Prevention of Clostridium difficile Infection in Critically Ill Adults.

abstract：:Recombinant human erythropoietin reverses the severe anemia associated with end-stage renal disease. Mean half-life values after a single intravenous bolus dose range from 4-13 hours. Renal clearance is not a significant route of elimination. Dosing schedules in chronic renal failure involve a single intravenous bolus...

journal_title：Pharmacotherapy

authors： Flaharty KK

更新日期：1990-03-01 00:00:00

abstract：:A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, wi...

journal_title：Pharmacotherapy

authors： McMahon FG,Vargas R

更新日期：1993-07-01 00:00:00

abstract：:This commentary from the 2010 Task Force on Acute Care Practice Model of the American College of Clinical Pharmacy was developed to compare and contrast the "unit-based" and "service-based" orientation of the clinical pharmacist within an acute care pharmacy practice model and to offer an informed opinion concerning w...

journal_title：Pharmacotherapy

authors： American College of Clinical Pharmacy.,Haas CE,Eckel S,Arif S,Beringer PM,Blake EW,Lardieri AB,Lobo BL,Mercer JM,Moye P,Orlando PL,Wargo K

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Historically, there is perceived pressure to achieve therapeutic levels of tacrolimus quickly after heart transplant (HT). We evaluated the association between time within therapeutic tacrolimus range and time to therapeutic trough and rejection in the 30 days following HT. METHODS:This is a single-center r...

journal_title：Pharmacotherapy

authors： Baker WL,Steiger S,Martin S,Patel N,Radojevic J,Darsaklis K,O'Bara L,Kutzler H,Dougherty J,Feingold A,Hammond J,Fusco D,Gluck JA

更新日期：2019-05-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the prevalence, over 40 years, of using the last-observation-carried-forward (LOCF) imputation method in clinical trials, the association between use of LOCF and how the trials were conducted, and the extent of information about attrition and LOCF use in published reports. DESIGN:Retrospec...

journal_title：Pharmacotherapy

authors： Woolley SB,Cardoni AA,Goethe JW

更新日期：2009-12-01 00:00:00

abstract：:We evaluated the efficacy and tolerability of amphotericin B triglyceride emulsion in 16 patients with acquired immunodeficiency syndrome-related candidal esophagitis and cryptococcosis, compared with standard amphotericin B in 24 patients. Compared with the conventional formulation, the fat emulsion was administered ...

journal_title：Pharmacotherapy

authors： Manfredi R,Chiodo F

更新日期：1998-09-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...

journal_title：Pharmacotherapy

authors： Lee CK,Swinford RD,Cerda RD,Portman RJ,Hwang W,Furth SL

更新日期：2012-07-01 00:00:00

abstract：STUDY OBJECTIVE:To assess the reproducibility of Naranjo Adverse Drug Reaction Probability Scale (APS) scores in published case reports. DESIGN:Reliability analysis. MEASUREMENTS AND MAIN RESULTS:Randomly selected case reports using the APS were identified from the Web of Science database. The APS scores were blinded...

journal_title：Pharmacotherapy

authors： Liang R,Borgundvaag B,McIntyre M,Thwaites C,Ragan K,Wyllie A

更新日期：2014-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine the frequency of medication errors, as well as the severity of harm resulting from these errors, related to the prescription, transcription, preparation, and administration of parenteral nutrition formulations. DESIGN:Prospective, observational study. SETTING:471-bed, academic teaching ho...

journal_title：Pharmacotherapy

authors： Sacks GS,Rough S,Kudsk KA

更新日期：2009-08-01 00:00:00

abstract：:Developing clinical pharmacists' research skills and their ability to compete for extramural funding is an important component of the American College of Clinical Pharmacy's (ACCP) vision for pharmacists to play a prominent role in generating the new knowledge used to guide patient pharmacotherapy. Given the recent em...

journal_title：Pharmacotherapy

authors： Parker RB,Ellingrod V,DiPiro JT,Bauman JL,Blouin RA,Welage LS

更新日期：2013-12-01 00:00:00

abstract：:Aneurysmal subarachnoid hemorrhage (SAH) accounts for a significant percentage of morbidity and mortality among patients admitted to neurosurgical centers throughout the world. Even for individuals surviving beyond the initial presentation and intervention for aneurysmal SAH, the occurrence of cerebral vasospasm has t...

journal_title：Pharmacotherapy

authors： Weant KA,Ramsey CN 3rd,Cook AM

更新日期：2010-04-01 00:00:00

abstract：:Antimicrobial lung penetration is thought to be predictive of efficacy in the treatment of lower respiratory tract infections. Lung penetration studies are commonly conducted with new antimicrobial agents to elucidate their potential utility in treating such infections. Although some very useful information may emerge...

journal_title：Pharmacotherapy

authors： Ritrovato CA,Deeter RG

更新日期：1991-01-01 00:00:00

abstract：:Meclofenamate sodium was compared, double-blind, with codeine and placebo for the treatment of acute episiotomy pain. One hundred sixty-eight women with moderate or severe episiotomy pain after normal delivery were assigned randomly to one of four treatment groups: one received meclofenamate sodium 200 mg at dose 1 an...

journal_title：Pharmacotherapy

authors： Hebertson RM,Storey N,Turner JL

更新日期：1986-09-01 00:00:00

abstract：:Few patients presenting with acute ischemic stroke (AIS) are eligible for alteplase, especially those receiving ongoing anticoagulation. We describe the first reported case of a patient receiving full-dose intravenous (IV) alteplase for AIS after heparin reversal with protamine. A 73-year-old man presented with AIS. H...

journal_title：Pharmacotherapy

authors： Fontaine GV,Smith SM

更新日期：2017-10-01 00:00:00

abstract：STUDY OBJECTIVE:To evaluate the effect of a potent experimental leukotriene receptor antagonist, MK-571, on airway responses to inhaled allergen. DESIGN:Randomized, double-blind, placebo-controlled, crossover trial. SETTING:Clinical research center. SUBJECTS:Eight male volunteers with allergic asthma. INTERVENTIONS...

journal_title：Pharmacotherapy

authors： Hendeles L,Davison D,Harman E,Sherman JM

更新日期：1999-11-01 00:00:00

abstract：STUDY OBJECTIVE:To determine whether recommendations made by pharmacists and accepted by hospital physicians resulted in fewer postdischarge readmissions and urgent care visits compared with recommendations that were not implemented. DESIGN:Prospective substudy of pharmacist recommendations. SETTING:Tertiary care aca...

journal_title：Pharmacotherapy

authors： Anderegg SV,Demik DE,Carter BL,Dawson JD,Farris K,Shelsky C,Kaboli P

更新日期：2013-01-01 00:00:00

abstract：:Patients enrolled in a fixed-dose clinical trial of oral ciprofloxacin had trough concentrations measured to document absorption and monitor compliance. The objective was to determine whether any demographic characteristics might be important predictors of the concentrations. Stepwise multivariate linear regression re...

journal_title：Pharmacotherapy

authors： Paladino JA,Forrest A,Wilton JH

更新日期：1993-09-01 00:00:00

abstract：:Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel res...

journal_title：Pharmacotherapy

authors： Momary KM,Dorsch MP,Bates ER

更新日期：2010-03-01 00:00:00

abstract：:Atrial fibrillation is the most common sustained cardiac arrhythmia and is associated with thromboembolic events and hemodynamic impairment that results in considerable morbidity, mortality, and cost. Cardioversion to sinus rhythm is a common approach to the treatment of these patients. However, cardioversion is assoc...

journal_title：Pharmacotherapy

authors： Wodlinger AM,Pieper JA

更新日期：2003-01-01 00:00:00

abstract：:Vancomycin-resistant enterococci (VRE) and methicillin-oxacillin-resistant Staphylococcus aureus (MRSA) originally predominated in large medical centers; however, these isolates are now common in community hospitals and community clinics. No simple answer is available regarding control of antimicrobial-resistant bacte...

journal_title：Pharmacotherapy

authors： Smith DW

更新日期：1999-08-01 00:00:00

abstract：:Infantile spasms describe a pediatric epilepsy syndrome characterized by frequent clusters of brief symmetric muscle contractions; the condition is often associated with developmental delay. When infantile spasms are accompanied by hypsarrhythmia on electroencephalogram, the condition is labeled West syndrome. The mai...

journal_title：Pharmacotherapy

authors： Pesaturo KA,Spooner LM,Belliveau P

更新日期：2011-03-01 00:00:00

abstract：:A few reports in the literature describe zidovudine (AZT) pharmacokinetics in patients undergoing hemodialysis; however, the effect of continuous ambulatory peritoneal dialysis (CAPD) on the drug's disposition has not been studied. The pharmacokinetics of AZT were evaluated in five patients, age 37-62 years, who were ...

journal_title：Pharmacotherapy

authors： Kremer D,Munar MY,Kohlhepp SJ,Swan SK,Stinnett EA,Gilbert DN,Young EW,Bennett WM

更新日期：1992-01-01 00:00:00

abstract：:A 58-year-old man experienced an asthma exacerbation after administration of nicotine nasal spray for smoking cessation. His medical history was significant for asthma, chronic obstructive pulmonary disease, hypertension, and tobacco use when he was prescribed nicotine nasal spray for smoking cessation in an outpatien...

journal_title：Pharmacotherapy

authors： Roth MT,Westman EC

更新日期：2002-06-01 00:00:00

abstract：:The role of the formulary system for effective cost containment is becoming increasingly important. With antimicrobial agents taking up a large proportion of most pharmaceutical budgets, this group of agents is an obvious target for cost reduction. The responsible interchange of selected antimicrobial agents offers a ...

journal_title：Pharmacotherapy

authors： Wright DB

更新日期：1991-01-01 00:00:00

abstract：:Graves' disease is an autoimmune process in which the thyroid gland is stimulated by autoantibodies, leading to hyperthyroidism. Graves' disease is the most common cause of hyperthyroid function, primarily affecting women in their 40s and 50s. Treatment may involve oral radioiodine, which is taken up by the follicular...

journal_title：Pharmacotherapy

authors： Kolade VO,Bosinski TJ,Ruffy EL

更新日期：2005-07-01 00:00:00

abstract：:Stroke is the third most common cause of death in the United States and is the number one cause of long-term disability. Legislative mandates, largely the result of the American Heart Association, American Stroke Association, and Brain Attack Coalition working cooperatively, have resulted in nationwide standardization...

journal_title：Pharmacotherapy

authors： Baldwin K,Orr S,Briand M,Piazza C,Veydt A,McCoy S

更新日期：2010-05-01 00:00:00

abstract：:The clinical significance of rifampin's induction of warfarin metabolism is well documented, but no published studies or case reports have quantified this interaction with respect to the international normalized ratio (INR). A patient receiving concomitant rifampin and warfarin to treat a mycobacterial infection and i...

journal_title：Pharmacotherapy

authors： Lee CR,Thrasher KA

更新日期：2001-10-01 00:00:00

abstract：:Ischemic stroke is a prevalent disease with a large burden on the health system. Preventive strategies, therefore, are paramount. Primary prevention is aimed at reducing the risk of stroke in asymptomatic people. The most effective prevention is through control of modifiable risk factors. Due to the large amount of li...

journal_title：Pharmacotherapy

authors： Baker WL,Marrs JC,Davis LE,Nutescu EA,Rowe AS,Ryan M,Splinter MY,Vardeny O,Fagan SC

更新日期：2013-06-01 00:00:00

abstract：:It is well recognized that drug absorption from the gastrointestinal tract is influenced by gastric and intestinal motility, surface area available for absorption, and physicochemical properties of the drug. Disease and surgery have been shown to alter these factors. Consequently, drug absorption can be altered as wel...

journal_title：Pharmacotherapy

authors： Gubbins PO,Bertch KE

更新日期：1989-01-01 00:00:00

abstract：:A 40-year-old Caucasian man diagnosed with right deep venous thrombosis secondary to trauma was treated with subcutaneous enoxaparin. Within minutes of administering the first dose (1 mg/kg), he experienced an apparent anaphylactoid reaction; symptoms were abdominal pruritus, severe cough, shortness of breath, anxiety...

journal_title：Pharmacotherapy

authors： MacLaughlin EJ,Fitzpatrick KT,Sbar E,Jewell C

更新日期：2002-11-01 00:00:00