however, these isolates are now common in community hospitals and community clinics. No simple answer is available regarding control of antimicrobial-resistant bacte...

journal_title：Pharmacotherapy

authors： Smith DW

更新日期：1999-08-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains the major obstacle for successful allogeneic bone marrow transplantation (BMT). The frequency of grade II or higher acute GVHD ranges from 30-50% in human leukocyte antigen (HLA)-matched sibling transplants and 50-80% in HLA-matched unrelated transplants. The mortality an...

journal_title：Pharmacotherapy

authors： Tse JC,Moore TB

更新日期：1998-09-01 00:00:00

abstract：:The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...

journal_title：Pharmacotherapy

authors： Rafie S,McIntosh J,Shealy KM,Borgelt LM,Forinash A,Shrader SP,Koepf ER,McClendon KS,Griffin BL,Horlen C,Karaoui LR,Rowe EL,Lodise NM,Wigle PR

更新日期：2014-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of acarbose on glycemic control and glycemic variability, using a continuous glucose-monitoring system, in patients with type 2 diabetes mellitus who were not well controlled on metformin and vildagliptin therapy. DESIGN:Multicenter, randomized, double-blind, placebo-controlled s...

journal_title：Pharmacotherapy

authors： Derosa G,Franzetti I,Querci F,D'Angelo A,Maffioli P

更新日期：2015-11-01 00:00:00

abstract：:Target drug programs and medication use evaluations are activities that are undertaken to improve the correct use of drugs. These programs should focus on inappropriate drug use, drug use problems, optimizing use of drugs, and improving the level of patient care. To monitor the effects of the programs, several types o...

journal_title：Pharmacotherapy

authors： Hekster YA

更新日期：2000-10-01 00:00:00

abstract：:Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is associated with high morbidity and mortality. Traditionally, antistaphylococcal penicillins (ASPs) have been considered the agents of choice for the treatment of MSSA bacteremia. Vancomycin has been demonstrated to have poorer outcomes in several studi...

journal_title：Pharmacotherapy

authors： Li J,Echevarria KL,Traugott KA

更新日期：2017-03-01 00:00:00

abstract：:Ondansetron hydrochloride dihydrate is a 5-hydroxytryptamine (5-HT3) antagonist that was recently approved by the Food and Drug Administration for the treatment of chemotherapy-induced emesis. The mechanism of action is thought to be due to competitive inhibition of specific serotonin receptors in the central nervous ...

journal_title：Pharmacotherapy

authors： Burnette PK,Perkins J

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:There are limited markers that could facilitate individualized tacrolimus treatment in the early posttransplantation period. Genetic factors have been found to play critical roles in determining tacrolimus pharmacokinetics. OBJECTIVE:We aimed to examine the association of donor and recipient Toll-like recep...

journal_title：Pharmacotherapy

authors： Ou B,Liu Y,Zhang T,Sun Y,Chen J,Peng Z

更新日期：2019-01-01 00:00:00

abstract：:Intravenous unfractionated heparin (UFH) remains an important therapeutic agent, particularly in the inpatient setting, for anticoagulation. Historically, the activated partial thromboplastin time (aPTT) has been the primary laboratory test used to monitor and adjust UFH. The aPTT test has evolved since the 1950s, and...

journal_title：Pharmacotherapy

authors： Vandiver JW,Vondracek TG

更新日期：2012-06-01 00:00:00

abstract：:In 2006, the American College of Clinical Pharmacy (ACCP) charged the Task Force on Residency Equivalency to define the professional experience expected of a clinically mature practitioner that would meet or exceed the knowledge and skills of an accredited postgraduate year one residency-trained pharmacist. In this co...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Jordan CJ,Wall GC,Lobo B,Wilkinson J,Creekmore FM,Sorrells K,Hartis C,Miller S,Uchal L

更新日期：2009-12-01 00:00:00

abstract：:Dabigatran, a direct thrombin inhibitor, is an oral anticoagulant indicated for the prevention of stroke in patients with atrial fibrillation (AF) and for the treatment and prevention of deep vein thrombosis and pulmonary embolism. Dabigatran, as well as the other new anticoagulants-rivaroxaban, apixaban, and edoxaban...

journal_title：Pharmacotherapy

authors： Wiggins BS,Northup A,Johnson D,Senfield J

更新日期：2016-02-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did no...

journal_title：Pharmacotherapy

authors： Shields SA,Gregor KJ,Young CH,James SP

更新日期：1998-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the feasibility of therapeutic drug monitoring for adjusting low serum antimycobacterial concentrations in patients with both tuberculosis and advanced human immunodeficiency virus (HIV). DESIGN:Retrospective cohort study. DATA SOURCE:De-identified dataset from a tuberculosis clinic. PAT...

journal_title：Pharmacotherapy

authors： Holland DP,Hamilton CD,Weintrob AC,Engemann JJ,Fortenberry ER,Peloquin CA,Stout JE

更新日期：2009-05-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is an acute inflammatory process that impairs the ability of the lungs to oxygenate and ultimately leads to respiratory failure. Patients who develop ARDS often have prolonged and complicated hospital courses putting them at risk for intensive care unit (ICU) delirium. Patien...

journal_title：Pharmacotherapy

authors： Torbic H,Duggal A

更新日期：2018-04-01 00:00:00

abstract：:Diazepam is frequently the subject of review by various agencies and institutions charged with determining whether or not to substitute another, more economical drug--in most instances, chlordiazepoxide. A review of the comparative literature has shown that, on clinical and pharmacokinetic grounds, chlordiazepoxide is...

journal_title：Pharmacotherapy

authors： Baskin SI,Esdale A

更新日期：1982-03-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...

journal_title：Pharmacotherapy

authors： Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

更新日期：2010-12-01 00:00:00

abstract：:Obesity is a worldwide epidemic often complicated by multiple comorbidities, including type 2 diabetes mellitus (T2DM). Bariatric surgery is an increasingly common and effective weight-loss strategy for obese patients that may result in resolution of metabolic-related disease states, such as T2DM. Although bariatric s...

journal_title：Pharmacotherapy

authors： Howard ML,Steuber TD,Nisly SA

更新日期：2018-06-01 00:00:00

abstract：:Cystic fibrosis affects 1/2500 individuals and is the most common lethal autosomal recessive disease in people of northern European descent. It is characterized by chronic infections with mucoid Pseudomonas aeruginosa and progressive deterioration of respiratory function. Much research has focused on the inflammatory ...

journal_title：Pharmacotherapy

authors： Gaylor AS,Reilly JC

更新日期：2002-02-01 00:00:00

abstract：:We attempted to determine physician prescribing patterns of angiotensin-converting enzyme (ACE) inhibitors in patients who experienced a myocardial infarction, stratified by left ventricular function. We retrospectively reviewed drug therapy at discharge in 534 patients to assess prescription of ACE inhibitor therapy,...

journal_title：Pharmacotherapy

authors： Luzier AB,Navsarikar A,Wilson MF,Ashai K,Forrest A

更新日期：1999-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate claims-related treatment adherence, health care resource utilization, and associated costs of therapy conversion from an insulin vial and syringe to a premixed biphasic insulin analog pen device among privately insured patients with type 2 diabetes mellitus. DESIGN:Retrospective, longitudin...

journal_title：Pharmacotherapy

authors： Cobden D,Lee WC,Balu S,Joshi AV,Pashos CL

更新日期：2007-07-01 00:00:00

abstract：:A 58-year-old man went to his physician with complaints of midepigastric pain, flatulence, belching, and shortness of breath. During a physical examination, the patient was in no acute distress. The patient underwent an ultrasound examination, which revealed cholelithiasis, a laparoscopic cholecystectomy, which reveal...

journal_title：Pharmacotherapy

authors： Baker EL,Baker WL,Cloney DJ

更新日期：2007-02-01 00:00:00