Abstract:
:Patients who experienced pain after surgery were administered a single dose of 1 of 3 treatments: acetaminophen 1000 mg, codeine phosphate 60 mg, or a combination of these. Patients rated their pain intensity on ordinal and visual analog scales just prior to medication and at intervals thereafter for up to 5 hours. They also rated pain relief, pain half gone, and any adverse effects. Sum of pain intensity difference and total pain relief scores were analyzed using Dunnett's procedure. The drug combination was statistically superior to codeine as measured by SPID, TOTPAR, pain half gone, and time to remedication. The combination achieved better mean scores than acetaminophen on all efficacy measures, but was (marginally) statistically superior only in pain half gone. No appreciable differences in adverse effects were noted among the treatments. The difficulty of showing the analgesic efficacy of codeine in a single dose trial is discussed.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Gertzbein SD,Tile M,McMurty RY,Kellam JF,Hunter GA,Keith RG,Harsanyi Z,Luffman Jdoi
10.1002/j.1875-9114.1986.tb03462.xsubject
Has Abstractpub_date
1986-05-01 00:00:00pages
104-7issue
3eissn
0277-0008issn
1875-9114journal_volume
6pub_type
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