Abstract:
:A 40-year-old Caucasian man diagnosed with right deep venous thrombosis secondary to trauma was treated with subcutaneous enoxaparin. Within minutes of administering the first dose (1 mg/kg), he experienced an apparent anaphylactoid reaction; symptoms were abdominal pruritus, severe cough, shortness of breath, anxiety, and global pruritus. Physical examination revealed an erythematous macular rash and stridor on auscultation secondary to cervical edema. No other drugs were given before the reaction occurred, and the patient's only drug therapy at home had consisted of a daily multivitamin, and acetaminophen and ibuprofen as needed. Administration of low-molecular-weight heparins such as enoxaparin is increasing, and clinicians must be aware of the potential for adverse drug events such as hypersensitivity reactions.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
MacLaughlin EJ,Fitzpatrick KT,Sbar E,Jewell Cdoi
10.1592/phco.22.16.1511.33688subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1511-5issue
11eissn
0277-0008issn
1875-9114journal_volume
22pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract::An 87-year-old African-American man came to the internal medicine clinic for a routine anticoagulation management visit. He had no complaints. His medical history was significant for stage IV-A follicular non-Hodgkin's lymphoma, atrial fibrillation, and hypertension. His long-term drug therapy consisted of warfarin, f...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.4.583
更新日期:2006-04-01 00:00:00
abstract::In 2006, the American College of Clinical Pharmacy (ACCP) charged the Task Force on Residency Equivalency to define the professional experience expected of a clinically mature practitioner that would meet or exceed the knowledge and skills of an accredited postgraduate year one residency-trained pharmacist. In this co...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.29.12.1495
更新日期:2009-12-01 00:00:00
abstract::A retrospective study evaluated the success of dosages of simvastatin lower than the 10-20 mg/day recommended by the manufacturer in patients with hypercholesterolemia. Records of 95 patients enrolled in a pharmacist-managed lipid clinic receiving stable dosages of simvastatin were reviewed. Data collected were demogr...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.19.6.399.31045
更新日期:1999-04-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has become the most prevalent cause of acute hematogenous osteomyelitis (AHO) in pediatric patients. This increase in MRSA is due to the rise in community-acquired MRSA. Therefore, it is important that clinicians are aware of the various and upcoming therapies that co...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2164
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To review the current pharmacotherapy for idiopathic pulmonary arterial hypertension (IPAH). METHODS:A search of the primary literature was conducted by using MEDLINE, the National Institutes of Health medical research Web site (www.clinicaltrials.gov), and the United States Food and Drug Administration's Ce...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.2006.26.1.68
更新日期:2006-01-01 00:00:00
abstract::Recent evidence suggests that periodontal disease may predispose to atherosclerotic cardiovascular disease. Data support mechanisms of host-derived local and systemic proinflammatory responses similar to atherosclerosis, consisting of monocytic-derived cytokines and other inflammatory mediators, which are induced by p...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.9.805.35189
更新日期:2000-07-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the reproducibility of Naranjo Adverse Drug Reaction Probability Scale (APS) scores in published case reports. DESIGN:Reliability analysis. MEASUREMENTS AND MAIN RESULTS:Randomly selected case reports using the APS were identified from the Web of Science database. The APS scores were blinded...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1496
更新日期:2014-11-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether early administration of adjuvant β-lactam in combination with vancomycin (COMBO) affects clinical outcomes compared to standard vancomycin therapy alone (STAN) among patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection. DESIGN:Retrospective, multic...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究
doi:10.1002/phar.2034
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Vancomycin (VAN) is associated with an increased risk of acute kidney injury (AKI). Evidence is conflicting regarding the risk of AKI when VAN is combined with an antipseudomonal β-lactam. OBJECTIVES:To determine the comparative incidence of AKI when VAN is combined with piperacillin-tazobactam (PTZ) or m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2179
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Our patient experienced acute renal failure but not fulminant hepatic failure from acetaminophen toxicity. OBJECTIVE:To review the clinical and laboratory characteristics of similar cases of acetaminophen nephrotoxicity. METHODS:A MEDLINE search and medical record search at two large teaching hospitals. R...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract::The appropriate level of sedation in patients with an open abdomen following damage control laparotomy (DCL) is debated. Chemical paralysis with neuromuscular blocking agents (NMBAs) has been used to decrease time to abdominal closure. We sought to evaluate the effect of NMBA use on sedation requirements in patients w...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2225
更新日期:2019-03-01 00:00:00
abstract::We characterized the effects of peracetic acid-hydrogen peroxide (PAHP) reprocessing on hemodialyzer permeability to water and solutes of various molecular weights and compared these effects within and between dialyzers. An aqueous-based solution containing urea, creatinine, vancomycin, inulin, myoglobin, and albumin ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.19.13.1042.31587
更新日期:1999-09-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the pharmacokinetic disposition of tobramycin in children undergoing stem cell transplantation (SCT) after intravenous administration either every 24 hours or every 8 hours, and to use this information to create initial dosing guidelines for administration every 24 hours in this patient popu...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.24.6.564.34743
更新日期:2004-05-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01095.x
更新日期:2012-07-01 00:00:00
abstract:STUDY OBJECTIVE:To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. DESIGN:Sixty-four-question survey SETTING:University of Minnesota. SUBJECTS:One hundred sixty-eight male and female Asian and Asian-American students, mean age 21 +/- 3.4 years. MAIN RES...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.22.12.1047.33608
更新日期:2002-08-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the usage patterns of the lipid-based amphotericin B formulations at our institution and to compare the observed nephrotoxicity and efficacy of these formulations. DESIGN:Prospective and retrospective observational study SETTING:Urban 350-bed teaching hospital. PATIENTS:Sixty-seven nonhe...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.21.13.1107.34613
更新日期:2001-09-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the microbiologic and clinical outcomes of patients with extended-spectrum beta-lactamase (ESBL)-producing isolates over a 2-year period. DESIGN:Retrospective analysis. SETTING:Tertiary care teaching hospital. PATIENTS:Twenty-one patients with cultures of confirmed ESBL-producing Escheric...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.12.1232.32706
更新日期:2003-10-01 00:00:00
abstract::Hypertension and diabetes appear to increase coronary heart disease risk in part by causing an abnormality in lipid metabolism. Most affected are patients with familial dyslipidemic hypertension (FDH) and noninsulin-dependent diabetes mellitus (NIDDM). The lipid disorders most often encountered in these patients are i...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1993-07-01 00:00:00
abstract::Methamphetamine is a highly potent and addictive drug that is abused in the United States and around the world. The drug is inexpensive and easily manufactured from simple chemicals such as pseudoephedrine. These features, coupled with its long half-life and highly addictive nature, contribute to the increasing proble...
journal_title:Pharmacotherapy
pub_type: 历史文章,杂志文章,评审
doi:10.1592/phco.26.8.1148
更新日期:2006-08-01 00:00:00
abstract::Omadacycline is a novel aminomethylcycline approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. This article reviews existing data pertaining to the biochemistry, mechanism of action, pharmacokinetics/pharmacodynamics, in vitro activity, and curre...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2185
更新日期:2018-12-01 00:00:00
abstract::Olanzapine has been associated with insulin resistance and new-onset diabetes mellitus. A 27-year-old African-American man developed new-onset severe hyperglycemia-glucose 1240 mg/dl, with ketonuria and acidosis, but no weight gain-2 years after starting olanzapine. Although his diabetes was stabilized with insulin, h...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.17.1448.34421
更新日期:2001-11-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effects of mild-to-moderate induced hypothermia-a neuroprotectant and/or therapeutic strategy for the management of intracranial hypertension in neurologically injured patients-on the pharmacokinetics of aminoglycoside therapy. DESIGN:Pharmacokinetic analysis. SETTING:Critical care un...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.30.7.654
更新日期:2010-07-01 00:00:00
abstract::Aortic stenosis (AS) is the most common form of valvular heart disease. A detailed diagnostic workup is necessary to promptly stage and classify disease severity to determine optimal management. Medical therapy and valvuloplasty are options that fail to delay or reverse disease progression. Surgical aortic valve repla...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2056
更新日期:2018-01-01 00:00:00
abstract::The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.25.4.491.61034
更新日期:2005-04-01 00:00:00
abstract::Resistance of nosocomial and community-acquired pathogens to antimicrobial agents is a serious problem with significant clinical consequences. Microbiologic surveillance data, such as those provided by the National Nosocomial Infections Surveillance System, supply information on current nosocomial pathogens in the Uni...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract::In recent years, there have been many updates in hormonal emergency contraception. Levonorgestrel emergency contraception has been available for several years to prevent pregnancy when used within 72 hours after unprotected intercourse or contraceptive failure, and it was recently approved for nonprescription status f...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.9.887
更新日期:2011-09-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate potential associations between the histamine N-methyltransferase (HNMT) gene, HNMT, C314T (Thr105Ile) polymorphism and atopic dermatitis in a cohort of Caucasian children. DESIGN:Prospective, multicenter, genotype-association study. SETTING:Four academic, tertiary care medical centers w...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究
doi:10.1592/phco.28.12.1495
更新日期:2008-12-01 00:00:00
abstract::Hospital pharmacists are often consulted for their knowledge about coagulation and therapeutic interventions for the management of critical bleeding. Many pharmacotherapies are available for this purpose, both systemic and topical, and others are in development. These agents and their mechanisms of action are reviewed...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.9part2.69S
更新日期:2007-09-01 00:00:00
abstract::Infection due to Mycobacterium tuberculosis continues to plague humanity. In the United States, conditions have taken a decided turn for the worse, with an increasing frequency of infection and the spread of multiple-drug-resistant strains. A number of strategies are available to improve the management of this epidemi...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00
abstract::Many physiologic differences between children and adults can result in age-related differences in pharmacokinetics. Understanding the effects of age on bioavailability, volume of distribution, protein binding, hepatic metabolic isoenzymes, and renal elimination can provide insight into optimizing doses for pediatric p...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.29.6.680
更新日期:2009-06-01 00:00:00