Optimizing pediatric dosing: a developmental pharmacologic approach.

abstract：:This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...

journal_title：Pharmacotherapy

authors： Cooney GF,Mochon M,Kaiser B,Dunn SP,Goldsmith B

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:There are limited markers that could facilitate individualized tacrolimus treatment in the early posttransplantation period. Genetic factors have been found to play critical roles in determining tacrolimus pharmacokinetics. OBJECTIVE:We aimed to examine the association of donor and recipient Toll-like recep...

journal_title：Pharmacotherapy

authors： Ou B,Liu Y,Zhang T,Sun Y,Chen J,Peng Z

更新日期：2019-01-01 00:00:00

abstract：:Aspirin has been used for the prevention and treatment of cardiovascular disease (CVD) for several decades. The efficacy of aspirin for secondary prevention of cardiovascular disease is well established, but the clinical benefit of aspirin for primary prevention of CVD is less clear. The primary literature suggests th...

journal_title：Pharmacotherapy

authors： Nemerovski CW,Salinitri FD,Morbitzer KA,Moser LR

更新日期：2012-11-01 00:00:00

abstract：:Bedaquiline is a diarylquinoline antitubercular drug with a novel mechanism of action against Mycobacterium tuberculosis. Bedaquiline works by inhibiting bacterial adenosine triphosphate (ATP) synthase and represents the first novel class of antituberculosis agents in more than 40 years. Bedaquiline is indicated for t...

journal_title：Pharmacotherapy

authors： Worley MV,Estrada SJ

更新日期：2014-11-01 00:00:00

abstract：:Limited data are available on ceftolozane/tazobactam dosing in patients receiving continuous renal replacement therapy (CRRT). Thus we performed a pharmacokinetic analysis of intravenous ceftolozane/tazobactam in a critically ill patient receiving CRRT at our medical center. A 47-year-old critically ill man with multi...

journal_title：Pharmacotherapy

authors： Bremmer DN,Nicolau DP,Burcham P,Chunduri A,Shidham G,Bauer KA

更新日期：2016-05-01 00:00:00

abstract：:We investigated the effect of endotoxemia on alpha1-adrenergic receptor-mediated smooth muscle contraction as measured by mean arterial pressure (MAP) in response to incremental doses of a vasopressor. Twelve male Sprague-Dawley rats were randomized to receive parenteral nutrition alone (PN) or in combination with a c...

journal_title：Pharmacotherapy

authors： Dickerson RN,Lima JJ,Kuhl DA,Brown RO,Hak LJ

更新日期：1998-01-01 00:00:00

abstract：:It is well recognized that drug absorption from the gastrointestinal tract is influenced by gastric and intestinal motility, surface area available for absorption, and physicochemical properties of the drug. Disease and surgery have been shown to alter these factors. Consequently, drug absorption can be altered as wel...

journal_title：Pharmacotherapy

authors： Gubbins PO,Bertch KE

更新日期：1989-01-01 00:00:00

abstract：STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...

journal_title：Pharmacotherapy

authors： Skrupky LP,Smith JR,Deal EN,Arnold H,Hollands JM,Martinez EJ,Micek ST

更新日期：2010-12-01 00:00:00

abstract：:A 63-year-old man with ventricular tachycardia (VT) refractory to drug therapy was admitted for surgical ablation of the VT with coronary artery bypass graft surgery. He developed increased theophylline concentrations with decreased calculated theophylline clearance after propafenone therapy for recurrent VT was initi...

journal_title：Pharmacotherapy

authors： Spinler SA,Gammaitoni A,Charland SL,Hurwitz J

更新日期：1993-01-01 00:00:00

abstract：:A 37-year-old Hispanic man with advanced acquired immunodeficiency syndrome developed extensive pulmonary disease with persistent cough, fever, night sweats, worsening dyspnea, and weight loss. Sputum samples showed scant growth of acid-fast bacilli. He failed to respond to the standard tuberculosis regimen of isoniaz...

journal_title：Pharmacotherapy

authors： Kang-Birken SL,Prichard JG

更新日期：2006-11-01 00:00:00

abstract：:Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...

journal_title：Pharmacotherapy

authors： Scheibner A,Remmel R,Schladt D,Oetting WS,Guan W,Wu B,Dorr C,Israni A,Jacobson PA

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:The bispectral index (BIS), a processed variable derived from the raw electroencephalogram (EEG) used to guide sedation in the intensive care unit (ICU), has not been tested during barbiturate therapy for elevated intracranial pressure. We determined the BIS and suppression ratio (SR) values during traditiona...

journal_title：Pharmacotherapy

authors： Riker RR,Fraser GL,Wilkins ML

更新日期：2003-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...

journal_title：Pharmacotherapy

authors： Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SL

更新日期：2012-07-01 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a frequently prescribed class of drugs that are generally well tolerated by most patients. A rare, yet serious side effect associated with these drugs is rhabdomyolysis. Although all HMG-CoA reductase inhibitors can cause this adverse effect, pre...

journal_title：Pharmacotherapy

authors： Ravnan SL,Locke C,Yee WP,Haase K

更新日期：2002-04-01 00:00:00

abstract：:Staphylococcus aureus (S. aureus) has proven to be a major pathogen with the emergence of methicillin-resistant S. aureus (MRSA) infections and recently with heteroresistant vancomycin-intermediate S. aureus (hVISA) and vancomycin-intermediate S. aureus (VISA) infections. Although vancomycin is traditionally a first-l...

journal_title：Pharmacotherapy

authors： Gomes DM,Ward KE,LaPlante KL

更新日期：2015-04-01 00:00:00

abstract：:A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-in...

journal_title：Pharmacotherapy

authors： Rubin DI,So EL

更新日期：1999-04-01 00:00:00

abstract：:Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The mai...

journal_title：Pharmacotherapy

authors： Pesaturo KA,Spooner LM,Belliveau P

更新日期：2011-03-01 00:00:00

abstract：:Few patients presenting with acute ischemic stroke (AIS) are eligible for alteplase, especially those receiving ongoing anticoagulation. We describe the first reported case of a patient receiving full-dose intravenous (IV) alteplase for AIS after heparin reversal with protamine. A 73-year-old man presented with AIS. H...

journal_title：Pharmacotherapy

authors： Fontaine GV,Smith SM

更新日期：2017-10-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and use of intravenous human cytomegalovirus immune globulin (CytoGam) in allogeneic bone marrow transplantation (BMT). DESIGN:Prospective, nonrandomized, nonblinded, single-center study. SETTING:University teaching hospital. PATIENTS:Five consecutive patients with he...

journal_title：Pharmacotherapy

authors： DeRienzo SY,Chiang KY,O'Neal WM,Godder K,Abhyankar S,Christiansen NP,Bridges KD,Henslee-Downey PJ

更新日期：2000-10-01 00:00:00

abstract：:A 40-year-old Caucasian man diagnosed with right deep venous thrombosis secondary to trauma was treated with subcutaneous enoxaparin. Within minutes of administering the first dose (1 mg/kg), he experienced an apparent anaphylactoid reaction; symptoms were abdominal pruritus, severe cough, shortness of breath, anxiety...

journal_title：Pharmacotherapy

authors： MacLaughlin EJ,Fitzpatrick KT,Sbar E,Jewell C

更新日期：2002-11-01 00:00:00

abstract：:Ketorolac tromethamine is a highly potent member of a class of compounds having both analgesic and antiinflammatory activity. In animal pain models using underlying inflammation, ketorolac markedly inhibited the pain response and increased the pain threshold; it did not exhibit any narcotic or central nervous system d...

journal_title：Pharmacotherapy

authors： Rooks WH 2nd

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To identify and describe the scope of practice that characterizes the critical care pharmacist and critical care pharmacy services. Specifically, the goals were to define the level of clinical practice and specialized skills characterizing the critical care pharmacist as clinician, educator, researcher, and m...

journal_title：Pharmacotherapy

authors：

更新日期：2000-11-01 00:00:00

abstract：:Subtherapeutic tacrolimus trough concentrations were noted in a 52-year-old woman who had undergone liver transplantation. Her tacrolimus dosage was increased from 7 to 28 mg twice/day, and ketoconazole therapy was added; however, her tacrolimus concentration remained undetectable. Metoclopramide 10 mg 4 times/day was...

journal_title：Pharmacotherapy

authors： Prescott WA Jr,Callahan BL,Park JM

更新日期：2004-04-01 00:00:00

abstract：:Patients with atrial fibrillation (AF) who suffer an acute ischemic stroke are at risk for both hemorrhagic transformation and recurrent ischemic stroke in the acute post-stroke period. Oral anticoagulants are recommended for secondary stroke prevention in patients with AF. The optimal time to initiate anticoagulant t...

journal_title：Pharmacotherapy

authors： Smythe MA,Parker D,Garwood CL,Cuker A,Messé SR

更新日期：2020-01-01 00:00:00

abstract：:The role of the formulary system for effective cost containment is becoming increasingly important. With antimicrobial agents taking up a large proportion of most pharmaceutical budgets, this group of agents is an obvious target for cost reduction. The responsible interchange of selected antimicrobial agents offers a ...

journal_title：Pharmacotherapy

authors： Wright DB

更新日期：1991-01-01 00:00:00

abstract：STUDY OBJECTIVE:To assess patients' perception of care delivery by anticoagulation clinics (ACs) throughout Alberta, Canada. DESIGN:Prospective postal survey. SETTING:Therapy provision by an AC to ambulatory-based patients for a minimum of 3 months across the province. PATIENTS:A total of 1687 patients (67.9%) recei...

journal_title：Pharmacotherapy

authors： Bungard TJ,Barry AR,Jones C,Brocklebank C

更新日期：2013-11-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and dose-proportionality of four dose strengths (5, 10, 20, and 40 mg) of oxymorphone extended release (ER) under both single-dose and steady-state conditions. DESIGN:Randomized, three-period, four-sequence, crossover study. SETTING:Bioavailability clinic. SUBJECTS:Tw...

journal_title：Pharmacotherapy

authors： Adams MP,Ahdieh H

更新日期：2004-04-01 00:00:00

abstract：OBJECTIVE:To determine if asthma control improves in patients who receive physician-pharmacist collaborative management (PPCM) during visits to primary care medical offices. DESIGN:Prospective pre-post study of patients who received the intervention in primary care offices for 9 months. The primary outcome was the sum...

journal_title：Pharmacotherapy

authors： Gums TH,Carter BL,Milavetz G,Buys L,Rosenkrans K,Uribe L,Coffey C,MacLaughlin EJ,Young RB,Ables AZ,Patel-Shori N,Wisniewski A

更新日期：2014-10-01 00:00:00

abstract：:Combination antiretroviral therapy including protease inhibitors such as ritonavir has added significant potency to therapy for human immunodeficiency viral (HIV) infection as well as substantial drug-drug interactions. Methadone metabolism is affected by cytochrome P450 (CYP) 3A4 inhibitors or inducers. Because riton...

journal_title：Pharmacotherapy

authors： Geletko SM,Erickson AD

更新日期：2000-01-01 00:00:00

abstract：:A 32-year-old woman with a history of deep vein thrombosis (DVT), steroid-dependent ulcerative colitis, and osteoporosis was prescribed azathioprine for a steroid-sparing effect. Stable, therapeutic international normalized ratios (INRs) were obtained with warfarin 35 mg/week during a 6-week postpartum course to treat...

journal_title：Pharmacotherapy

authors： Havrda DE,Rathbun S,Scheid D

更新日期：2001-03-01 00:00:00