Abstract:
:We present a case of eosinophilic pneumonia due to ceftaroline used for the treatment of methicillin-resistant Staphylococcus aureus bacteremia associated with a postoperative spinal infection. Our patient developed shortness of breath and hypoxemia on the fifth week of ceftaroline therapy. Chest imaging disclosed diffuse bilateral infiltrates. Laboratory abnormalities included peripheral eosinophilia and eosinophilic predominant bronchoalveolar lavage fluid. The combination of ceftaroline discontinuation plus initiation of steroid treatment resulted in complete resolution of signs, symptoms, and radiologic abnormalities. We speculate about possible mechanisms underlying this adverse event and diagnostic criteria for drug-induced eosinophilic pneumonia.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Desai KR,Burdette SD,Polenakovik HM,Hagaman J,Pleiman CMdoi
10.1002/phar.1286subject
Has Abstractpub_date
2013-07-01 00:00:00pages
e166-9issue
7eissn
0277-0008issn
1875-9114journal_volume
33pub_type
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