Expanding Opportunities in the Postacute Long-Term Care Setting: Bringing Medication Safety to the Next Level.

abstract：:Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, occurring in up to 65% of cardiac surgical patients. It is a condition associated with increased morbidity, increased length of hospital stay, and increased health care costs. One of the many potential causes of POAF is...

journal_title：Pharmacotherapy

authors： Worden JC,Asare K

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:As one of the most accessible health care professionals, pharmacists are in an ideal position to provide tobacco-cessation and prevention services. Although there is growing interest in expanding the pharmacist's role in tobacco treatment, few published studies have assessed the efficacy or effectiveness of ...

journal_title：Pharmacotherapy

authors： Dent LA,Harris KJ,Noonan CW

更新日期：2007-07-01 00:00:00

abstract：:Cisplatin in combination with other cytotoxic agents is the backbone for a potential cure of testicular germ cell neoplasms and is a critical factor in the substantial activity observed in the treatment of small cell lung cancer, bladder cancer, and ovarian germ cell tumors. Resistance to cisplatin at the onset of tre...

journal_title：Pharmacotherapy

authors： Gosland M,Lum B,Schimmelpfennig J,Baker J,Doukas M

更新日期：1996-01-01 00:00:00

abstract：:The Institute of Medicine has identified adverse drug events as factors that significantly contribute to increased patient morbidity and mortality. As critically ill patients receive numerous drugs to treat a multitude of complicated health problems, they are at high risk for adverse drug events. Sedation is often a k...

journal_title：Pharmacotherapy

authors： Corbett SM,Montoya ID,Moore FA

更新日期：2008-02-01 00:00:00

abstract：:Stenotrophomonas maltophilia, Burkholderia cepacia complex, Elizabethkingia spp., Chryseobacterium spp., Achromobacter spp., and Alcaligenes spp. are less-common non-lactose-fermenting bacteria that have emerged as important opportunistic pathogens. Patients at the highest risk for these infections include the immunoc...

journal_title：Pharmacotherapy

authors： Spencer HK,Spitznogle SL,Borjan J,Aitken SL

更新日期：2020-09-01 00:00:00

abstract：STUDY OBJECTIVE:To compare the effectiveness of darbepoetin alfa with epoetin alfa (recombinant human erythropoietin [rHuEPO]) for achieving transfusion independence and increasing hemoglobin concentrations in critically ill patients. DESIGN:Retrospective, descriptive study. SETTING:Level I trauma center intensive ca...

journal_title：Pharmacotherapy

authors： Voils SA,Harpe SH,Brophy GM

更新日期：2007-04-01 00:00:00

abstract：:The complexities of oral anticoagulation with warfarin have led to the search for more practical alternative agents. Novel direct factor IIa inhibitors and direct factor Xa inhibitors currently in development can be administered at a fixed dose and do not require routine coagulation monitoring and ongoing dosage adjus...

journal_title：Pharmacotherapy

authors： Wittkowsky AK

更新日期：2011-12-01 00:00:00

abstract：:Graves' disease is an autoimmune process in which the thyroid gland is stimulated by autoantibodies, leading to hyperthyroidism. Graves' disease is the most common cause of hyperthyroid function, primarily affecting women in their 40s and 50s. Treatment may involve oral radioiodine, which is taken up by the follicular...

journal_title：Pharmacotherapy

authors： Kolade VO,Bosinski TJ,Ruffy EL

更新日期：2005-07-01 00:00:00

abstract：:Methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia is associated with high morbidity and mortality. Traditionally, antistaphylococcal penicillins (ASPs) have been considered the agents of choice for the treatment of MSSA bacteremia. Vancomycin has been demonstrated to have poorer outcomes in several studi...

journal_title：Pharmacotherapy

authors： Li J,Echevarria KL,Traugott KA

更新日期：2017-03-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the hemodynamic and electrocardiographic effects of a single dose of commercially available bitter-orange dried-fruit extract, which is increasingly being used in dietary supplements. DESIGN:Randomized, double-blind, placebo-controlled, crossover study. SETTING:University of Connecticut, S...

journal_title：Pharmacotherapy

authors： Min B,Cios D,Kluger J,White CM

更新日期：2005-12-01 00:00:00

abstract：STUDY OBJECTIVES:To evaluate the occurrence of bleeding and venous thromboembolic (VTE) events in patients receiving rivaroxaban, warfarin, or warfarin with the addition of enoxaparin during the immediate postoperative period following major orthopedic surgery. METHODS:Patients older than 18 years who received at leas...

journal_title：Pharmacotherapy

authors： Cieri NE,Kusmierski K,Lackie C,Van Opdorp A,Hassan AK

更新日期：2017-02-01 00:00:00

abstract：:A 67-year-old woman with iron deficiency anemia required parenteral iron therapy and was treated with intravenous ferric gluconate. She tolerated the first dose, but after the second dose, she developed a tingling feeling all over her body, along with swelling in her hands and feet, and a rash with hives over most of ...

journal_title：Pharmacotherapy

authors： Sane R,Baribeault D,Rosenberg CL

更新日期：2007-04-01 00:00:00

abstract：:The incidence and severity of Clostridium difficile infection (CDI) remain high across intensive care units in the United States despite national efforts to decrease this escalating health care burden. Most published literature and guidelines address treatment rather than prevention, yet this approach may be too downs...

journal_title：Pharmacotherapy

authors： Leedahl DD,Personett HA,Nagpal A,Barreto EF

更新日期：2019-03-01 00:00:00

abstract：:Idiopathic recurrent pericarditis (IRP) can be challenging to treat. Even after guideline-directed first-line treatment consisting of aspirin (ASA) or a nonsteroidal antiinflammatory drug (NSAID) in combination with colchicine therapy, recurrences still occur in greater than 20% of patients. Many patients then require...

journal_title：Pharmacotherapy

authors： Schwier NC,Hale GM,Davies ML

更新日期：2017-03-01 00:00:00

abstract：:The American College of Clinical Pharmacy (ACCP) published an initial white paper on herbal products in 2000. Since then, the global market for natural products has continued to expand, with tens of millions of consumers using such products on an annual basis in the United States alone. However, despite this expansion...

journal_title：Pharmacotherapy

authors： Gabay M,Smith JA,Chavez ML,Goldwire M,Walker S,Coon SA,Gosser R,Hume AL,Musselman M,Phillips J,Abe AM

更新日期：2017-01-01 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV) has resulted in significant morbidity and mortality reductions. Lifelong antiretroviral therapy must be incorporated into each patient's medical regimen. Patients with HIV may also have simultaneous chronic medical conditions, resultin...

journal_title：Pharmacotherapy

authors： Fulco PP,Zingone MM,Higginson RT

更新日期：2008-07-01 00:00:00

abstract：STUDY OBJECTIVES:To determine the incidence of Clostridium difficile infection (CDI) at one community hospital by identifying patients with stool samples positive for C. difficile toxin A or B, and to compare the incidence with a 2008 national estimate; and to determine which patient characteristics and concomitant ant...

journal_title：Pharmacotherapy

authors： King RN,Lager SL

更新日期：2011-07-01 00:00:00

abstract：:Venous thromboembolism (VTE) is an important medical problem that affects millions of patients each year. With appropriate prophylaxis, many of these thromboembolic events can be prevented. Although strong evidence supporting VTE prophylaxis spans several decades, several large American and global registries have docu...

journal_title：Pharmacotherapy

authors： Dobesh PP,Wittkowsky AK,Stacy Z,Dager WE,Haines ST,Lopez LM,Nutescu E,Phillips KW,Trujillo TC,Vondracek T

更新日期：2009-04-01 00:00:00

abstract：:The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility ...

journal_title：Pharmacotherapy

authors： Brooks KM,Sherman EM,Egelund EF,Brotherton A,Durham S,Badowski ME,Cluck DB

更新日期：2019-05-01 00:00:00

abstract：:This study compared limited sampling methods (LSM) of estimating area under the plasma concentration versus time curve (AUC) based on a Bayesian regularized neural network, the Bayesian approach, and multiple forward stepwise regression models from selected concentration-time points. Plasma concentration versus time d...

journal_title：Pharmacotherapy

authors： Ng CM

更新日期：2003-08-01 00:00:00

abstract：STUDY OBJECTIVE:Bevacizumab is used in the treatment of recurrent glioblastoma, but evidence is limited on the incidence of thromboembolic complications regarding the use of this drug in real-world settings. We evaluated the risk of arterial thromboembolism (ATE) and venous thromboembolism (VTE) associated with the use...

journal_title：Pharmacotherapy

authors： Lee I,Adimadhyam S,Nutescu EA,Zhou J,Asfaw AA,Sweiss KI,Patel PR,Calip GS

更新日期：2019-09-01 00:00:00

abstract：:Combination antiretroviral therapy including protease inhibitors such as ritonavir has added significant potency to therapy for human immunodeficiency viral (HIV) infection as well as substantial drug-drug interactions. Methadone metabolism is affected by cytochrome P450 (CYP) 3A4 inhibitors or inducers. Because riton...

journal_title：Pharmacotherapy

authors： Geletko SM,Erickson AD

更新日期：2000-01-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did no...

journal_title：Pharmacotherapy

authors： Shields SA,Gregor KJ,Young CH,James SP

更新日期：1998-11-01 00:00:00

abstract：:A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-in...

journal_title：Pharmacotherapy

authors： Rubin DI,So EL

更新日期：1999-04-01 00:00:00

abstract：:Diabetes mellitus has reached epidemic proportions worldwide, eliciting extensive research on both the disease process and its treatment. Regardless of diabetes type, the progressive nature of the disease makes insulin the long-term mainstay of diabetes management. Recently, the insulin analog glargine was reported in...

journal_title：Pharmacotherapy

authors： Edwards KL,Riche DM,Stroup JS,Goldman-Levine JD,Padiyara RS,Cross LB,Kane MP

更新日期：2010-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the pharmacokinetics and dose-proportionality of four dose strengths (5, 10, 20, and 40 mg) of oxymorphone extended release (ER) under both single-dose and steady-state conditions. DESIGN:Randomized, three-period, four-sequence, crossover study. SETTING:Bioavailability clinic. SUBJECTS:Tw...

journal_title：Pharmacotherapy

authors： Adams MP,Ahdieh H

更新日期：2004-04-01 00:00:00

abstract：:Limitations of traditional anticoagulants have led to the need for structured services to provide anticoagulation monitoring. Anticoagulation management services have historically filled this role. Novel antithrombotic agents currently in development have the potential to improve on the limitations of vitamin K antago...

journal_title：Pharmacotherapy

authors： Nutescu EA,Spinler SA,Dager WE,Bussey HI

更新日期：2004-10-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the effect of Niaspan--a niacin preparation with both immediate- and extended-release characteristics--on lipid and glycemic control in patients with type 2 diabetes. DESIGN:Retrospective study SETTING:Private-practice endocrinology group. PATIENTS:Thirty-two patients (mean age 60 yrs; 7...

journal_title：Pharmacotherapy

authors： Kane MP,Hamilton RA,Addesse E,Busch RS,Bakst G

更新日期：2001-12-01 00:00:00

abstract：STUDY OBJECTIVE:To establish the clinical equivalence (noninferiority) of one tablet containing abacavir 300 mg-lamivudine 150 mg-zidovudine 300 mg (Trizivir) versus a tablet containing lamivudine 150 mg-zidovudine 300 mg (Combivir) given with one abacavir (ABC) 300-mg tablet, administered twice/day, in antiretroviral-...

journal_title：Pharmacotherapy

authors： Fischl MA,Burnside AE Jr,Farthing CE,Thompson MA,Bellos NC,Williams VC,Kauf TL,Wannamaker PG,Shaefer MS,ESS40005 Study Team.

更新日期：2003-11-01 00:00:00

abstract：:A major factor in delivering patient care is documenting activities by pharmacists. This documentation is not only essential to sustain existing programs but necessary to justify future growth of resources. A computerized documentation system for clinical interventions and workload activities was developed in a 340-be...

journal_title：Pharmacotherapy

authors： Zimmerman CR,Smolarek RT,Stevenson JG

更新日期：1995-03-01 00:00:00