Recurrent peripheral arterial thrombosis induced by cisplatin and etoposide.

abstract：:Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...

journal_title：Pharmacotherapy

authors： Gomes DM,Ward KE,LaPlante KL

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Cutaneous small vessel vasculitis (CSVV) has been reported after exposure to direct oral anticoagulants (DOACs), such as dabigatran, rivaroxaban, apixaban, and edoxaban. OBJECTIVE:We used the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) to describe clinical characteristics associ...

journal_title：Pharmacotherapy

authors： Mohamoud M,Horgan C,Eworuke E,Dee E,Bohn J,Shapira O,Munoz MA,Stojanovic D,Sansing-Foster V,Ajao A,La Grenade L

更新日期：2020-11-01 00:00:00

abstract：:Neuroleptic malignant syndrome (NMS) is an idiosyncratic and uncommon but serious adverse effect that has been reported with both typical and atypical antipsychotic agents. We describe a 58-year-old man with Down syndrome and dementia who was receiving low-dose olanzapine and rivastigmine therapy; he developed NMS 4 m...

journal_title：Pharmacotherapy

authors： Stevens DL,Lee MR,Padua Y

更新日期：2008-03-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...

journal_title：Pharmacotherapy

authors： Cies JJ,Fugarolas KN,Moore WS 2nd,Mason RW,Menkiti OR

更新日期：2017-04-01 00:00:00

abstract：:Meglumine antimoniate was administered to a patient with visceral leishmaniasis with normal renal function. Soon after the first intramuscular administration of meglumine antimoniate 20 mg/kg, equivalent to 510 mg antimony (Sb), the patient developed septic shock with oliguria. Creatinine clearance decreased to 23 ml/...

journal_title：Pharmacotherapy

authors： Hantson P,Luyasu S,Haufroid V,Lambert M

更新日期：2000-09-01 00:00:00

abstract：:Acute graft-versus-host disease (GVHD) remains the major obstacle for successful allogeneic bone marrow transplantation (BMT). The frequency of grade II or higher acute GVHD ranges from 30-50% in human leukocyte antigen (HLA)-matched sibling transplants and 50-80% in HLA-matched unrelated transplants. The mortality an...

journal_title：Pharmacotherapy

authors： Tse JC,Moore TB

更新日期：1998-09-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the absorption profile of cyclosporine after preprandial administration with that after postprandial administration, and to determine which administration time resulted in a more stable absorption profile and the timing of the drug concentration that was the most reliable marker for monitorin...

journal_title：Pharmacotherapy

authors： Kusaba T,Konno Y,Hatta S,Fujino T,Yasuda T,Miura H,Sasaki H,Okabayashi J,Murao M,Sakurada T,Imai G,Shirai S,Kuboshima S,Shima Y,Ogimoto G,Sato T,Masuhara K,Kimura K

更新日期：2005-01-01 00:00:00

abstract：:Nausea and vomiting are common complaints in the postoperative period and contribute to patient distress and delay of discharge for outpatient surgical procedures. Laparoscopic procedures are associated with a high incidence of postoperative nausea and vomiting (PONV) episodes. Parenteral use of metoclopramide prevent...

journal_title：Pharmacotherapy

authors： Wagner BK,Berman SL,Devitt PA,Halvorsen MB,O'Hara DA

更新日期：1996-11-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the pharmacokinetic profile of palifermin after intravenous dosing with either a collapsed dose of 180 microg/kg/day for 1 day or a standard dose of 60 microg/kg/day for 3 days, before and after myeloablative chemoradiotherapy and peripheral blood progenitor cell (PBPC) transplantation. DESIG...

journal_title：Pharmacotherapy

authors： Zia-Amirhosseini P,Hurd DD,Salfi M,Cheah TC,Aycock J,Cesano A

更新日期：2007-10-01 00:00:00

abstract：:Outpatient transesophageal echocardiography was performed in a 69-year-old man with a history of aortic valve repair. During the procedure the patient became markedly cyanotic and hypotensive. Oxygen saturation measured by pulse oximetry decreased from 97% to the mid-80s. The man's condition continued to deteriorate. ...

journal_title：Pharmacotherapy

authors： Wurdeman RL,Mohiuddin SM,Holmberg MJ,Shalaby A

更新日期：2000-06-01 00:00:00

abstract：:The immune system is a complex network of components functioning to provide host defense. This network consists of immunologic cells and their products (e.g., interleukins and colony-stimulating factors), organs, tissues, complement, and major histocompatibility complex antigens. These components are organized into sp...

journal_title：Pharmacotherapy

authors： McIntyre WJ,Tami JA

更新日期：1992-01-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the effects of food on the bioavailability of testosterone undecanoate, testosterone, and 5alpha-dihydrotestosterone (DHT) after administration of a new oral testosterone undecanoate formulation, Andriol Testocaps. DESIGN:Randomized, open-label, crossover study with a 1-week washout period. ...

journal_title：Pharmacotherapy

authors： Bagchus WM,Hust R,Maris F,Schnabel PG,Houwing NS

更新日期：2003-03-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether alvimopan for prevention of postoperative ileus in patients undergoing small- or large-bowel resection by laparotomy is associated with lower total costs compared with standard care. DESIGN:Pharmacoeconomic analysis using a formal decision model. DATA SOURCE:Four phase III clinica...

journal_title：Pharmacotherapy

authors： Touchette DR,Yang Y,Tiryaki F,Galanter WL

更新日期：2012-02-01 00:00:00

abstract：:Death is the ultimate adverse drug event. Despite its importance, the frequency of fatal adverse drug events is unknown. Estimates in the United States are as high as 140,000/year, although this number is heavily disputed. Potential reasons and risks for fatal adverse drug events, as well as epidemiologic designs for ...

journal_title：Pharmacotherapy

authors： Kelly WN

更新日期：2001-05-01 00:00:00

abstract：:We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed dif...

journal_title：Pharmacotherapy

authors： Desai KR,Burdette SD,Polenakovik HM,Hagaman J,Pleiman CM

更新日期：2013-07-01 00:00:00

abstract：:Antithrombin deficiency is a hypercoagulable state that can increase the risk for thrombosis, especially in the presence of other procoagulant triggers. Unfractionated heparin and low-molecular-weight heparins may not provide effective anticoagulation since they require antithrombin for activity. Direct thrombin inhib...

journal_title：Pharmacotherapy

authors： Dager WE,Gosselin RC,Owings JT

更新日期：2004-05-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the prevalence of hyperlipidemia and the effectiveness of hyperlipidemia management in a large population of transplant recipients. A secondary objective was to assess the effect of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III guidelines on hyperlipidemia man...

journal_title：Pharmacotherapy

authors： Schonder KS,McKaveney TP,Lynch KJ

更新日期：2005-07-01 00:00:00

abstract：:Certain demographic, practice, staffing, and pharmacist satisfaction variables may contribute to dispensing errors. A survey was randomly mailed to 7298 (50%) Texas pharmacists, of which 2862 were returned (39% response rate). Responders were 2437 pharmacists who indicated that they were in practice. Of these, 535 (23...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL

更新日期：2001-05-01 00:00:00

abstract：:Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...

journal_title：Pharmacotherapy

authors： Scheibner A,Remmel R,Schladt D,Oetting WS,Guan W,Wu B,Dorr C,Israni A,Jacobson PA

更新日期：2018-07-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if development of acneiform rash is a predictor of objective response rate with lapatinib. DESIGN:Subanalysis of data from a prospective, phase II study. SETTING:Academic breast care clinic. PATIENTS:Forty-nine treatment-naïve patients with human epidermal growth factor receptor-2 (HER2)...

journal_title：Pharmacotherapy

authors： Parma J,Pavlick A,Schiff R,Osborne CK,Chang JC,Rimawi M,Trivedi MV

更新日期：2013-10-01 00:00:00

abstract：:Levodopa is one of the principal agents administered to treat patients with Parkinson's disease (PD). Several pharmacologic strategies can limit its side effects and enhance its activity. Although certain exceptions apply, dosage adjustments and drug changes should be instituted slowly. Levodopa is typically introduce...

journal_title：Pharmacotherapy

authors： Berchou RC

更新日期：2000-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether a relationship exists between medication adherence to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) and distance to dispensing pharmacies and prescribers among an urban public aid population with diabetes mellitus. DESIGN:Retrospective...

journal_title：Pharmacotherapy

authors： Syed ST,Sharp LK,Kim Y,Jentleson A,Lora CM,Touchette DR,Berbaum ML,Suda KJ,Gerber BS

更新日期：2016-06-01 00:00:00

abstract：:Rituximab has been approved by the United States Food and Drug Administration in combination with methotrexate for the treatment of rheumatoid arthritis in patients who failed to achieve adequate benefit from tumor necrosis factor-alpha inhibitors. Rituximab is a biologic agent that depletes peripheral B cells--an act...

journal_title：Pharmacotherapy

authors： Schuna AA

更新日期：2007-12-01 00:00:00

abstract：:Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihyperte...

journal_title：Pharmacotherapy

authors： Barksdale JD,Gardner SF

更新日期：1999-05-01 00:00:00

abstract：:Vancomycin-resistant enterococci (VRE) and methicillin-oxacillin-resistant Staphylococcus aureus (MRSA) originally predominated in large medical centers; however, these isolates are now common in community hospitals and community clinics. No simple answer is available regarding control of antimicrobial-resistant bacte...

journal_title：Pharmacotherapy

authors： Smith DW

更新日期：1999-08-01 00:00:00

abstract：:Lenalidomide is commonly used for multiple myeloma as either induction or maintenance therapy. The agent is associated with a host of adverse effects, but hypoglycemia has only been reported in one phase I trial in patients with solid tumors. We describe a 74-year-old woman who experienced grade 3 hypoglycemia (blood ...

journal_title：Pharmacotherapy

authors： Przybylski DJ,Birhiray R,Reeves DJ

更新日期：2018-01-01 00:00:00

abstract：:Verapamil and diltiazem are effective in terminating paroxysmal supraventricular tachycardias and slowing ventricular response during atrial fibrillation or flutter. Results from clinical trials for each individual drug demonstrate comparative efficacy rates, and both drugs share the same contraindications and relativ...

journal_title：Pharmacotherapy

authors： Cheiman DM,Shea BF,Kelly RA

更新日期：1996-09-01 00:00:00

abstract：STUDY OBJECTIVE:To establish the clinical equivalence (noninferiority) of one tablet containing abacavir 300 mg-lamivudine 150 mg-zidovudine 300 mg (Trizivir) versus a tablet containing lamivudine 150 mg-zidovudine 300 mg (Combivir) given with one abacavir (ABC) 300-mg tablet, administered twice/day, in antiretroviral-...

journal_title：Pharmacotherapy

authors： Fischl MA,Burnside AE Jr,Farthing CE,Thompson MA,Bellos NC,Williams VC,Kauf TL,Wannamaker PG,Shaefer MS,ESS40005 Study Team.

更新日期：2003-11-01 00:00:00

abstract：:Recent attention has been called to the interpretation of studies of antiinfective agents demonstrating effects on the QTc interval. It seems that the effects of many of these agents on the QTc interval are small, but in some patient populations, these drugs may cause morbidity and mortality related to TdP. It would b...

journal_title：Pharmacotherapy

authors： Owens RC Jr,Ambrose PG

更新日期：2002-05-01 00:00:00

abstract：:Synercid (RP 59500), the first injectable streptogramin antibiotic, is composed of two semisynthetic pristinamycin derivatives, quinupristin and dalfopristin. Individually, each component has bacteriostatic activity against staphylococci and streptococci, but together, the agents exhibit synergy, leading to bactericid...

journal_title：Pharmacotherapy

authors： Delgado G Jr,Neuhauser MM,Bearden DT,Danziger LH

更新日期：2000-12-01 00:00:00