Pharmacokinetics of intranasal and intratracheal pentoxifylline in rabbits.

abstract：STUDY OBJECTIVE:Evaluate dabigatran adverse event reports with a reported bleeding event and/or reported fatal outcome compared with warfarin. DESIGN:Retrospective analysis of the FDA Adverse Event Reporting System (FAERS) database. MEASUREMENTS AND MAIN RESULTS:We identified reports from October 1, 2010, through Dec...

journal_title：Pharmacotherapy

authors： McConeghy KW,Bress A,Qato DM,Wing C,Nutescu EA

更新日期：2014-06-01 00:00:00

abstract：:Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have docu...

journal_title：Pharmacotherapy

authors： Dobesh PP,Wittkowsky AK,Stacy Z,Dager WE,Haines ST,Lopez LM,Nutescu E,Phillips KW,Trujillo TC,Vondracek T

更新日期：2009-04-01 00:00:00

abstract：:Cardiotoxicity due to tacrolimus is documented infrequently in the medical literature. Sinus bradycardia associated with intravenous tacrolimus occurred in a 15-year-old orthotopic liver transplant recipient. The mechanism of this adverse effect is unknown; however, it does not appear to be concentration dependent, an...

journal_title：Pharmacotherapy

authors： Cox TH,Baillie GM,Baliga P

更新日期：1997-11-01 00:00:00

abstract：:Antimicrobial susceptibility testing for the polymyxins-colistin and polymyxin B-is fraught with technical challenges. Key among these is the propensity of the polymyxins to adsorb to polystyrene, a material often used for in vitro minimum inhibitory concentration testing devices. This effect may be mitigated by the a...

journal_title：Pharmacotherapy

authors： Humphries RM

更新日期：2015-01-01 00:00:00

abstract：:Endothelin (ET)-1 is an endothelium-derived peptide with potent vasoconstrictor and proliferative properties. The ET system is activated in several cardiovascular disease states associated with functional and structural vascular changes, including hypertension and heart failure. The two ET receptor subtypes are known ...

journal_title：Pharmacotherapy

authors： Ergul A

更新日期：2002-01-01 00:00:00

abstract：:We retrospectively reviewed the charts of 120 patients who received an initial prescription of iron from a resident physician in internal medicine to determine how accurately house officers diagnose iron-deficiency anemia before initiating iron therapy. Each patient's laboratory records were reviewed for the 3-month p...

journal_title：Pharmacotherapy

authors： Abernathy KA,Meuleman JR

更新日期：1996-05-01 00:00:00

abstract：:We sought to summarize and assess original evaluations of the economic impact of clinical pharmacy services published from 1996-2000, and to provide recommendations and methodologic considerations for future research. A systematic literature search was conducted to identify articles that were then blinded and randomly...

journal_title：Pharmacotherapy

authors： Schumock GT,Butler MG,Meek PD,Vermeulen LC,Arondekar BV,Bauman JL,2002 Task Force on Economic Evaluation of Clinical Pharmacy Services of the American College of Clinical Pharmacy.

更新日期：2003-01-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the extent to which nitrofurantoin is transferred into human milk. DESIGN:Prospective, single-dose pharmacokinetic study. SETTING:University-affiliated clinical research center. PATIENTS:Four healthy lactating women 8-26 weeks postpartum. INTERVENTION:All subjects received a single, ora...

journal_title：Pharmacotherapy

authors： Gerk PM,Kuhn RJ,Desai NS,McNamara PJ

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic data show reduced mycophenolic acid levels in renal transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. This reduced exposure could increase rejection risk. The typical initial MMF dose post renal transplantation is 2 g/day, which often re...

journal_title：Pharmacotherapy

authors： Patel KS,Stephany BR,Barnes JF,Bauer SR,Spinner ML

更新日期：2017-12-01 00:00:00

abstract：:Triclosan is a synthetic biocide found in many household products, including antimicrobial hand soap. Levels of triclosan have been found throughout the environment and in human urine, blood, and even breast milk. Increasing levels of exposure to triclosan have led to concerns over the development of resistance to tri...

journal_title：Pharmacotherapy

authors： Giuliano CA,Rybak MJ

更新日期：2015-03-01 00:00:00

abstract：:Cephalosporins are often administered to prevent infections that can follow total joint replacements (TJR) and other arthroplastic procedures. However, recommendations contained within published guidelines and review articles vary greatly from those given by the manufacturer in product information circulars. Similarly...

journal_title：Pharmacotherapy

authors： Heath AF

更新日期：1991-01-01 00:00:00

abstract：:A formerly infrequently isolated strain of Clostridium difficile known as BI/NAP1 has resulted in geographically diverse outbreaks of C. difficile-associated disease. Such rapid dissemination and distribution of an outbreak strain of C. difficile are unprecedented, with many regions across North America, as well as se...

journal_title：Pharmacotherapy

authors： Owens RC

更新日期：2006-03-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a frequently prescribed class of drugs that are generally well tolerated by most patients. A rare, yet serious side effect associated with these drugs is rhabdomyolysis. Although all HMG-CoA reductase inhibitors can cause this adverse effect, pre...

journal_title：Pharmacotherapy

authors： Ravnan SL,Locke C,Yee WP,Haase K

更新日期：2002-04-01 00:00:00

abstract：:We reviewed the spectrum of activity, pharmacokinetics, clinical efficacy, adverse effects, and relative advantages of piperacillin-tazobactam, a new beta-lactam-beta-lactamase inhibitor. Piperacillin-tazobactam has a wide spectrum of activity that includes gram-positive organisms such as staphylococci and streptococc...

journal_title：Pharmacotherapy

authors： Daniel KP,Krop LC

更新日期：1996-03-01 00:00:00

abstract：:Midazolam is a commonly used sedative in critically ill, mechanically ventilated patients in intensive care unit (ICU) settings worldwide. We used a nine-step decision-making algorithm to determine whether therapeutic monitoring of midazolam in the ICU is warranted. Midazolam has a higher clearance and shorter half-li...

journal_title：Pharmacotherapy

authors： Spina SP,Ensom MH

更新日期：2007-03-01 00:00:00

abstract：:The newer quinolone antibiotics, including levofloxacin, moxifloxacin, and gatifloxacin, offer coverage of the likely pathogens in community-acquired pneumonia (CAP) and have been shown to be safe and effective treatments for CAP. Two of these agents, levofloxacin and gatifloxacin, have pharmacokinetic and antibacteri...

journal_title：Pharmacotherapy

authors： Press RA

更新日期：2001-07-01 00:00:00

abstract：:Apixaban, a direct factor Xa inhibitor, is a novel oral anticoagulant (NOAC) indicated for prevention of embolic events in patients with nonvalvular atrial fibrillation. The agent is associated with a lower risk of bleeding compared with vitamin K antagonists such as warfarin. Hemopericardium is a life-threatening ble...

journal_title：Pharmacotherapy

authors： Sigawy C,Apter S,Vine J,Grossman E

更新日期：2015-07-01 00:00:00

abstract：STUDY OBJECTIVE:To contrast the characteristics of two groups of anabolic-androgenic steroid (AAS) users-those with versus those without AAS dependence. DESIGN:Subanalysis of data from the Anabolic 500, a cross-sectional survey. PARTICIPANTS:One hundred twelve male AAS-dependent users and 367 AAS-nondependent users w...

journal_title：Pharmacotherapy

authors： Ip EJ,Lu DH,Barnett MJ,Tenerowicz MJ,Vo JC,Perry PJ

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Anticoagulation monitoring during transition from direct oral anticoagulants (DOAC) to heparin infusions is a significant challenge. Factor Xa inhibitors influence the heparin calibrated antifactor Xa assay. The University of Virginia (UVA) Medical Center utilized a corrected antifactor Xa assay (c-AXA) duri...

journal_title：Pharmacotherapy

authors： Plum MD,Hedrick JN,Hockman R,Bazydlo L,Palkimas S

更新日期：2020-09-01 00:00:00

abstract：:Clarithromycin is rarely reported to cause disturbances in anticoagulation. Theoretically, clarithromycin administered concurrently with warfarin could result in enhanced anticoagulation, since many properties of clarithromycin are similar to those of erythromycin, which interacts with warfarin. A search of the Nation...

journal_title：Pharmacotherapy

authors： Oberg KC

更新日期：1998-03-01 00:00:00

abstract：:In critically ill patients with acute renal failure, continuous arteriovenous hemodiafiltration (CAVHD) has become an increasing popular supportive technique. An adult with acute renal failure during CAVHD therapy received fluconazole. Drug clearance by the hemodiafilter system and its total body clearance during the ...

journal_title：Pharmacotherapy

authors： Nicolau DP,Crowe H,Nightingale CH,Quintiliani R

更新日期：1994-07-01 00:00:00

abstract：:Fluoxetine hydrochloride is the sixth most prescribed drug in the United States and is administered to treat major depression. A cadaveric skin donation was obtained from a 46-year-old woman who died as a result of a fluoxetine overdose. Due to the potential penetration of the drug and its major metabolite, norfluoxet...

journal_title：Pharmacotherapy

authors： Neudeck BL,Taddonio TE,Garner WL,Welage LS

更新日期：1998-07-01 00:00:00

abstract：:In a double-blind, placebo-controlled study of 200 patients with moderate to moderately severe anxiety we compared the anxiolytic efficacy and safety of alprazolam and lorazepam. Dosing was flexible and ranged from 1 to 4.5 mg/day of alprazolam and from 2 to 9 mg/day of lorazepam. The mean daily dose at the end of the...

journal_title：Pharmacotherapy

authors： Cohn JB,Wilcox CS

更新日期：1984-03-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of hepatotoxicity in critically ill patients who were treated with voriconazole and to identify potential risk factors for voriconazole-associated hepatotoxicity in these patients. DESIGN:Single-center prospective observational study. SETTING:Intensive care unit (ICU) in a ...

journal_title：Pharmacotherapy

authors： Wang Y,Wang T,Xie J,Yang Q,Zheng X,Dong W,Xing J,Wang X,Dong Y

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:As one of the most accessible health care professionals, pharmacists are in an ideal position to provide tobacco-cessation and prevention services. Although there is growing interest in expanding the pharmacist's role in tobacco treatment, few published studies have assessed the efficacy or effectiveness of ...

journal_title：Pharmacotherapy

authors： Dent LA,Harris KJ,Noonan CW

更新日期：2007-07-01 00:00:00

abstract：:Recombinant human erythropoietin reverses the severe anemia associated with end-stage renal disease. Mean half-life values after a single intravenous bolus dose range from 4-13 hours. Renal clearance is not a significant route of elimination. Dosing schedules in chronic renal failure involve a single intravenous bolus...

journal_title：Pharmacotherapy

authors： Flaharty KK

更新日期：1990-03-01 00:00:00

abstract：:A 69-year-old woman was admitted for control of intractable rectal pain caused by a 4-cm malignant mass. She was treated successfully with EMLA (eutectic mixture of local anesthetics) cream applied every 8 hours and covered with a Xeroform dressing. Despite an increase in tumor size to 6 cm, her pain control was maint...

journal_title：Pharmacotherapy

authors： Stegman MB,Stoukides CA

更新日期：1996-07-01 00:00:00

abstract：:Abstract Therapeutic hypothermia has emerged as an effective means of improving neurologic outcomes among cardiac arrest survivors. To achieve optimal results, clinicians must understand and anticipate potential adverse effects of cooling and provide rigorous monitoring and/or pharmacologic interventions as appropriat...

journal_title：Pharmacotherapy

authors： Arpino PA,Greer DM

更新日期：2008-01-01 00:00:00

abstract：:Currently available anesthetic induction agents provide adequate hypnosis but are not ideal, particularly in the high risk patient (ASA class III-V), because most cause myocardial and/or respiratory depression and some have other important side effects. Etomidate was recently marketed as an intravenous anesthetic indu...

journal_title：Pharmacotherapy

authors： Giese JL,Stanley TH

更新日期：1983-09-01 00:00:00

abstract：:Nabilone, a synthetic cannabinoid, is approved in many countries including, but not limited to, Canada, the United States, Mexico, and the United Kingdom for the treatment of severe nausea and vomiting associated with chemotherapy. Clinical evidence is emerging for its use in managing pain conditions with different et...

journal_title：Pharmacotherapy

authors： Tsang CC,Giudice MG

更新日期：2016-03-01 00:00:00