Efficacy and Safety of the Use of Pulmonary Arterial Hypertension Pharmacotherapy in Patients with Pulmonary Hypertension Secondary to Left Heart Disease: A Systematic Review.

abstract：BACKGROUND:It is known that γ-glutamyl hydrolase (GGH) is involved in the disposition of methotrexate (MTX), and GGH activity is regulated by DNA methylation in acute lymphoblastic leukemia (ALL) cells. The present study explores the methylation status of the GGH promoter in peripheral blood and its association with MT...

journal_title：Pharmacotherapy

authors： Wang SM,Kong XY,Li M,Sun LL,Yan D

更新日期：2020-07-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the pharmacokinetics and pharmacodynamics of fludarabine in patients with rheumatoid arthritis (RA). DESIGN:Open-label, staggered trial conducted in conjunction with a phase I-II clinical trial. SETTING:Government research hospital. PATIENTS:Twenty-six patients with refractory RA. INTERV...

journal_title：Pharmacotherapy

authors： Knebel W,Davis JC Jr,Sanders WD,Fessler B,Yarboro C,Pucino F,Boumpas DT

更新日期：1998-11-01 00:00:00

abstract：:The field of acid suppression has been advanced by therapeutics of increasing specificity for inhibiting gastric acid secretion. Particularly important are proton pump inhibitors (PPIs), which inhibit the activity of the gastric acid pump (H+,K(+)-adenosine triphosphatase), the final common step in gastric acid produc...

journal_title：Pharmacotherapy

authors： Sachs G

更新日期：2003-10-01 00:00:00

abstract：:Low-molecular-weight heparins (LMWHs) are safe and effective in the treatment of venous thromboembolic disease. Since they require less therapeutic monitoring than unfractionated heparin and may be administered to outpatients, it is possible to decrease overall health care costs of patients diagnosed with deep vein th...

journal_title：Pharmacotherapy

authors： Yurkowski P

更新日期：1998-11-01 00:00:00

abstract：:Ongoing improvements in immunosuppression and posttransplantation care have dramatically improved patient and graft outcomes after transplantation. The frequency of graft loss due to acute rejection has declined considerably as a result of the availability of a variety of more potent immunosuppressive agents and proba...

journal_title：Pharmacotherapy

authors： Lo A,Alloway RR

更新日期：2002-03-01 00:00:00

abstract：:The complexities of oral anticoagulation with warfarin have led to the search for more practical alternative agents. Novel direct factor IIa inhibitors and direct factor Xa inhibitors currently in development can be administered at a fixed dose and do not require routine coagulation monitoring and ongoing dosage adjus...

journal_title：Pharmacotherapy

authors： Wittkowsky AK

更新日期：2011-12-01 00:00:00

abstract：:Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...

journal_title：Pharmacotherapy

authors： Nutescu EA,Spinler SA,Dager WE,Bussey HI

更新日期：2004-10-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the feasibility of therapeutic drug monitoring for adjusting low serum antimycobacterial concentrations in patients with both tuberculosis and advanced human immunodeficiency virus (HIV). DESIGN:Retrospective cohort study. DATA SOURCE:De-identified dataset from a tuberculosis clinic. PAT...

journal_title：Pharmacotherapy

authors： Holland DP,Hamilton CD,Weintrob AC,Engemann JJ,Fortenberry ER,Peloquin CA,Stout JE

更新日期：2009-05-01 00:00:00

abstract：:Warfarin is considered a high-risk drug because of its narrow therapeutic window, variability in dose response, and multitude of drug and food interactions. Although travel advice is available for patients who are taking warfarin, it is geared toward patients who are traveling to developed countries and tends to be la...

journal_title：Pharmacotherapy

authors： Truong T,Armor BL

更新日期：2012-03-01 00:00:00

abstract：:Females of childbearing age represent a large population of solid organ transplant recipients. With fertility commonly restored after transplantation, the possibility of pregnancy becomes a reality for many patients. Since the first published report of a successful pregnancy after solid organ transplantation in 1963, ...

journal_title：Pharmacotherapy

authors： Casale JP,Doligalski CT

更新日期：2016-09-01 00:00:00

abstract：:Genotype-guided warfarin dosing algorithms are a rational approach to optimize warfarin dosing and potentially reduce adverse drug events. Diverse populations, such as African Americans and Latinos, have greater variability in warfarin dose requirements and are at greater risk for experiencing warfarin-related adverse...

journal_title：Pharmacotherapy

authors： Kaye JB,Schultz LE,Steiner HE,Kittles RA,Cavallari LH,Karnes JH

更新日期：2017-09-01 00:00:00

abstract：:Meta-analyses are key components of evidence-based decision making. The numbers of meta-analyses published in different areas of health care increased dramatically during the past 10 years. Many of them covered different pharmacologic interventions, making them useful resources to clinical pharmacists. Although a well...

journal_title：Pharmacotherapy

authors： Etminan M,Levine M

更新日期：1999-06-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the extent of hospital-based clinical pharmacy services in 1992. DESIGN:National survey with trend comparison to 1989. SETTING:All 1597 United States acute care, general medical-surgical and pediatric hospitals with 50 or more licensed beds and one or more full-time pharmacists (43% of al...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL,Pitterle ME

更新日期：1994-05-01 00:00:00

abstract：:Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in clinical studies. For this reason, in vitro and animal models were developed to investigate the effects of critical illness on hepatic drug metabolism...

journal_title：Pharmacotherapy

authors： McKindley DS,Hanes S,Boucher BA

更新日期：1998-07-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of Niaspan--a niacin preparation with both immediate- and extended-release characteristics--on lipid and glycemic control in patients with type 2 diabetes. DESIGN:Retrospective study SETTING:Private-practice endocrinology group. PATIENTS:Thirty-two patients (mean age 60 yrs; 7...

journal_title：Pharmacotherapy

authors： Kane MP,Hamilton RA,Addesse E,Busch RS,Bakst G

更新日期：2001-12-01 00:00:00

abstract：:Antithrombin deficiency is a hypercoagulable state that can increase the risk for thrombosis, especially in the presence of other procoagulant triggers. Unfractionated heparin and low-molecular-weight heparins may not provide effective anticoagulation since they require antithrombin for activity. Direct thrombin inhib...

journal_title：Pharmacotherapy

authors： Dager WE,Gosselin RC,Owings JT

更新日期：2004-05-01 00:00:00

abstract：:In recent years, there have been many updates in hormonal emergency contraception. Levonorgestrel emergency contraception has been available for several years to prevent pregnancy when used within 72 hours after unprotected intercourse or contraceptive failure, and it was recently approved for nonprescription status f...

journal_title：Pharmacotherapy

authors： Shrader SP,Hall LN,Ragucci KR,Rafie S

更新日期：2011-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effects of acetaminophen, naproxen, and acetylsalicylic acid on the pharmacokinetics of the centrally acting analgesic tapentadol in healthy subjects. DESIGN:Two randomized, open-label, crossover, drug-drug interaction studies. SETTING:Clinical research facilities in the United States ...

journal_title：Pharmacotherapy

authors： Smit JW,Oh C,Rengelshausen J,Terlinden R,Ravenstijn PG,Wang SS,Upmalis D,Mangold B

更新日期：2010-01-01 00:00:00

abstract：:Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence of abuse potential. Buspirone is both a dopamine agonist and anta...

journal_title：Pharmacotherapy

authors： Goldberg HL

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:Neurocritically ill patients have clinically significant alterations in pharmacokinetic parameters of renally eliminated medications that may result in subtherapeutic plasma and cerebrospinal fluid antibiotic concentrations. METHODS:We conducted a prospective randomized open-label study of adult neurocriticall...

journal_title：Pharmacotherapy

authors： Kassel LE,Van Matre ET,Foster CJ,Fish DN,Mueller SW,Sherman DS,Wempe MF,MacLaren R,Neumann RT,Kiser TH

更新日期：2018-09-01 00:00:00

abstract：:A prospective cohort study was conducted in 35 hospitals with oncology units to determine the incidence of symptomatic cardiotoxicity in patients receiving continuous infusions of 5-fluorouracil (5-FU), and to identify risk factors that could contribute to the development of 5-FU-associated cardiotoxicity. A sample of...

journal_title：Pharmacotherapy

authors： Meyer CC,Calis KA,Burke LB,Walawander CA,Grasela TH

更新日期：1997-07-01 00:00:00

abstract：:Agitation in the elderly, manifested by verbal and physical aggression, frequently results in increased morbidity and mortality for nursing home residents and reduced morale for the family and nursing home staff. It is also responsible for increased costs associated with caring for these residents. Pharmacologic inter...

journal_title：Pharmacotherapy

authors： Grossman F

更新日期：1998-05-01 00:00:00

abstract：:The systemic polymyxins, colistin and polymyxin B, are increasingly used for multidrug-resistant bacterial infections and have a long history of dose-limiting toxicity. This review summarizes the most recent available information about the mechanisms, incidence, risk factors, and minimization strategies for polymyxin ...

journal_title：Pharmacotherapy

authors： Justo JA,Bosso JA

更新日期：2015-01-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the frequency and type of complementary and alternative medicine (CAM) use among healthy volunteers participating in research, and to investigate the potential for interactions between commonly used CAM modalities and various drugs. DESIGN:Prospective evaluation. SETTING:University gener...

journal_title：Pharmacotherapy

authors： Welder GJ,Wessel TR,Arant CB,Schofield RS,Zineh I

更新日期：2006-12-01 00:00:00

abstract：:We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...

journal_title：Pharmacotherapy

authors： Zimmermann AE,Katona BG,Plaisance KI

更新日期：1995-01-01 00:00:00

abstract：:For many years, a regimen of fluorouracil and cisplatin has been the standard of care for the treatment of patients with metastatic gastric cancer. More recently, triplet regimens that incorporate fluorouracil and cisplatin with epirubicin (ECF) or docetaxel are being used in the management of patients with metastatic...

journal_title：Pharmacotherapy

authors： Comella P,Franco L,Casaretti R,de Portu S,Menditto E

更新日期：2009-03-01 00:00:00

abstract：:Oral anticoagulation with warfarin requires routine monitoring of prothrombin time, expressed as the international normalized ratio (INR). Patient self-testing for INR is common in Europe but not in the United States. In order to determine the frequency of INR self-testing among patients whose anticoagulant therapy is...

journal_title：Pharmacotherapy

authors： Wittkowsky AK,Sekreta CM,Nutescu EA,Ansell J

更新日期：2005-02-01 00:00:00

abstract：:Infections in the cerebrospinal fluid (CSF) occur in an area of impaired host defenses; therefore, bactericidal antibiotics that reach adequate concentrations in the CSF are necessary for treatment. Measurements of antibiotic penetration into the CSF include CSF inhibitory and bactericidal titers, the absolute antibio...

journal_title：Pharmacotherapy

authors： Friedrich LV,White RL,Reboli AC

更新日期：1990-01-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the ability of seven widely known herbal references and electronic databases to answer questions about herbal products asked at drug information centers. DESIGN:Cross-sectional study. SETTING:Five academic and institutional drug information centers. METHODS:Fifty-seven herbal-related ques...

journal_title：Pharmacotherapy

authors： Walker JB

更新日期：2002-12-01 00:00:00

abstract：:Albuterol is a 50:50 mixture of R-albuterol, the active enantiomer, and S-albuterol, which appears to be inactive in humans. The Food and Drug Administration recently approved levalbuterol, the pure R-isomer, as a preservative-free nebulizer solution. Published studies indicate that it is neither safer nor more effect...

journal_title：Pharmacotherapy

authors： Asmus MJ,Hendeles L

更新日期：2000-02-01 00:00:00