Abstract:
:The effects of proton pump inhibitors on the pharmacokinetics of atazanavir and amprenavir (administered as fosamprenavir) were rigorously evaluated in healthy volunteers in two studies, but formal studies in persons infected with human immunodeficiency virus (HIV) are lacking. We describe a 65-year-old man with HIV who underwent a 12-hour intensive pharmacokinetic study while receiving esomeprazole with atazanavir-ritonavir and subsequently, an 8-hour study while receiving esomeprazole with fosamprenavir-ritonavir. Consistent with the data in healthy volunteers, a major interaction between esomeprazole and atazanavir-ritonavir was observed in this patient-marked reductions in atazanavir trough plasma concentration and in the area under the concentration-time curve from 0-24 hours-whereas an interaction between esomeprazole and fosamprenavir-ritonavir was not apparent in this patient.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Kiser JJ,Lichtenstein KA,Anderson PL,Fletcher CVdoi
10.1592/phco.26.4.511subject
Has Abstractpub_date
2006-04-01 00:00:00pages
511-4issue
4eissn
0277-0008issn
1875-9114journal_volume
26pub_type
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