Abstract:
:Granulocyte-macrophage colony-stimulating factor (GMCSF) is a hematopoietic protein that has been studied both in vitro and in vivo in human immunodeficiency virus (HIV) infection. Since both HIV infection primarily and zidovudine (formerly AZT) treatment secondarily may result in neutropenia, administration of GMCSF to persons with HIV infection is generating considerable interest. Despite in vitro studies demonstrating that the agent may stimulate HIV replication, in the presence of zidovudine a synergistic inhibition of replication occurs. Early clinical studies in patients with the acquired immunodeficiency syndrome indicate that GMCSF can raise neutrophil counts with or without concurrent zidovudine treatment. The long-term safety and tolerance of the combination has to be established.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Hewitt RG,Morse GDsubject
Has Abstractpub_date
1992-01-01 00:00:00pages
455-61issue
6eissn
0277-0008issn
1875-9114journal_volume
12pub_type
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