Abstract:
:A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-induced akinetic mutism in a patient with normal renal function. The pathophysiology of this condition is unknown, but it may result from selective binding of the drug to the gamma-aminobutyric acid-B receptors located in the frontal lobes or thalamic nuclei, interrupting the thalamocortical limbic pathways.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Rubin DI,So ELdoi
10.1592/phco.19.6.468.31053subject
Has Abstractpub_date
1999-04-01 00:00:00pages
468-70issue
4eissn
0277-0008issn
1875-9114journal_volume
19pub_type
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