Abstract:
:Combination antiretroviral therapy including protease inhibitors such as ritonavir has added significant potency to therapy for human immunodeficiency viral (HIV) infection as well as substantial drug-drug interactions. Methadone metabolism is affected by cytochrome P450 (CYP) 3A4 inhibitors or inducers. Because ritonavir can induce CYP3A, it can decrease methadone plasma levels. An HIV-infected patient receiving methadone maintenance experienced withdrawal symptoms after ritonavir, saquinavir, and stavudine were added to his regimen; the most likely cause was ritonavir.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Geletko SM,Erickson ADdoi
10.1592/phco.20.1.93.34654subject
Has Abstractpub_date
2000-01-01 00:00:00pages
93-4issue
1eissn
0277-0008issn
1875-9114journal_volume
20pub_type
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