Abstract:
:High-performance capillary electrophoresis (HPCE) is a new separation technique that is applied in the pharmaceutical sciences. Separations by HPCE occur in a narrow-bore capillary under the influence of an applied electrical field. Components of the sample matrix are separated and migrate at different rates based on physicochemical properties, including ionic charge, charge to mass ratio, lipid solubility, and spatial orientation. Detection is achieved through an on-line capillary detection window. The technique has several advantages, such as rapid analysis times, automation, and minute sample volume requirements. However, a significant disadvantage of HPCE is the high concentration limit of detection. Although HPCE will not displace traditional separation techniques, it will add another dimension to existing laboratories.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Brunner LJ,DiPiro JT,Feldman Ssubject
Has Abstractpub_date
1995-01-01 00:00:00pages
1-22issue
1eissn
0277-0008issn
1875-9114journal_volume
15pub_type
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