Abstract:
STUDY OBJECTIVE:To compare the performance of polyclonal fluorescence polarization immunoassay (pFPIA) with that of enzyme-multiplied immunoassay technique (EMIT) in patients receiving vancomycin and hemodialysis. SETTING:Outpatient hemodialysis center. PATIENTS:Seven subjects with end-stage renal disease treated with hemodialysis 3 times/week with a cellulose triacetate hemodialyzer. INTERVENTION:Subjects received vancomycin 1000 mg intradialytically during the first study session and 750 mg every other hemodialysis session thereafter for 4 weeks. MEASUREMENTS AND MAIN RESULTS:Blood samples were obtained throughout the study, and vancomycin serum concentrations were determined by pFPIA and EMIT. The mean +/- SD difference (estimate of bias) between assays was -1.10 +/- 1.35 mg/L. The limits of agreement (mean difference +/- 1.96 x SD) between them were -3.80-1.60 mg/L. CONCLUSION:Our data suggest that the manufacturer's changes in the vancomycin pFPIA eliminated overestimation of drug concentrations in patients undergoing high-permeability hemodialysis.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Kingery JR,Sowinski KM,Kraus MA,Klaunig JE,Mueller BAdoi
10.1592/phco.20.7.653.35177subject
Has Abstractpub_date
2000-06-01 00:00:00pages
653-6issue
6eissn
0277-0008issn
1875-9114journal_volume
20pub_type
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