Abstract:
:Cyclosporine can be given intravenously or orally, as a solution or soft gelatin capsule. Because of the drug's poor water solubility, ethoxylated plant fats and ethanol are added to the commercially available dosage forms.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Yee GCsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
149S-152Sissue
6eissn
0277-0008issn
1875-9114journal_volume
11pub_type
杂志文章,评审相关文献
PHARMACOTHERAPY文献大全abstract::A hiccup is a myoclonic jerk of the diaphragm, and cases of hiccups may last for more than 48 hours (persistent hiccups) or even more than 2 months (intractable hiccups). Current pharmacologic treatment of persistent or intractable hiccups mainly includes antidopaminergic drugs. We describe the case of a 60-year-old m...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1523
更新日期:2014-12-01 00:00:00
abstract::Several pivotal clinical trials have generated new knowledge regarding drug therapy for heart failure. Thus, the Heart Failure Society of America (HFSA) and the American College of Cardiology-American Heart Association (ACC-AHA) guidelines were updated in 2006 and 2005, respectively. We review the evidence from these ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.4part2.12S
更新日期:2007-04-01 00:00:00
abstract::Various pharmacologic agents are available for the treatment of hypercholesterolemia, including 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, commonly referred to as statins, which offer favorable lipid-lowering effects and reductions in morbidity and mortality. Statins are usually better toler...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.24.13.1194.38084
更新日期:2004-09-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.1.36
更新日期:2007-01-01 00:00:00
abstract::Nausea and vomiting are common complaints in the postoperative period and contribute to patient distress and delay of discharge for outpatient surgical procedures. Laparoscopic procedures are associated with a high incidence of postoperative nausea and vomiting (PONV) episodes. Parenteral use of metoclopramide prevent...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-11-01 00:00:00
abstract::This study documents a pharmacokinetic interaction between carbamazepine and cyclosporine (CsA) in pediatric renal transplant recipients. Noncompartmental steady-state CsA pharmacokinetics were determined in three pediatric renal transplant recipients who were receiving both CsA and carbamazepine as long-term therapy ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract::Major depression afflicts a significant percentage of the population, and optimum therapy is often limited by the poor tolerability and lethality in overdose of the tricyclic antidepressants. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline, and, more recently, paroxetine are viewed as welcom...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1994-03-01 00:00:00
abstract:STUDY OBJECTIVE:To describe the pharmacokinetics and pharmacodynamics of fludarabine in patients with rheumatoid arthritis (RA). DESIGN:Open-label, staggered trial conducted in conjunction with a phase I-II clinical trial. SETTING:Government research hospital. PATIENTS:Twenty-six patients with refractory RA. INTERV...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:As tenofovir disoproxil fumarate substantially increases plasma concentrations of didanosine in patients with human immunodeficiency virus-1 infection, we sought to determine whether tenofovir and didanosine showed a similar intracellular interaction in human peripheral blood mononuclear cells (PBMCs). DESIG...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.6.695.32189
更新日期:2003-06-01 00:00:00
abstract::The authors sought to evaluate the impact on length of hospital stay and treatment duration of morphine after implementation of a change in the institutional protocol for managing neonatal abstinence syndrome (NAS) in an effort to improve patient outcomes. A single-center, retrospective chart review was conducted at a...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1966
更新日期:2017-07-01 00:00:00
abstract::The pharmacokinetic disposition of numerous antimicrobial agents is altered in critically ill patients. Pharmacokinetics of trovafloxacin, a fluoroquinolone indicated specifically for severe, life-threatening infections in the intensive care unit, have not been well studied in this population. We characterized the pha...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1592/phco.20.5.400.35056
更新日期:2000-04-01 00:00:00
abstract::The incidence and severity of Clostridium difficile infection (CDI) remain high across intensive care units in the United States despite national efforts to decrease this escalating health care burden. Most published literature and guidelines address treatment rather than prevention, yet this approach may be too downs...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2200
更新日期:2019-03-01 00:00:00
abstract::Use of oral N-acetylcysteine for preventing radiographic contrast material-induced nephropathy (RCIN) has become widespread, despite conflicting results from clinical trials and meta-analyses. The variability in study results may reflect differences in baseline risks in study patients, hydration regimens, choice of co...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.2005.25.8.1095
更新日期:2005-08-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the effects of atorvastatin on low-density lipoprotein cholesterol (LDL) particle size and C-reactive protein (CRP) concentrations in patients undergoing long-term hemodialysis. Another objective was to compare the effects of atorvastatin on lipoprotein profiles as determined by direct ver...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.25.3.335.61599
更新日期:2005-03-01 00:00:00
abstract:STUDY OBJECTIVE:To compare adverse events related to anticoagulation in patients assigned to a pharmacist-managed anticoagulation service versus those receiving usual care. DESIGN:Retrospective cohort analysis. SETTING:Three hundred-bed community hospital. PATIENTS:Four hundred twenty patients referred for anticoagu...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.25.5.685.63582
更新日期:2005-05-01 00:00:00
abstract::An 87-year-old African-American man came to the internal medicine clinic for a routine anticoagulation management visit. He had no complaints. His medical history was significant for stage IV-A follicular non-Hodgkin's lymphoma, atrial fibrillation, and hypertension. His long-term drug therapy consisted of warfarin, f...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.4.583
更新日期:2006-04-01 00:00:00
abstract::Hypertension remains a major risk factor for cardiovascular disease. The optimal choice of pharmacologic and nonpharmacologic treatment regimens is based on a plethora of published literature. This compilation is the initial update to the Key Articles and Guidelines in the Management of Hypertension authored by member...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.28.8.1041
更新日期:2008-08-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the efficacy of a single, low-dose injection of botulinum toxin type A in relieving pain in Korean patients with piriformis syndrome resistant to conventional therapy, and to assess the drug's influence on these patients' quality of life. DESIGN:Prospective, single-site, open-label trial. ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.27.5.657
更新日期:2007-05-01 00:00:00
abstract:STUDY OBJECTIVE:To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN:Prospective follow-up study. DATA SOURCE:General practitioners' computerized patients records (intervention ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.2.254
更新日期:2006-02-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the pharmacokinetics and dose-proportionality of four dose strengths (5, 10, 20, and 40 mg) of oxymorphone extended release (ER) under both single-dose and steady-state conditions. DESIGN:Randomized, three-period, four-sequence, crossover study. SETTING:Bioavailability clinic. SUBJECTS:Tw...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1592/phco.24.5.468.33347
更新日期:2004-04-01 00:00:00
abstract::Peripheral blood has replaced bone marrow as a source of hematopoietic stem cells for autologous rescue after high-dose chemotherapy. Patients who receive peripheral blood stem cell (PBSC) transplants experience rapid and sustained hematopoietic reconstitution. As a result, transplant-related mortality is now less tha...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Colistin, the most widely used polymyxin antibiotic, was originally introduced in the late 1950s before the establishment of the present-day drug approval process. Originally shelved due to toxicity concerns, colistin, in the form of its inactive prodrug colistin methanesulfonate, has undergone a renaissance in the pa...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1484
更新日期:2015-01-01 00:00:00
abstract::A 39-year-old woman was evaluated for possible liver transplantation due to rapidly developing hepatic failure 4 weeks after initiation of oral minocycline 100 mg twice a day for the treatment of acne. The patient developed a maculopapular rash, malaise, fever, nausea, and vomiting 2 weeks prior to admission to the ho...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Acute graft-versus-host disease remains a devastating complication following hematopoietic cell transplantation, resulting in increased morbidity and mortality. Vast research efforts continue to refine or develop new means of prediction, assessment, prevention, and treatment of this syndrome. Recent updates in acute g...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2436
更新日期:2020-08-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effects of low-dose pioglitazone on plasma adipocyte-derived cytokines, high-sensitivity C-reactive protein (hs-CRP), and components of the metabolic syndrome in adults with the metabolic syndrome without diabetes mellitus. DESIGN:Prospective, randomized, double-blind, placebo-controll...
journal_title:Pharmacotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1002/phar.1713
更新日期:2016-03-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.4.405
更新日期:2010-04-01 00:00:00
abstract::Low-molecular-weight heparins (LMWHs) are safe and effective in the treatment of venous thromboembolic disease. Since they require less therapeutic monitoring than unfractionated heparin and may be administered to outpatients, it is possible to decrease overall health care costs of patients diagnosed with deep vein th...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::Fifteen percent of premenopausal women, 10-40% of postmenopausal women, and 10-25% of women receiving systemic hormone therapy experience urogenital atrophy. The most common symptoms are dryness, burning, pruritus, irritation, and dyspareunia. Estrogen loss, drugs, and chemical sensitivities are causes. Estrogen or ho...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.21.5.464.34486
更新日期:2001-04-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effect of Niaspan--a niacin preparation with both immediate- and extended-release characteristics--on lipid and glycemic control in patients with type 2 diabetes. DESIGN:Retrospective study SETTING:Private-practice endocrinology group. PATIENTS:Thirty-two patients (mean age 60 yrs; 7...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.21.20.1473.34481
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:The bispectral index (BIS), a processed variable derived from the raw electroencephalogram (EEG) used to guide sedation in the intensive care unit (ICU), has not been tested during barbiturate therapy for elevated intracranial pressure. We determined the BIS and suppression ratio (SR) values during traditiona...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.10.1087.32766
更新日期:2003-09-01 00:00:00