Delaying the onset of type 2 diabetes mellitus in patients with prediabetes.

abstract：:The purpose of the American College of Clinical Pharmacy (ACCP) is to advance human health by extending the frontiers of clinical pharmacy. Consistent with this mission and its core values, ACCP is committed to ensuring that clinical pharmacists possess the knowledge, skills, attitudes, and behaviors necessary to deli...

journal_title：Pharmacotherapy

authors： Saseen JJ,Ripley TL,Bondi D,Burke JM,Cohen LJ,McBane S,McConnell KJ,Sackey B,Sanoski C,Simonyan A,Taylor J,Vande Griend JP

更新日期：2017-05-01 00:00:00

abstract：:Fatigue is one of the most debilitating and common symptoms associated with hematologic and oncologic disorders and treatment strategies. Patient factors influence etiology and symptom manifestation, which in turn affect diagnosis, management, and monitoring. Fatigue instruments can assist with the identification, man...

journal_title：Pharmacotherapy

authors： Schwartz AH

更新日期：2002-11-01 00:00:00

abstract：:Antiretroviral therapy has significantly improved the typical course of human immunodeficiency virus (HIV) infection in industrialized nations, and life expectancies associated with the infection have increased. However, infection rates have generally remained unchanged, with increases noted among certain subpopulatio...

journal_title：Pharmacotherapy

authors： Romanelli F,Murphy B

更新日期：2010-10-01 00:00:00

abstract：:Dabigatran, a direct thrombin inhibitor, is an oral anticoagulant indicated for the prevention of stroke in patients with atrial fibrillation (AF) and for the treatment and prevention of deep vein thrombosis and pulmonary embolism. Dabigatran, as well as the other new anticoagulants-rivaroxaban, apixaban, and edoxaban...

journal_title：Pharmacotherapy

authors： Wiggins BS,Northup A,Johnson D,Senfield J

更新日期：2016-02-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...

journal_title：Pharmacotherapy

authors： Weant KA,Ramsey CN 3rd,Cook AM

更新日期：2010-04-01 00:00:00

abstract：:Two drugs commonly used in triple-drug therapy for treatment of a Helicobacter pylori infection, clarithromycin and omeprazole, have rarely been associated with hypoglycemia when given alone. No documented interactions between H. pylori treatment with clarithromycin, amoxicillin, and omeprazole and insulin detemir hav...

journal_title：Pharmacotherapy

authors： Otsuka SH

更新日期：2013-04-01 00:00:00

abstract：:Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel res...

journal_title：Pharmacotherapy

authors： Momary KM,Dorsch MP,Bates ER

更新日期：2010-03-01 00:00:00

abstract：:The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...

journal_title：Pharmacotherapy

authors： Brooks KM,Sherman EM,Egelund EF,Brotherton A,Durham S,Badowski ME,Cluck DB

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To review the current pharmacotherapy for idiopathic pulmonary arterial hypertension (IPAH). METHODS:A search of the primary literature was conducted by using MEDLINE, the National Institutes of Health medical research Web site (www.clinicaltrials.gov), and the United States Food and Drug Administration's Ce...

journal_title：Pharmacotherapy

authors： Hackman AM,Lackner TE

更新日期：2006-01-01 00:00:00

abstract：:Anemia is an undertreated but common complication of cancer and is associated with debilitating symptoms that impair the patient's ability to perform daily functions of life. Treatment with darbepoetin alfa, a novel erythropoiesis-stimulating protein, is appropriate for chemotherapy-induced anemia. Guidelines on darbe...

journal_title：Pharmacotherapy

authors： Bloomfield M,Jaresko G,Zarek J,Dozier N

更新日期：2003-12-01 00:00:00

abstract：:We have developed a method for measuring the efficacy of a single dose of an analgesic for 12 hours after administration to outpatients with postoperative oral surgery pain. Using a self-rating record, patients evaluate their pain and its relief for 12 hours after medication. We have used this method successfully in a...

journal_title：Pharmacotherapy

authors： Beaver WT,Forbes JA,Shackleford RW

更新日期：1983-03-01 00:00:00

abstract：:Consensus guidelines recommend antimicrobial stewardship in all hospitals with the following goals in mind: appropriate and judicious use of antimicrobial agents leading to increased drug safety, reduced antimicrobial utilization, reduction in the development and selection of resistant organisms, cost containment, and...

journal_title：Pharmacotherapy

authors： Tverdek FP,Rolston KV,Chemaly RF

更新日期：2012-08-01 00:00:00

abstract：:Methemoglobin, a form of hemoglobin that does not bind oxygen, is produced when iron in red blood cells is oxidized from the ferrous state to the ferric state. Methemoglobinemia develops in the presence of oxidizing agents, such as benzocaine-containing topical anesthetic sprays, and it is characterized by cyanosis. I...

journal_title：Pharmacotherapy

authors： Throm MJ,Stevens MD,Hansen C

更新日期：2007-08-01 00:00:00

abstract：:A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...

journal_title：Pharmacotherapy

authors： Christiansen SR,Broniscer A,Panetta JC,Stewart CF

更新日期：2009-07-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the extent to which nitrofurantoin is transferred into human milk. DESIGN:Prospective, single-dose pharmacokinetic study. SETTING:University-affiliated clinical research center. PATIENTS:Four healthy lactating women 8-26 weeks postpartum. INTERVENTION:All subjects received a single, ora...

journal_title：Pharmacotherapy

authors： Gerk PM,Kuhn RJ,Desai NS,McNamara PJ

更新日期：2001-06-01 00:00:00

abstract：:In a double-blind, placebo-controlled study of 200 patients with moderate to moderately severe anxiety we compared the anxiolytic efficacy and safety of alprazolam and lorazepam. Dosing was flexible and ranged from 1 to 4.5 mg/day of alprazolam and from 2 to 9 mg/day of lorazepam. The mean daily dose at the end of the...

journal_title：Pharmacotherapy

authors： Cohn JB,Wilcox CS

更新日期：1984-03-01 00:00:00

abstract：:We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed dif...

journal_title：Pharmacotherapy

authors： Desai KR,Burdette SD,Polenakovik HM,Hagaman J,Pleiman CM

更新日期：2013-07-01 00:00:00

abstract：:A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as se...

journal_title：Pharmacotherapy

authors： Owens RC

更新日期：2006-03-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the pharmacokinetics and pharmacodynamics of fludarabine in patients with rheumatoid arthritis (RA). DESIGN:Open-label, staggered trial conducted in conjunction with a phase I-II clinical trial. SETTING:Government research hospital. PATIENTS:Twenty-six patients with refractory RA. INTERV...

journal_title：Pharmacotherapy

authors： Knebel W,Davis JC Jr,Sanders WD,Fessler B,Yarboro C,Pucino F,Boumpas DT

更新日期：1998-11-01 00:00:00

abstract：:After the introduction of penicillin G into therapeutics, bacteria became increasingly resistant to this penicillin and subsequent beta-lactam antibiotics. The major cause of this resistance is beta-lactamase, an enzyme produced by the bacterium, that destroys the antibiotic before it reaches its target within the bac...

journal_title：Pharmacotherapy

authors： Jackson D

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of telephone follow-up on the physical well-being dimension of health-related quality of life in patients with cancer. DESIGN:Randomized, controlled trial. SETTING:Public teaching hospital. PATIENTS:One hundred fifty patients with cancer who were discharged to home from the hospital....

journal_title：Pharmacotherapy

authors： Beney J,Devine EB,Chow V,Ignoffo RJ,Mitsunaga L,Shahkarami M,McMillan A,Bero LA

更新日期：2002-10-01 00:00:00

abstract：:Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (sALCL), which is a subtype of non-Hodgkin lymphoma, are relatively uncommon lymphoproliferative types of cancer. These malignancies are highly curable with initial treatment. Nonetheless, some patients are refractory to or relapse after first- and seco...

journal_title：Pharmacotherapy

authors： Newland AM,Li JX,Wasco LE,Aziz MT,Lowe DK

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy of a single dose of basiliximab with two doses in preventing acute rejection in selected low-risk renal transplant recipients. METHODS:This observational study of 760 kidney transplant recipients considered to be at low immunologic risk (peak panel reactive antibody less than 10%) co...

journal_title：Pharmacotherapy

authors： Cunningham KC,Hager DR,Fischer J,D'Alessandro AM,Leverson GE,Kaufman DB,Djamali A

更新日期：2016-07-01 00:00:00

abstract：:Bedaquiline is a diarylquinoline antitubercular drug with a novel mechanism of action against Mycobacterium tuberculosis. Bedaquiline works by inhibiting bacterial adenosine triphosphate (ATP) synthase and represents the first novel class of antituberculosis agents in more than 40 years. Bedaquiline is indicated for t...

journal_title：Pharmacotherapy

authors： Worley MV,Estrada SJ

更新日期：2014-11-01 00:00:00

abstract：:Serious gram-positive infections present an increasingly common therapeutic dilemma. Combination antimicrobial regimens (e.g., linezolid with rifampin) aimed at improving bacterial eradication and preventing resistance are often used; however, most data supporting this treatment strategy are not from randomized contro...

journal_title：Pharmacotherapy

authors： Gebhart BC,Barker BC,Markewitz BA

更新日期：2007-03-01 00:00:00

abstract：:Although heparin-dependent antibodies (HDAs) typically manifest with thrombocytopenia as in heparin-induced thrombocytopenia (HIT), they may also manifest with preserved platelet counts. We describe a 35-year-old woman who developed severe thrombotic complications due to heparinization and unrecognized HDAs. She had r...

journal_title：Pharmacotherapy

authors： Bream-Rouwenhorst HR,Hobbs RA

更新日期：2008-11-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the influence of withholding continuous enteral nutrition for 1 hour before and after warfarin administration compared with the coadministration of warfarin with continuous enteral nutrition on changes in international normalized ratios (INRs). DESIGN:Retrospective, crossover case series. SE...

journal_title：Pharmacotherapy

authors： Dickerson RN,Garmon WM,Kuhl DA,Minard G,Brown RO

更新日期：2008-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of a high-fat breakfast on single-dose, zidovudine (ZDV) pharmacokinetics. DESIGN:Open-label, randomized, crossover study. PATIENTS:Eighteen asymptomatic subjects (12 men, 6 women) infected with the human immunodeficiency virus (mean CD4 cell counts of 512 +/- 178/mm3). INTERV...

journal_title：Pharmacotherapy

authors： Shelton MJ,Portmore A,Blum MR,Sadler BM,Reichman RC,Morse GD

更新日期：1994-11-01 00:00:00

abstract：:The renal pharmacologic effects of intravenous dopamine in doses of 0.5-3.0 micrograms/kg/min include increases in renal blood flow, glomerular filtration rate, solute excretion, and urine flow. Clinical studies revealed that low-dose dopamine can reverse oliguria, but these studies were poorly controlled, were confou...

journal_title：Pharmacotherapy

authors： Dasta JF,Kirby MG

更新日期：1986-11-01 00:00:00

abstract：:The objective of this study was to describe the postinduction clearance of carbamazepine (CBZ) in adult psychiatric patients by population pharmacokinetic analysis using the NONMEM program. Specifically, an estimate of CBZ clearance and insight into the effect of common patient characteristics on clearance were sought...

journal_title：Pharmacotherapy

authors： Martin ES 3rd,Crismon ML,Godley PJ

更新日期：1991-01-01 00:00:00