Abstract:
STUDY OBJECTIVE:To determine whether a relationship exists between medication adherence to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) and distance to dispensing pharmacies and prescribers among an urban public aid population with diabetes mellitus. DESIGN:Retrospective cohort study using claims data. DATA SOURCE:Illinois Department of Healthcare and Family Services database. PATIENTS:A total of 6532 patients aged 18-64 years with diabetes who had at least one prescription fill for an ACEI or ARB and had continuous Medicaid coverage in the greater Chicago area in 2009. MEASUREMENTS AND MAIN RESULTS:We assessed medication adherence, defined as proportion of days covered (PDC) of 0.8 or higher, to ACEIs and ARBs and its association with distances between patients and their pharmacies and prescribers. Of the 6532 patients included in the analyses, 2930 (45%) had PDC levels of 0.8 or higher. No significant differences were observed between patients who were adherent versus those who were nonadherent in distance to pharmacy (median 1.39 vs 1.35 miles, p=0.15) or distance to prescriber (median 4.39 vs 4.48 miles, p=0.80). In a multivariate regression model including age, sex, race/ethnicity, number of pharmacies, number of prescribers, distance to pharmacy, and distance to prescriber, a greater number of prescribers was associated with higher adherence (two prescribers vs one prescriber: odds ratio [OR] 1.396, 95% confidence interval [CI] 1.233-1.580; three or more prescribers vs one prescriber: OR 2.208, 95% CI 1.787-2.727). CONCLUSION:ACEI or ARB adherence was not associated with distances to pharmacies and prescribers.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Syed ST,Sharp LK,Kim Y,Jentleson A,Lora CM,Touchette DR,Berbaum ML,Suda KJ,Gerber BSdoi
10.1002/phar.1757subject
Has Abstractpub_date
2016-06-01 00:00:00pages
590-7issue
6eissn
0277-0008issn
1875-9114journal_volume
36pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract::Widespread anecdotal use of sublingual tacrolimus administration has arisen, although little literature exists to guide practice. Given the paucity of data, we conducted a survey to evaluate the practice of sublingual tacrolimus administration at transplant centers across the United States and evaluated the literature...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1492
更新日期:2014-11-01 00:00:00
abstract::The National Kidney Foundation developed and oversees the Kidney Disease Outcomes Quality Initiative, a process that develops clinical practice guidelines in nephrology. Recent guidelines address the evaluation, classification, and stratification of chronic kidney disease (CKD). These guidelines provide, for the first...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.25.4.491.61034
更新日期:2005-04-01 00:00:00
abstract::The pharmacokinetic disposition of numerous antimicrobial agents is altered in critically ill patients. Pharmacokinetics of trovafloxacin, a fluoroquinolone indicated specifically for severe, life-threatening infections in the intensive care unit, have not been well studied in this population. We characterized the pha...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1592/phco.20.5.400.35056
更新日期:2000-04-01 00:00:00
abstract::Addressing the issue of unintended pregnancy is a national priority. One proposed strategy to reduce unintended pregnancy is to improve access to oral contraceptives by changing them to over-the-counter (OTC) status. Existing data indicate that oral contraceptives meet safety criteria required of OTC products. Availab...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.31.4.424
更新日期:2011-04-01 00:00:00
abstract::We attempted to determine physician prescribing patterns of angiotensin-converting enzyme (ACE) inhibitors in patients who experienced a myocardial infarction, stratified by left ventricular function. We retrospectively reviewed drug therapy at discharge in 534 patients to assess prescription of ACE inhibitor therapy,...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.19.8.655.31524
更新日期:1999-05-01 00:00:00
abstract::Tobacco use continues to be a major cause of morbidity and mortality. Even with behavioral and pharmacologic treatment, long-term tobacco cessation rates are low. Electronic nicotine delivery systems, commonly referred to as electronic cigarettes or e-cigarettes, are increasingly used for tobacco cessation. Because e-...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2103
更新日期:2018-05-01 00:00:00
abstract::The immune system is a complex network of components functioning to provide host defense. This network consists of immunologic cells and their products (e.g., interleukins and colony-stimulating factors), organs, tissues, complement, and major histocompatibility complex antigens. These components are organized into sp...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::A 12-year-old girl with cystic fibrosis was diagnosed with a high-grade glioma after radiographic and biopsy results confirmed the primary intracranial lesion. She was treated with single-agent erlotinib during and after daily localized radiation therapy. Pharmacokinetic studies were conducted to assess the effect of ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.29.7.858
更新日期:2009-07-01 00:00:00
abstract::Acute graft-versus-host disease remains a devastating complication following hematopoietic cell transplantation, resulting in increased morbidity and mortality. Vast research efforts continue to refine or develop new means of prediction, assessment, prevention, and treatment of this syndrome. Recent updates in acute g...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.2436
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To determine if asthma control improves in patients who receive physician-pharmacist collaborative management (PPCM) during visits to primary care medical offices. DESIGN:Prospective pre-post study of patients who received the intervention in primary care offices for 9 months. The primary outcome was the sum...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/phar.1468
更新日期:2014-10-01 00:00:00
abstract::Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract::Intravenous immunoglobulins are biologic substances and differ in many respects from chemical pharmaceuticals. To produce a safe and efficacious preparation, special points must be considered. Careful screening procedures and excluding high-risk donor populations reduce the risk of transmitting viral disease from the ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.1987.tb03512.x
更新日期:1987-01-01 00:00:00
abstract::Diazepam is frequently the subject of review by various agencies and institutions charged with determining whether or not to substitute another, more economical drug--in most instances, chlordiazepoxide. A review of the comparative literature has shown that, on clinical and pharmacokinetic grounds, chlordiazepoxide is...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.1982.tb03181.x
更新日期:1982-03-01 00:00:00
abstract::Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.24.15.199s.43159
更新日期:2004-10-01 00:00:00
abstract::Verapamil hydrochloride, a prototype calcium antagonist, is now marketed in the United States for the acute treatment of supraventricular tachyarrhythmias and for chronic management of vasospastic and chronic stable angina. It inhibits the slow inward channel in in the heart and blocks calcium influx in smooth muscle....
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.1982.tb03210.x
更新日期:1982-11-01 00:00:00
abstract::Anemia is an undertreated but common complication of cancer and is associated with debilitating symptoms that impair the patient's ability to perform daily functions of life. Treatment with darbepoetin alfa, a novel erythropoiesis-stimulating protein, is appropriate for chemotherapy-induced anemia. Guidelines on darbe...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.23.16.110s.31970
更新日期:2003-12-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the absorption profile of cyclosporine after preprandial administration with that after postprandial administration, and to determine which administration time resulted in a more stable absorption profile and the timing of the drug concentration that was the most reliable marker for monitorin...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.25.1.52.55617
更新日期:2005-01-01 00:00:00
abstract:STUDY OBJECTIVES:To compare the effectiveness of bivalirudin and argatroban in achieving anticoagulation goals and to compare clinical outcomes assessing the safety and efficacy in patients with known or suspected heparin-induced thrombocytopenia (HIT). DESIGN:Single-center, retrospective analysis. SETTING:Large tert...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.30.12.1229
更新日期:2010-12-01 00:00:00
abstract::Warfarin, a vitamin K antagonist, has been the only orally available anticoagulant for > 60 years. During the past decade, the U.S. Food and Drug Administration has approved several target-specific oral anticoagulants (TSOACs) for the prophylaxis and treatment of arterial and venous thromboembolism and stroke preventi...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1532
更新日期:2015-02-01 00:00:00
abstract::Postoperative pain is one of the most common forms of acute pain. Optimal pain management decreases the stress response to surgery, reduces complications, improves recovery time, and results in improved economic and quality-of-life outcomes. A preoperative, multimodal approach to postoperative analgesia can be achieve...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.24.17.1714.52339
更新日期:2004-12-01 00:00:00
abstract::Atorvastatin calcium is an HMG-coenzyme A (CoA) reductase inhibitor that was approved by the Food and Drug Administration on December 17, 1996. Like other such agents, it inhibits the action of HMG-CoA reductase and thereby decreases endogenous cholesterol synthesis, leading to a decrease in circulating low-density li...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1997-11-01 00:00:00
abstract::Diabetes mellitus has reached epidemic proportions worldwide, eliciting extensive research on both the disease process and its treatment. Regardless of diabetes type, the progressive nature of the disease makes insulin the long-term mainstay of diabetes management. Recently, the insulin analog glargine was reported in...
journal_title:Pharmacotherapy
pub_type: 杂志文章,实务指引
doi:10.1592/phco.30.9.955
更新日期:2010-09-01 00:00:00
abstract::Several pivotal clinical trials have generated new knowledge regarding drug therapy for heart failure. Thus, the Heart Failure Society of America (HFSA) and the American College of Cardiology-American Heart Association (ACC-AHA) guidelines were updated in 2006 and 2005, respectively. We review the evidence from these ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.4part2.12S
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:There are limited markers that could facilitate individualized tacrolimus treatment in the early posttransplantation period. Genetic factors have been found to play critical roles in determining tacrolimus pharmacokinetics. OBJECTIVE:We aimed to examine the association of donor and recipient Toll-like recep...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2204
更新日期:2019-01-01 00:00:00
abstract::We investigated the effect of endotoxemia on alpha1-adrenergic receptor-mediated smooth muscle contraction as measured by mean arterial pressure (MAP) in response to incremental doses of a vasopressor. Twelve male Sprague-Dawley rats were randomized to receive parenteral nutrition alone (PN) or in combination with a c...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Cytochrome P450 3A5 (CYP3A5) and cytochrome P450 3A4 (CYP3A4) are the predominate enzymes responsible for tacrolimus metabolism. The presence of CYP3A4 and CYP3A5 genetic variants significantly affects tacrolimus clearance and dose requirements. CYP3A5*3 is a loss-of-function variant resulting in no CYP3A5 enzyme prod...
journal_title:Pharmacotherapy
pub_type:
doi:10.1002/phar.2131
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Historically, there is perceived pressure to achieve therapeutic levels of tacrolimus quickly after heart transplant (HT). We evaluated the association between time within therapeutic tacrolimus range and time to therapeutic trough and rejection in the 30 days following HT. METHODS:This is a single-center r...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2262
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Opioid prescribing by dentists for older patients receiving medications with potential contraindications and the subsequent impact on acute care outcomes is not well described. OBJECTIVES:Our objective of this paper was to evaluate the use of potentially inappropriate medication combinations (PIMCs) involvi...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.2452
更新日期:2020-10-01 00:00:00
abstract::We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::A 71-year-old Caucasian woman was admitted to the hospital with right-sided weakness and slurred speech. Glioblastoma multiforme was diagnosed, and resection of the tumor was performed. During the patient's hospitalization, blood and urine cultures were obtained after her temperature rose to 103.3 degrees F. Four bloo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.27.1.161
更新日期:2007-01-01 00:00:00