The effect of low-dose phenytoin on high-density lipoprotein cholesterol.

abstract：:Drug-induced neutropenia and agranulocytosis are rare adverse events but can be fatal. Neutropenia can be induced by a myriad of drugs from almost every pharmacologic class. Octreotide is a somatostatin analog that has been used to treat variceal bleeding, acromegaly, and severe diarrhea associated with metastatic tum...

journal_title：Pharmacotherapy

authors： Tse SS,Kish T

更新日期：2017-06-01 00:00:00

abstract：:Drug-induced thrombocytopenia is a rare but serious adverse event that has been associated with multiple drugs including β-lactams. Although it mostly occurs with prolonged medication use, some cases of rapid-onset thrombocytopenia have been reported. We describe the case of a 69-year-old man who developed severe and ...

journal_title：Pharmacotherapy

authors： Nguyen VD,Tourigny JF,Roy R,Brouillette D

更新日期：2015-12-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the relationship of the 33 single nucleotide polymorphisms (SNPs) previously associated with fasting glucose in Caucasians in genome-wide association studies (GWAS) with glucose response to antihypertensive drugs shown to increase risk for hyperglycemia and diabetes. DESIGN:Randomized, multic...

journal_title：Pharmacotherapy

authors： Gong Y,McDonough CW,Beitelshees AL,Karnes JH,O'Connell JR,Turner ST,Chapman AB,Gums JG,Bailey KR,Boerwinkle E,Johnson JA,Cooper-DeHoff RM

更新日期：2014-02-01 00:00:00

abstract：STUDY OBJECTIVE:To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. DESIGN:Sixty-four-question survey SETTING:University of Minnesota. SUBJECTS:One hundred sixty-eight male and female Asian and Asian-American students, mean age 21 +/- 3.4 years. MAIN RES...

journal_title：Pharmacotherapy

authors： Nguyen DN,O'Connell MB

更新日期：2002-08-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effects of low-dose pioglitazone on plasma adipocyte-derived cytokines, high-sensitivity C-reactive protein (hs-CRP), and components of the metabolic syndrome in adults with the metabolic syndrome without diabetes mellitus. DESIGN:Prospective, randomized, double-blind, placebo-controll...

journal_title：Pharmacotherapy

authors： Vu A,Kosmiski LA,Beitelshees AL,Prigeon R,Sidhom MS,Bredbeck B,Predhomme J,Deininger KM,Aquilante CL

更新日期：2016-03-01 00:00:00

abstract：:The purpose of the American College of Clinical Pharmacy (ACCP) is to advance human health by extending the frontiers of clinical pharmacy. Consistent with this mission and its core values, ACCP is committed to ensuring that clinical pharmacists possess the knowledge, skills, attitudes, and behaviors necessary to deli...

journal_title：Pharmacotherapy

authors： Saseen JJ,Ripley TL,Bondi D,Burke JM,Cohen LJ,McBane S,McConnell KJ,Sackey B,Sanoski C,Simonyan A,Taylor J,Vande Griend JP

更新日期：2017-05-01 00:00:00

abstract：:A 64-year-old woman receiving intravenous chemotherapy for stage IIIB non-small cell lung cancer experienced acute arterial thrombosis of the distal radial and entire ulnar arteries with subsequent arterial occlusion of the right popliteal artery. Two separate arterial occlusions occurred after administration of cispl...

journal_title：Pharmacotherapy

authors： Cool RM,Herrington JD,Wong L

更新日期：2002-09-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the extent to which nitrofurantoin is transferred into human milk. DESIGN:Prospective, single-dose pharmacokinetic study. SETTING:University-affiliated clinical research center. PATIENTS:Four healthy lactating women 8-26 weeks postpartum. INTERVENTION:All subjects received a single, ora...

journal_title：Pharmacotherapy

authors： Gerk PM,Kuhn RJ,Desai NS,McNamara PJ

更新日期：2001-06-01 00:00:00

abstract：:Although in the last few years new antidepressants have become available in the United States, responses in many patients differ, from none, to partial, to delayed therapeutic response to the agents. If the antidepressant properties of these drugs could be enhanced or accelerated, it might be possible to improve patie...

journal_title：Pharmacotherapy

authors： Puzantian T,Kawase K

更新日期：1999-02-01 00:00:00

abstract：:For convenience, many pediatric hospitals are preparing solutions for continuous nebulized albuterol using the 0.5% 20-ml multidose albuterol dropper bottle. This product contains benzalkonium chloride (BAC) that, by itself, produces bronchospasm that is dose dependent and cumulative. The bronchoconstrictive effects o...

journal_title：Pharmacotherapy

authors： Prabhakaran S,Abu-Hasan M,Hendeles L

更新日期：2017-05-01 00:00:00

abstract：:The American College of Clinical Pharmacy (ACCP) published an initial white paper on herbal products in 2000. Since then, the global market for natural products has continued to expand, with tens of millions of consumers using such products on an annual basis in the United States alone. However, despite this expansion...

journal_title：Pharmacotherapy

authors： Gabay M,Smith JA,Chavez ML,Goldwire M,Walker S,Coon SA,Gosser R,Hume AL,Musselman M,Phillips J,Abe AM

更新日期：2017-01-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...

journal_title：Pharmacotherapy

authors： Gomes DM,Ward KE,LaPlante KL

更新日期：2015-04-01 00:00:00

abstract：:Central nervous system stimulants are a commonly used first-line treatment option for attention-deficit/hyperactivity disorder (ADHD). Stimulants are generally well tolerated, with anorexia and insomnia the most common adverse effects. However, there are some concerns with long-term use of stimulants, such as potentia...

journal_title：Pharmacotherapy

authors： Troksa K,Kovacich N,Moro M,Chavez B

更新日期：2019-06-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of hepatotoxicity in critically ill patients who were treated with voriconazole and to identify potential risk factors for voriconazole-associated hepatotoxicity in these patients. DESIGN:Single-center prospective observational study. SETTING:Intensive care unit (ICU) in a ...

journal_title：Pharmacotherapy

authors： Wang Y,Wang T,Xie J,Yang Q,Zheng X,Dong W,Xing J,Wang X,Dong Y

更新日期：2016-07-01 00:00:00

abstract：:Warfarin, a vitamin K antagonist, has been the only orally available anticoagulant for > 60 years. During the past decade, the U.S. Food and Drug Administration has approved several target-specific oral anticoagulants (TSOACs) for the prophylaxis and treatment of arterial and venous thromboembolism and stroke preventi...

journal_title：Pharmacotherapy

authors： Mo Y,Yam FK

更新日期：2015-02-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate claims-related treatment adherence, health care resource utilization, and associated costs of therapy conversion from an insulin vial and syringe to a premixed biphasic insulin analog pen device among privately insured patients with type 2 diabetes mellitus. DESIGN:Retrospective, longitudin...

journal_title：Pharmacotherapy

authors： Cobden D,Lee WC,Balu S,Joshi AV,Pashos CL

更新日期：2007-07-01 00:00:00

abstract：:Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The mai...

journal_title：Pharmacotherapy

authors： Pesaturo KA,Spooner LM,Belliveau P

更新日期：2011-03-01 00:00:00

abstract：:The management of heart failure is complex. Initiating and maintaining drug therapy in patients with heart failure can be challenging. Many factors influence the heart failure syndrome and are important to account for when evaluating these patients. Concomitant diseases such as ischemic heart disease and hypertension ...

journal_title：Pharmacotherapy

authors： Gattis WA

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic data show reduced mycophenolic acid levels in renal transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. This reduced exposure could increase rejection risk. The typical initial MMF dose post renal transplantation is 2 g/day, which often re...

journal_title：Pharmacotherapy

authors： Patel KS,Stephany BR,Barnes JF,Bauer SR,Spinner ML

更新日期：2017-12-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the toxicity of amphotericin B deoxycholate formulations. DESIGN:In vitro experiment. SETTING:University research center. MATERIAL:Human mononuclear THP-1 cells. INTERVENTION:The human mononuclear cells were exposed in vitro for 2 hours to the following deoxycholate formulations of ampho...

journal_title：Pharmacotherapy

authors： Cleary JD,Rogers PD,Chapman SW

更新日期：2003-05-01 00:00:00

abstract：:The primary objective of this study was to determine if a pharmacist-managed anticoagulation monitoring service (AMS) improved the outcomes of patients receiving warfarin in a family practice setting and was cost effective in treating and preventing thromboembolic disorders. A retrospective chart review was performed ...

journal_title：Pharmacotherapy

authors： Wilt VM,Gums JG,Ahmed OI,Moore LM

更新日期：1995-11-01 00:00:00

abstract：:We characterized the effects of peracetic acid-hydrogen peroxide (PAHP) reprocessing on hemodialyzer permeability to water and solutes of various molecular weights and compared these effects within and between dialyzers. An aqueous-based solution containing urea, creatinine, vancomycin, inulin, myoglobin, and albumin ...

journal_title：Pharmacotherapy

authors： Scott MK,Mueller BA,Sowinski KM

更新日期：1999-09-01 00:00:00

abstract：:The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...

journal_title：Pharmacotherapy

authors： Lee CR,Thrasher KA

更新日期：2001-10-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if transitioning patients from a pharmacist- managed anticoagulation clinic after stabilization of warfarin therapy to physician-managed care alters the quality of anticoagulation care. DESIGN:Retrospective medical record review. SETTING:Pharmacist-managed, urban academic medical center-b...

journal_title：Pharmacotherapy

authors： Garwood CL,Dumo P,Baringhaus SN,Laban KM

更新日期：2008-01-01 00:00:00

abstract：:Agitation in the elderly, manifested by verbal and physical aggression, frequently results in increased morbidity and mortality for nursing home residents and reduced morale for the family and nursing home staff. It is also responsible for increased costs associated with caring for these residents. Pharmacologic inter...

journal_title：Pharmacotherapy

authors： Grossman F

更新日期：1998-05-01 00:00:00

abstract：:In critically ill patients with acute renal failure, continuous arteriovenous hemodiafiltration (CAVHD) has become an increasing popular supportive technique. An adult with acute renal failure during CAVHD therapy received fluconazole. Drug clearance by the hemodiafilter system and its total body clearance during the ...

journal_title：Pharmacotherapy

authors： Nicolau DP,Crowe H,Nightingale CH,Quintiliani R

更新日期：1994-07-01 00:00:00

abstract：:Infections caused by yeasts and molds continue to be associated with high rates of morbidity and mortality in both immunocompromised and immunocompetent patients. Many antifungal drugs have been developed over the past 15 years to aid in the management of these infections. However, treatment is still not optimal, as t...

journal_title：Pharmacotherapy

authors： Mohr J,Johnson M,Cooper T,Lewis JS,Ostrosky-Zeichner L

更新日期：2008-05-01 00:00:00

abstract：:Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is associated with high morbidity and mortality. Traditionally, antistaphylococcal penicillins (ASPs) have been considered the agents of choice for the treatment of MSSA bacteremia. Vancomycin has been demonstrated to have poorer outcomes in several studi...

journal_title：Pharmacotherapy

authors： Li J,Echevarria KL,Traugott KA

更新日期：2017-03-01 00:00:00

abstract：:Torsade de pointes is a rare but potentially fatal ventricular arrhythmia that is often triggered by drugs that prolong the rate-corrected QT (QTc) interval. This arrhythmia has been attributed to levacetylmethadol and methadone, synthetic opioids used to treat heroin addiction. Levacetylmethadol, a derivative of meth...

journal_title：Pharmacotherapy

authors： Krantz MJ,Garcia JA,Mehler PS

更新日期：2005-04-01 00:00:00

abstract：STUDY OBJECTIVES:To assess the use and safety of concurrent administration of voriconazole and sirolimus-which is contraindicated-and to determine approaches for appropriately managing patients who receive both drugs. DESIGN:Retrospective medical record review. SETTING:University-affiliated medical center. PATIENTS:...

journal_title：Pharmacotherapy

authors： Surowiec D,DePestel DD,Carver PL

更新日期：2008-06-01 00:00:00