Iontophoretic drug delivery system: focus on fentanyl.

abstract：:We cared for a patient in whom iron dextran administration interfered with the determination of total serum calcium concentration. An unexpected elevation in serum phosphorus concentration also occurred after the iron dextran infusion. A MEDLINE search from 1966 to present was conducted, and the manufacturer of the ir...

journal_title：Pharmacotherapy

authors： Newsom L,Erstad BL,Nakazato PZ,Daller JA

更新日期：1995-11-01 00:00:00

abstract：:Dabigatran, a direct thrombin inhibitor, is an oral anticoagulant indicated for the prevention of stroke in patients with atrial fibrillation (AF) and for the treatment and prevention of deep vein thrombosis and pulmonary embolism. Dabigatran, as well as the other new anticoagulants-rivaroxaban, apixaban, and edoxaban...

journal_title：Pharmacotherapy

authors： Wiggins BS,Northup A,Johnson D,Senfield J

更新日期：2016-02-01 00:00:00

abstract：:The popularity of amiodarone has grown due to its effectiveness in converting arrhythmia and its formulation availability. Formulations of the drug also contain iodine; the iodine content is 75 mg in a 200-mg tablet of amiodarone and 18.7 mg/ml in the intravenous solution. Approximately 10% of the iodine content of or...

journal_title：Pharmacotherapy

authors： Brouse SD,Phillips SM

更新日期：2005-03-01 00:00:00

abstract：:Substantial error occurs when individual saliva theophylline concentrations are used to predict serum theophylline concentrations. However, the use of saliva theophylline concentrations to determine product bioavailability has never been evaluated. Subjects in this study were 18 stable patients (20-51 yr) with a histo...

journal_title：Pharmacotherapy

authors： Uden DL,Strand LM,Miller KW,Zaske DE

更新日期：1983-07-01 00:00:00

abstract：:Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is associated with high morbidity and mortality. Traditionally, antistaphylococcal penicillins (ASPs) have been considered the agents of choice for the treatment of MSSA bacteremia. Vancomycin has been demonstrated to have poorer outcomes in several studi...

journal_title：Pharmacotherapy

authors： Li J,Echevarria KL,Traugott KA

更新日期：2017-03-01 00:00:00

abstract：:Erectile dysfunction, a problem estimated to affect up to 30 million American men, is associated with a number of systemic illnesses and drugs. Age is not thought to be an independent risk factor for the disorder, but accompanying illnesses and their treatments may contribute to its onset. Newer classes of antihyperte...

journal_title：Pharmacotherapy

authors： Barksdale JD,Gardner SF

更新日期：1999-05-01 00:00:00

abstract：:Warfarin is considered a high-risk drug because of its narrow therapeutic window, variability in dose response, and multitude of drug and food interactions. Although travel advice is available for patients who are taking warfarin, it is geared toward patients who are traveling to developed countries and tends to be la...

journal_title：Pharmacotherapy

authors： Truong T,Armor BL

更新日期：2012-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the ability of seven widely known herbal references and electronic databases to answer questions about herbal products asked at drug information centers. DESIGN:Cross-sectional study. SETTING:Five academic and institutional drug information centers. METHODS:Fifty-seven herbal-related ques...

journal_title：Pharmacotherapy

authors： Walker JB

更新日期：2002-12-01 00:00:00

abstract：:A 67-year-old woman with iron deficiency anemia required parenteral iron therapy and was treated with intravenous ferric gluconate. She tolerated the first dose, but after the second dose, she developed a tingling feeling all over her body, along with swelling in her hands and feet, and a rash with hives over most of ...

journal_title：Pharmacotherapy

authors： Sane R,Baribeault D,Rosenberg CL

更新日期：2007-04-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the extent of hospital-based clinical pharmacy services in 1992. DESIGN:National survey with trend comparison to 1989. SETTING:All 1597 United States acute care, general medical-surgical and pediatric hospitals with 50 or more licensed beds and one or more full-time pharmacists (43% of al...

journal_title：Pharmacotherapy

authors： Bond CA,Raehl CL,Pitterle ME

更新日期：1994-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the disposition of pentoxifylline and its metabolite, lisofylline, in New Zealand rabbits after two alternative routes of administration, intranasal and intratracheal. DESIGN:Pharmacokinetics study in an animal model. SETTING:University-affiliated animal care facility. SUBJECTS:Twenty New...

journal_title：Pharmacotherapy

authors： Adcock KG,Kyle PB,Deaton JS,Olivier JH,Hogan SM

更新日期：2007-02-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...

journal_title：Pharmacotherapy

authors： DeRonde KJ,Girotto JE,Nicolau DP

更新日期：2018-10-01 00:00:00

abstract：:Abstract Cetuximab and panitumumab, monoclonal antibodies used to target the epidermal growth factor receptor (EGFR), were recently approved by the United States Food and Drug Administration for use as single agents or in combination with other chemotherapy drugs in the treatment of metastatic colorectal cancer. The a...

journal_title：Pharmacotherapy

authors： Patel DK

更新日期：2008-11-01 00:00:00

abstract：:Good admissions decisions are essential for identifying successful students and good practitioners. Various parameters have been shown to have predictive power for academic success. Previous academic performance, the Pharmacy College Admissions Test (PCAT), and specific prepharmacy courses have been suggested as acade...

journal_title：Pharmacotherapy

authors： Allen DD,Bond CA

更新日期：2001-07-01 00:00:00

abstract：STUDY OBJECTIVE:To characterize a time-dependent disposition of oral tacrolimus and its relationship with plasma endothelin-1 concentrations. DESIGN:Randomized, crossover study. SETTING:Clinical research center of a university-affiliated hospital. PATIENTS:Twelve stable liver transplant recipients. INTERVENTIONS:In...

journal_title：Pharmacotherapy

authors： Min DI,Chen HY,Lee MK,Ashton K,Martin MF

更新日期：1997-05-01 00:00:00

abstract：:Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...

journal_title：Pharmacotherapy

authors： Nutescu EA,Spinler SA,Dager WE,Bussey HI

更新日期：2004-10-01 00:00:00

abstract：:This article on pharmacoepidemiology, the second of two parts, is a more focused discussion of the methodology of cohort studies and case-control studies, the basic methodologies of which were discussed in part I. The nested case-control study incorporates the strengths of both the cohort and case-control studies but ...

journal_title：Pharmacotherapy

authors： Etminan M

更新日期：2004-09-01 00:00:00

abstract：:Intravenous unfractionated heparin (UFH) remains an important therapeutic agent, particularly in the inpatient setting, for anticoagulation. Historically, the activated partial thromboplastin time (aPTT) has been the primary laboratory test used to monitor and adjust UFH. The aPTT test has evolved since the 1950s, and...

journal_title：Pharmacotherapy

authors： Vandiver JW,Vondracek TG

更新日期：2012-06-01 00:00:00

abstract：STUDY OBJECTIVE:To quantify the relative risk of cardiovascular events associated with microalbuminuria in patients with both diabetes mellitus and hypertension. DESIGN:A structured literature search from January 1990-December 2002 using MEDLINE, IPA, and CINAHL. MEASUREMENTS AND MAIN RESULTS:We identified original s...

journal_title：Pharmacotherapy

authors： Park HY,Schumock GT,Pickard AS,Akhras K

更新日期：2003-12-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the frequency and type of complementary and alternative medicine (CAM) use among healthy volunteers participating in research, and to investigate the potential for interactions between commonly used CAM modalities and various drugs. DESIGN:Prospective evaluation. SETTING:University gener...

journal_title：Pharmacotherapy

authors： Welder GJ,Wessel TR,Arant CB,Schofield RS,Zineh I

更新日期：2006-12-01 00:00:00

abstract：:Fluconazole is a commonly prescribed antifungal agent with a favorable safety profile. A patient experienced agranulocytosis and eosinophilia associated with the drug. Similar bone marrow-suppressive effect due to the azoles is rarely described in the English-language literature. ...

journal_title：Pharmacotherapy

authors： Wong-Beringer A,Shriner K

更新日期：2000-04-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the population pharmacokinetics and pharmacodynamic target attainment of ampicillin in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing controlled hypothermia (CH). DESIGN:Prospective, open-label pharmacokinetic study. SETTING:A 189-bed, freestanding children's tertiary care ...

journal_title：Pharmacotherapy

authors： Cies JJ,Fugarolas KN,Moore WS 2nd,Mason RW,Menkiti OR

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To identify and describe the scope of practice that characterizes the critical care pharmacist and critical care pharmacy services. Specifically, the goals were to define the level of clinical practice and specialized skills characterizing the critical care pharmacist as clinician, educator, researcher, and m...

journal_title：Pharmacotherapy

authors：

更新日期：2000-11-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the occurrence of bleeding and venous thromboembolic (VTE) events in patients receiving rivaroxaban, warfarin, or warfarin with the addition of enoxaparin during the immediate postoperative period following major orthopedic surgery. METHODS:Patients older than 18 years who received at leas...

journal_title：Pharmacotherapy

authors： Cieri NE,Kusmierski K,Lackie C,Van Opdorp A,Hassan AK

更新日期：2017-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of fluoxetine on the pharmacokinetics and cardiovascular safety of cisapride at steady state in healthy men. DESIGN:Open-label, three-phase, sequential study. SETTING:Clinical research center. SUBJECTS:Twelve healthy male volunteers. INTERVENTIONS:Each subject was treated acco...

journal_title：Pharmacotherapy

authors： Zhao Q,Wojcik MA,Parier JL,Pesco-Koplowitz L

更新日期：2001-02-01 00:00:00

abstract：STUDY OBJECTIVE:To review quantitatively and qualitatively the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (AERS) database to provide clinicians with a general understanding of the comparative occurrence of clinically meaningful adverse events associated with 15 antimicrobial new molecular en...

journal_title：Pharmacotherapy

authors： Khadem TM,van Manen RP,Brown J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Cutaneous small vessel vasculitis (CSVV) has been reported after exposure to direct oral anticoagulants (DOACs), such as dabigatran, rivaroxaban, apixaban, and edoxaban. OBJECTIVE:We used the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) to describe clinical characteristics associ...

journal_title：Pharmacotherapy

authors： Mohamoud M,Horgan C,Eworuke E,Dee E,Bohn J,Shapira O,Munoz MA,Stojanovic D,Sansing-Foster V,Ajao A,La Grenade L

更新日期：2020-11-01 00:00:00

abstract：:A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...

journal_title：Pharmacotherapy

authors： Christiansen SR,Broniscer A,Panetta JC,Stewart CF

更新日期：2009-07-01 00:00:00

abstract：:Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and curre...

journal_title：Pharmacotherapy

authors： Barber KE,Bell AM,Wingler MJB,Wagner JL,Stover KR

更新日期：2018-12-01 00:00:00

abstract：:Status epilepticus (SE) has a high mortality rate and is one of the most common neurologic emergencies. Fast progression of this neurologic emergency and lack of response to traditional antiepileptic drugs (AEDs) in most cases has challenged clinicians to use new agents. This article evaluates the efficacy and safety ...

journal_title：Pharmacotherapy

authors： Farrokh S,Bon J,Erdman M,Tesoro E

更新日期：2019-03-01 00:00:00