Resolution of a phytobezoar with Aldoph's Meat Tenderizer.

abstract：:In comprehensive clinical studies, diflunisal--a new nonsteroidal antiinflammatory drug with a long duration of action--was shown to be highly effective and generally well tolerated in the short- and long-term treatment of the pain of osteoarthritis. In double-blind comparison studies, diflunisal was comparable in eff...

journal_title：Pharmacotherapy

authors： Umbenhauer ER

更新日期：1983-03-01 00:00:00

abstract：:Cabozantinib is an oral small-molecule multitargeted tyrosine kinase inhibitor (TKI) that may confer an advantage over other TKIs that target a single receptor. It was approved by the U.S. Food and Drug Administration for the treatment of both advanced renal cell carcinoma and progressive metastatic medullary thyroid ...

journal_title：Pharmacotherapy

authors： Markowitz JN,Fancher KM

更新日期：2018-03-01 00:00:00

abstract：:Levodopa is one of the principal agents administered to treat patients with Parkinson's disease (PD). Several pharmacologic strategies can limit its side effects and enhance its activity. Although certain exceptions apply, dosage adjustments and drug changes should be instituted slowly. Levodopa is typically introduce...

journal_title：Pharmacotherapy

authors： Berchou RC

更新日期：2000-01-01 00:00:00

abstract：STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...

journal_title：Pharmacotherapy

authors： Locke C,Ravnan SL,Patel R,Uchizono JA

更新日期：2005-05-01 00:00:00

abstract：:We conducted an extensive literature review to evaluate the appropriate use, route, and dose of vitamin K to reverse excessive anticoagulation. Issues such as sample size, study design, different patient populations, and various study end points confounded results. Of 18 studies published, 8 enrolled 229 patients to e...

journal_title：Pharmacotherapy

authors： Taylor CT,Chester EA,Byrd DC,Stephens MA

更新日期：1999-12-01 00:00:00

abstract：:Various pharmacologic agents are available for the treatment of hypercholesterolemia, including 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly referred to as statins, which offer favorable lipid-lowering effects and reductions in morbidity and mortality. Statins are usually better toler...

journal_title：Pharmacotherapy

authors： Chong PH,Boskovich A,Stevkovic N,Bartt RE

更新日期：2004-09-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the efficacy of a single, low-dose injection of botulinum toxin type A in relieving pain in Korean patients with piriformis syndrome resistant to conventional therapy, and to assess the drug's influence on these patients' quality of life. DESIGN:Prospective, single-site, open-label trial. ...

journal_title：Pharmacotherapy

authors： Yoon SJ,Ho J,Kang HY,Lee SH,Kim KI,Shin WG,Oh JM

更新日期：2007-05-01 00:00:00

abstract：STUDY OBJECTIVES:To determine changes in bone mineral density (BMD) and T scores of patients after 2 years of teriparatide therapy, and to determine the number of fractures that occurred during therapy. DESIGN:Prospective, observational study. SETTING:Pharmacist-run teriparatide clinic in a private-practice endocrino...

journal_title：Pharmacotherapy

authors： Stroup JS,Rivers SM,Abu-Baker AM,Kane MP

更新日期：2007-06-01 00:00:00

abstract：:The prevalence of diabetes mellitus has grown to staggering numbers, and its incidence is expected to rise in the next 2 decades. The need for novel approaches to treat hyperglycemia cannot be ignored. Current agents have been shown to modestly improve glycemia and in some cases prevent complications of diabetes, but ...

journal_title：Pharmacotherapy

authors： Shah NK,Deeb WE,Choksi R,Epstein BJ

更新日期：2012-01-01 00:00:00

abstract：:The effect of treatment for hepatitis C viral infection on hemoglobin A(1c) (A1C) levels is not well described in the literature. We describe a 59-year-old man with type 2 diabetes mellitus whose A1C level became falsely low when ribavirin and peginterferon alfa-2b therapy were started for treatment of hepatitis C. Af...

journal_title：Pharmacotherapy

authors： Gross BN,Cross LB,Foard JC,Wood YA

更新日期：2009-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...

journal_title：Pharmacotherapy

authors： Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SL

更新日期：2012-07-01 00:00:00

abstract：:Thirty-six indigent patients hospitalized within 6 months of study initiation and who met criteria were enrolled in a 6-month assistance program to determine if provision of both medical care and prescription drugs at no cost would be associated with a change in overall health care charges secondary to a change in the...

journal_title：Pharmacotherapy

authors： Nykamp D,Ruggles D

更新日期：2000-02-01 00:00:00

abstract：:Resistance of nosocomial and community-acquired pathogens to antimicrobial agents is a serious problem with significant clinical consequences. Microbiologic surveillance data, such as those provided by the National Nosocomial Infections Surveillance System, supply information on current nosocomial pathogens in the Uni...

journal_title：Pharmacotherapy

authors： Thornsberry C

更新日期：1995-01-01 00:00:00

abstract：:Death is the ultimate adverse drug event. Despite its importance, the frequency of fatal adverse drug events is unknown. Estimates in the United States are as high as 140,000/year, although this number is heavily disputed. Potential reasons and risks for fatal adverse drug events, as well as epidemiologic designs for ...

journal_title：Pharmacotherapy

authors： Kelly WN

更新日期：2001-05-01 00:00:00

abstract：:Prostaglandins have been shown to relax the smooth muscle of the ductus arteriosus in the fetus in utero. This physiologic action has been applied to the management of newborn infants with certain types of congenital malformations. Infants with lesions producing right ventricular outflow obstruction have a compromised...

journal_title：Pharmacotherapy

authors： Heymann MA,Clyman RI

更新日期：1982-05-01 00:00:00

abstract：:The purpose of the American College of Clinical Pharmacy (ACCP) is to advance human health by extending the frontiers of clinical pharmacy. Consistent with this mission and its core values, ACCP is committed to ensuring that clinical pharmacists possess the knowledge, skills, attitudes, and behaviors necessary to deli...

journal_title：Pharmacotherapy

authors： Saseen JJ,Ripley TL,Bondi D,Burke JM,Cohen LJ,McBane S,McConnell KJ,Sackey B,Sanoski C,Simonyan A,Taylor J,Vande Griend JP

更新日期：2017-05-01 00:00:00

abstract：:Paclitaxel is a novel antineoplastic that effects cytotoxicity by promoting intracellular tubulin polymerization and stabilizes abnormal microtubule structures against depolymerization. Although its clinical development had been hampered by misconceptions about its pharmacology, its scarcity, difficulties extracting i...

journal_title：Pharmacotherapy

authors： Kohler DR,Goldspiel BR

更新日期：1994-01-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...

journal_title：Pharmacotherapy

authors： Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

更新日期：2010-12-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the feasibility of therapeutic drug monitoring for adjusting low serum antimycobacterial concentrations in patients with both tuberculosis and advanced human immunodeficiency virus (HIV). DESIGN:Retrospective cohort study. DATA SOURCE:De-identified dataset from a tuberculosis clinic. PAT...

journal_title：Pharmacotherapy

authors： Holland DP,Hamilton CD,Weintrob AC,Engemann JJ,Fortenberry ER,Peloquin CA,Stout JE

更新日期：2009-05-01 00:00:00

abstract：:A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...

journal_title：Pharmacotherapy

authors： Vandell AG,DiPiro JT

更新日期：2002-05-01 00:00:00

abstract：:An area of unidirectional conduction block is one requirement for reentrant arrhythmias to occur. Functional block caused by dispersion of repolarization and refractoriness is the most probable mechanism of drug-induced unidirectional conduction block. We assessed the effects of lidocaine on spatial dispersion of myoc...

journal_title：Pharmacotherapy

authors： Sims JJ,Winecoff AP,Ujhelyi MR

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVES:To compare the usage and cost of antibiotics in the United States and United Kingdom in children younger than 10 years. METHODS:A follow up of some 160,000 young children enrolled in U.S. private health insurance companies and an equal number in general practices in the United Kingdom in 2009, based on two ...

journal_title：Pharmacotherapy

authors： Jick H,Wilson A,Chamberlin D

更新日期：2014-01-01 00:00:00

abstract：:The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...

journal_title：Pharmacotherapy

authors： Brooks KM,Sherman EM,Egelund EF,Brotherton A,Durham S,Badowski ME,Cluck DB

更新日期：2019-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...

journal_title：Pharmacotherapy

authors： McCollum M,Stringer KA,Wittkowsky AK,Young S,Spinler SA

更新日期：2007-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the efficacy of reteplase administration in clearing hemodialysis catheters. DESIGN:Open-label, uncontrolled, observational trial. SETTING:University medical center. PATIENTS:Thirty-four patients with end-stage renal disease undergoing long-term hemodialysis. INTERVENTION:Patients had du...

journal_title：Pharmacotherapy

authors： Hilleman DE,Dunlay RW,Packard KA

更新日期：2003-02-01 00:00:00

abstract：:A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, wi...

journal_title：Pharmacotherapy

authors： McMahon FG,Vargas R

更新日期：1993-07-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the success of an initial tobramycin dosing regimen to achieve target peak and trough concentrations in adult patients with pulmonary exacerbations of cystic fibrosis (CF). DESIGN:Retrospective single-center medical record review. SETTING:Large tertiary care academic medical center. PATIE...

journal_title：Pharmacotherapy

authors： Staubes BA,Metzger NL,Walker SD,Peasah SK

更新日期：2016-06-01 00:00:00

abstract：:This commentary from the 2010 Task Force on Acute Care Practice Model of the American College of Clinical Pharmacy was developed to compare and contrast the "unit-based" and "service-based" orientation of the clinical pharmacist within an acute care pharmacy practice model and to offer an informed opinion concerning w...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Haas CE,Eckel S,Arif S,Beringer PM,Blake EW,Lardieri AB,Lobo BL,Mercer JM,Moye P,Orlando PL,Wargo K

更新日期：2012-02-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：:Data obtained from 23 critically ill patients treated with intravenous ciprofloxacin in two clinical trials were used to validate prospectively a previously developed maximum a posteriori (MAP)-Bayesian estimator and optimal plasma-sampling strategy (OSS). Dosages ranged from 200 mg every 12 hours to 400 mg every 8 ho...

journal_title：Pharmacotherapy

authors： Amsden GW,Ballow CH

更新日期：1996-09-01 00:00:00