Prolonged, but not diminished, zidovudine absorption induced by a high-fat breakfast.

abstract：:A major factor in delivering patient care is documenting activities by pharmacists. This documentation is not only essential to sustain existing programs but necessary to justify future growth of resources. A computerized documentation system for clinical interventions and workload activities was developed in a 340-be...

journal_title：Pharmacotherapy

authors： Zimmerman CR,Smolarek RT,Stevenson JG

更新日期：1995-03-01 00:00:00

abstract：:Warfarin is an anticoagulant available as a racemic mixture. The R- and S-isomers differ with respect to relative plasma concentrations, clearance, potency, sites of metabolism, and cytochrome P450 (CYP) isoenzymes responsible for metabolism. S-Warfarin, the more potent isomer, is metabolized primarily by CYP2C9. Gene...

journal_title：Pharmacotherapy

authors： Redman AR

更新日期：2001-02-01 00:00:00

abstract：:Limited data are available on ceftolozane/tazobactam dosing in patients receiving continuous renal replacement therapy (CRRT). Thus we performed a pharmacokinetic analysis of intravenous ceftolozane/tazobactam in a critically ill patient receiving CRRT at our medical center. A 47-year-old critically ill man with multi...

journal_title：Pharmacotherapy

authors： Bremmer DN,Nicolau DP,Burcham P,Chunduri A,Shidham G,Bauer KA

更新日期：2016-05-01 00:00:00

abstract：:The effects of proton pump inhibitors on the pharmacokinetics of atazanavir and amprenavir (administered as fosamprenavir) were rigorously evaluated in healthy volunteers in two studies, but formal studies in persons infected with human immunodeficiency virus (HIV) are lacking. We describe a 65-year-old man with HIV w...

journal_title：Pharmacotherapy

authors： Kiser JJ,Lichtenstein KA,Anderson PL,Fletcher CV

更新日期：2006-04-01 00:00:00

abstract：:A 38-year-old woman with type 1 diabetes underwent kidney-pancreas transplantation. Her postoperative course was complicated due to recurrent acute graft rejections and pancreatitis. After initial immunosuppression with microemulsion cyclosporine, mycophenolate mofetil, and prednisone with muromonab-CD3 induction, cyc...

journal_title：Pharmacotherapy

authors： Min DI,Ku YM,Rayhill S,Corwin C,Wu YM,Hunsicker LG

更新日期：1999-07-01 00:00:00

abstract：:Idiopathic recurrent pericarditis (IRP) can be challenging to treat. Even after guideline-directed first-line treatment consisting of aspirin (ASA) or a nonsteroidal antiinflammatory drug (NSAID) in combination with colchicine therapy, recurrences still occur in greater than 20% of patients. Many patients then require...

journal_title：Pharmacotherapy

authors： Schwier NC,Hale GM,Davies ML

更新日期：2017-03-01 00:00:00

abstract：:Substantial error occurs when individual saliva theophylline concentrations are used to predict serum theophylline concentrations. However, the use of saliva theophylline concentrations to determine product bioavailability has never been evaluated. Subjects in this study were 18 stable patients (20-51 yr) with a histo...

journal_title：Pharmacotherapy

authors： Uden DL,Strand LM,Miller KW,Zaske DE

更新日期：1983-07-01 00:00:00

abstract：:The antiretroviral combination of emtricitabine-tenofovir disoproxil fumarate (FTC/TDF) was approved by the U.S. Food and Drug Administration for use as pre-exposure prophylaxis (PrEP) in individuals at high risk for acquiring human immunodeficiency virus (HIV) in July 2012. Since then, Centers for Disease Control and...

journal_title：Pharmacotherapy

authors： Adams JL,Shelley K,Nicol MR

更新日期：2019-04-01 00:00:00

abstract：:Our objective was to describe the implementation and clinical outcomes of an employer-sponsored, pharmacist-provided medication therapy management (MTM) program for health plan beneficiaries with diabetes mellitus and/or hypertension. We conducted a single-center retrospective medical record review. The setting was a ...

journal_title：Pharmacotherapy

authors： Theising KM,Fritschle TL,Scholfield AM,Hicks EL,Schymik ML

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Assess the effects of linezolid on hematologic outcomes in newly diagnosed patients with acute myeloid leukemia (AML) following induction chemotherapy. DESIGN:Single-center, retrospective, observational, cohort study. SETTING:Large, tertiary care academic medical center. PATIENTS:A total of 225 patients ≥ ...

journal_title：Pharmacotherapy

authors： Nedved AN,DeFrates SR,Hladnik LM,Stockerl-Goldstein KE

更新日期：2016-10-01 00:00:00

abstract：:Thrombin, a serine protease, is the keystone of the twin processes of hemostasis and thrombosis. Through procoagulant, anticoagulant, and antifibrinolytic mechanisms, thrombin helps maintain vascular integrity in the face of hemorrhage. These same mechanisms, however, allow for the pathologic formation of thrombi in r...

journal_title：Pharmacotherapy

authors： Nappi J

更新日期：2002-06-01 00:00:00

abstract：:A 71-year-old Caucasian woman was admitted to the hospital with right-sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3 degrees F. Four bloo...

journal_title：Pharmacotherapy

authors： Pound MW,Fulton KB,Chima CO

更新日期：2007-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether alvimopan for prevention of postoperative ileus in patients undergoing small- or large-bowel resection by laparotomy is associated with lower total costs compared with standard care. DESIGN:Pharmacoeconomic analysis using a formal decision model. DATA SOURCE:Four phase III clinica...

journal_title：Pharmacotherapy

authors： Touchette DR,Yang Y,Tiryaki F,Galanter WL

更新日期：2012-02-01 00:00:00

abstract：:We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new beta-lactam-beta-lactamase inhibitor. Piperacillin-tazobactam has a wide spectrum of activity that includes gram-positive organisms such as staphylococci and streptococc...

journal_title：Pharmacotherapy

authors： Daniel KP,Krop LC

更新日期：1996-03-01 00:00:00

abstract：STUDY OBJECTIVE:To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN:Prospective follow-up study. DATA SOURCE:General practitioners' computerized patients records (intervention ...

journal_title：Pharmacotherapy

authors： van der Elst ME,Bouvy ML,de Blaey CJ,de Boer A

更新日期：2006-02-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the bioavailability and renal elimination of para-aminosalicylic acid (PAS) and its inactive metabolite acetyl-para-aminosalicylic acid (AcPAS) from a new PAS formulation. DESIGN:(a) Single-dose pharmacokinetic study in healthy volunteers; (b) Day-1 and day-8 pharmacokinetic comparison in ...

journal_title：Pharmacotherapy

authors： Peloquin CA,Henshaw TL,Huitt GA,Berning SE,Nitta AT,James GT

更新日期：1994-01-01 00:00:00

abstract：:Fentanyl iontophoretic transdermal system (ITS) is a novel, patient-activated drug delivery device used for the management of acute postoperative pain in the hospital setting. This credit-card-sized device uses an imperceptible current of 170 milliampere to actively deliver a fentanyl hydrochloride 40-microg dose into...

journal_title：Pharmacotherapy

authors： Herndon CM

更新日期：2007-05-01 00:00:00

abstract：:Low-molecular-weight heparins (LMWHs) are safe and effective in the treatment of venous thromboembolic disease. Since they require less therapeutic monitoring than unfractionated heparin and may be administered to outpatients, it is possible to decrease overall health care costs of patients diagnosed with deep vein th...

journal_title：Pharmacotherapy

authors： Yurkowski P

更新日期：1998-11-01 00:00:00

abstract：:Recent literature has demonstrated significant improvements in neurologic outcomes in patients who have received induced hypothermia in the setting of out-of-hospital cardiac arrest. Through multiple metabolic mechanisms, the induction of hypothermia slows the progression and devastation of transient cerebral hypoxia....

journal_title：Pharmacotherapy

authors： Weant KA,Martin JE,Humphries RL,Cook AM

更新日期：2010-08-01 00:00:00

abstract：:Clinical trials continue to evaluate the pharmacologic management of myocardial infarction for benefits in mortality, degree of infarct artery patency, and frequency of reocclusion. The discovery of thrombus formation in the development of the myocardial infarction renewed interest in thrombolytic therapy. In appropri...

journal_title：Pharmacotherapy

authors： Talbert RL

更新日期：1996-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS...

journal_title：Pharmacotherapy

authors： Hendeles L,Davison D,Harman E,Sherman JM

更新日期：1999-11-01 00:00:00

abstract：:The U.S. population continues to experience an alarmingly high rate of unintended pregnancies that have an impact on individual families and society alike. Lack of effective contraception accounts for most unintended pregnancies, along with incorrect use of contraceptives. The most common reversible contraceptive meth...

journal_title：Pharmacotherapy

authors： Rafie S,McIntosh J,Shealy KM,Borgelt LM,Forinash A,Shrader SP,Koepf ER,McClendon KS,Griffin BL,Horlen C,Karaoui LR,Rowe EL,Lodise NM,Wigle PR

更新日期：2014-09-01 00:00:00

abstract：:Recombinant human erythropoietin reverses the severe anemia associated with end-stage renal disease. Mean half-life values after a single intravenous bolus dose range from 4-13 hours. Renal clearance is not a significant route of elimination. Dosing schedules in chronic renal failure involve a single intravenous bolus...

journal_title：Pharmacotherapy

authors： Flaharty KK

更新日期：1990-03-01 00:00:00

abstract：:It is well recognized that drug absorption from the gastrointestinal tract is influenced by gastric and intestinal motility, surface area available for absorption, and physicochemical properties of the drug. Disease and surgery have been shown to alter these factors. Consequently, drug absorption can be altered as wel...

journal_title：Pharmacotherapy

authors： Gubbins PO,Bertch KE

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:It is known that γ-glutamyl hydrolase (GGH) is involved in the disposition of methotrexate (MTX), and GGH activity is regulated by DNA methylation in acute lymphoblastic leukemia (ALL) cells. The present study explores the methylation status of the GGH promoter in peripheral blood and its association with MT...

journal_title：Pharmacotherapy

authors： Wang SM,Kong XY,Li M,Sun LL,Yan D

更新日期：2020-07-01 00:00:00

abstract：:Health care-associated infections, especially those caused by multidrug-resistant gram-positive organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), are a growing public health threat. In 2014, the U.S. Food and Drug Administration approved two new lipoglycopeptides, oritavancin and dalbavancin, for ...

journal_title：Pharmacotherapy

authors： Roberts KD,Sulaiman RM,Rybak MJ

更新日期：2015-10-01 00:00:00

abstract：:Rituximab has been approved by the United States Food and Drug Administration in combination with methotrexate for the treatment of rheumatoid arthritis in patients who failed to achieve adequate benefit from tumor necrosis factor-alpha inhibitors. Rituximab is a biologic agent that depletes peripheral B cells--an act...

journal_title：Pharmacotherapy

authors： Schuna AA

更新日期：2007-12-01 00:00:00

abstract：:A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...

journal_title：Pharmacotherapy

authors： Vandell AG,DiPiro JT

更新日期：2002-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of standardized Ginkgo biloba leaf extracts (GBE) on outcome parameters of hemostasis associated with risk of bleeding. DESIGN:Meta-analysis of 18 randomized controlled trials. SUBJECTS:A total of 1985 adults were enrolled to receive either GBE or placebo; 87% were patients wit...

journal_title：Pharmacotherapy

authors： Kellermann AJ,Kloft C

更新日期：2011-05-01 00:00:00

abstract：:The American College of Clinical Pharmacy (ACCP) published an initial white paper on herbal products in 2000. Since then, the global market for natural products has continued to expand, with tens of millions of consumers using such products on an annual basis in the United States alone. However, despite this expansion...

journal_title：Pharmacotherapy

authors： Gabay M,Smith JA,Chavez ML,Goldwire M,Walker S,Coon SA,Gosser R,Hume AL,Musselman M,Phillips J,Abe AM

更新日期：2017-01-01 00:00:00