Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer.


:Abstract Cetuximab and panitumumab, monoclonal antibodies used to target the epidermal growth factor receptor (EGFR), were recently approved by the United States Food and Drug Administration for use as single agents or in combination with other chemotherapy drugs in the treatment of metastatic colorectal cancer. The anti-EGFR monoclonal antibodies, either as single agents or in combination with chemotherapy, have demonstrated clinical activity in this setting. When combined with standard cytotoxic chemotherapy or other targeted agents (e.g., bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody), anti-EGFR monoclonal antibodies have been well tolerated and produced minimal toxicities. However, cetuximab and panitumumab appear to benefit only select patients. Predictive markers of efficacy, including EGFR overexpression, development of skin rash, and the absence of a K-ras mutation, have been evaluated in clinical studies to identify patients likely to respond to anti-EGFR monoclonal antibody therapy. This review discusses recent clinical studies of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer, predictive markers of their efficacy, and common toxicities associated with their use.






Patel DK




Has Abstract


2008-11-01 00:00:00




11 Pt 2










  • Clinical implications of vancomycin heteroresistant and intermediately susceptible Staphylococcus aureus.

    abstract::Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...


    pub_type: 杂志文章,评审


    authors: Gomes DM,Ward KE,LaPlante KL

    更新日期:2015-04-01 00:00:00

  • Tissue plasminogen activator: an evaluation of clinical efficacy in acute myocardial infarction.

    abstract::Recombinant tissue plasminogen activator (t-PA) is a synthetic fibrinolytic protein which activates plasminogen or converts plasminogen to plasmin specifically in the presence of fibrin. With its "clot-selectivity", t-PA is capable of lysing clots without having a significant effect on circulating plasminogen. In cont...


    pub_type: 杂志文章,评审


    authors: Rogers SD,Riemersma LB,Clements SD

    更新日期:1987-01-01 00:00:00

  • Asian and Asian-American college students' awareness of osteoporosis.

    abstract:STUDY OBJECTIVE:To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. DESIGN:Sixty-four-question survey SETTING:University of Minnesota. SUBJECTS:One hundred sixty-eight male and female Asian and Asian-American students, mean age 21 +/- 3.4 years. MAIN RES...


    pub_type: 杂志文章


    authors: Nguyen DN,O'Connell MB

    更新日期:2002-08-01 00:00:00

  • Impact of an institution-specific hospital-acquired pneumonia protocol on the appropriateness of antibiotic therapy and patient outcomes.

    abstract:STUDY OBJECTIVE:To evaluate the impact of a hospital-acquired pneumonia (HAP) protocol on appropriateness of empiric antibiotic therapy, antibiotic deescalation, antibiotic duration, patient mortality, and length of stay. DESIGN:Before- and after-study of protocol implementation. SETTING:A 450-bed, academic medical c...


    pub_type: 杂志文章


    authors: Lancaster JW,Lawrence KR,Fong JJ,Doron SI,Garpestad E,Nasraway SA,Devlin JW

    更新日期:2008-07-01 00:00:00

  • A computerized system to improve documentation and reporting of pharmacists' clinical interventions, cost savings, and workload activities.

    abstract::A major factor in delivering patient care is documenting activities by pharmacists. This documentation is not only essential to sustain existing programs but necessary to justify future growth of resources. A computerized documentation system for clinical interventions and workload activities was developed in a 340-be...


    pub_type: 杂志文章


    authors: Zimmerman CR,Smolarek RT,Stevenson JG

    更新日期:1995-03-01 00:00:00

  • Practical pharmacologic aspects of therapeutic hypothermia after cardiac arrest.

    abstract::Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriat...


    pub_type: 杂志文章,评审


    authors: Arpino PA,Greer DM

    更新日期:2008-01-01 00:00:00

  • Discrepancies in identification of bleeding events after percutaneous coronary intervention.

    abstract:STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...


    pub_type: 杂志文章


    authors: McCollum M,Stringer KA,Wittkowsky AK,Young S,Spinler SA

    更新日期:2007-01-01 00:00:00

  • Methotrexate in rheumatoid arthritis: an update.

    abstract::Methotrexate, a folic acid antagonist, is being employed more frequently in an attempt to control rheumatoid arthritis that has not responded adequately to conventional therapies. Systemic administration of 7.5-15 mg weekly in a pulse fashion appears to be effective without precipitating serious adverse effects. Conce...


    pub_type: 杂志文章,评审


    authors: Miller DR,Letendre PW,DeJong DJ,Fiechtner JJ

    更新日期:1986-07-01 00:00:00

  • Randomized, multicenter comparison of oral granisetron and oral ondansetron for emetogenic chemotherapy.

    abstract:STUDY OBJECTIVES:To compare the antiemetic effectiveness and safety of oral granisetron plus dexamethasone with those of oral ondansetron plus dexamethasone administered before emetogenic chemotherapy. DESIGN:Randomized, prospective, multicenter, open-label study. SETTINGS:University-teaching hospital and veterans he...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Herrington JD,Kwan P,Young RR,Lagow E,Lagrone L,Riggs MW

    更新日期:2000-11-01 00:00:00

  • Prospective surveillance of intravenous amphotericin B use patterns.

    abstract::Information on amphotericin B use patterns and infusion-related adverse events were prospectively collected from 397 hospitalized adults. The methods of initiating amphotericin B varied greatly, with the majority of patients being gradually titrated to a full maintenance dose over 1-5 days. Overall, 71% of patients ex...


    pub_type: 临床试验,杂志文章,多中心研究,评审


    authors: Grasela TH Jr,Goodwin SD,Walawander MK,Cramer RL,Fuhs DW,Moriarty VP

    更新日期:1990-01-01 00:00:00

  • Last-observation-carried-forward imputation method in clinical efficacy trials: review of 352 antidepressant studies.

    abstract:STUDY OBJECTIVE:To determine the prevalence, over 40 years, of using the last-observation-carried-forward (LOCF) imputation method in clinical trials, the association between use of LOCF and how the trials were conducted, and the extent of information about attrition and LOCF use in published reports. DESIGN:Retrospec...


    pub_type: 杂志文章,评审


    authors: Woolley SB,Cardoni AA,Goethe JW

    更新日期:2009-12-01 00:00:00

  • Alfuzosin treatment improves the rate and time for stone expulsion in patients with distal uretral stones: a prospective randomized controlled study.

    abstract:OBJECTIVE:To evaluate the safety and efficacy of alfuzosin treatment on rate and time of stone expulsion in patients with uncomplicated distal ureteral stones. PATIENTS AND METHODS:Prospective, randomized, open-label, controlled study. Patients > 18 years of age presenting to the outpatient urology clinic with uncompl...


    pub_type: 杂志文章,随机对照试验


    authors: El Said NO,El Wakeel L,Kamal KM,Morad Ael R

    更新日期:2015-05-01 00:00:00

  • Early-onset pentamidine-associated second-degree heart block and sinus bradycardia: case report and review of the literature.

    abstract::Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described. In addition, cardiac adverse effects usually develop after at least 6 days of therapy. We describe a 54-year-old, human immunodeficien...


    pub_type: 杂志文章,评审


    authors: Antoniou T,Gough KA

    更新日期:2005-06-01 00:00:00

  • Treatment of supraventricular tachyarrhythmias with intravenous calcium channel blockers: are subtle differences worth the cost?

    abstract::Verapamil and diltiazem are effective in terminating paroxysmal supraventricular tachycardias and slowing ventricular response during atrial fibrillation or flutter. Results from clinical trials for each individual drug demonstrate comparative efficacy rates, and both drugs share the same contraindications and relativ...


    pub_type: 杂志文章,评审


    authors: Cheiman DM,Shea BF,Kelly RA

    更新日期:1996-09-01 00:00:00

  • Evolution of beta-lactamase inhibitors.

    abstract::After the introduction of penicillin G into therapeutics, bacteria became increasingly resistant to this penicillin and subsequent beta-lactam antibiotics. The major cause of this resistance is beta-lactamase, an enzyme produced by the bacterium, that destroys the antibiotic before it reaches its target within the bac...


    pub_type: 杂志文章


    authors: Jackson D

    更新日期:1991-01-01 00:00:00

  • Association of vancomycin serum concentrations with outcomes in patients with gram-positive bacteremia.

    abstract::We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...


    pub_type: 杂志文章


    authors: Zimmermann AE,Katona BG,Plaisance KI

    更新日期:1995-01-01 00:00:00

  • Epinephrine overdose-associated hypokalemia and rhabdomyolysis in a newborn.

    abstract::Epinephrine overdose induces many negative complications in adults because of its alpha- and beta-adrenoreceptor activity. However, complications in newborns or children are rarely described. A 4-day-old, 2004-g female newborn was inadvertently given epinephrine at 100 times the usual dose; she developed hypokalemia a...


    pub_type: 杂志文章


    authors: Fang W,Chen JY,Fang Y,Huang JL

    更新日期:2005-09-01 00:00:00

  • Intravenous amiodarone for conversion of atrial fibrillation: misled by meta-analysis?

    abstract::Therapeutic goals for atrial fibrillation (AF) include ventricular rate control, stroke prevention, conversion to normal sinus rhythm, and maintenance of normal sinus rhythm. The optimal strategy of rate versus rhythm control for acute management of patients with AF is a continuing debate. However, selected patients m...


    pub_type: 杂志文章,评审


    authors: Slavik RS,Zed PJ

    更新日期:2004-06-01 00:00:00

  • Acute renal failure, anterior myocardial infarction, and atrial fibrillation complicating epinephrine abuse.

    abstract::After injecting the solution extracted from a Primatene Mist inhaler, a patient experienced epinephrine overdose that resulted in an acute myocardial infarction and acute renal failure. The exact amount of epinephrine injected was unknown, but was thought to be between 82.5 and 124 mg, more than 25 times higher than t...


    pub_type: 杂志文章


    authors: Woodard ML,Brent LD

    更新日期:1998-05-01 00:00:00

  • Buspirone hydrochloride: a unique new anxiolytic agent. Pharmacokinetics, clinical pharmacology, abuse potential and clinical efficacy.

    abstract::Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. It achieves peak serum concentrations within one hour and has a serum half-life of 2 to 5 hours. Animal studies have suggested antianxiety activity and the absence of abuse potential. Buspirone is both a dopamine agonist and anta...


    pub_type: 杂志文章,评审


    authors: Goldberg HL

    更新日期:1984-11-01 00:00:00

  • Rapid-Onset Thrombocytopenia Following Piperacillin-Tazobactam Reexposure.

    abstract::Drug-induced thrombocytopenia is a rare but serious adverse event that has been associated with multiple drugs including β-lactams. Although it mostly occurs with prolonged medication use, some cases of rapid-onset thrombocytopenia have been reported. We describe the case of a 69-year-old man who developed severe and ...


    pub_type: 杂志文章


    authors: Nguyen VD,Tourigny JF,Roy R,Brouillette D

    更新日期:2015-12-01 00:00:00

  • Discontinuation rates of Helicobacter pylori treatment regimens: a meta-analysis.

    abstract::We conducted a meta-analysis to determine what factors in treatment regimens for Helicobacter pylori are associated with increased discontinuation rates. Studies were selected from the 1990-1996 MEDLINE data base, and references in published articles and reviews were obtained. Each article was uniformally abstracted f...


    pub_type: 杂志文章,meta分析


    authors: Buring SM,Winner LH,Hatton RC,Doering PL

    更新日期:1999-03-01 00:00:00

  • Asthma exacerbation after administration of nicotine nasal spray for smoking cessation.

    abstract::A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...


    pub_type: 杂志文章


    authors: Roth MT,Westman EC

    更新日期:2002-06-01 00:00:00

  • Pharmacoepidemiology II: the nested case-control study--a novel approach in pharmacoepidemiologic research.

    abstract::This article on pharmacoepidemiology, the second of two parts, is a more focused discussion of the methodology of cohort studies and case-control studies, the basic methodologies of which were discussed in part I. The nested case-control study incorporates the strengths of both the cohort and case-control studies but ...


    pub_type: 杂志文章


    authors: Etminan M

    更新日期:2004-09-01 00:00:00

  • Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia.

    abstract:STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...


    pub_type: 杂志文章


    authors: Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

    更新日期:2010-12-01 00:00:00

  • Selecting a decongestant.

    abstract::Antihistamines and decongestants often are used interchangeably and in combination for a variety of upper respiratory illnesses ranging from allergic rhinitis to the common cold; yet, these two classes of drugs have distinct therapeutic actions. When administered alone, antihistamines are of no value in reducing nasal...


    pub_type: 杂志文章,评审


    authors: Hendeles L

    更新日期:1993-11-01 00:00:00

  • Clinical and economic burden of opioid use for postsurgical pain: focus on ventilatory impairment and ileus.

    abstract::Opioid-related adverse drug events (ORADEs) can have a significant impact on patient recovery after surgery. This review investigates the impact of two ORADEs, respiratory depression and postoperative ileus (POI), on clinical and economic outcomes. Opioid-induced ventilatory impairment is a potentially serious ORADE t...


    pub_type: 杂志文章,评审


    authors: Barletta JF

    更新日期:2012-09-01 00:00:00

  • Clostridium difficile-associated disease: an emerging threat to patient safety: insights from the Society of Infectious Diseases Pharmacists.

    abstract::A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as se...


    pub_type: 杂志文章,评审


    authors: Owens RC

    更新日期:2006-03-01 00:00:00

  • Mycobacterial infections.

    abstract::Infection due to Mycobacterium tuberculosis continues to plague humanity. In the United States, conditions have taken a decided turn for the worse, with an increasing frequency of infection and the spread of multiple-drug-resistant strains. A number of strategies are available to improve the management of this epidemi...


    pub_type: 杂志文章,评审


    authors: Peloquin CA

    更新日期:1993-11-01 00:00:00

  • Appropriateness of iron prescribing: a retrospective study.

    abstract::We retrospectively reviewed the charts of 120 patients who received an initial prescription of iron from a resident physician in internal medicine to determine how accurately house officers diagnose iron-deficiency anemia before initiating iron therapy. Each patient's laboratory records were reviewed for the 3-month p...


    pub_type: 杂志文章


    authors: Abernathy KA,Meuleman JR

    更新日期:1996-05-01 00:00:00