Abstract:
:Graves' disease is an autoimmune process in which the thyroid gland is stimulated by autoantibodies, leading to hyperthyroidism. Graves' disease is the most common cause of hyperthyroid function, primarily affecting women in their 40s and 50s. Treatment may involve oral radioiodine, which is taken up by the follicular cells of the thyroid, where it emits ionizing radiation to promote destruction of those cells. Radioiodine therapy is typically safe, effective, and inexpensive. We describe the case of a 51-year-old woman who developed acute promyelocytic leukemia within 27 months of completing a cumulative dose of radioiodine 22.1 mCi (817.7 MBq) for treatment of Graves' disease. Assessment of causality using the Naranjo probability scale showed that a possible relationship existed between this patient's acute promyelocytic leukemia and the use of radioiodine. Strict hematologic follow-up of patients treated with radioiodine may be warranted, along with a high index of suspicion in those with coagulopathy.
journal_name
Pharmacotherapyjournal_title
Pharmacotherapyauthors
Kolade VO,Bosinski TJ,Ruffy ELdoi
10.1592/phco.2005.25.7.1017subject
Has Abstractpub_date
2005-07-01 00:00:00pages
1017-20issue
7eissn
0277-0008issn
1875-9114journal_volume
25pub_type
杂志文章相关文献
PHARMACOTHERAPY文献大全abstract::Use of oral N-acetylcysteine for preventing radiographic contrast material-induced nephropathy (RCIN) has become widespread, despite conflicting results from clinical trials and meta-analyses. The variability in study results may reflect differences in baseline risks in study patients, hydration regimens, choice of co...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.2005.25.8.1095
更新日期:2005-08-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if milk thistle (silymarin) alters the pharmacokinetics of indinavir. DESIGN:Sequential crossover trial. SETTING:General clinical research center. SUBJECTS:Ten healthy subjects. INTERVENTION:Indinavir 800 mg 3 times/day was given for four doses on days 1 and 2. Silymarin 160 mg 3 times/...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.23.7.866.32723
更新日期:2003-07-01 00:00:00
abstract::We attempted to determine if an association exists between vancomycin serum concentrations resulting from traditional dosing regimens, and efficacy and toxicity outcomes. We reviewed the medical charts of 273 consecutive patients prescribed 273 courses of vancomycin therapy for documented, gram-positive bacteremia. Of...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Drug-induced thrombocytopenia is a rare but serious adverse event that has been associated with multiple drugs including β-lactams. Although it mostly occurs with prolonged medication use, some cases of rapid-onset thrombocytopenia have been reported. We describe the case of a 69-year-old man who developed severe and ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1675
更新日期:2015-12-01 00:00:00
abstract::A literature search was conducted to examine the safety and effectiveness of low-dosage methotrexate for treatment and maintenance of remission in patients with inflammatory bowel disease. Nine published articles indicated that for patients with Crohn's disease, oral or intramuscular methotrexate 20-25 mg/week is safe...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.22.8.613.33208
更新日期:2002-05-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if development of acneiform rash is a predictor of objective response rate with lapatinib. DESIGN:Subanalysis of data from a prospective, phase II study. SETTING:Academic breast care clinic. PATIENTS:Forty-nine treatment-naïve patients with human epidermal growth factor receptor-2 (HER2)...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1308
更新日期:2013-10-01 00:00:00
abstract:STUDY OBJECTIVES:To assess the use and safety of concurrent administration of voriconazole and sirolimus-which is contraindicated-and to determine approaches for appropriately managing patients who receive both drugs. DESIGN:Retrospective medical record review. SETTING:University-affiliated medical center. PATIENTS:...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.28.6.719
更新日期:2008-06-01 00:00:00
abstract::A man anticoagulated with warfarin 57.5 mg/week (international normalized ratio [INR] 1.94) was diagnosed with nonsmall cell lung cancer and prescribed weekly gemcitabine. With the first dose of the first cycle, his INR rose to 3.52, and his weekly warfarin dose was decreased to 52.5 mg. The lower warfarin dose was co...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.19.16.1331.30873
更新日期:1999-11-01 00:00:00
abstract::A pharmacist consult service was developed to evaluate the appropriateness of enteral feeding through a permanent ostomy in 24 nonambulatory patients with severe developmental disabilities. Several problems with enteral nutrition were identified. Policies to improve them were instituted, and several educational presen...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:STUDY OBJECTIVE:To determine prescribing patterns and clinical outcomes of enoxaparin for anticoagulation of atrial fibrillation. DESIGN:Retrospective analysis. SETTING:A 650-bed, tertiary care, community teaching hospital. SUBJECTS:Two hundred thirteen patients who received enoxaparin for thromboprophylaxis during ...
journal_title:Pharmacotherapy
pub_type: 临床试验,杂志文章
doi:10.1592/phco.23.5.651.32208
更新日期:2003-05-01 00:00:00
abstract:STUDY OBJECTIVES:To determine the frequency and type of complementary and alternative medicine (CAM) use among healthy volunteers participating in research, and to investigate the potential for interactions between commonly used CAM modalities and various drugs. DESIGN:Prospective evaluation. SETTING:University gener...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.26.12.1794
更新日期:2006-12-01 00:00:00
abstract::Since the discovery of penicillin 80 years ago, gram-negative bacteria have become proficient at evading the lethal activity of β-lactam antibiotics, principally through the production of β-lactamases. The rapid emergence of penicillinases in both gram-positive and gram-negative bacteria led to the development of ceph...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/j.1875-9114.2012.01035.x
更新日期:2012-05-01 00:00:00
abstract:STUDY OBJECTIVE:To assess patients' perception of care delivery by anticoagulation clinics (ACs) throughout Alberta, Canada. DESIGN:Prospective postal survey. SETTING:Therapy provision by an AC to ambulatory-based patients for a minimum of 3 months across the province. PATIENTS:A total of 1687 patients (67.9%) recei...
journal_title:Pharmacotherapy
pub_type: 杂志文章,多中心研究
doi:10.1002/phar.1318
更新日期:2013-11-01 00:00:00
abstract::In patients infected with chronic hepatitis B virus (HBV) that goes untreated, therapeutic options are limited once the disease decompensates, and orthotopic liver transplantation is often the only treatment available to save the patient's life. After liver transplantation, combined therapy with hepatitis B immune glo...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1306
更新日期:2013-09-01 00:00:00
abstract::Starting lipid-lowering therapy in the hospital, especially with statins, has become an important component in the management of patients with acute coronary syndromes (ACS). It improves outcomes and increases patient motivation and long-term adherence. In addition, discontinuation of statin therapy in patients with A...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.23.4.506.32129
更新日期:2003-04-01 00:00:00
abstract::The Institute of Medicine has identified adverse drug events as factors that significantly contribute to increased patient morbidity and mortality. As critically ill patients receive numerous drugs to treat a multitude of complicated health problems, they are at high risk for adverse drug events. Sedation is often a k...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.28.2.250
更新日期:2008-02-01 00:00:00
abstract::Albuterol is a 50:50 mixture of R-albuterol, the active enantiomer, and S-albuterol, which appears to be inactive in humans. The Food and Drug Administration recently approved levalbuterol, the pure R-isomer, as a preservative-free nebulizer solution. Published studies indicate that it is neither safer nor more effect...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.20.3.123.34776
更新日期:2000-02-01 00:00:00
abstract::A 39-year-old woman was evaluated for possible liver transplantation due to rapidly developing hepatic failure 4 weeks after initiation of oral minocycline 100 mg twice a day for the treatment of acne. The patient developed a maculopapular rash, malaise, fever, nausea, and vomiting 2 weeks prior to admission to the ho...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract::Antiretroviral therapy has significantly improved the typical course of human immunodeficiency virus (HIV) infection in industrialized nations, and life expectancies associated with the infection have increased. However, infection rates have generally remained unchanged, with increases noted among certain subpopulatio...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.30.10.1021
更新日期:2010-10-01 00:00:00
abstract::In recent years, there have been many updates in hormonal emergency contraception. Levonorgestrel emergency contraception has been available for several years to prevent pregnancy when used within 72 hours after unprotected intercourse or contraceptive failure, and it was recently approved for nonprescription status f...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.31.9.887
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:As one of the most accessible health care professionals, pharmacists are in an ideal position to provide tobacco-cessation and prevention services. Although there is growing interest in expanding the pharmacist's role in tobacco treatment, few published studies have assessed the efficacy or effectiveness of ...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1592/phco.27.7.1040
更新日期:2007-07-01 00:00:00
abstract::Panic disorder is a frequently chronic condition with extensive patterns of psychiatric comorbidity. Optimum pharmacotherapy with traditional agents is limited by side effects, long-term tolerability, and other problems. Recent research findings support the characterization of panic disorder as an illness involving de...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-01 00:00:00
abstract::With the emergence of new anticoagulants, clinicians need a thorough understanding of coagulation assays. Various laboratory assays exist to measure the effectiveness of anticoagulants. Coagulation assays are the primary method for measuring the effectiveness of anticoagulants; therefore, a comprehensive understanding...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:10.1002/phar.1283
更新日期:2013-11-01 00:00:00
abstract::The pharmacokinetics of methylprednisolone sodium succinate (MPHS) and methylprednisolone (MP) were determined in six patients undergoing open heart surgery with cardiopulmonary bypass. Plasma concentrations of both compounds were measured by high-performance liquid chromatography after doses of MPHS of 1.7-2.4 g. The...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::Levonorgestrel implants (Norplant) are an alternative to oral contraceptives and medroxyprogesterone acetate intramuscular injections. An interaction may exist between levonorgestrel and agents that induce the hepatic microsomal enzyme system. A 21-year-old woman with a history of a seizure disorder, treated with phen...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a rare, complex, idiosyncratic drug reaction that can be fatal. Systemic symptoms include lymphadenopathy, hepatic failure, and possibly renal failure. The syndrome has been primarily associated with anticonvulsants, whereas antimicrobials are less ...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/phar.1142
更新日期:2012-12-01 00:00:00
abstract::Combination antiretroviral therapy including protease inhibitors such as ritonavir has added significant potency to therapy for human immunodeficiency viral (HIV) infection as well as substantial drug-drug interactions. Methadone metabolism is affected by cytochrome P450 (CYP) 3A4 inhibitors or inducers. Because riton...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1592/phco.20.1.93.34654
更新日期:2000-01-01 00:00:00
abstract::Infection due to Mycobacterium tuberculosis continues to plague humanity. In the United States, conditions have taken a decided turn for the worse, with an increasing frequency of infection and the spread of multiple-drug-resistant strains. A number of strategies are available to improve the management of this epidemi...
journal_title:Pharmacotherapy
pub_type: 杂志文章,评审
doi:
更新日期:1993-11-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the accuracy of four equations based on serum creatinine concentration-the original Schwartz equation and the Leger, Bedside Chronic Kidney Disease in Children (CKiD), and Counahan-Barratt equations-for determining glomerular filtration rate (GFR) in pediatric patients with chronic kidney di...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:10.1002/j.1875-9114.2012.01095.x
更新日期:2012-07-01 00:00:00
abstract::We conducted a retrospective analysis to evaluate the relationship between anxiolytic or hypnotic therapy and maintenance of therapy with selective serotonin reuptake inhibitors (SSRIs). Subjects were 654 patients who received anxiolytics or hypnotics early in SSRI therapy (study group ) and 15,172 patients who did no...
journal_title:Pharmacotherapy
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00