Abstract:
OBJECTIVES:To compare the efficacy of a single dose of basiliximab with two doses in preventing acute rejection in selected low-risk renal transplant recipients. METHODS:This observational study of 760 kidney transplant recipients considered to be at low immunologic risk (peak panel reactive antibody less than 10%) compared patient and graft outcomes following a single-dose versus a two-dose regimen of basiliximab. MAIN RESULTS:No differences were found in patient survival (92% vs 92%, p=0.6), graft survival (86% vs 83%, p=0.2), acute rejection (cellular [4% vs 7%, p=0.2], antibody-mediated rejection [19% vs 19%, p=0.9]), or opportunistic infections (34% vs 30%, p=0.3) between the single versus two-dose regimens, respectively. In multivariate analyses, the number of doses of basiliximab was not associated with acute rejection or patient/graft survival despite adjustment with Cox regression and propensity scores. However, delayed graft function (DGF), donor age older than 65 years, and human leukocyte antigen mismatch of 3 or higher were associated with acute rejection (hazard ratio [HR] 2.64, 1.91, and 1.57, respectively, p≤0.04), and DGF and diabetes were associated with death/graft loss (HR 2.56 and 1.63, respectively, p≤0.009). PRINCIPAL CONCLUSIONS:A single dose of basiliximab is safe and effective for induction in low-risk kidney transplant recipients.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Cunningham KC,Hager DR,Fischer J,D'Alessandro AM,Leverson GE,Kaufman DB,Djamali Adoi
10.1002/phar.1774subject
Has Abstractpub_date
2016-07-01 00:00:00pages
823-9issue
7eissn
0277-0008issn
1875-9114journal_volume
36pub_type
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