Insulin Glargine in Critically ill Patients: Once/Day versus Twice/Day Dosing.

abstract：:Evidence and inferences from clinical research, clinical observation, and literature review support an etiologic paradigm for the pathophysiology of spinal cord injury (SCI). According to this paradigm, changes in immunoregulation and in the activation of cytokines or intercellular adhesion molecules (ICAMs) contribut...

journal_title：Pharmacotherapy

authors： Segal JL

更新日期：2005-02-01 00:00:00

abstract：STUDY OBJECTIVE:To describe the pharmacokinetics and pharmacodynamics of fludarabine in patients with rheumatoid arthritis (RA). DESIGN:Open-label, staggered trial conducted in conjunction with a phase I-II clinical trial. SETTING:Government research hospital. PATIENTS:Twenty-six patients with refractory RA. INTERV...

journal_title：Pharmacotherapy

authors： Knebel W,Davis JC Jr,Sanders WD,Fessler B,Yarboro C,Pucino F,Boumpas DT

更新日期：1998-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine if transitioning patients from a pharmacist- managed anticoagulation clinic after stabilization of warfarin therapy to physician-managed care alters the quality of anticoagulation care. DESIGN:Retrospective medical record review. SETTING:Pharmacist-managed, urban academic medical center-b...

journal_title：Pharmacotherapy

authors： Garwood CL,Dumo P,Baringhaus SN,Laban KM

更新日期：2008-01-01 00:00:00

abstract：:The accuracy of 2- and 8- hour urine collections for estimating creatinine clearance was compared with that of the standard 24-hour procedure in 45 hospitalized elderly patients (age > or = 65 yrs) with indwelling urethral catheters. Urine was collected at blocked intervals from 0-2, 2-8, and 8-24 hours and then added...

journal_title：Pharmacotherapy

authors： O'Connell MB,Wong MO,Bannick-Mohrland SD,Dwinell AM

更新日期：1993-03-01 00:00:00

abstract：STUDY OBJECTIVES:To characterize patient sociodemographics and health, describe vancomycin treatment parameters and clinician-rated outcomes, and determine costs associated with treatment including preparation and administration, adverse events, and toxicity. DESIGN:A prospective study to develop a model for costs ass...

journal_title：Pharmacotherapy

authors： Garrelts JC,Horst WD,Silkey B,Gagnon S

更新日期：1994-07-01 00:00:00

abstract：:Low-molecular-weight heparins (LMWHs) are safe and effective in the treatment of venous thromboembolic disease. Since they require less therapeutic monitoring than unfractionated heparin and may be administered to outpatients, it is possible to decrease overall health care costs of patients diagnosed with deep vein th...

journal_title：Pharmacotherapy

authors： Yurkowski P

更新日期：1998-11-01 00:00:00

abstract：:Limited data are available on ceftolozane/tazobactam dosing in patients receiving continuous renal replacement therapy (CRRT). Thus we performed a pharmacokinetic analysis of intravenous ceftolozane/tazobactam in a critically ill patient receiving CRRT at our medical center. A 47-year-old critically ill man with multi...

journal_title：Pharmacotherapy

authors： Bremmer DN,Nicolau DP,Burcham P,Chunduri A,Shidham G,Bauer KA

更新日期：2016-05-01 00:00:00

abstract：:Certification of pharmacotherapy specialists is proceeding smoothly. Modifications to the examination process, which include reapportioning domains, offering the examination at several sites, and establishing the recertification process, have occurred. The guidelines for petitioners and structure of specialization con...

journal_title：Pharmacotherapy

authors： Zarowitz BJ,Vlasses PH,Dukes GE,Gal P,Miller WA,Porter WC,Rush DR,Schneider P,Talbert RL

更新日期：1993-05-01 00:00:00

abstract：:Atorvastatin calcium is an HMG-coenzyme A (CoA) reductase inhibitor that was approved by the Food and Drug Administration on December 17, 1996. Like other such agents, it inhibits the action of HMG-CoA reductase and thereby decreases endogenous cholesterol synthesis, leading to a decrease in circulating low-density li...

journal_title：Pharmacotherapy

authors： Chong PH,Seeger JD

更新日期：1997-11-01 00:00:00

abstract：:A 64-year-old woman receiving intravenous chemotherapy for stage IIIB non-small cell lung cancer experienced acute arterial thrombosis of the distal radial and entire ulnar arteries with subsequent arterial occlusion of the right popliteal artery. Two separate arterial occlusions occurred after administration of cispl...

journal_title：Pharmacotherapy

authors： Cool RM,Herrington JD,Wong L

更新日期：2002-09-01 00:00:00

abstract：:Developing clinical pharmacists' research skills and their ability to compete for extramural funding is an important component of the American College of Clinical Pharmacy's (ACCP) vision for pharmacists to play a prominent role in generating the new knowledge used to guide patient pharmacotherapy. Given the recent em...

journal_title：Pharmacotherapy

authors： Parker RB,Ellingrod V,DiPiro JT,Bauman JL,Blouin RA,Welage LS

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Pharmacokinetic data show reduced mycophenolic acid levels in renal transplant recipients taking mycophenolate mofetil (MMF) and proton pump inhibitors (PPIs) concomitantly. This reduced exposure could increase rejection risk. The typical initial MMF dose post renal transplantation is 2 g/day, which often re...

journal_title：Pharmacotherapy

authors： Patel KS,Stephany BR,Barnes JF,Bauer SR,Spinner ML

更新日期：2017-12-01 00:00:00

abstract：:Pharmacists are uniquely qualified to play essential roles in the clinical implementation of pharmacogenomics. However, specific responsibilities and resources needed for these roles have not been defined. We describe roles for pharmacists that emerged in the clinical implementation of genotype-guided clopidogrel ther...

journal_title：Pharmacotherapy

authors： Owusu-Obeng A,Weitzel KW,Hatton RC,Staley BJ,Ashton J,Cooper-Dehoff RM,Johnson JA

更新日期：2014-10-01 00:00:00

abstract：:Warfarin is a commonly used oral anticoagulant that is usually initiated after the definitive diagnosis of a certain thromboembolic disorder or disease. Warfarin therapy will usually be prescribed for 6-12 weeks or more, and some patients may continue therapy throughout life, depending on the type of thromboembolic di...

journal_title：Pharmacotherapy

authors： Yamreudeewong W,Johnson JV,Cassidy TG,Berg JT

更新日期：1996-11-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the performance of polyclonal fluorescence polarization immunoassay (pFPIA) with that of enzyme-multiplied immunoassay technique (EMIT) in patients receiving vancomycin and hemodialysis. SETTING:Outpatient hemodialysis center. PATIENTS:Seven subjects with end-stage renal disease treated wit...

journal_title：Pharmacotherapy

authors： Kingery JR,Sowinski KM,Kraus MA,Klaunig JE,Mueller BA

更新日期：2000-06-01 00:00:00

abstract：:Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have docu...

journal_title：Pharmacotherapy

authors： Dobesh PP,Wittkowsky AK,Stacy Z,Dager WE,Haines ST,Lopez LM,Nutescu E,Phillips KW,Trujillo TC,Vondracek T

更新日期：2009-04-01 00:00:00

abstract：:The objective of this study was to describe the postinduction clearance of carbamazepine (CBZ) in adult psychiatric patients by population pharmacokinetic analysis using the NONMEM program. Specifically, an estimate of CBZ clearance and insight into the effect of common patient characteristics on clearance were sought...

journal_title：Pharmacotherapy

authors： Martin ES 3rd,Crismon ML,Godley PJ

更新日期：1991-01-01 00:00:00

abstract：:Females of childbearing age represent a large population of solid organ transplant recipients. With fertility commonly restored after transplantation, the possibility of pregnancy becomes a reality for many patients. Since the first published report of a successful pregnancy after solid organ transplantation in 1963, ...

journal_title：Pharmacotherapy

authors： Casale JP,Doligalski CT

更新日期：2016-09-01 00:00:00

abstract：:Telavancin is a once-daily lipoglycopeptide antibiotic structurally derived from vancomycin. It has broad-spectrum activity against gram-positive bacteria, including strains with reduced susceptibility to vancomycin. Telavancin's multifunctional mechanism of action, including inhibition of peptidoglycan synthesis and ...

journal_title：Pharmacotherapy

authors： Leonard SN,Rybak MJ

更新日期：2008-04-01 00:00:00

abstract：:The traditional role of theophylline as a bronchodilator has been expanded by recent findings that suggest this drug has more than smooth muscle relaxant properties. Several investigators indicate that theophylline has an inotropic effect on respiratory muscle, causing enhanced muscular contraction and prevention of m...

journal_title：Pharmacotherapy

authors： Landsberg KF,Vaughan LM,Heffner JE

更新日期：1990-01-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the level of agreement between one subjective definition of major bleeding (criteria A) and two objective definitions: the International Society on Thrombosis and Haemostasis ([ISTH] criteria B) and the Italian Study of Complications of Anticoagulant Therapy ([ISCOAT] criteria C). DESIGN:Retr...

journal_title：Pharmacotherapy

authors： Seto AC,Kenyon K,Wittkowsky AK

更新日期：2008-09-01 00:00:00

abstract：:Hepatic drug metabolism is altered in critically ill patients. The etiology and mechanisms of the alterations are not clearly understood and are difficult to address in clinical studies. For this reason, in vitro and animal models were developed to investigate the effects of critical illness on hepatic drug metabolism...

journal_title：Pharmacotherapy

authors： McKindley DS,Hanes S,Boucher BA

更新日期：1998-07-01 00:00:00

abstract：:We characterized the effects of peracetic acid-hydrogen peroxide (PAHP) reprocessing on hemodialyzer permeability to water and solutes of various molecular weights and compared these effects within and between dialyzers. An aqueous-based solution containing urea, creatinine, vancomycin, inulin, myoglobin, and albumin ...

journal_title：Pharmacotherapy

authors： Scott MK,Mueller BA,Sowinski KM

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. Therefore, the aim of this review is to provide a compreh...

journal_title：Pharmacotherapy

authors： Rizk HG,Lee JA,Liu YF,Endriukaitis L,Isaac JL,Bullington WM

更新日期：2020-12-01 00:00:00

abstract：:Subtherapeutic tacrolimus trough concentrations were noted in a 52-year-old woman who had undergone liver transplantation. Her tacrolimus dosage was increased from 7 to 28 mg twice/day, and ketoconazole therapy was added; however, her tacrolimus concentration remained undetectable. Metoclopramide 10 mg 4 times/day was...

journal_title：Pharmacotherapy

authors： Prescott WA Jr,Callahan BL,Park JM

更新日期：2004-04-01 00:00:00

abstract：:Patients with various rheumatologic and inflammatory disease states commonly require drugs known to decrease the inflammatory or autoimmune response for adequate control of their condition. Such drugs include nonsteroidal antiinflammatory drugs (NSAIDs), cyclooxygenase (COX)-2 inhibitors, corticosteroids, disease-modi...

journal_title：Pharmacotherapy

authors： Busti AJ,Hooper JS,Amaya CJ,Kazi S

更新日期：2005-11-01 00:00:00

abstract：:Nausea and vomiting, common symptoms during pregnancy, often are regarded as an unpleasant but normal part of pregnancy during the first and early second trimesters. Nausea and vomiting of pregnancy (NVP) occurs in approximately 75-80% of pregnant women. The exact etiology and pathogenesis of NVP are poorly understood...

journal_title：Pharmacotherapy

authors： Badell ML,Ramin SM,Smith JA

更新日期：2006-09-01 00:00:00

abstract：:Since the discovery of penicillin 80 years ago, gram-negative bacteria have become proficient at evading the lethal activity of β-lactam antibiotics, principally through the production of β-lactamases. The rapid emergence of penicillinases in both gram-positive and gram-negative bacteria led to the development of ceph...

journal_title：Pharmacotherapy

authors： Rapp RP,Urban C

更新日期：2012-05-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the level of agreement between two sets of criteria, the Thrombolysis in Myocardial Infarction (TIMI) criteria and investigator-developed criteria, for identifying bleeding events in patients who had undergone a percutaneous coronary intervention (PCI) and to measure length of hospital stay ...

journal_title：Pharmacotherapy

authors： McCollum M,Stringer KA,Wittkowsky AK,Young S,Spinler SA

更新日期：2007-01-01 00:00:00

abstract：:Human herpesvirus infections continue to be a concern in immunocompetent as well as immunocompromised hosts. They are often life threatening in the immunocompromised patient. In the healthy immunocompetent person the infections tend to be self-limited, although they can directly or indirectly cause periods of severe d...

journal_title：Pharmacotherapy

authors： Dudley MN

更新日期：1995-09-01 00:00:00